We have seen through the human genome project data that “gene theory” alone can not explain the complexity of human life when we have fewer genes than our ancestors, and yet, we have extraordinary physiologic traits never seen before in our primate tree. Might there be another way to transfer information other than DNA? This series has shown you that in fact, there is another method to go this. That is the big implication of QT#1.
Might it be that the information in a proton be able to change DNA? I believe it is . WE know DNA has a massive array of proton tunneling taking place we just have no idea how it happens. QT # 1 give you my idea of how I think it is happening every moment.
Darwinian biology describes phenomena that are a result of a myriad of interactions but have no particular dominant factor at play. Genetics is 180 degree opposite this paradigm today. They believe there is a reductive pathway from a gene to cell to tissue to physiologic function to explain everything we observe in life, and then we have QED who says we can have “spooky action at a great distance” because of nonlocality, quantum tunneling, etc. The organic chemists believe that there is no such action possible at a distance in chemistry. No wonder modern medicine is a mess! We know energy and information about electrons and protons transfer and that input come from sunlight. It is based on the core beliefs of these fields as well. Your results are this way because of this thinking that science should be studied in special areas independent of a more global view. Medicine today, is like a giant game of telephone.
When you were kid it was funny to see how the message was changed by a chain of people as the message passed to other people. I have a sense our DNA and RNA gets those information transfers from protons. The main different between these examples is today in medicine, the message is seeing your health disappear as one person talks to another via a journal filled with RCT instead of using nature’s wisdom in proton quanta transfer.
Instead of a reductive view, we need a top-down approach, to include all principles to come up with a 30,000 foot understanding of how life works using biology, chemistry, and physics. The study of circadian biology is the best place for this to begin, in my humble view, because this is where protons learn their lessons, from the teacher, the sun.
It is hard to repair this mechanism when you have no idea that the loss resonant energy transfer from the nnEMF to electrons and protons is changing the messages from the Sun and Earth. The mechanism is clearly found in QED theory to water is behind “the curtain” causing all neolithic disease. If you scour the chronobiology literature every known disease has a link back to problems with the molecular clock at some level. Sadly, no one is making these connections yet. But they are getting what I have been saying for 13 years.
I am in the process now of releasing my 5G hacks in the CPC blogs because 5G is now a reality in most USA cities in case you do not know it. The Big carriers are now actively unleashing the network by testing its functionality in many cities. In QT #1 and #2 you are seeing how it links to mitochondrial function by making sense of second law of thermodynamics in mitochondria.
For 150 years no one has questioned to see if science has missed something quite basic in this law. Maxwell, wrote a letter to a friend who laid the case out clearly. I am going to put some data on what I told you in QT #1.
Some people will find this science dense but it won’t be for those of you who have been keeping up with your reading to see how things are coming together.
Now, the question should be………..
Why is it that some mammals can live in freezing cold regions of Earth with little sunlight and modern humans worry about hypothermia in temperatures that are not even close to this cold?
What is the thermodynamic issue here?
THE ANSWER: The foundations of “Quantum thermodynamics.”
What did I teach you about long ago about how polar bears and penguins repel cold temperatures so they can live in polar water? How did they do it? Why do we struggle with it?? What do they both eat and where do they both live? What is special about that environment? Is there something special about these animals compared to us? Do you sense an entanglement yet with these concepts? A food guru will struggle to see the gorgeous threads nature provide living quantum systems. A mitochondriac will begin to see something different.
The invisible threads nature weaved into electron and proton spin are the strongest ties in the Quilt of our lives. Today this blog is about the foundations of thermodynamics in living systems. How these new concepts link to the quantum spin states of electrons and protons in mitochondria are critical to get correct before we can see nature’s wisdom manifest in tissues.
ELECTRONS/PROTONS and THE STANDARD MODEL
The Standard Model of particle physics, tries to get at what exists in the universe (matter), the laws of thermodynamics only say what can and can’t be done with this matter. But one of the strangest things about the theory is that these rules seem subjective because the idea of dissipation of energy depends on the extent of our KNOWLDEGE. Yes, you read that correctly. What is possible thermodynamically in any system depends 100% on the extent of what we know about that system.
This implies that any study of the thermodynamics of quantum systems means you must accept that what you do not know is the single most important part of the equation. This idea forces you to realize the Dunning Kruger (DK) effect is not some amorphous concept, but something that PHYSICALLY matters deeply in living systems. DK is not a cognitive bias, it is actually a REAL physical thing. I hinted at this in the Tensegrity 13 blog.
“Quantum thermodynamics” is a field in the making that will completely change how medicine is delivered globally, in my opinion.
The paradox hinting at the connection between thermodynamics and information, was put forth by James Clerq Maxwell in 1867 in a letter he wrote to a friend. In this letter the concept of a “Maxwell demon” was born. The demon concept he mentioned was a thought experiment that really was all about informtion transfer in the system and not about the transfer or transmutation of energy. Most people lost that nuance until information theory in quantum computing was mentioned by Feynman in the 1960’s. The ‘paradoxical demon‘ he came up with in this letter concerned the second law of thermodynamics — the rule that entropy always increases in systems. Today, we now know that entropy can lead to self assembly and order. This new idea is also rather shocking to the foundation of physics. It challenges everything we know today about how heat operates. The new data on entropy is beginning to make physics stop buying its own hype around classic interpretations of thermodynamics.
JACK, WHY DOES THIS MATTER?
Ask better questions when you get new bits of information.
Why do things organize they way they do? Is it only chemical or electrostatic interactions, or is there something else we’re missing?? Look at the picture of my rhubarb below.
What allows them to assume this pattern? Is it a chemical bond? Is it a hydrogen bond? Is it electrostatics? No, it is none of those things. The pattern emergence come from the entropy I introduced into the system by way of the crafty knife cuts I put on all the pieces as I put them in the pot.
JACK, WHY IS THIS IMPORTANT?
EMERGENCE — the phenomenon whereby simple objects give rise to surprising collective behaviors. For example, consider the tetrahedra crystal; it’s the simplest Platonic solid — the simplest three-dimensional shape. When they arrange with one another based solely on entropy (randomness), meaning they have no direct physical interactions between them — they didn’t want to stick together; there’s no charges; there’s no nothing binding them but their shape. Using entropy alone, the tetrahedra organize into a quasicrystal format — this really complex, ordered structure. Take a look at the picture above again. That is a topologic organization. Now I want to make you look back to another blog. Go look at the first picture you see in the TIME #24 blog right now. Do you see anything that is similar to the picture above?
Nature organizes living quantum systems using nothing but entropy.
Order in biology, always emerges from DISORDER.
At its core, nature is asymmetric because of this design.
Mathematics actually now contains proofs that show this is true even though it is counterintuitive to logic and reason. Logic and reason are not good enough to understand how nature operates, it appears. It may show you why many of the things I post about seem to shock those people whose brains are filled with conventional ideas. To see how order hides within chaos, imagine coloring number pairs in an infinite set according to this rule in this HYPERLINK
People normally understand the law of increasing entropy as the tendency of things to get messier, but science and mathematics are now reporting that entropy leads to order in nature too.
The philosopher steeped in epistemology will say, “Jack, Why is that not a paradox thermodynamically?”
ANSWER: CARNOT TRUTH WAS A HALF TRUTH: CARNOT NO MORE
Maxwell wondered how a law of nature could depend on one’s knowledge — or ignorance — of the positions and velocities of molecules. He realized that the Dunning Kruger effect could be at play behind dissipative structures long ago because of what he wrote in that letter. Ilya Prigogine developed the concept and contributed to the theories of dissipative structures for which he won the 1977 Nobel Prize in Chemistry. Maxwell is who gave Prigogine confidence to guess correctly to get that Prize. Good science always begins with a good guess. Maxwell sensed that the things we do not know now, might lead to massive changes in our beliefs down the road. He wrote that in his letter to his friend about his ‘demons.‘
If the second law of thermodynamics depends subjectively on one’s information, in what sense is it true? Maybe, it is not always absolute and maybe living quantum systems are the observable fact of his warnings from that letter?
Ludwig Boltzmann showed that energy disperses, and entropy increases, as a simple matter of statistics: There are many more ways for energy to be spread among the particles in a system than concentrated in a few, so as particles move around and interact, they naturally tend toward states in which their energy is increasingly shared. Maxwell described his thought experiment in which “an enlightened being” — we later called Maxwell’s demon — uses its knowledge it acquired from the environment to lower entropy and appear to violate the second law from an energy perspective.
Maxwell theorized to do this, the “demon” had to know the positions and velocities of every molecule in a container of gas. By partitioning the container and opening and closing a small door between the two chambers, the demon lets only fast-moving molecules enter one side, while allowing only slow molecules to go the other way. The demon’s actions divide the gas into hot and cold, concentrating its energy and lowering its overall entropy. The once useless gas can now be put to work. Paraphrasing his own words, this is how he believed life might finds a way to win.
He had no idea that quantum spin could share information to other conserved traits of nature. If he had, he would have relaized that every electron and proton is a Maxwell demon.
Could it be that the real demon in our mitochondria is the a trap door that does this for deuterium and light hydrogen?
Today classic thermodynamic theory separates information and energy when it is taught to scientists and engineers. This has not caught the attention of biology yet. Information is now known to be a physical thing in quantum thermodynamics.
KEY POINT: The more information the living system can acquire, the more work that system can extract from any living system. Does this mean that information and consciousness might be linked via an emergent property of matter? Yes, I believe it does. Now with the insights from information theory, we wouldn’t and cannot say entropy is a property of a system, but a property of an observer who describes a system.
This is very different from the past. It implies information cannot be lost because like angular momentum and charge it is a conserved property in nature.
The present state of the universe preserves all information about the past. Understanding entropy as a subjective measure allows the universe as a whole to evolve without ever losing any information. They is understanding how the information is transferred. Even as parts of the universe, such as coffee, engines and people, experience rising entropy as their quantum information dilutes, the global entropy of the universe stays forever zero satisfying the 2nd law at all times.
The relationship among information, energy and other “conserved quantities,” can “change hands” but never be destroyed, took a new turn in 2017. Two groups of researchers found that the quantum information describing the particles’ energy and quantum spin states can act as a kind of currency that enables trading between the reservoir’s energy and angular momentum supplies. I covered this in the April 2018 webinar called QT #1.
This has a big implication for mitochondriacs because this organelle deals exclusively in the spin of electrons and protons and the energy and information they contain.
The notion that conserved quantities in subatomic particles can be traded for one another in quantum systems is brand new to thermodynamic science and really helps us understand what mitochondria and chloroplasts are really up to inside living systems. They are casino dealers of information about our environment.
This work suggested to me the need for a more complete thermodynamic theory had to exist within the framework of the second law that would help explain life more fully. This idea would describe not only the flow of energy and information, but also the interplay between all the conserved quantities in the universe in our cells.
Angular momentum and charge are two such conserved factors that continue to confuse scientists today. If biology realized that the addition or subtraction of electrons and protons could change proteins they’d realize finally why we do not need DNA/RNA change to explain the human genome. More complex animals can have less genes, but gain their complexity because they have systems in them that allow them to extract more information than lower animal forms.
For example, consider the human brain compared to the chimpanzee brain.
Fundamental Brain Development
In mammals, the nervous system develops from ectoderm, the surface layer of the gastrula. Later in development, the mesoderm gives rise to the notochord, which releases the organizer proteins noggin and chordin. These proteins block the suppressive effects of bone morphogenetic protein (BMP), allowing the ectoderm to form the neural plate, then the neural tube, and eventually the ventricular system, where neurogenesis proceeds within the walls of the tube to form the CNS, including the brain and spinal cord (Butler & Hodos, 2005; Siegel & Sapru, 2015). The neural plate and neural tube are composed of a single layer of neuroepithelial cells, which can be considered as neural stem cells (NSCs) (Gotz & Huttner, 2005). After closure of the neural tube, neuroepithelial cells undergo asymmetric division to generate a daughter stem cell, plus a more differentiated cell, such as a radial glial (RG) cell or a neuron (Gotz & Huttner, 2005; Huttner & Brand, 1997). With the switch to neurogenesis, all neuroepithelial cells undergo a transformation and give rise to RG cells. RG cells are fate-restricted progenitors, which can either generate nascent neurons by symmetric division or undergo self-renewal by asymmetric division (Gotz & Huttner, 2005; Yao & Jin, 2014).
The epigenetic changes to cytosine in the human brain is all it took to change the chimp brain to homo. Methylation adds 3 H+ atoms to every cytosine and this allows us to transfer massive amounts of information to the neurons in our frontal lobes. This simple change is the largest difference between us and chimps and allows us to have less genes than they do. Why is having less genes an advantage to humans? It saves us in energy costs as Wallace has pointed out in his papers! How does this happen?
5-hydroxymethylcytosine (5-hmC), a derivative of 5-methylcytosine (5-mC), is abundant in the brain. Methyl groups have 3H+ on each one. The rediscovery of 5-hmC in mammals demonstrates that covalent DNA modifications are more dynamic than previously believed. Is the reason why the brain, especially the frontal lobes and neocortex are loaded with H+ on cytosine residues and how these cells get more information during morphogenesis?
Yes it is. How?
A protein called nogging mention in Quantum Biology #7 blog post 5 years ago is loaded with deuterium and this protein from our bone cells is used to control brain growth in humans.
Noggin has a very interesting protein structure that can modify human brain growth by altering cytosine.
Hydrogen/deuterium exchange in spaces or proteins can be monitored by mass spectrometry (HDX-MS). HDX-MS has recently emerged as a powerful method for characterizing protein conformational dynamics. The basis of this method is the fact that backbone amides in stable hydrogen-bonded structures (e.g., α-helices and β-sheets) are protected against exchange with the aqueous solvent like extracellular water from the blood plasma, lymph, or the interstitium.
All protein structures are dynamic, however, and eventually all of the protecting hydrogen bonds will transiently break as the protein—according to thermodynamic principles—cycles through partially unfolded states that correspond to excited free energy levels. As a result, all of the backbone amide groups in proteins will eventually become temporarily solvent-exposed and exchange-competent over time.
Consequently, a folded protein in D2O will gradually incorporate deuterium into its backbone amide hydrogen fractionation and this will change its physiologic abilities because H+ delivers more information than deuterium can. Unfolded proteins react differently. Deuterium however can cause matrix swelling to drive tissue proliferation compared to H+. Since humans have a large amount of deuterium in their blood plasma this source can be tightly controlled to affect the ECF space to change the kinetics of the process. This process can be readily monitored by mass spectrometry. How is the process controlled? The optical swtich that is deuterium fractionation between the blood and matrix.
It seems to me, living quantum systems are experts in the information sharing side of the equation to organize matter in specific ways in mitochondria, while simultaneously minimizing chaos, while extracting massive amounts of information about the universe they exist in.
This means that Dr. Doug Wallace might be on “the wrong side” of understanding too. It is not energy that is key to the black swan mitochondriac……..it is information transfer that is MOST critical.
I think what Doug has found in the inter-mitochondrial junctions (IMJ) of mitochondria is not just tied to energy (see bottom right of pic below). IMJ’s are electron dense structures. IMJ’s are conserved across species, resistant to genetic disruption of cristae organization, dynamically modulated by mitochondrial bioenergetics, independent of known inter-mitochondrial tethering proteins mitofusins and are rapidly induced by the stable rapprochement of organelles via inducible synthetic linker technology. The information from eleectrons protons and light appears to lead to the rearrangements in the cristae maybe the key to how energy is made. Wallace has focused on the energy angle because that is all he can measure. Information transfer from quantum spin to angular momentum is not easy to measure in living systems. We know information transfer show macroscopic shape changes in matter. The changing crystals in proteins, lipids, and water is critical to understanding how information alters physiologic function.
It should be obvious this new idea in quantum thermodynamics is massively important to a mitochondriac, but one has to be careful with this concept, because information does behave differently than other physical properties, like power, torque, and space-time.
HOW DOES THIS SITUATION LOOK TO AN OBSERVER IN A CELL?
Information transfer in light is buried in the controls in autophagy and apoptosis when they are coupled at a quantum level.
What couples them? Harmonic oscillators in the circadian mechanism, is the answer.
The connection is built via light WIRELESSLY because photons also have a spin. Few people seem to realize light has a quantum spin number too. Photons have a quantum spin number of one but the key is light appears to have no limit on how high its angular momentum number can rise to transfer information. This implies organizational power can be massively concentrated in light waves. This is why coherent light (laser) appears to raise its OAM as a laser gets powered up. Angular momentum was recognized as an important property of light after the pioneering works of J.H. Poynting and R.A. Beth showed that a circularly polarized light beam exerts a torque on objects with mass.
Mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or enable interactions between mitochondria have not been defined. I believe light is the connecting fabric. Below you can see all the areas and spaces in which information can be carried.
When physicists have looked at light waves headed straight on to a target they have noticed that leading edge of the light wave can look very different. That difference likely carries different data from the environment to proteins, lipids, and water in cells. (pic below)
Bacteria also communicate with one another via bacterial quorum sensing and I believe mitochondria share data via photons in much the same way as bacteria do.
HOW DO WE GET THE INFORMATION?
We get it from our surfaces. The eye, skin, gut, and lung surfaces.
In my opinion, with time it will be proven surface quantum effects within the skin and gut is more important than biochemistry of these organs for humans. The light these surfaces gain use the information to control biochemistry below their surfaces transferring the data from quantum spin numbers to orbital angular momentum of things in our cells.
For example, sunlight increases the redox potential in our blood to affect the temperature, pressure and peroxiredoxins in RBC’s.
Peroxiredoxins are regulated by phosphorylation, redox status, acetylation, nitration, truncation and oligomerization states in the blood plasma. This is why young animals blood help keeps older animals mitochondria younger in parabiosis studies. The proton information is shared into the matrix and this changes what is possible physiologically.
Parabiosis and transfusion of young blood have strong anti-aging effects. Parabiosis is the surgical union of two organisms resulting in the development of a single, shared circulatory system. When animals of different ages are conjoined (i.e. heterochronic parabiosis), blood-borne factors from the younger animal can often beneficially affect the older animal and recapitulate the youthful phenotype & function in target tissues.
Parabiosis experiments will not work without CREB. CREB is short for cAMP response element. Cyclic AMP (cAMP) regulates the expression of many genes via a conserved gene promoter element. CREB is that element. CREB is a nuclear factor that is regulated by protein kinase A phosphorylation. Inorganic phosphorus in the blood can interact with light and electrons to stimulate cAMP creation in blood. CREB is stimulated by sunlight hitting our skin. CREB is also critical in controling circadian cycles in animals.
These two systems are harmonic oscillators with one another that need to be properly coupled by protons and sunlight to work together. What connects these two oscillators in our body? Water networks do in both organs. Why don’t we realize it? Sunlight makes the water in our cells and our arteries a liquid crystalline PLASMA.
What is the other plasma that links the sun to our blood in our eyes, skin, and gut? The ionospheric skin of Earth.
This is the plasma right over your head literally and figuratively at all times. You live within this plasma. Changes to that plasma via geo-engineering can also affect the peroxiredoxins in our blood. Peroxiredoxins are heme proteins that also react to red light from the sun. They are ubiquitous in all forms of life and the key to understanding how the circadian mechanism works with proton spin and angula rmomentum in your tissues. The levers that control how quantum spin of electrons and protons inside of you is controlled by the plasma in you and around you. Sunlight powers the system and the biophysical lever of sunlight must traverse the plasma on Earth called the ionosphere to get to you to do its magic.
ONCE THE SUN GETS THROUGH YOUR OPTICAL WINDOW
When sunlight and blood plasma interact another phase transition occurs to allow information and energy transfer. This is how the blood plasma becomes another plasma in water. I covered this in the Quantum biology blog series in detail. I also followed it up in Tensegrity #13. Bulk water is changed to a a liquid crystal. It is called an exclusion zone. What does it exclude? Anything larger than a PROTON.
It turns out, it excludes deuterium too because of this reason…….and this is how we get rid of deuterium and how we direct it to where it needs to be. Might this fit Maxwell’s description above for the demon and the trap door?
The blood plasma is loaded with deuterium (pic above) yet the mitochondrial environment is devoid of it. What is the trap door between these two areas? Could it be sunlight and water that makes the EZ? Does it use something else to accomplish this task? Could this be why we have so many uncoupling proteins in the matrix? Yes.
That EZ water is created inside cells and it fills the outer mitochondrial membrane space to be distributed to surround all proteins in us. Our mitochondrial matrix and cytosol around the matrix makes DDW using H+ while avoiding deuterium to make this plasma; this is how eukaryotes brought the sea to a land-based existence. It needed to use the water cycle in the ionopshere to give it a boost by lowering the deuterium levels in rain compare to seawater. Humans really used this to evolve from chimps because of how the environment changed in the East African Rift Zone 4-6 million years ago. The change in sunlight and protons over 3 tectonic plates over a massive magnetic flux is what drove this process. If you look at the picture below imagine a human on top of the moutain and a chimp on the surface. What changes would you see in protons in that case?
The liquid crystalline state = builds coherent water networks that provide millions of free electrons to drive biochemical pathways = exclusion zone water = excludes protons and deuterium = creates a bounty of them in blood = travels via ECF to delivery energy and information over the entrie animal instantaneously.
THE QUANTUM THERMODYNAMICS OF WATER
Liquid crystalline water possesses long-range orientational order by pointing all the molecules in the same direction. It also allows for a translational order that allows them to keep their position as they move. Think about my rhubarb cuts abive now. Sunlight makes cuts in water because certain mosaics in light create crystalline hydrogen networks in water. Not all are the same. I talked about two state water in the Quantum biology blogs long ago. Liquid crystals are mobile and flexible and highly responsive to the power density of EMF’s around them. Our cells and tissues are optimized to solar EMF’s, not man made ones. This is only one octave of 73 octaves in the entire light spectrum. If we are afflicted by nnEMF the resultant free radical signals are not the same as they are when sun shines on our tissues. Free radicals have one unpaired electron and protons are programmed as they are made. Any time free radicals increase so does the amount of ELF-UV light a cell emits. (See pg 74-95 in Van Wijk’s book)
This changes optical signaling in cells. When signaling is changes quantum probabilities are altered. This means energy and information is entangled and exchanged within the cell to build order. This allows them to undergo rapid changes in orientation or phase transitions when energy is added or subtracted from the water and can be shared with the surfaces of proteins. Remember all human proteins are hydrated or they cannot work. This is why cell water responds vigorously to electric or magnetic fields of ANY light radiations we experience in our environment.
Is this curious set of circumstances why water responds vigorously to temperature, pressure, pH, hydration, and concentrations of inorganic ions like phosphorus and iodine in tissues linked to the ECF????
Yep.
I told you in the Tensegrity #6 blog hydrogen can also act as a group 7 halogen. This means ‘light hydrogen’ can gain electrons to become a non metal. When hydrogen does this in an aqueous environment, and when it is associated with iodine atoms, it forms an ionic liquid. Ionic liquids are now receiving special attention in science, owing to their unique properties such as high ionic conductivity, non-volatility and non-flammability. This ability makes these fluids versatile alternatives to conventional solvent-based systems used to make batteries, fuel cells, and super capacitors that hold large charges.
Water is unique because it can be both an acceptor and a donor of hydrogen (H+). It means water can be a “switch hitter” in many biochemical reactions in cells. This is why water is the universal solvent on Earth.
A biological cell is fundamentally a dissipative system by its very nature. It is a playground for light rays. A dissipative system is a thermodynamically open system which is operating far from thermodynamic equilibrium in an environment/plasma with which it constantly exchanges energy, information, and matter. This implies when water is hit by sunlight and becomes an ionic plasma (EZ) that has the purpose to break symmetry in nature. This singular act creates a metastable system in our tissues to react to all environmental possibilities/probabilities that the cell may face. Water is the molecule that allows a cell to break symmetry in nature. When water is confined in microtubules (below 1.4nm), it is done this way in cells to maximize its ability to transfer energy and information to the surrounding neurons. (OSF 3 blog)
All these things are vital in understanding the quantum thermodynamics of life.
Iodine-hydrogen bonding in aqueous environments are also quite helpful as heat-transfer fluids to move infrared energies within a system. Iodine’s addition to iodide-based ionic liquids leads to extraordinarily efficient charge transport, vastly exceeding that expected for a standard viscous liquid crystalline system. You saw above that turning water from a bulk fluid to a liquid crystalline structure is the key thermodynamic step life uses to capture energy and information in protons and electrons. What you need to understand is that just touching a protein can lead to a thermodynamic change.
Where does the blood and matrix touch one another?
The TCA cycle and urea cycle are linked in the cytosol by fumerase. This is right outside the cell membrane. How is the infromation from H+ or deuterium transferred to mitochondria to alter the spin rate of both cycles? All mitochondria rely on a stream of proteins to sustain their energy production. Nearly all their proteins are manufactured in the surrounding gel-like cytoplasm, and must be imported into the mitochondria to keep the powerhouse running. This is where cytosolic fumerase exists.
WHY IS DEUTERIUM A PROBLEM FOR LIFE IN THE MATRIX AND NOT THE BLOOD?
In the blood plasma, deuterium is not a problem. It is necessary for function as you’ll soon find out. In the mitochondrial matirx it can be a real problem when oxygen is around. The TCA cycle and urea cycle use oxygen as their terminal electron accpetor. That is not true with other metabolic pathways. When oxygen is low it acts as a metabolic controller of anions in the TCA and urea cycle. This control area is called “Kreb’s Bicycle.”
HOW DOES THIS WORK IN THE BRAIN?
Hydrogen and iodine form an ionic plasma within CSF of the human brain. Deuterium and iodine form a very unusual bond because of the kinetic isotope effect between these two atoms. The choroid plexus of the human brain is designed to add iodine to CSF. CSF, you will recall is an ultra-filtrate of blood plasma and is made up of 99.3% water with 150ppm of deuterium.
Grotthuss was the first person to realize the correct concept for the charge transport in electrolytes using iodine as the transfer mechanism; and it still remains valid for the charge transport in water. The Grotthuss mechanism allows for protons (H+) cable construction within an ionic fluid by using a current of protons that use a “hopping mechanism.” That “hopping mechanism” is referred to as quantum tunneling of protons. Quantum tunneling of protons becomes more probable the smaller the mass of the cation is, and the proton is the lightest possible stable cation on Earth.
Deuterium is DOUBLE THE ATOMIC MASS of H+.
Iodine and iodides turbocharges H+ that are excluded in cell water; this ability occurs by turning the sea of protons into a positively charged ionic plasma. This is why the thyroid gland, choroid plexus, and intestinal gut lining all concentrate iodine and iodides and H+. The mitochondrial matrix concentrates it 1,000 fold compared to the blood plasma.
What about the brain CSF?
When iodine meets water that has been charged separated by IR/UV light or by the hydrophilic proteins in the dura matter covering the brain’s neurocortex, we become able to exclude a massive amount of H+ in the CSF.
Since iodine/iodides become able to further condense the excluded H+ from the EZ. This makes the hydrogen (H+) ions come closer together at the atomic level. The H+ excluded is then used to make proton cables in water networks to make positive electric currents used for energy and information transfer in the brain. Is this the brains biggest information collection scheme that fuels our instincts and subconscious with knowledge?
Is this why lions and hippos know what to do when they are born????
The brain specializes in both operations in every living thing on Earth with one. The only difference is how efficient each brain is using these protons. The exclusion zone (EZ) also excludes deuterium to the blood plasma, because it is LARGER than H+. The more deuterium in the brain the less proton cabling can be formed in CSF. This leads to cognitive haze and neurologic decline. Remember, H+ is equivalent to a proton. Deuterium is a proton and a neutron bonded together = larger atomic mass = loss of energy and information transfer via “quantum thermodynamics”
Using the Grotthuss mechanism, iodine is able to move protons (H+) closer together than we would normally expect, to alter their hydrogen bonding network to allow them to form superconducting proton cables that act like a positively charge electric current. The Grotthuss mechanism does not work properly with deuterium because of its larger atomic size. Iodine condenses and makes the H+ cabling in water more likely by making hydrogen bonding networks in water more DENSE. It cannot do this when deuterium is in the aqueous environment because of kinetic isotope effect.
The Grotthuss mechanism between iodine and H+ allows for charges to be transported not by the movement of protons, by the breaking and reformation of chemical bonds EASILY. Deuterium impedes the breaking and reformation of chemical bonds because of the kinetic isotope effect between iodine and deuterium. This alters the hydrogen bonding networks in cell water. As water is charge separated by UV/IR light or by hydrophilic substances, excess H+ ions are made adjacent to surfaces in cells like cell membranes and collagen. Gerald Pollack’s experiments have shown this actually occurs in nafion. The excluded protons become capable of diffusing through the hydrogen bond network of water molecules (iodized CSF) through the formation or cleavage of covalent bonds.
WHY IS ASYMMETRY FAVORED BY NATURE?
Symmetry is broken by any phase transition in any chemical reaction. This is also true in biochemistry. Any time symmetry is broken, energy and information transfers, and the law that controls the proces is the second law of thermodynamics.
This post is all about the “quantum thermodynamics” in a living system. This occurs many times in biochemical reaction of cells when they are using hydrogen in specific parts of biochemical substrates. The picture below shows you just how specific the movement of H+ and deuterium is controled in biochemical substrates of the TCA cycle.
The specificity of where deuterium can or should be is the ONLY reason why carbohydrates out of season are killers for our health span. Humans are omnivores and can eat carbohydrates when nature’s quality assurance programs built by chloroplasts and mitochondrion remain intact by the circadian mechanism.
You can see the Vitamin B5 need for fatty acids entering the cycle (acetyl Co A) Comparison of metabolic profile changes associated with:
1) natural deuterium depletion by low deuterium fatty acid oxidation. Avastin® and Glivec® exert similar effect and require intact mitochondria for efficacy (Red boxes #1)
2) low deuterium metabolic water recycling from the mitochondrial matrix during citrate, isocitrate and malate formation; the target of fumarate hydratase activation and hyperbaric oxygen treatment combined with a ketogenic diet (Red box #2).
Mitochondrial shuttles, such as the malate shuttle, pass low deuterium carrying fatty acid carbons to gluconeogenesis, where glyceraldehyde-3-phosphate becomes the source of extensive carbon exchange reactions for the non-oxidative pentose cycle to maintain low deuterium saturation in C3’-C5’ pentose sugar carbon positions in RNA and DNA (Red box #3).
This ^^^^ is where cancers really come from. Cancers are due to a loss of information in the system and this uncouples autophagy from apoptosis in mitochondria. The May 2018 webinar is really going to make this concept ridiculous simple to understand. This blog is not simple by design. It is being written for the scientist critic. I implore the non scientist to take your time getting these details down because they are critical to the remainder of the series.
When too much deuterium is in the C3′-C5′ you can bet cancers will be following. It appears from the data I have found over 13 years that if we can keep our deuterium levels below 135 ppm in the matrix and cytosol the chances of cancer drop dramatically. The best way to follow that level is using the calcium index score I mentioned in CPC #23 blog. The blood plasma fraction is unimportant in to this mechanism. This area is not well studied, except in the history of the building of the MRI machine by Damadian. If you want more information on it read this book below. You also might want to read Damadian’s book about building the MRI machine. It is eye opening for the mitochondriac.
These are the carbon sites are where DNA stability, radiation, and chemotherapy derived hydroxyl radical sensitivities that are regulated by hydrogen/deuterium fractionation methods. This is due to primary and secondary intrinsic kinetic isotope effects in the anions in the TCA and urea cycle at the junction of Kreb’s bicycle where fumerase joins the urea and TCA cycles. This process is partially controlled by collective proton tunneling at fumerase. The protons must be H+ that impart that wisdom to the mitochondria.
Besides the C3’–C5’ nucleic acid sugar backbone fragment, de novo nucleic acid base syntheses, hydrogen bonding and deuterium channeling into hydrogen bonds are controlled by the serine oxidation glycine cleavage single carbon cycle pathways [SOGC pathway mentioned in previous patreon blogs] (Red box #4).
Serine use is actually a better hack for oral melatonin use to improve sleep by improving autophagy if you understand this blog. This is a critical link to make as the series goes on.
When tumor cells revert to the Warburg phenotype and reductive carboxylation-driven mitochondria, deuterium depletion in free (drinking) water becomes the only deuterium depleting mechanism for specific carbon sites in nucleic acid backbone sugars and the bases (Red box #5). This is the 5G mitochondrial pathways you should get facile with.
KREB’S BICYCLE IS THE CRITICAL TAKE HOME
So the take home is that deuterium limits the breaks in symmetry in nature because it limits the movement of anionic substrates in both cycles by its actions at fumerase. Why is this bad for nature?
Nature needs hydrogen to be constantly on the move in our mitochondria when oxygen is present to share data. When the environment is pseudohypoxic or hypoxic it must use glycolysis and the PPP for biosynthesis (EMF4). Protons cannot share information quanta when this occurs. This means our tissues are not as wise as they could be. They are in a state of suspended animation and growth is limited. That leads to redox changes in our mitochondria to make sure growth is controlled.
As such, all breaks of symmetry in biochemistry require a transfer of energy and information by the laws of physics to satisfy the Second Law of Thermodynamics.
Symmetry is also broken any time temperature rises or falls when electrons or protons are moving in any biochemical reactions. Don’t the uncoupling proteins play a huge role in temperature changes in the matrix of mitochondria? Yes they do. Is this the demons trap door?
Yep.
Any transfer of energy has the potential to break symmetry and therefore to give rise to emergent properties in the protein polymers or products of these reactions. This is really how evolution works. Darwin’s theory leaves a lot to be desired.
I think the entire universe is powered by water electricity (negative/positive) and I believe every cell is powered in the same way using the same quantum thermodynamic laws. Water is the universal electron and proton donor. Why?
When you understand these concepts, you begin to see that proton and electron currents in water made by sunlight create currents inside of cells and over extracellular distances that are capable of delivering physical and chemical messages concerning the energy and information redox status of all parts of the cell. Redox has two sides to understand. Prior to now, we have only focused on energy and ignored information.
Water networks communicate this information to lipid, proteins and DNA.
TIME7
SUMMARY
Life does not violate the second law of thermodynamics, but it utilizes the information quanta in electrons protons and photons. It is this side of thermodynamics we fail to account for in mitochondrial biology today.
Until recently, physicists were unable to use thermodynamics to explain why it should arise in the first place. In Schrödinger’s day, they could solve the equations of thermodynamics only for closed systems in equilibrium. In the 1960s, the Belgian physicist Ilya Prigogine made progress on predicting the behavior of open systems weakly driven by external energy sources. But the behavior of systems that are far from equilibrium (life), which are connected to the outside environment and strongly driven by external sources of energy, could not be predicted because we had no idea how information was being shared.
This situation changed in the late 1990s, due primarily to the work of Chris Jarzynski, now at the University of Maryland, and Gavin Crooks, now at Lawrence Berkeley National Laboratory. Jarzynski and Crooks showed that the entropy produced by a thermodynamic process, such as the cooling of a cup of coffee, corresponds to a simple ratio: the probability that the atoms will undergo that process divided by their probability of undergoing the reverse process (that is, spontaneously interacting in such a way that the coffee warms up).
As entropy production increases, so does this ratio: A system’s behavior becomes more and more “irreversible.” The simple yet rigorous formula could in principle be applied to any thermodynamic process, no matter how fast or far from equilibrium it is at any time. Our understanding of far-from-equilibrium statistical mechanics greatly improved, and now some scientists have decided to apply the new knowledge of statistical physics to biology. This will open the door widely to quantum biology. It is why I am very optimistic about the future of medicine.
Change is coming and no one seems to see what it will lead too for humans.
Living quantum nanomachines inside of our cells appear to be able to do some unique things with respect to infromation quanta. This occurs because living systems are sometimes able to extract the work much more quickly, giving them more power and range using information over energy flux. This is what allows life to organize to do the things we observe it to do. Life is capable of some amazing emergent properties, like consciousness. The smaller our quantum nanomachines get, the more efficient they become in extracting information from the spin of electrons and protons. This explains fundamentally why mitochondrial prefer H+ over the heavier deuterium isotope. Deuterium is useful in the blood plasma for another reason I will reveal soon.
What the mitochondriac will like about quantum thermodynamics is that “you have these two fundamental quantities — energy and quantum information — and these two things meet together in living systems to bring the diversity we observe in reality. How it happens is the story that will be built by quantum biologists, clinicians, thermodynamic specialists. This is my new job description.
DNA is really a switchboard for sunlight cells trap. Interestingly, the code is self referencing and regions of it are co-dependent irreducably complex. Maintaining the system far from equilibrium is what DHA from seafood does in the cell membrane structure of eukaryotes. In fact, living oyster reefs, have been shown to dissipate wave energy in the oceans. It turns out their matter does the very same thing inside of our tissues. This is why oysters are at the top of the list for mitochondriacs. The patterns in us, is built by the sun, and builds organization in us that is tied to entropy. This entropy is what organizes what life is all about.
In today’s medical environment…….my science is alien because of how I look through the lens of reality, but the reasons supporting my beliefs are 100% native and natural to Earth, to humans in their native form………it offends the modern beliefs of science, however. It’s my particular way of looking at the world that offends others common sense because it’s typically not how we experience life to interpret science, and certainly not how we experience other selves. But it seems to me that you can also get an interesting thought out of this one, if you turn it the other way around, and ask if science, properly, is something you “look through”. So the scientific method has been effective because it excludes everything that is unobservable in terms of measurement and quantification. This is precisely what allowed the scientific revolution to take off long ago. Today the revolution is a stalled paradigm because the things we cannot observe and measure are the things that are critical to disease reversals.
Sometimes we don’t choose our path. It chooses us…….and it then becomes our job to carry the message no matter how much it pisses off the ignorant. You only get mad because you now might realize you’ve been duped by “experts” for so long. You now know what the essence of the Dunning Kruger effect really is. I could care less what anyone thinks about me, I’d rather be their wake up call than everyone’s cup of tea.
CITES:
http://aip.scitation.org/doi/abs/10.1063/1.1734134
https://www.quantamagazine.org/scant-evidence-of-power-laws-found-in-real-world-networks-20180215/
J. H. Poynting, Proc. Roy. Soc. A82, 560 (1909).
R. A. Beth, Phys. Rev. 50, 115 (1936).
https://www.nature.com/articles/ncomms7259
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048046
https://phys.org/news/2018-04-scientists-pathway-protein-import-mitochondria.html#jCp
