A day in your life on Earth is just a collection of hours, but a life to a person is a collection of memories that build a coherent wisdom. It requires you to be awake during the day and asleep when the sun is absent. This rule is axiomatic for diurnal mammals. The final blog of 2023 brings you the best papers to illuminate the ideas in this opening paragraph.
Why is melanopsin/retinol key to understanding all human disease? In physics, time in itself, absolutely, does not exist; it is always relative to some observer or some object because of how light builds it. Without a clock I say ‘I do not know the time’. You do not. This is why evolution built one in the SCN and uses melanopsin and retinol to control the peripheral clock genes to drive renovation. The SCN clock must run fast than the melanopsin mechanism to make sense of the chaos around us.
The implications of this statement are far reaching. Without matter time itself is unknowable. Time is a function of matter; and matter therefore is the clock that makes infinity real. This is why the time crystals in you are coded for DNA. If you ask me, the brain, in fact all neuroectoderm was innovated by evolution to tell time. I think it is the single most important function of the nervous system.
Time is a function of how entropy flows and entropy flows according to how heat flows in a system. Mitochondria create heat when they are irradiated by light. Clocks become more accurate the higher periodicity they have. Daily & seasonal light alters the circadian periodicity of clock genes. The diurnal changes of sunlight from sunrise to sunset change the amount of water made in your mitochondria. Sunlight creates water.
Biology is so difficult to explain without understanding what light is doing at the subcellular level. What an impressive cycling process like a multifunction relay signaling flow switch multiplied to reduce. Wouldn’t it be so much easier to just use numbers. Then everyone would get it crystal clear even the fifth grader.
1. Sato and Sato said in their July 2023 paper that “the circadian regulation of metabolism for health and disease, “dominates” metabolic homeostasis = light trumps food. Imagine that.
2. Light disrupts clock gene BMAL1. CLOCK and BMAL1 are positive regulators of circadian gene expression, and PER and CRY are the negative regulators that operate under day and night cycles.
And in a curious feed-forward mechanism, CLOCK and BMAL1 enhance SIRT1 expression… genetic deletion of any of these players induces insulin resistance. Indoor life under manufactured light decrease SIRT 1 causing insulin resistance. No food needed. Do you hear that?
Did you know in in 2023 we found out that the very same core clock gene, Bmal1,that impaired glucose absorption in the intestine in mice also happens in humans? No food needed. Just bad light can do it. This goes on to affect systemic glucose homeostasis. Imagine that. https://academic.oup.com/endo/article/163/9/bqac119/6651710
3. SIRT 1 lowers with INDOOR living.
Why is this a big deal?
NAD+ is one of the more immediate players in cytochrome 1 that is a huge driver of circadian biology in humans. It is the coenzyme called nicotinamide adenine dinucleotide (NAD+). It participates in a variety of redox reactions in the matrix that help generate DDW. Solar exposure and fasting work with light frequencies to slow ECT flow and this can increase the intracellular NAD/NADH ratio if the light environment is dominated by sunlight. It won’t do this with artificial light. It lowers NAD+. This is what sets off a cascade of circadian events that can destroy tissues because they involve epigenetics and the regulation of growth and metabolism of man. LIGHT DOES THIS. NOT FOOD OR FUELS.
NAD+ major effect is to activate the sirtuins as the reaction above shows. This is a family of deacetylase enzymes. When you understand what UV and IR light are doing to a matrix, you can see why fasting could potentially be seen as a circadian reset biohack. It won’t work in fake light when ALAN is present.
4. Centralized scientism relies on mice studies to create beliefs they hold to be truthful as part of the dogma. Did you know despite the importance of the mouse in centralized research, the levels of circulating gonadal steroids across the estrous cycle are not established with any temporal precision? True. The observations made in the study once again prove the decentralized axiom that you can never learn the truth from lab mice without light controls. Why? The paper provided the first detailed assessment of fluctuating gonadal steroid and reproductive hormone levels across the mouse estrous cycle and it indicated that species differences exist between mice and other spontaneously ovulating mammalian species. Imagine that. https://academic.oup.com/endo/article/164/6/bqad070/7159815
5. Many textbooks on biochemistry and endocrinology will tell you growth hormone is released during slow wave sleep. It is simply not true. POMC controls it in the medial basal hypothalamus.
GH-releasing hormone (GHRH) and somatotropin release-inhibiting factor (SRIF; somatostatin). GHRH stimulates GH release whereas SRIF inhibits GH. Human males exhibit life long ‘pulsatile’ secretion versus female’s who exhibit a ‘continuous’ secretion from their somatotrophs. One sex continuously makes endogenous UV light biophontons in the hypothalamus and one does not. UV light stimulates POMC translation and cleavage.
Slow waves (SWs) are thought essential for sleep-dependent recovery processes.
Their amplitude, incidence, frequency and slope reflect synaptic strength.
Their regulation has been postulated to be independent of circadian phase by centralized dogma.
We now have data below that all characteristics of SWs depend on circadian phase control of the SCN
When melanin is degraded by hypoxia it becomes norepinephrine and dopamine. Norepinephrine decreases GH secretion by increasing the release of somatostatin. This central effect, due to the activation of α1-adrenergic receptors, has been demonstrated in mammals.
Dopaminergic agonists have been shown to increase GH release, as well as to decrease hypoglycemia-, levodopa-, and arginine-induced increases in GH release. Because dopamine can increase both GHRH and somatostatin release, it appears that this balance can change under different physiological conditions. Light stress is critical here.
The dorsal longitudinal fasciculus (QE #47) is found within the dorsal brainstemtegmentum. It passes through the periaqueductal gray matter and contains both ascending and descending fibers.
The ascending fibers pass from the reticular formation (sleep center) passing to the hypothalamus thus transmitting information related to the viscera. In turn, the descending portion arises also from the hypothalamus and passes to a variety of brain areas responsible for processing pain, cardiorespiratory functions and the autonomic system. Finally, the efferent fibers will also terminate on the preganglionic fibers of the autonomic nervous system.
6. Kids with high risk type 2 diabetes should have their urine assessed for circadian dysruption. When melanin degrades internally more catecholamines are made and this will be filtered through the kidneys. Urinary catecholamines are a great marker endogenous melanin destruction.
7. Why is shift work always associated with metabolic issues in humans? Experimental circadian misalignment data have shown minimal effects on steroidogenesis at the adrenal gland level. The same was not true of the sex steroids. This is why gonadal cancers occur so often in shift workers. This dichotomy also predisposes night-shift workers to metabolic ill health. The decentralized clinician should always look at the adrenal steroid cascade, including cortisol and the main adrenal androgen 11-ketostosterone. Why? It should always be evaluated during the biological morning in the case of shift workers because testosterone and estrogen, are highly dependent on the shift-work schedule. https://academic.oup.com/jes/article/6/12/bvac153/6731224
PCOS is characterized by a constellation of interrelated reproductive abnormalities, including disordered gonadotropin secretion, increased androgen production, chronic anovulation, and polycystic ovarian morphology. It is frequently associated with insulin resistance and obesity. These reproductive and metabolic derangements cause major morbidities across the lifespan, including anovulatory infertility and type 2 diabetes (T2D). Most centralized textbooks report PCOS has no known cause. Shift work and light and night are the main offender. The paper above explains why it happens. No more mystery for PCOS ladies. Turn the lights off after sunset and avoid all nnEMFs. In Endocrine Reviews this year, authorsDapas and Dunaif discussed these insights
8. Type 1 diabetic women teach us a lot about how light controls female oocyte behavior.
Often modern women living with type 1 diabetes complain of changes in glucose values according to the different phases of menstruation. This has been confirmed in several studies showing that the glycemic pattern varies according to the different phases of menstrual cycle in most women with T1D. Why? Did you know that menstuation links to NO and blood glucose variations in the capillary bed?
The moon used to control the reproductuve cycle in humans. Artificial light from fire onward effectively extinguished this link in modern women. Can we still experience the real effect in a disease model? Yes. Type 1 diabetic women show the effect because they have no light controls. Normal non diabetic women experience a transient pregnenolone steal syndrome to stimulate ovulation. This is how a light stress event every month was used by biology to control fertility timing.
Lunar cycles modulate the estrus cycle of many mammals because the moon can and does reflect blue light from the sun at night to the Earth as it goes through its revolutions monthly around Earth. That is why they influence woman’s hormone cycles assuming she is properly connected to Earth, sun and the lunar cycles. MOST ladies aren’t properly coupled, therefore, their hormone effects are muted and lowered in modern females. This is why estrus has vanished in modern humans and proof it still has influence can be seen when women get together and live together their cycle will all become coupled oscillator again, just like molecular resonance theory predicts. When the negative and positive feedback loop in the circadian mechanism is uncoupled from one another the result is the extinction of both sides of the coupled system. This extinction effect manifests in the pregnenolone steal syndrome. Look at the link of T1D to latitude below.
In high latitudes cold stimulates increasing blood glucose over time.
In T1D women glucose levels rise linearly throughout the menstrual cycle, reaching a maximum in the late luteal phase. Then a sharp decrease was seen for most participants at the beginning of menstrual bleeding. This links light blood glucose to the lunar cycle because of how light varies.
T1D human females and corals teach us how important light is to fecundity. Remember fecundity in humans is controlled by the leptin melanocortin pathways.
Among all, probably the most spectacular and documented event orchestrated by animals according to the lunar cycle is certainly the mass spawning of corals. Like inside a shaken snow globe, once every year, the barrier reef explodes of eggs and sperms, few days after Full Moon, during late spring/summer nights, a phenomenon even visible from space. Unfortunately, reef corals are losing this critical reproductive synchrony, due to the anthropogenic impact of artificial light at night. This phenomenon threatens several species, not only corals but entire reef communities. This is why modern infertility in humans is increasing as well.
Starting with the beginning of the last century, a multitude of scientific studies have documented that the lunar cycle times behaviors and physiology in many organisms. It is plausible that even the first life forms adapted to the different rhythms controlled by the moon. Consistently, many marine species exhibit lunar rhythms, and also the number of documented “lunar-rhythmic” terrestrial species is increasing.
Organisms follow diverse lunar geophysical/astronomical rhythms, which differ significantly in terms of period length: from hours (circalunidian and circatidal rhythms) to days (circasemilunar and circalunar cycles). Evidence for internal circatital and circalunar oscillators exists for a range of species based on past behavioral studies, but those species with well-documented behaviorally free-running lunar rhythms are not typically used for molecular studies.
Thus, the underlying molecular mechanisms are largely obscure: light reflection from of the moon varies with every day to increase blood glucose.
Lunar rhythms of light, dark, and gravitation changes cause alteration in the human transcriptome, proteome, and physiology. The proxy for these effects is seen in the hormonal variation of humans.
Most women who have circadian control experience a menstrual cycle that is connected to every new moon. And the 4 phases of the menstrual cycle seem to correspond to the 4 phases of the moon (new moon: menstruations, first quarter: follicular, full moon: ovulation and last quarter: lutheal). https://academic.oup.com/jcem/article/107/10/2793/6648857
9. Papers are now out showing how POMC cleavage and light cause type 2 diabetes and lead to sleep apnea. It turns out that the steeper your diurnal cortisol slope is, it will be associated with a smaller and higher midnight cortisol levels. As this POMC effect occurs you will see a greater risk of developing type 2 diabetes in people. As this occurs the clinician should expect comorbid rise of hypertension and obstructive sleep apnea. This is all due to light effects on POMC translation. It shows you why type diabetics are created by modern light choices. https://academic.oup.com/jcem/article/108/9/e679/7109980
10. Neurosurgeons deal with patients with Cushing disease due to pituitary tumors. In my 30 year career one thing I always saw in every case I dealt with was a loss of the pulsatile effects of cortisol secretion in those with a tumor. Because of this I knew light was behind the growth of the tumor. Now we have a paper showing you my instincts were correct. ACTH variability is suppressed in patient with Cushing disease, and that remission of the pulsatile release of cortisol is associated with restoration of this variability. Seeing AM and PM light helps these people recover this ability tremendously and this is why seeing the sunrise and sunset matter in POMC biology. https://academic.oup.com/jcem/article/108/11/2812/7187942
In this list, you will get my insight into how I treat several diseases, like autism, long covid, and cancers.
I hope you carefully watch the video above before progressing.
Winning and nature have much in common
• Winning isn’t loyal to you
• Winning doesn’t care about you •
Winning doesn’t care how sore you are
• Winning doesn’t care how hard you work
• Winning doesn’t care how much sleep you get, either
But this should hit you like a punch in the face from Iron Mike Tyson if you are a mitochondriac.
Are you willing to sprint when the distance is unknown because nature requires you to live by her light laws and not the ones mandated by man?
Are you willing to dig deep to discover the truth about where diseases come from, or will you be a comfortably lazy centralized human buying the story of centralized paradigms?
The annual traditions continue but with a new twist. Everyone knows about the 12 days of Christmas as a carol. This year, I will use the song to create a list of the DUMMIES in your life. If you want them to be wiser than they have been, this list is for you.
1. On the first day of Christmas, you will receive “the gift of information” from me this year. The 12 days of Christmas begin with the gift of “CHARGE.” Did you know “charge” is conserved by nature? Quantum mechanics tells us this. Uncle Jack, is this why Astra Zeneca and JNJ jabs were associated with more clots than myocarditis in Pfizer and Moderna jabs? Yep. The liquid nanoparticles (LNP) charge was different in each jab.
The LNP of each jab has a unique “charge” density. It can have a neutral charge, positive charge (+), or negative charge (-). The RNA and DNA have a negative charge (-). The ionizable lipids have a positive charge (+).
How do impurities from plasmids and SV 40 cause damage? They alter the charge, too. Inside the positively charged lipids inside an RNA/LNP covalently bond w/ DNA plasmids, allowing positively charged lipids to “hitch a ride” into the nucleus with the DNA (as an adduct) of cells, impacting histones (and causing frameshift mutations and aggressive cancer):
For those who think this implausible, you are wrong. This is an interesting study related to charge changes in brain cancer. “The observed alterations in biochemical profiles upon incubation with the Pfizer/BioNT in the specific organelles of the glial cells are similar to those we observe for brain cancer vs grade of aggressiveness.” HYPERLINK
Impurities in Positively Charged Lipids in the LNP can MUTATE mRNA in LNP (Packer et al., 2021), potentially mutating other nucleic acids (RNA, DNA) that could lead to: -Point mutation -Aberrant Protein (toxic) -Noncoding (can be oncogenic) -Misfold that protein/aggregation.
Any RNA impacted would not express protein properly. Could cause cellular toxicity and immunogenicity. Reaction with nucleic acids can lead to gene mutation/carcinogenesis. An aberrant protein can have altered amino acid sequences, folding patterns, and functional properties. Partial Translation or Misfolding: truncated proteins or proteins with missing functional domains can lead to disease and oncogenesis. This could impact human RNA/DNA if it comes in contact. Positively charged lipids may enter the nucleus if contaminated with DNA. HYPERLINK
Electrons are negatively charged protons, and deuterium is positively charged. Charge density actually determines where in the body it goes and what it does. This is basic redox chemistry at work in your tissues. It’s why I see so many clots in brains irradiated by blue light RF and microwaves from tech devices some humans abuse.
Bonus gift on day one: did you know nnEMF alters charge in different octaves of the electromagnetic spectrum? Guess which one neutralizes charge best? Visible spectrum octave. Imagine that. Might this be why Corona = sun is linked to the family of viruses tied to this shit storm created by Fauci et al. In Wuhan and Ukraine bioweapon labs?
Evil done with good intent is bottomless.
SO WHAT DID FAUCI et al. ORGANIZE IN WUHAN AND UKRAINE?
Anything with an altered negative charge in humans usually appears first in the lungs, then blood, and then the brain. Ask any ER doctor what the progression of death march for clots in Emergency rooms post mandate. Answer you’ll get: first, we saw Pulmonary Embolisms, then we saw clots in weird vessels, and now we see 7-13 brain bleeds a week like this one below in a 43-year-old vegan bodybuilder.
This is the epidemiological window of how altered redox changes in mammals with variable mitochondrial capacity in organs. It is the quantum mechanics of charge loss at a tissue level because charge is a physical trait that is conserved by Nature.
2. On the second day of Christmas, my true love gave to me, a circumpolar flight. How does charge work on planes?
What other things do humans do that alter charge fast and do similar things? Ever taken a circumpolar flight through a proton shower and seen an aurora? Yep. Ask Carrie Fisher how that worked out. There are lessons everywhere in Nature if your mind is open. Remember, the fruit doesn’t magically appear immediately when you plant seeds. So it is with health and disease.
Hey, can you ground well when you fly? NOPE. Grounding is how we transfer charge from the sun to Earth and into us. We must have melanin, water, and other batteries in us to hold the charge. You will learn about them below.
3. Whether we realize it or not, we carry in our mouths the legacy of our evolution under the power of Mother Nature. Our teeth are like living fossils that can be studied and compared to those of our ancestors to teach us how we became human. You may not know that transitioning from yesterday’s ignorance, misapprehension, and superstition to today’s enlightened and nerve-deadened protocols has been a long, slow, and very painful process for me.
I want to share a story relayed to me by an ENT specialist.
Lindsey Hanes burst into tears at the wheel of her black Dodge Caravan when she left her son’s doctor appointment. It was ugly crying that many people saw in the parking lot. Heaving sobs. Through raindrops on her car window, she glanced back at the medical building she’d just exited. That therapist in the ENT office had been her last hope to address her son Micah’s sleep and breathing problems. Her sweet, cheerful baby had transformed into a withdrawn, ornery, uncooperative 5-year-old. As a registered “nighttime ICU nurse,” The picture below really explains Micah’s real problem.
Hanes felt convinced that sleep deprivation lay at the root of his problems. He snored, tossed and turned at night, and woke up with bags under his eyes. At age 4, Micah underwent a sleep study and received a diagnosis of apnea — intermittent waking due to a blocked airway. The ENT surgeon she just left removed Micah’s tonsils and adenoids, and the operation seemed to work initially: Fluid no longer collected in his ears, previously a recurring problem. But a year later, he still snored — a possible sign of continued airway obstruction. It was back to the ear-nose-throat doctor, who ruled out apnea after a second sleep study. The ENT offered no other ideas. Desperate, Hanes tracked down the only myofunctional therapist in her state trained in teaching tongue and lip exercises that might reshape Micah’s mouth muscles. Maybe that would facilitate better breathing and sleep.
Micah behaved wildly in the appointment, jumping all over the chair and hiding behind Hanes. He refused to let the therapist look in his mouth, no matter how she coaxed or tried to engage his interest. By the end of the appointment, Hanes felt sweaty and exhausted, a familiar experience. She apologized profusely to the therapist, who declined to charge the family. Hanes trudged back to her car with Micah, where she dissolved into sobs. The Hanes family felt they had reached the limits of established centralized medical practice and found no cure for Micah’s sleep and breathing problems. So Hanes did what any modern parent would: she turned to Dr. Google. She discovered a whole community of decentralized researchers and Dr. Ungar’s work there.
On the third day of Christmas, we go out and buy the dummies in our life, the book “In Evolution’s Bite.” It is written by the noted paleoanthropologist Peter Ungar. Ungar is a personal friend of one of my classmates from dental school. It was because of this classmate Uncle Jack wised up about fluoride, flossing, and tooth brushing. All these ideas are superfluous under the power of sunlight and redox charge. Why? Ungar found thousands of ancient skulls with perfect dentitions without access to dentists, modern dentistry, and fluoridation. It appears the ancients did not need an orthodontist either because every skull he found had a perfect class one occlusion.
WHAT HAVE CENTRALIZED PARADIGMS TAUGHT ME ABOUT MODERN LIFE AND TEETH?
For example, did you know that:
*Among the toothache remedies favored by Pierre Fauchard, the father of dentistry, was rinsing the mouth liberally with one’s own urine.
*George Washington never had wooden teeth. However, his chronic dental problems may have impacted the outcome of the American Revolution.
*Soldiers in the Civil War needed at least two opposing front teeth to rip open powder envelopes. Some men called up for induction had their front teeth extracted to avoid service.
*Teeth were harvested from as many as fifty thousand corpses after the Battle of Waterloo, a huge crop later used for dentures and transplants that became known as “Waterloo Teeth.”
Modern life is a big difference, specifically in how we live in light. How do we know this lesson? Egyptologists have studied the rich who lived 5000 years ago, and the slaves who lived outside in the sun and built the pyramids had perfect skulls like Ungar’s specimens, but the pharaohs who lived in temples with fire did not. They had all the diseases modern man has. CT scans of the mummies have confirmed this. This might offend your beliefs. That is good. This is why it is on the dummy list. I gave this very talk to the NY State Dental Society in 2013, and none of them could believe what I told you here on the third day of Christmas.
In his book, Ungar brought together cutting-edge advances in understanding human evolution for the first time with new approaches to uncovering natural clues from fossil teeth and human skulls. The result is a remarkable investigation into how teeth―their shape, chemistry, and wear―reveal how we came to be. Traveling the four corners of the globe and combining scientific breakthroughs with vivid narratives, Evolution’s Bite presents a unique dental perspective on our astonishing human development. Teeth are neuroectodermal derivatives linked to POMC and melanin biology. Imagine that. No wonder the teeth respond to the energy and information in the sun. Human teeth also fluoresce. There are no coincidences in Nature, just lessons to stack. Recall that melanin is made from alpha MSH, a cleavage product of POMC.
POMC is a human gene only translated when endogenous or exogenous UV is present. Melanin has a unique ability to conduct charges simultaneously, both electronically & ionically. When it is heated by mitochondrial metabolism, it becomes a better electronic conductor of light energy. So, when a mother works in an ICU at night, this reduces the amount of endogenous UV light she can generate, and this loss can shrink the child’ skull, dentition, and brain in ways most cannot fathom. Do you think nighttime ICU nurses see a lot of sun in the daytime? Or are they sleeping when the sun is out so they can go to their job the next night? See how this thing called NATURE works?
Charge is quantized in Nature, and it is also conserved in Nature. POMC creates melanin from UV light so charges can be added to living tissue. This is why Micah and millions of humans have the problems they do. It also explains why his mom, an ICU nurse, cannot understand it. Her education level was fully centralized.
Over the last 250 years, our skulls have morphed in dangerous and troubling ways because of our choices around light. Our Skulls Are Out-Evolving Us because of the light we abuse to see and to eat. Eating food out of season and eating processed food can also shrink your skull & jaws. The same thing happened to Neanderthals when they got to the 51st latitude and began to live in caves. Homosapiens replaced them. Who and what are going to replace today’s dummies? I submit to you that is what autism is really all about. Cognitive de-evolution is here and prominent. Re-read Patreon #45 in my Quantum Engineering series with a more serious perspective on this illuminating topic.
Last point on dentistry. The oral microbiome folks could and should teach the gut microbiome folks a decentralized lesson in charge transfer. No matter where the microbiome is, it should be considered a SUN in that tissue. People forget that Fritz Popp found that prokaryotes emit 5000 times more light than eukaryotes. This fact always told me that the skin, gut, vaginal, or oral microbiome has specific spectra of light that work with the non-visual photoreceptors used in that tissue need to transfer charges to do the physiological job of the tissues in question.
Consider the oral microbiome response to light.
Dental plaque is a biofilm that develops naturally on teeth. It consists of aggregates of 500 to 600 different bacterial taxa embedded in a matrix of bacterial and salivary origin polymers. In healthy subjects, dental plaque remains stable for prolonged periods of time because of a dynamic balance among the resident members of its microbial community. Disease arises when the microbial homeostasis within the plaque breaks down because of disruption of the habitat’s ecology. As the microbiome changes, so does the light the prokaryotes emit. In periodontal disease, there is a shift in the composition of subgingival plaque’s microflora that colonizes tooth surfaces and epithelial cells in the periodontal pocket to a more proteolytic gram-negative anaerobic community, including the pigmented rods in the genera Porphyromonas and Prevotella. These bacteria change the charge density signal of the tissue. As a result, black-pigmented anaerobes such as Porphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens manifest in the periodontal pocket and have been implicated as pathogens associated with the initiation and progression of periodontitis.
Periodontal disease proceeds cardiovascular disease in humans.
When dental plaque samples from human subjects were irradiated with light, P. melaninogenica showed the highest susceptibility to light, followed by P. nigrescens, P. intermedia, and P. gingivalis. All of the Prevotellaspecies showed similar patterns of susceptibility to light, with growth inhibition ratios ranging between 2.1 (4.2 J/cm2) and 3.4 (21 J/cm2). The growth of P. gingivalis was inhibited 1.4 (4.2 J/cm2) to 1.9 (21 J/cm2) times. This is an instructive lesson on how light sculpts life in your mouth.
This data on light frequency and dose are in accordance with those obtained in a previous study in which exposure of human subgingival plaque samples to red light at 633 nm led to 60 and 40% elimination of Prevotellaspecies and P. gingivalis, respectively. The sun is 43% red in the IR-A range.
Red light from the sun or a manmade light can alter the oral microbiome. The data shows not all light is the same. Each part of the visible spectrum has its own charge density ability. People need to understand the microbiome provides the hierarchy of light for the tissue in question. The hierarchy goes from wellness to disease. Hence, bacteria act inside of us just as the sun does to living things on Earth. It powers the local environment to action. If it is unwell, light emission suffers, and so will the redox state of the tissue in question. We clearly see that in periodontal disease. This microbiome change is a predictor of future cardiac and peripheral arterial disease. The light from one bad star in the mouth can ruin the biology in another world, the cardiovascular system.
The interesting point is that UV light is devasting to bacteria, and the dose needed to sculpt the microbiome is small. Red light, however, is massively underpowered, giving a different effect in the hierarchy. Within the red bands, the energy fluence delivered to the species was 360 J/cm2 since the red light corresponded to the long-wavelength absorption maximum of porphyrins. The same study demonstrated a reduction in the number of CFUs of other anaerobic and aerobic dental plaque microorganisms by 50% due to their exposure to red light in this study.
Some of the non-black-pigmented oral microbiome species use chemicals mimicking chlorophyll and hemoglobin porphyrins. They contain porphyrins and/or other cell pigments, which can explain their susceptibility to light.
This data suggests that visible light could be used prophylactically to stabilize the normal microbial composition of plaque by suppressing potentially pathogenic BPB. Compared with other forms of periodontal therapy (scaling, mouthwashes, surgery), this form of treatment would offer many advantages: it is painless, rapid, and devoid of drug toxicity; it has no effect on taste; and it is selective in its effect. Dentistry can and should be decentralized as well. Let your Dummies know this.
4. RED LIGHT DOES NOT EQUAL SUNLIGHT BECAUSE IT HAS A DIFFERENT CHARGE DENSITY.
Stop buying all the red light panel sellers telling you they are the same. They aren’t. This is why I do not tell you which red light is best because nothing is better than the sun. Only 43% of the sun is red. Is the McCullough protocol for Spike protein degradation as good as sunlight is? NOPE.
These are the basics of how charge density operates in your mitochondria. If you do not listen to it and give it to your Dummy list, you’ve failed in 2023 being decentralized.
6. On the sixth day of Christmas, my true love gave to me……. a lesson on transition metal decentralized wisdom. Does titanium or other heavy metals change the charge density of your tissues? What do you know of this? Did you know that TiO2 is being added to foodstuffs? For example, pastries, confectioneries, baked goods, toothpaste, dairy goods, cosmetics, and prescription drug coatings. I use dentition cleaning products with baking soda and salt; they work great. You can add coconut oil if you like. Even those organic brands hide it in their branding. Remember, marketing is legalized lying.
Those are the most common ways people get it, but are there other ways?
Sunscreen, makeup, and medical devices. Wait, what did you just say? Every joint replacement, spine surgery with implants, cardiac stents, and most drugs and supplements carries the risk of altered charge density from Titanium. Nothing makes you bulletproof but the sun! Did you know that melanin gets rid of heavy metals?
I hope you know that UV light from the sun creates alpha MSH from POMC to make melanin. I also hope you remember I told you in 2023 that melanin is destroyed when tissues are hypoxic. I hope you know that all nnEMFs outside the visible light spectrum CREATE TISSUE-LEVEL hypoxia (above pic).
Titanium is a transition metal on the periodic table……and all transition metals are dramatically attractive to microwave radiation. This is how stars become supernovas when they begin to burn atom number 26 as a fuel source. The red giant then blows up, which is how we get atoms above atom number 26 on the periodic table. Nature is a furnace of creation. She uses the electromagnetic spectrum to do it. The same things can kill ya’ too. Wait……what, Uncle Jack, what the hell does that mean? Oh, you forgot what I told ya’ in 2018?
I cannot wait until people find out what they have been doing around candy, which is going on much longer with sunscreen.
Sunscreens have massive amounts of Titanium dioxide in them, a DNA-damaging chemical. Did your experts know that?
Do they know how it links to the Melanin story? Or the melanoma story in my blogs?
For example, CereVe marketing tools tell us, “Choosing a sunscreen with gentle yet effective ingredients for all skin types—including babies’ skin and sensitive skin—is a key step in protecting your skin against sun damage. Mineral-based sunscreens commonly contain titanium dioxide (along with zinc oxide) because of this ingredient’s ability to reflect and scatter damaging UVA and UVB rays off the skin’s surface.
CeraVe offers an array of mineral sunscreens containing titanium dioxide, including hydrating sunscreen lotions for your face and body, formulas specially designed for babies, and water-resistant sunscreen sticks for touch-ups on the go. Every CeraVe SPF sunscreen product is non-greasy, helps prevent sunburn, and contains three essential ceramides to help restore the skin’s protective barrier and lock in moisture.”
Skittles, Starburst, and thousands of other sweet treats marketed to children contain titanium dioxide – an additive European food safety regulators say is no longer safe for human consumption. Yet the U.S. hasn’t reassessed the potential threats in over 50 years. It seems like the same story around the jabs now with the FDA, right?
Titanium dioxide is used in popular candies and other processed foods to give a smooth texture or to work as a white colorant. SUNSCREENS ARE ALL WHITE GUESS WHY? White semiconductors reflect all forms of the sun. This is why melanin is black because it absorbs the frequencies of light to use it and protect cells.
The titanium and zinc pigments used in sunscreen and candy can brighten other colors, making the food more vibrant and appealing, but the additive has no nutritional benefit and harms DNA. Imagine that. Candy and sunscreen have a lot in common.
For years, some scientists have raised concerns about the potential toxicity of titanium dioxide. Its use in the U.S. continues because of regulatory folly by the Food and Drug Administration, which allows problematic ingredients to remain undetected and unreviewed. The FDA last examined the risks of the additive in 1966, but research in recent years shows there are possible health harms from titanium dioxide that warrant a fresh look from the agency.
CENTRALIZED SCIENCE IS FOS, folks. I posted about this years ago, but y’all have short memories. Take the Skittles out of the stockings now.
It is not just candy keto meat heads. Do they put titanium dioxide on the outside of French cheese (like- camembert and Brie) to keep it white? YIKES
7. On the 7th day of Christmas, your true love wants to talk about the non-visual photoreceptors in you. Light alters the non-visual photoreceptor system because it changes the charge density of things. This is why UV light bleaches your Sunbrella furniture. It needs to be treated with UV-protective chemicals. This is why blue light toxicity also drives high LDL cholesterol and low HDL levels as well. Many things blamed on poor nutrition are based on poor light environments. We have to stop blaming food for what light causes. B12 and cholesterol are two biomolecules used in the human non-visual photoreceptor cascade in cells.
More on the Christmas Dummy list: Centralized healthcare’s ignorance of the basics of this Tweet thread has led to incalculable errors for public health. I mentioned this to @RickRubin & @hubermanlab when we spoke about Dr. Changs’ belief it made 50% of what is in the textbooks obsolete. I said this on 3/4/23, so it’s been on the dummy list for a long time. It was one of the year’s biggest hits, but dummies missed it. I am telling you, 99.9% is hot garbage. Why? The number one opsin in mammals is MELANOPSIN, the human blue light detector, & we no longer live under the sun. We live in the light that killed Steve Jobs!
We live inside under LED light that destroys this non-visual photoreceptive circuit. People want to blame glucose and insulin, yet when you look at your blood, you see a loss of charge. Does Nature make mistakes, or has centralized medicine ignored many facts they should have been asking questions about? When deuterium is let into the matrix, this is what redox shifts all biochemical pathways the longevity experts THINK never change. Does this alter the charge, my dummies? This is why none of them understand how mTOR and UCP-2 work with 380nm light generated inside of us.
Those proteins embedded in the lipid rafts or connected to them by the tensegrity system change how they respond to charge and light. Why does NO fall as we age? Because modern humans live under an alien light. Why do APO proteins and LpA look like a problem to the Peter Attias of the world? Because none of his patients in NYC or San Diego live in sunlight. If they did, their LDL cholesterol would be low, and their HDL would be high, and he would not write a new book (@billgifford alert) telling everyone to take a statin because it is a GOOD plan for longevity. This message is DEAD WRONG. Send that to your dummy list on day three of Christmas! Stop making dummies popular and rich this Christmas!
B12 is a visual photoreceptor in humans. Bad blue light actually atrophies the CNS and PNS and makes your skin pale by degrading melanin. This is why MS and ALS are made worse by the blue light hazard. The same thing is true for autism and brain gliomas.
Did you know B12 has another quantum function? B12 limits the production of Nitric oxide in tissues. It lowers the NO level to quench the effect of UVA sunlight. What happens if you are vegan or vegetarian or a tech abuser and you do not have the right amount of B12? It means your tissues won’t have the right amount of NO either. UVA light heats tissues up, especially at the skin’s surface. Did you know that heated-up skin and subcutaneous tissues make wake less likely to dissolve gases like NO, so they act longer on the tissue level to oxygenate them? This is a reason people in the sun have higher tissue O2 levels. It is why their blood has a higher venous saturation of oxygen, and it was the basis of how I realized my dying friend Jeremy Thomley was able to breathe through his skin by living on a Christmas tree farm in Hattiesburg, MS confounding all the centralized doctors at UAB medical center.
Without the right amount of NO, will your capillary beds be filled with the right amount of blood for that tissue? Nope. Might that cause hypoxia and lower other batteries, capacitors, or charge density carriers in your cells to lead to disease? YEP.
Cobalamins also affects another battery that holds electromagnetic charge called the MTHFR system. Methionine is part of the story you will learn about on the 11th day of Christmas below.
Blue light & nnEMF are net catabolic for your tissues, all loaded with several non-visual photoreceptors; moreover, light radiation destroys them. If melanin is not present, the destruction is even more rapid. Why? Melanin protects us from stray electromagnetic radiation. Could mixing EMF with a Big Pharma toxin lead to a rapid death because of these lessons? What did I tell people in LA in 2015?
There are a lot of Dummies who need this wisdom. I made all these predictions way before COVID hit. You can see the effect of vaccines when they are mixed with nnEMF because all vaccines are mitochondrial toxins. And mitochondrial toxins ruin our tans outside and inside of our bodies. This leads to a discharged battery and disease. If your batteries already suck because you live in a city with 14 million other dummies, you can die fast from a flu shot.
WHAT IS THE NUMBER ONE nnEMF AFFLICTING HUMANS TODAY?
Blue light is.
This is why Anjan Katta’s new daylight computer is critical to buy for the dummies on your Dummy list. It is anabolic for the brain. It stops human brain breakdown. The rhythm or color palate used in nature can be found in a molecule’s absorption and emission spectra. I told Ray Peat this over a decade ago, and he ignored it at his tribe’s peril. You should not, or you too will wind up a smoothed-brained Peatatarian. I lit many of them on fire in August of 2023. You might hear something about that in March of 2024. The only supplement for my tribe is FSS. See the cites below.
On the seventh day of Christmas, Uncle Jack said to me, why do I need Anjan Katta’s Daylight Computer? The answer is in his screen tech design. Wake up and go in the sun with it, and you’ll alter your charge like Nature built ya’. This is Christmas for Dummies Day! It’s a gift for people who thought they had everything and don’t. If someone had bought this for Steve Jobs, he’d likely still be alive. It is the gift of time given to your dummy list.
Start with every parent who babysits their kids with a phone or an iPad. There are at least half a billion of those dummies in your continent.
8. On the eighth day of Christmas, I hope some of you gift the Patreon wisdom to 5 dummies on your list. Or the smart dummies on your list, just pay five bucks a month for my Patreon insight and give them the gift of good thinking. I promise to add charge density to the life for five bucks a month or 60 bucks a year. You can join them up here at patreon.com/DrJackKruse
Do you use time wisely? Do you prioritize your choices by weighing the value of information and wisdom against the cost of choice and decision? Life is always wrapped in opportunity cost. Decentralized medicine is both science and art in a unique package blended by perspectives of how the world is affected by Nature. Looked at from this vantage point, a good decentralized artist knows he has less time than ideas, and this pushes him to act, create, and share the ideas born in his craft. Time is too precious to waste. The job of Nature is always to deepen the mystery for the artist. The artist’s job is to find the inspiration of Nature and reflect it in your creation and wisdom.
9. On the 9th day of Christmas, some reality comes to the tribe. Increasing your charge density comes with a cost in a tissue. This is why Nature compartmentalized its mitochondria in tissues. Not all tissues have the same redox capability. The brain and heart have the most. The bone and immune systems have the next most. This is why Sodium & potassium concentration is so critical in certain tissues and not in others. K+ in the endolymphatic sac. Sodium in the brain and Calcium in the heart are key examples. The amount of UV light absorption correlates with this charging ability. I taught the world that in the Vermont 2018 talk. You can find that talk and the slide here on Patreon as an ala carte purchase.
With respect to the density of the electrolyte in a battery, If a high-density electrolyte is put in a battery, the capacity will increase to a certain extent. However, increasing density also means that the battery life is shorter. That means redox collapse can happen. Uncle Jack, can you give us an example?
Let us discuss the skin. When you get overexposure to the skin and exceed your charge density capability, the sign that it happens is that you will itch in your skin, and your melanin upregulation will be slowed. A sunburn should not itch as it develops. If it does, it is evidence of a topological change in the skin. We see this in many cases of atopy, dermatitis, mast cell dysregulation, lupus hypersensitivity, solar hypersensitivity, etc. Many drugs do this.
Phenothiazines, methylene blue, antihistamines, and many diabetes meds like sulfonylureas. Sulfated antibiotics do it, as do all the floxin antibiotic drugs. The biggest offender is birth control pills and NSAIDs. Drugs are used to treat psoriasis, and many skin disorders do it. What are the implications of this day 9 lesson on “charging?” All of these drugs DEGRADE melanin everywhere. They are not part of a melanin renovation program. The Dummy list will get the post in this series.
If you do not know how to use MB, you can harm yourself. MB increases NO delivery to tissues, and if you do that too long, you ruin the charge density of the tissue. I have an older member on my forum who believes everyone should be on Nitric oxide because he listens to NO videos from people who don’t have a full view of the process, and I have to delete most of his threads. Sometimes, members have to be taught lessons, too. If they don’t like it they can exit. I have taught all these things about NO to my tribe. Now you know why I have to protect my tribe sometimes from overzealous members who lack comprehension of what I have written. Never forget that NO is a free radical and must be quantized properly to marry tissue charge density. Just because you’re old is no reason to pop NO daily.
The analogy to land this punch: before you can eat the juicy fruit of health, you have to understand the destructive existence a seed goes through on the way to growing the tree in sunlight to create fruit photosynthetically.
How did I learn about battery life and charge density decades years ago? As a neurosurgeon, patients with Parkinson’s disease who used a lot of L-Dopa before surgery always were deathly pale. So, I asked my mentors about this situation. The answer I got from our Medtronic rep on the early DBS stimulation trial data was instructive to my ignorance.
In cardiac pacemakers and DBS patients, manufacturers found that patients on certain drugs have poor battery performance of their implants, and this could lead to increased symptoms. It turns out battery estimations, charge density, total power, and clinical symptoms were important to follow in patients with these devices. The observation of clinical worsening that was rescued following neurostimulator replacement only reinforced the notion that changes in clinical symptoms can be associated with battery drain. This was one of my early introductions to physics in neurosurgery. I found that in PD patients with poor battery life they often had co-morbid thyroid problems while being pale, and many were often on thyroid medication replacements. It turns out low thyroid function also ruins battery function because it means melanin cannot do its job in the brain stem. Why?
Melanin loses its electrical conductivity as heat is lost. So, more battery power is used in these patients to generate the DC electric current where melanin is missing in the brain. Melanin electrical conductance is better when patients can maintain their own endogenous temperatures. I did not know this as a young surgeon. I began to realize why people who flew more got more blood clots. The zeta potential in their blood was getting zapped by the solar wind and by a lack of grounding = fewer electrons in the blood.
Yes, RBCs are a type of battery that holds a charge, too, because they are loaded with another heme-based non-visual photoreceptor called hemoglobin, an iron porphyrin.
When I learned about this, I asked more questions. I found that PD patients lost temperature regulatory abilities as they got worse. They all had excessive sweating like diabetics do. As they lost water and became dehydrated, they lost the ability to make Vitamin D, and they all became pale because they could not make melanin. I then found out that altered NO levels were related to developing type 1 diabetes. Most of them suffered from chronic hypoxia at the cellular level.
Many papers felt this was protective of lowering ROS signaling to prevent damage, but I found out in 2013 that pseudohypoxia drives NAD+ to low levels and is associated with more rapid aging of tissues. I also found out that NAD+ recycling controls the circadian mechanisms in humans, and when NAD+ levels drop, you can bet there is ongoing melanin destruction in the brainstem of PD patients.
NAD+ is the link between the sun and HIF1, and taking exogenous NAD+ supplements down-regulates NAD/NADH function and physiology. NAD+ only carries 2 electrons, while melanin creates 4 electrons from the charge separation of water. If melanin is being degraded simultaneously as NAD+, you can see a serious lack of electrons in the system. Melanin, not NAD+, is more critical in health and longevity. See Rabinowitz’s papers in the Journal Nature for proof of concept. If there is a lack of electrons in tissues, light cannot be utilized properly to make energy in humans. All of these things made me realize this is why people with hypothyroidism, diabetes, and PD all carry high risks of developing melanoma compared to other patients. It is a “charge density” loss in the skin story.
10. On the tenth day of Christmas, my true love said to me…….get all the dummies OFF any and all NAD+/NADH supplements once and for all. Why?
Information transfer costs us energy = heteroplasmy is built in. Landauer predicted that erasing even one bit of information would release a tiny amount of heat, a figure that he calculated. This implies mitochondria are time machines because they also transform light energy into CO2, water, and heat = mtDNA is a hydrogen heat engine. If information is energy, as Wheeler has told us, Information, once created, has to have a “finite and quantifiable mass.” This connects information theory directly to energy and mass equivalence. E-mc^2. This is how they are linked. Where is the link in biology? NAD+ links to the heat shock proteins like HIF1. Sinclair’s 2013 paper missed the real point of why pseudohypoxia aging and NAD+ dropping are linked. Broken circadian clocks are 100% due to lack of sunlight or too much light at night = “charge” density story is missed.
NAD/NADH drugs are just slick marketing bullshit. How do cells do it? Your epigenetic mutation load (EML) of your tissues is the key to understanding how the light you use in your environment builds the life you live. Nature has built a clock timing mechanism as you live a life based on your light choices. A higher EML has been associated with age-related pathological conditions like X chromosome activation skewing. What is X-linked chromosome activation skewing?
X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Remember, males and females have different mtDNA inheritance, so there has to be a compensation mechanism for energy balance.
The higher latitude or, the more tech abuse you live with implies a lack of melanin. As such, you have a higher risk of X-linked activation skewing in tissues with redox problems. This sets the table for lots of problems in the sexes. It might also be the smoking gun for childhood cancers. If your kids have cancer, I usually ask my female farm members to get X-linked activation testing done. Most are surprised until I explain why. Think of your child as a battery. You are designed by nature to transfer the surface charge in your tissues to your child. You transfer more of it than your spouse because we inherit most of our mitochondria from mom. Yes, ladies, there are papers. Dad can do it, too, but it is not common.
Inactivation of the X chromosome may indicate a putative tumor suppressor gene on the X chromosome and the combination of a germline mutation of this gene and nonrandom X-chromosome inactivation. Because leptin controls this process, these circumstances are more likely to be associated with a circadian mismatch in mammals. This situation allows for the elimination of the wild-type activity of the tumor suppressor gene, and this results in an elevated risk of developing cancer in these females and in their kids. Your kid is like a battery of your cells. Imagine that.
For ladies, this, I believe, is why the BRCA1 gene can be a problem even when you do not have the classic inheritance. Ladies with BRCA1 always have high-latitude lifestyles and are tech-addicted (think Angelina Jolie); skewed X-chromosome inactivation can arise independently but can and would cause enhanced tumor susceptibility. Last warning about altered charge density: skewed inactivation can result in heterozygous females manifesting X-linked diseases that are usually seen only in males too. I have seen several females with Duchene’s phenotype that their geneticist could not explain. Skewed activation testing did. Somatic tissue needs to be examined before declaring a sample “ clonal.” Solid research work has revealed a strong link between pluripotency and XCR in placental mammals. When naive embryonic stem cells (ESCs) differentiate, random XCI is induced in mammals with placentae = YOU!.
The circadian clock in humans controls chromatin marking in humans (pic below). BMAL1 is a clock gene, and HSF1 is a HEAT shock protein.
In humans, 55–70% of the transcriptome is under circadian control in any given cell type. This is the basis for circadian control of major physiological processes, including immune functions and, most importantly for this investigation, cell proliferation, morphogenesis, and X chromosome inactivation.
Circadian clocks operate in most tissues at the single-cell level. These clocks are based on clock genes at the molecular level, which participate in auto-regulatory feedback loops. In the core loop, the transcription factors CLOCK and BMAL1 activate the expression of Per and Cry genes, whose protein products negatively feedback on their own expression.
Dosage compensation between XX female and XY male cells is achieved by X chromosome inactivation (XCI) in mammals. XCI is initiated early during development in female cells and is subsequently stably maintained in most female somatic cells. What maintains it? CIRCADIAN CLOCK MANAGEMENT! Despite its stability, the robust transcriptional silencing of XCI is reversible in the embryo and in several reprogramming settings.
Examine the picture closely because it is decentralized science-dense. Mouse and humans are mammals. One is nocturnal, and one is diurnal. XCI during female mouse and human development shows us how this works. During mouse development, embryonic cells around the 4-cell stage inactivate the paternally inherited X chromosome. Cells of the primitive endoderm and trophectoderm in the preimplantation blastocyst keep this inactivation pattern, while those in the epiblast reactivate the paternal Xi. Around implantation in the uterus controlled by leptin-melanocortin pathways, an X chromosome is randomly inactivated within epiblast cells. What if melanin is not there? What if leptin is not optimized?
Following the specification of PGCs, these cells activate the Xi. Primary oocytes within the fetus and adult mouse do not contain an Xi, while all somatic cells retain the Xi pattern of their epiblast precursor. During human development, random XCI is seen as a gradual process beginning in the early blastocyst and completing just prior to implantation; this pattern of inactivation is retained in all future somatic cells. Following the specification of PGCs, these cells reactivate the Xi, which remains active in all future germ cells. Do you think melanin might affect this system with its ability to increase CHARGE DENSITY in cells? Read on. This list is for the Dummies in our lives.
Cells are colored by their lineage displayed in the upper right panel; primary oocytes (green) within the fetus and adults represent the primary oocytes contained in the ovaries of born offspring. The picture above does not accurately represent relative mouse and human development times, but you should get the gist. What does all the abbreviations mean? PGCs, primordial germ cells; Xa, active X chromosome; Xi, inactive X chromosome; Xip, inactive paternally inherited X chromosome. Reproduced and adapted with permission from Pasque and Plath (2015).
Nature needs that to adapt to changing light and temperature in the environment, which is why those are the TWO METRICS the SCN pays attention to. “Charge density” is the key to the periodicity of molecular clocks!
This is why all this stuff is linked. STACK THE LESSONS IN THIS BLOG FOLKS. I am giving you bombs here for Christmas to smarten up the Dummies in your life. When leptin-melanocortin signaling is lost, NAD+ drops, and that tissue is aging faster on a relative basis than it should. Aging is a loss of charge density when you have this perspective. A healthy cell phone can hold a charge after you plug it in. During sleep, we recharge and go back to the default state. When NAD+ is low, or melanin is absent, you cannot recharge the battery no matter what. Examples: chordomas, fibromyalgia, Lyme disease, melasma, Hashimotos, ME, and soft tissue sarcomas.
11. On the eleventh day of Christmas, my true loves said to me……What about the viruses or jabs? What if I told you that outbreaks of chicken pox, Shingles, and the herpes virus only come out when you lose charge density in a tissue? Might that be related to a lack of melanin or lack of NAD+ in tissues? YEP.
What if I told you that there is a way to repair any neurological disease by improving the mitochondrial redox power of your eyes and skin via the sun to import melanin through your blood-brain barrier without any help from Big Pharma? Would you believe me?
In 2014, bacterial melanin was proven to stimulate regeneration after mammal CNS lesions. Imagine that.
Uncle Jack, is there anything else we should wise up about on the 11th day of Christmas? You remember your mitochondria have a bacterial origin, right?
Did you know that your mitochondria can tan your guts and insides by using their bacterial-based mitochondria as a point source of light and a novel non-visual photoreceptor called melanogenin? Yes, that is not a misprint. I said exactly what you read and heard in your brain. Do you believe me?
In 2005, this paper was written. How come your experts did not tell you about it? Melanogenin was discovered in NYC 15 years after leptin was. Amazing how this research stayed hidden all these years.
Do you want to guess this biomolecule’s absorption and emission spectra, or should we save that little treat for another day? It is in the visible range of sunlight. I had to tell you!
Is there a missed charge density story that could explain myocarditis from the mRNA jabs linked to the wisdom on the 11th day of Christmas? If you are vaccinated and a highly paid professional athlete, you should be screened for the SCN5A polymorphism and Bruguda syndrome. Why would a P450 SNP be linked to this story? All P450 SNP are cytochrome and subject to the destruction by blue light, silly! See the picture below on line 1. The P450 system is all heme-based biomolecules.
Four known common polymorphisms of the SCN5A gene are related to BrS, including R34C, H558R, S1103Y, and R1193Q. We always suggested this hack to my professional athlete clients who were forced to get the jab. The Rx for it was “endogenous and exogenous melanin renovation therapies” done in the offseason to prevent some of the things you saw last NFL season. If you are a vaccinated human with heart rhythm abnormalities, you should ask your cardiologist to screen you, too, even if you are not a million-dollar athlete. Most centralized cardiologists have yet to learn about this decentralized wisdom. In 28 NFL cities, I have asked many of them about this science and got blank looks. That explains this—> JJ Watt and Hamlin both had heart issues after the mandated vax by the NFL.
These SCN5A polymorphisms often decrease the expression of sodium‐channel proteins and alter gating properties, resulting in prolongation of the QRS duration and slow conduction in the heart, making sudden cardiac death and rhythm changes more common in the face of mRNA damage = higher cardiac heteroplasmy in young people = unexpected morbidity and mortality.
I wrote about it here last year after the Buffalo/Cincy episode. If you have the defect, you better avoid nnEMF too. nnEMF causes C terminus problems = MTHFR. You need this system to recycle methionine in your cells. Remember the methionine and tryptophan blogs on Patreon?
You also MIGHT have a charge density problem if you have an MTHFR SNP that goes awry. Do you know that COVID-19 and LONG-COVID patients suffer from this effect? At the beginning of the pandemic, I was seeing so many people who were fit yet developed rapid onset diabetes. In fact, I just got interviewed by someone in LA about this topic who it happened to. I do not think she, her family, or her fancy rich doctors in LA know what I will tell you.
When I was in LA meeting with Rick and Bobby Kennedy Jr, I met three people with pancreatic cancer and sudden onset diabetes after COVID and their jabs. The pic above and below show you why they got it. How much do you know about methylglyoxal (MGO) for short?
Right about now, my driver in LA, Dan, is probably reading this and thinking about all the Dummies out there in LA-La land he met who need this information but just could not fathom I was right about what I told them. Right now, Dan probably knows why I was so pissed at a breakfast we had when the discussion went from gold course to LA’s nnEMF burden and why that is such a problem for diabetes and tumors of the pancreas and brain. Did you know excessive methylation, a C terminus issue, causes cancers by altering methylation? I just wrote you a C terminus blog!
One of the staples of my LONG COVID Rx I use for my farm clients is MGO inhibitors. I doubt you’ve heard of them. Some of my therapeutic approaches with my tribe who got COVID because they REFUSED TO MOVE include (1) MGO scavengers such as aminoguanidine, alagebrium, and pyridoxamine; (2) MGO synthesis inhibitors such as metformin and benfotiamine (thiamine); and (3) Glyoxalase 1 inducer, via activation of the Nrf2, such as phenethyl isothiocyanate and selenium sulforaphanes. (4) I use special concoctions of IVFs (below) to help change the surface charge of cells damaged by COVID-19 and/or the jabs. Each jab and COVID variant has its own particular fluid I use. It is 100% based on the charge these things impart to tissues. We do the same thing in heart and kidney failure cases with low Vitamin D proxies, but few people understand decentralized thinking.
These folks have kept me busy. I have had to turn away many people who only want to give 10% when they demand 100% of me because I no longer have time for people who refuse to do what I ask of them. That is not how decentralized medicine operates.
LONG COVID-19 FOLKS NEED A TON OF SUN BECAUSE OF PEGYLATION
DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used inmRNA vaccines. Why is it used? It improves the shelf of the jab by hiding it from your immune system cells. This comes with trade-offs.
All the cells in the blood become PEGGED with LNPs to alter their zeta potential. Think about PEGylation like a magnetic force field around every biomolecule in your blood. It ruins the electromagnetic signals normally present. See my slide below from Vermont 2018. This slide below is why I could easily understand the problem with the jabs. The PEGylation changed the electromagnetic footprint in the blood that the sun is built to control.
The electromagnetic shielding from pegylation would form a protein corona around things in the blood like immunoglobulins or albumin. It would also inhibit it from binding to platelet factor 4, altering normal clot time! Yes, clotting is controlled by the sun’s light, too. The alteration of the zeta potential is an electromagnetic change. As you can see from the picture above, the zeta potential of all Pegged things interacts with their surroundings. When it does, forces are generated that are not quantized properly, and viscosity changes, and so does flow. When the zeta force is strong, we know too much highly negative charge density exists. This could be high nitric oxide or way too many electrons. When this happens, blood cells will act to repel objects with like charge and keep them at a distance.
Big Pharma has figured out how to navigate the circulatory system to get into every organ system using the surface charge variation of drugs. Pegylation is just one way. Pharma scientists can customize any cell’s zeta potential based on the specific route they want to take in the body via the blood. Ralph Baric et al. and his friends in the DoD built spike proteins with a zeta potential to interact with human endothelium and the heart. This is why so many young people get myocarditis and clots. The science is so advanced now that they have learned how to control pegylation effects remotely with RF radiation. This operates just like your TV remote control. They learned this from CORONA virus gain of function research. It is called the “corona” virus because its activity varies with the zeta potential changes found in seasonal sunlight. In nature things in the blood are quantized by sunlight. In long covid, your decentralized doctor must figure out the charge density variations to come up with the right Rx for you. No one Rx fits everyone. This is why protocol medicine fails. It is also why I am not advocating McCoullough’s protocol.
What could make a cytochrome go awry in a big American city with a ton of people abusing nnEMF? Did you know the MTHFR photoreceptor system is how evolution built us to survive winter when glucose is rare? It allows our immune system to work even when the sun is not shining. MTHFR is a capacitor for electromagnetic energy. Capacitors hold charges. Melanin and water are charge capacitors. So is MTHFR. Can you imagine the effect of all this and then adding some DNA plasmids and SV 40 to the mix? What do you think might happen to people in that risk strata? Does Nature have a hack for people with long-term COVID-19? Staying immune through the fall & winter and a city with nnEMF is a quantum mechanical human longevity trick. It’s a good thing I stopped being a dummy 20 years ago.
Every week, I put out a new podcast on how energy is transformed by the aging silly talking clade of primates called humans. Physics tells us energy cannot be created or destroyed; it is just transformed in cells. Rarely do biochemistry books get the story correct. Physics tells us time is relative, and how we experience it is tied to tissue-level entropy. Tissue level entropy is called heteroplasmy by mitochondrial experts. The lesson?
Blue light stimulates insulin and blood glucose. This means ALAN never allows us to create glucose from our fatty acids. So, biochemistry books were written after 1951, and all said that it is impossible to create glucose from them. Is this another reason why blue light and nnEMF help make us fat? We never recycle our adipocytes, and they remain filled?
Let’s talk about winter. What happens when insulin levels fall, and ketone levels rise, as occurs when our carbohydrate intake is low, is our cells increase their supply of CYP2E1 and thereby activate the conversion of fatty acids to glucose. It appears the books were wrong, and Mother Nature found a way to a costly candy store in the magical land of ketogenesis when it is cold and the sun is not strong. What happens when melanin is absent from mammals?
When I was in medical school in the 1980s, two reviews were published outlining the evidence for converting fatty acids to glucose. One of them dated to the early 1950s. One of them emphasized that biochemistry students were taught that such pathways do not exist. The same Ph.D. (Peter Setlow at UCONN) who warned that the cholesterol story was BS, told me that we could make glucose from fatty acids because mammals like cows, guinea pigs, mice, and rats all turn acetone into glucose if they have to. He told us that this is why some diabetics have acetone breath odors. He told us the same thing about chronic alcoholics. This explained to me that alcohol was not a longevity toxin if you lived in the sun and why Jean Calment could live to 122.4 years old drinking red wine every day in the south of France. This lesson taught me never to trust textbooks. You have to read the PublMed papers to see the real truth. Centralized academics just regurgitate bullshit beliefs they hold as truths.
The most cost-efficient way of converting fatty acids to glucose is by converting acetol to methylglyoxal, facilitated by an SNP called CYP2E1. CYP2E1 is a P450 cytochrome. Did you know that the cytochrome P450 system is a heme-based semiconductive system that is part of the non-visual photoreceptor system mentioned above? CYP2E1 is involved in acetone catabolism by converting acetone to acetol and then to methylglyoxal (MGO); both intermediates in the gluconeogenic pathway. These metabolites are prominent in the brains of mammals where mitochondria reign. This P450 enzyme also catabolizes safely exogenous compounds such as inhalational anesthetics, ethanol, nicotine, acetaminophen, acetone, chloroform, chlorzoxazone, and tetrachloride. It is also important in the melanin renovation Rx because it removes aspartame. Aspartame lowers melanin levels endogenously. Excessive use of it leads to many problems in humans. One problem is that all mammals become more sensitive to electromagnetic radiation when their tissues lack melanin. Another thing that happens is that mammals seem to get diabetes more easily than ever before. Might it have something to do with melanin, NAD+, and the P450 system? All those lessons are in this blog for the Dummies on your list.
12. On the twelfth day of Christmas, my true love gave to me…………a relationship filled with electrons. Being with the right person is a net positive to your charge density. I wrote an entire series on relationship redox on Patreon, so have your Dummy list read it. So, if you think you are with the right person, ensure you get them everything on this list. Make sure you kiss and love them and add electrons to their life. Tell your honey how you feel about them today on the final day of Christmas.
You. You are a gift. It is a year-long Christmas gift, not a seasonal novelty with a shelf life. Your circle of six should always be proud of you and not jealous. They should build you up, not tear you down. They don’t give you a total pass all the time. They will keep you on your toes and prune your branches when needed. They love to see you win. Their wisdom is fertilizer for your growth and not criticism to stunt it. They certainly do not deserve your friendship and time if they cannot celebrate your success. Never forget how amazing some of us think you are every day. Write your story. I’m utterly convinced that our circle of six experiences is meant to support one another, and they are all relevant in some form or fashion. Every one of these experiences matters, and the Universe is so well-designed that we need these experiences to thrive. You are a gift to some of us, not all of us. Parcel your time wisely.
DUMMY SUMMARY
Instructions for Dummies have to be explicit, or they lose the plot. Retweeting without reading is not capturing wisdom. It just gets you an army of dummies.
Surface charge = topological change. Therefore, surface charge changes are the starting point for most adverse events in disease.
How do we determine the surface charge of anything? The surface charge can have either a negative or positive electrical state. It is determined by the balance of charges between negatively charged and positively charged nanoparticles at the surface. The cell membrane surface of living cells has an electric potential different from that of the cell’s interior, namely membrane potential.
For example, here is a study on inhaled LNPs with a POSITIVE ZETA POTENTIAL OF 42! This tells you there are a lot of protons in this LNP.
It should be clear for those who are actually reading my Patreon blogs or tweets and learning the lesson. What do you think might happen when you introduce an LNP with a large positive charge (zeta potential big) to the lungs? ANSWER: That is how you get a pulmonary embolus or MASSIVE THROMBOSIS in an arterial bed.
A strong increase in the surface energy is obtained when the size of the lipid nanoparticle decreases, both in the solid and liquid states.
The latest results show that the nanofluids’ surface tension increases with concentration and nanoparticle sizes. TiO2-DW nanofluids exhibit higher surface tension than Al2O3-DW and SiO2-DW nanofluids, respectively. Yes, Titanium dioxide in your foods and cheese as a lot in common with pegylation in the mRNA jabs.
Thermodynamics is defined by energy and charge. Size and shape changes alter charges, and the zeta potential is how this is measured in blood. In a tissue or biomolecular real or manufactured, when we hold a constant pH and salt concentration, the magnitude of surface charge decreases with an increase in the particle size and reaches a constant when the particle size exceeds a critical value. This is why lipid biochemistry is a joke as a risk factor for heart disease. Calcium Index scoring is a way better marker for heart disease because it is a topological effect telling us that the circulatory system’s surface charge is abnormal.
4. Navarro, P.; Chambers, I.; Karwacki-Neisius, V.; Chureau, C.; Morey, C.; Rougeulle, C.; Avner, P. Molecular Coupling of Xist Regulation and Pluripotency. Science (80-)2008, 321, 1693–1695.
5. Escamilla-Del-Arenal, M.; Da Rocha, S.T.; Heard, E. Evolutionary diversity and developmental regulation of X-chromosome inactivation. Hum. Genet.2011, 130, 307–327.
Many forget light is both a particle and wave. It has a duality. Life uses that advantage. Light from the sun acts more like a wave than a particle and that is how we use it as ainformation. Light created by photosynthesis (food) or by cells (bio-photons) acts more like a particle. No one should forget both pathways LIGHT IS INFORMATION. How it is used as information is what varies in Nature. I covered that here.
INTRODUCTION
Do you use time wisely? Do you prioritize your choices by weighing the value of information and wisdom against the cost of choice and decision?
Life always is wrapped in opportunity cost.
Decentralized medicine is both science and art in a unique package blended by perspectives of how the world is affected by Nature. Looked at from this vantage point, a good decentralized artist knows he has less time than ideas and this pushes him to act, to create, and to share his ideas born in his craft. Time is too precious to waste.
The job of the Nature is to always deepen the mystery for the artist. The job of the artist is to find the inspiration of Nature and reflect it in your creation and wisdom.
Optical biophysics studies how light is transformed into information for cells. Cells are filled with non-visual photoreceptors to capture the electromagnetic properties buried in photons of the cosmos. Biology is not a foundational science. Physics is. Optics forms the solid-state physics of the living state. This means paying attention to the light emissions and absorption frequencies from cells, DNA, and molecules of organic matter and how these interface with water. At birth, we are 80% water; at age 60, we are at 55-60% water by weight. Cells capture light and create water and are moderated by the nested array of electric and magnetic fields transformed by mitochondria located on the quantum level and capable of stretching up to the galactic level where plasma is ubiquitous. This plasma connects everything in an electrical circuit at unfathomable ranges and power. We do not operate at all ranges of this spectrum. This plasma has a pulse or rhythm to it. Our cells pay attention to this music and to its rhythm. The rhythm can be found in the absorbtion and emission spectra of a molecule.
Melatonin is a hormone that is naturally made by the mitochondria in your tissues, and its production is closely tied to light. In response to darkness, the mitochondria in our tissues initiates production of melatonin but light exposure at might or artificial light during the day slows or halts that production in mitochondria. The pineal gland is not where the melatonin story begins on circadian clock maintence.
This is the range of nature’s music, which we are part of and can tune into. All parts of this spectrum have biological effects. Some are good, and some are harmful to cells. This is the nature of light exogenous to our cells.
The organism creates its own music endogenously— of a somewhat more restricted but still enormous range between 10^-7 m and 10^8 and beyond — it is both exquisite and subtle. With the present level of ‘man-made’ electromagnetic pollution of the environment, one might very well ask whether the organism’s melody is in grave danger of being drowned out altogether by our mitochondria.
When we listen to a good talk, book, or podcast, whether off-the-cuff or seared into our memory by emotion, something in us is built to hear this music, not just in its register, the lilt, the cadence or its rhythm, but, in those moments, there are no words to be heard; all you can hear is the enveloping silence.
The same is true with cells…..the photons in the sun are sounds, while the silence is found in the darkness of night. The real music of life is found at night when light is absent. This is why ALAN, called artificial light at night, is so dangerous to humans. Feedback coupling has many facades in reality, and few in centralized science realize it.
Melatonin is made in the morning and during the day, but it only acts to delocalize electrons under the cover of darkness. Melatonin is like a conductor of Nature’s music. Few understand how sunlight gives its information to serotonin to create melatonin in our mitochondria. Sunlight transforms serotonin into melatonin and melatonin, then IMBIBES our cells with quantum information to ensure cells display significantly higher amounts of both p53 and acetylated p53. This biochemical signal is the basis of the anticancer effect of mitochondrial melatonin. This is how light becomes biochemical information.
Not to discount the bio-chemical nature of life, which is hegemonic in the health science realm, the optical bio-physician asks: which of these is PRIMARY in the growth, replication, and division of labor of individual cells or entire species of organisms? Is it the chemical attributes of living matter or the electromagnetic properties?
Mitochondria, the transformer of light to melatonin, are not mechanical machines; you should never think of them this way.
Mechanical systems work by centralized control. Centralization is a hierarchy of controllers and the control that returns the systems to set points (equilibrium). Life is never at equilibrium. Mitochondria are fully built to be decentralized to light and dark cycles.
HOW DID WE COME TO KNOW THAT LIGHT IS INFORMATION AND BOTH LINK TO ENERGY?
Claude Shannon is regarded as the father of information theory. Alan Turing is known as the father of computer science. In 1943, Shannon and Turing worked on different projects at Bell Labs in New York City.
In 1948, intersecting with Shannon’s pioneering theory on information, Alan Turing simultaneously wrote a report at the National Physical Laboratory on “Intelligent Machinery” that laid the groundwork for the emerging fields of information networks and artificial intelligence.
They had discussions together, including about Turing’s “Universal Machine,” a type of computational brain. Turing seemed quite surprised that in a sea of code and computers, Shannon envisioned the emergence of arts and culture as an integral part of the digital revolution – a digital mitochondria of sorts. What was dreamlike to Turing’s imagination in 1943 has become today’s reality. Shannon’s early connections between the arts, information, entropy, and computing intuit the future we are experiencing today. Turing famously said “Shannon wants to not just feed data to a brain, but cultural things! He wants to play music to it!” Shannon knew there was art buried in the nature of information. There was an inherent rhythm in both men’s ideas.
Order and chaos are deeply linked in nature by rhythms. The paper above was the first paper that showed us how feedback loops could organize chaos in light & dark to build circadian biology using waves in rhythm. It requires no complexity and is a feature of Nature’s self-organization ability. All it requires is a feedback loop to operate. Turing was the first to crack the key biological rhythms in life.
WHAT DID TURING STUMBLE INTO?
More light = more information in the system to build complexity. Darkness makes the information durable and usable. Energy tends to dissipate in the universe — and entropy, a measure of its dissipation, increases over time.
Time appears as entropy in cells and is coded for by molecular clocks. All clocks are flow meters of entropy. This is how matter organizes disorder into order. When a dissipative system controls entropy, life can manifest. This is a very basic idea in quantum biology that Turning explored before quantum biology became a disciple of decentralized science.
Three years before Turing’s paper in 1951, Claude Shannon shook up the world with his work on information theory.
In 1948, Claude Shannon’s paper showed that entropy is linked to information. Entropy is a way to measure the amount of information in a source. The more information you have, the higher the entropy of the source is. A high-entropy message means low information gain and a low-entropy message means high information gain. Biology wants to create a low entropy game in cells so cells can collect massive amounts of information. Mother Nature built cells filled with clocks to take advantage of this idea. Information gain can be thought of as the message fidelity in a system: the amount of clean knowledge available in a system.
To physicists John Wheeler, the ideas of Turing and Shannon implied energy and information are deeply linked. John Wheeler proved that was true in physics using the Landauer Principle (1961). Biologists still have no idea about the implications of this work.
Landauer’s principle is a physical principle pertaining to the lower theoretical limit of energy consumption of computation. It holds that an irreversible change in information stored in a computer, such as merging two computational paths, dissipates a minimum amount of heat to its surroundings. Landauer’s principle states that the minimum energy needed to erase one bit of information is proportional to the temperature at which the system is operating.
At room temperature, the Landauer limit represents an energy of approximately 0.018 eV (2.9×10^−21 J). Modern computers in 2023 use about a billion times as much energy per operation. This means information transfer in nature always has an energy cost. This is why nature uses a PoW mechanism. It explains why John Wheeler said information and energy are the same physical entity in Nature. It might also explain why cells are filled with water to dissipate the effect of heat created during information processing. Remember water has a massive heat capacity.
Wheeler divided his own life into three parts. The first part he called “Everything is Particles.” The second part was “Everything is Fields.” And the third part, which Wheeler considered the bedrock of his physical theory, he called “Everything is Information.”
When Shannon was at Bell Lab in 1948, Bell labs had tons of information buried in their messages but had no way to mine or collect the information to make the data useful. Shannon thought about the problem and wrote a paper about using mathematics to data-mine information.
The paper was called “A Mathematical Theory of Communication.”
Once Shannon connected these dots mathematically, it opened the door to signal processing, compression, and converting messages into an algorithm code to transmit them digitally. It gave rise to the Cambrian revolution in computers after 1948. Turing died in 1951, but his ideas lived on in many computer engineers.
THE LINK TO ENERGY AND THERMODYNAMICS
Shannon’s limit in information transfer mathematically looks exactly like Boltzmann’s equation for entropy in thermodynamics. Entropy was an idea originated in the 1824 by Carnot. I’ve written Patreon entries on Carnot’s theorem. Both concepts, bit and photon, share the same roots: nineteenth-century thermodynamics and the concept of entropy.
In 1877, Boltzman gave us a statistical explanation of the second law of thermodynamics. In 1877, he provided the current definition of entropy. Shannon’s papers gave us a similar answer for information as his equation shows below.
Because these two equations are nearly identical mathematically, physicists began to realize in the 1960s that information and energy are linked physically in reality. Nature is revealing her secrets in these equations.
Shannon’s work on information entropy links to Michael Crawford’s theory on DHA. These ideas coordinate with Einstein’s special relativity (1905). Einstein’s work directly ties to the Landauer Principle (1961) to explain how cells use light to communicate. Information transfer costs us energy.
Landauer predicted that erasing even one bit of information would release a tiny amount of heat, a figure that he calculated. This implies mitochondria are time machines because they also transform light energy into CO2, water, and heat = mtDNA is a hydrogen heat engine.
If information is energy, as Wheeler has told us, Information, once created, has to have a “finite and quantifiable mass.”
This connects information theory directly to energy and the mass equivalence equation of Einstein, E-mc^2.
This is how they are linked. Light is light energy in photon form.
HOW DOES THERMODYNAMICS LINK TO THE CIRCADIAN CLOCK?
How do cells do it? Your epigenetic mutation load (EML) of your tissues is the key to understanding how the light you use in your environment builds the life you live. Nature has built a clock timing mechanism as you live life based on your light choices. A higher EML has been associated with age-related pathological conditions like X chromosome activation skewing. The circadian clock in humans controls chromatin marking. BMAL1 is a clock gene, and HSF1 is a HEAT shock protein.
Remember what I said about Landauer’s principle above. As information is transfered, so is heat. This is why we have heat shock proteins in cells. Both get optimized by sunlight exposure. HSF1 is an important transcription factor for the induction of NAT1 in human cells and is required for androgen activation of the NAT1 promoter. This is why Neil Armstrong had lifelong problems with his testosterone levels when he returned from the moon, and it is why so many women struggle with sex hormone problems in their lives when they are filled with methylation problems from alien light. This is how humans inactivate the X chromosome to limit disease and create time. If we choose badly, the opposite occurs.
Shannon realized that the quantity of the message had ZERO to do with its true meaning. No one yet realizes the same thing is true in humans in how their colony of mitochondria works with sunlight.
Shannon found just using a “one and zero” is all it took to solve Bell Labs’ problems around understanding information = where the word “bit” comes from.
Physicist John Wheeler gave us the idea that everything is information.” = it from bit……..
Wheeler tells us every particle in the universe emanates from the information locked inside it.
Mitochondria are Turing machines that use Shannon’s binary code of 0 and 1, where 0 = H+ and 1 = deuterium, and solar photons drive the Boolean logic gates in the mitochondria to action. Mother Nature-innovation was profound. She created an electromechanical switching circuit that could decide things. She proved 3.8 billion years before Shannon that it was possible to perform complex operations by means of electromagnetic relay circuits built from hydrogen isotopes. I covered how mitochondria do this here ——-> https://optimalklubs.com/kruse-for-dummies-general/
NAD+/NADH is a proxy for melatonin production in our mitochondria by the rhythm and time of sunlight and by darkness in our lives we get. Melatonin is the key light hormone that protects the heteroplasmy rate mitochondrial DNA to keep clocks operating well. You won’t hear that from a food guru. This means melatonin is the photochemical gate keeper of the % of heteroplasmy in mitochondria in a cell. It not only controls inflammation (entropy) but it also controls turnover of DHA in the membranes of our cells. This complex dance begins in the skin and eye, at the RPE, where ocular melanin and melatonin begins its quantum magic by using AM light to regenerate the melanopsin receptors in broad daylight by using UV and IR light. They operate together when UV-IRA light are present simultaneously.
The spins of electrons/protons are not only manipulated by light. Light has both electric and magnetic fields. Spins of electrons and protons are also affected by magnetic fields (ATPase of mitochondria or the dynamo of Earth or those found in tech gear). It turns out spin states can also be affected by electrical fields (emitted from proteins side chains) and can be used to collect and store information optically from electrons or the photons they carry. This allows energy and information to be buried and included in the atomic structure of cells.
Brain entrainment through light pulsing hinges on synchronizing the brain’s electrical patterns with external stimuli. By emitting light at specific frequencies from mitochondrial metabolism, the brain is coaxed into a ‘frequency following response‘, aligning its brainwave patterns to the rhythm of the light.
This synchronization isn’t just fascinating; it’s profoundly useful from a physiological and evolutionary perspective. Our brainwaves mirror our mental states – beta waves dominate when we’re focused, while alpha waves signify relaxation. By entraining these frequencies with light, we can potentially steer our mental state, precisely guiding the cognitive ship.
The cellular organization is the key to precision optical signaling. Life is all about optimizing optical physics inside cells. It transforms energy from the environment to do this. Modern physics has now proven that energy and information are equivalent in physics. Landauer & Shannon’s work was critical in making this linkage.
The cellular organization is the key to precision optical signaling. Life is all about optimizing atomic molecular organization (AMO physics) INSIDE OF CELLS. It transforms energy into information from the environment. Modern physics has now proven that energy and information are equivalent in physics. Landauer & Shannon’s work was critical in making this linkage. Modern quantum biology has experimentally proven that energy is trapped directly at the electronic level in cells. Energy is stored not only as vibrational and electronic bond energies in biochemicals but also in the structure of the system: its membranes, gradients, fields and flow patterns, compartments, organelles, cell water, the size and shape of our ventricles, and tissues. All this, in turn, enables organisms to mobilize their energies coherently at any time it is needed and hence make available the entire spectrum of stored energies for physiological work. Life really is energy transformed on demand by Nature’s atomic design in cells. Light is the information powering the ENTIRE system.
SUMMARY
Who described the mathematics of decision-making? Claude Shannon did. Shannon showed how to map logic onto the physical world (ledger). Turing showed how to design computers in the language of mathematical logic.
Mother Nature pre-dated both men’s ideas by 3.8 billion years. Evolution was Nature’s laboratory that ended by creating a mitochondria which acts as a Turing machine.
Our brains need to optimally encode different options and compare between them. So, how did Nature build the brain? It created an organ filled with mitochondria that responds at an attosecond level to electric and magnetic fields at 90 degrees to each other in light waves. Our brain is measuring light waves to decipher the chaos in our environment. In an abstract way, it mimics the double-slit experiment in physics.
With this brain, decision making became more probable. During human decision-making, attention plays a pivotal role by guiding information sampling between alternative pathways in the brain’s mitochondria.
One of the hallmarks of the living system in cells is that they are exquisitely sensitive to specific, weak rhythmic signals.
During human decision-making, attention plays a pivotal role by guiding information sampling between alternative pathways in the brain. Our brains need to encode different options and compare them optimally using optics. So, how did Nature build the human brain? It created an organ that responds at an attosecond level to electric and magnetic fields at 90 degrees to each other in light waves. Our brain is measuring waves to decipher the chaos in our environment. It mimics the double-slit experiment in physics.
So far, the role of attention in decision-making has only been addressed through saccadic displacements in our eyes. Might saccade be the first clue that the brain is using our eyelids to episodically polarize unpolarized sunlight to create a new type of rhythm to make sense of our world? This NEW idea implies that seeing is not always attending, and attending is not always seeing.
Brain entrainment with light pulsing is more than a biological evolutionary advance. It might be the next frontier for neuroscientific technological advancement; it’s a window into peering into the vast potential of the human mind.
When Shannon met Turing
Computing fell in love
with digital information
A transformation
A revolution
New computations
Sparking innovations
When Shannon met Turing
a moment enduring
Alluring algorithms
touched information theorems
Man is way behind Mother Nature. Wolfgang Pauli realized that the free electrons in metal must obey the Fermi–Dirac statistics. Using this idea, he developed the theory of paramagnetism in 1926. Shortly after, Sommerfeld incorporated the Fermi–Dirac statistics into the free electron model and made it better to explain the heat capacity. Two years later, Bloch used quantum mechanics to describe the motion of an electron in a periodic lattice.
The mathematics of crystal structures developed by Auguste Bravais, Yevgraf Fyodorov, and others was used to classify crystals by their symmetry group, and tables of crystal structures were the basis for the International Tables of Crystallography series, first published in 1935. The band structure calculations were first used in 1930 to predict the properties of new materials, and in 1947, John Bardeen, Walter Brattain, and William Shockley developed the first semiconductor-based transistor, heralding a revolution in electronics.
Why did Nature innovate chlorophyll and hemoglobin before moving on to melanin in the evolutionary history of mammals? She learned that nitrogen and hydrogen could be liquefied under the right conditions and would then behave as metals. Then she had some solid-state physics she could innovate life with. Nature innovated the idea that a classical electron can move freely through a metallic solid in an aqueous liquid crystal. She realized the power embedded in anisotropic crystals, built us from them, and self-assembled them in sunlight’s electric and magnetic fields.
Birefringence is the optical property of a material with a refractive index that depends on light’s polarization and propagation direction. Birefringence occurs in anisotropic materials that are said to be birefringent. Piezoelectric materials, like bone or collagen,, are anisotropic; they do not have the same properties in all axes.
Is the ATPase ANISOTRPIC?
What do you know about phosphoresce and ATP? Is this important in creating the spectrum of biophotons from mitochondrial metabolism? Is this how it can vary? The answer is yes. Metabolism makes heat, light, CO2, and water. You do not see the light because mitochondrial matrix-created water is an electromagnetic capacitor for these bio-photons. The water is structured in coherent domains to be transformed for physiologically useful energy in a cell. This is the PoW mechanism at the core of the quantum cell.
In simple terms, phosphorescence is a process in which energy absorbed by a substance is released relatively slowly in the form of light. This is, in some cases, the mechanism used for glow-in-the-dark materials, which are “charged” by exposure to light.
Do you know that outside of the visible light spectrum, nnEMF causes calcium efflux? What is the effect of calcium efflux on the ATPase?
Did you know that the presence of excess calcium ions has been found to cause a 20% decrease in the phosphorescence emission anisotropy in a cell?
In centralized science, this is interpreted as being due to a conformational change in the protein based on the methodologies being studied. Moreover, it is supported by data from time-resolved phosphorescence measurements. These measurements also show a hard physical effect of nnEMF: nnEMF toxicity lowers the anisotropy.
Anisotropy is a basic property of all crystalline materials. Living tissue is anisotropic. The organism is a dynamic liquid crystalline continuum with coherent motions on every scale.
Even in nanocrystals and amorphous solids, e.g., metallic glasses, anisotropy is present on an atomic level. Therefore, magnetic anisotropy is an intrinsic property of magnetization in general.
For nanoparticles that are used in the quantum cellular design, this is hard to achieve: because of their small size, they are generally only slightly polarizable by light, and thus, the difference in potential energy will, for accessible electric fields, below. This implies that the conditions for alignment are specific and sensitive to electric fields in cells. Physics has shown that the minimum size to align a particle depends on the size and shape of the particle because of a nontrivial competition between particle bulkiness and anisotropy.
Anisotropy, denoted by lowercase “r” in physics equations, indicates molecular size, diffusion, and viscosity.
Several physical techniques or forces in nature can be employed to assist the self-assembly process in cells, such as alignment of the particles by introducing a substrate to the system (atoms), employing a fluid flow (viscosity), or applying external magnetic (free radicals) or electric fields (Becker’s DC). An external electric field can align an anisotropic particle due to its anisotropic polarizability, which causes the particle’s potential energy to vary with its orientation in the field present in cells. nnEMF changes this thermodynamic variable.
Since the thermal Brownian motion (Einstein’s most cited 1905 paper) competes with the tendency to align, the potential energy difference has to be high enough to overcome these fluctuations and substantially align the particle.
The dependence of the minimum size of an alignable particle on the shape ratio of the particle is non-trivial, as it is not in general true that for alignment, the more anisotropic the particle, the better, nor are bulkier particles always better: for all the particle shapes studied so far, the optimum shape lies in-between these variables. This implies abnormal Calcium movements in mitochondria have huge anisotropic effects in mitochondria. This larvae shows that effect below.
This change in the decay of the emission anisotropy is associated with only minor changes in the rotational relaxation time of the protein and is again suggestive of a conformational change in the protein. This means that one of the biological effects of nnEMF is an altered conformational change in protein semiconductors.
For example, muscle contractions reduce anisotropy; for instance, contraction of the quadriceps muscle can decrease anisotropy of the patellar tendon. If that muscle contraction is done under blue light, it compounds the effect inside of mitochondria.
In the brain anisotropy can be seen on MRI. Anisotropy measures describe the directional dominance of water diffusion within a region. Within a voxel, the anisotropy provides an index of the degree of uniformity of water diffusion for a specific orientation. Strongly directionally organized tissue, such as the corpus callosum, which is primarily comprised of tightly packed medial–lateral projecting fibers, has a high degree of anisotropy because there is a tendency for diffusion to be highly restricted along the fiber membranes to follow this medial–lateral direction.
However, when the callosal fibers intersect other pathways in the brain, such as the corticospinal tracts which control motor movement, this unidirectional organization is disrupted and the anisotropy is reduced. This has implications in diseases like ALS, Parkinson’s disease, and Alzheimer’s disease. Thus, there is a normal anatomy of the cerebral white matter of both high and low regions of anisotropy, and it is therefore not the case that greater anisotropy is always indicative of greater tissue integrity in human brain MRI. In fact, measurements of anisotropy have been performed for various brain diseases, and abnormalities (mostly reduction) have been reported.
In strokes of the human brain, diffusion tensor imaging shows an
increase in fractional anisotropy because of changes in the ATPase and mitochondrial response to hypoxia.
Welding fumes contain several metals, including manganese (Mn), iron (Fe), and copper (Cu) that at high exposure, may co-influence welding-related neurotoxicity. The relationship between brain accumulation of these metals and neuropathology, especially in welders with subclinical exposure levels, when compared with controls, welders had significantly lower fractional anisotropy in the globus pallidus where Parkinson’s Disease occurs.
SUMMARY
It was Albert Einstein who created the modern field of condensed matter physics, starting with his seminal 1905 article on the photoelectric effect and photoluminescence, which opened the fields of photoelectron spectroscopy and photoluminescence spectroscopy, and later his 1907 article on the specific heat of solids which introduced, for the first time, the effect of lattice vibrations on the thermodynamic properties of crystals, in particular the specific heat.
Condensed matter physics is the field of physics that deals with the macroscopic and microscopic physical properties of matter, especially the solid and liquid phases, which arise from electromagnetic forces between atoms and electrons. This field concerns itself with soft matter. This is the matter cells are made from.
Condensed matter physicists seek to understand the behavior of these phases by experiments to measure various material properties and by applying the physical laws of quantum mechanics, electromagnetism, statistical mechanics, and other physics theories to develop mathematical models and predict the properties of extremely large groups of atoms.
Anisotropy is firmly in the scientific realm of the condensed matter physicists. The diversity of systems and phenomena available for study makes condensed matter physics the most active field of contemporary centralized physics: one-third of all American physicists self-identify as condensed matter physicists.
Anisotropy is most typically examined using the calculation for fractional anisotropy (FA); described in Basser and Pierpaoli, 1996; applied in several manuscripts, e.g. Pfefferbaum et al., 2000; Abe et al., 2002), yet similar metrics such as relative anisotropy (RA) have also been applied in the diffusion-imaging literature examining lifespan changes (e.g. Huppi et al., 1998, 2001; Nusbaum et al., 2001; Miller et al., 2002; van Pul et al., 2005; Y. Zhang et al., 2005; Camara et al., 2007; Schneiderman et al., 2007; Stahl et al., 2007).
In some of the papers I have read on this fundamental process, ATP was also observed to lower the time-averaged phosphorescence anisotropy inside of cells, possibly via an interaction with the low-affinity regulatory site of the protein.
None of these things are controlled for in nnEMF toxicity studies. When my @Bitcoinandbeef interview
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Lucchini R. G., Martin C. J., Doney B. C. (2009). From manganism to manganese-induced parkinsonism: A conceptual model based on the evolution of exposure. Neuromol. Med. 11, 311–321.
Hashimoto R., Mori T., Nemoto K., Moriguchi Y., Noguchi H., Nakabayashi T., Hori H., Harada S., Kunugi H., Saitoh O. (2009). Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging. World J. Biol. Psychiatry 10, 65–69.
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Watch the video above and head to daylightcomputer.com and use password KRUSE2023 to see more on this great innovation from Anjan Katta of Daylight Computer, based for now in San Francisco. Below is my receipt as the first customer of this innovation.
BLUE LIGHT IS A STIMULANT THAT CREATES ROS/RNS NORMALLY
And stimulants are 👍 great. Most Americans drink a few cups of stimulants each morning ☕️ to get themselves up to face the daily grind.
But you know what’s not great? Being stimulated 24 hours of every day by blue light. This ruins the dose-response curve of the ROS/RNS. That is precisely what is occurring to modern humans because they live indoors and use tech screens excessively. What else is different about this version of blue light? The blue light that wakes us up in the sun is NEVER present without 42% IR-A light, which is red light. AM sunlight has 42% red light in it and only 1600K of blue light. This small stimulus of blue light is about to improve the executive function of the prefrontal cortex. This blue light needs red light to control the oxidation ROS/RNS that blue light makes when it is present without red light in our light environment.
ALL CELLS contain ion channels in their outer (plasma) and inner (organelle) membranes. Like other proteins, Ion channels are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction, or coordination of the cell cycle.
An important class of ion channels is the family of potassium (K+) channels; they are not only in charge of the membrane resting potential or the repolarization of the action potentials but also control cell proliferation or transmitter/hormone release, to name a few. A subgroup of K+ channels are the so-called calcium (Ca2+) activated K+ channels, which need either an increase of Ca2+ at their intracellular face to open or a combination of Ca2+ and voltage to function correctly. Maxi Ca2+-activated K+ channels, also named BK channels, constitute a subgroup of Ca2+-activated K+ channels.
Do you know where these ion channels exist in humans? They are found on the inner mitochondrial membrane. EXCESSIVE BLUE LIGHT exposure destroys these potassium ion channels to ruin signaling of cells that control the circadian mechanism and are associated with leptin and melanopsin. LET THAT SINK IN.
Mitochondria are a significant source of ROS generation targeting BK channels. Blue light creates that stimulus when RED LIGHT IS ABSENT.
C TERMINAL CHANGES ARE A BLUE LIGHT STORY.
The inner membrane of mitochondria contains BK channels (mtBK), which appear essential in the production of ROS. mtBK channels appear to be inserted into the mitochondrial membrane with the toxin binding sites for charybdotoxin and iberiotoxin exposed to the mitochondrial intermembrane space. This can be accessed using outside-out patch configuration of the inner mitochondrial membrane. Consequently, the C-terminal tail domain, including the Ca2+ binding site, is localized to the mitochondrial matrix where the proton gradient exists.
RED LIGHT MOVES PROTONS BEST. Blue light creates the most ROS. Do you understand why subtracting red light and UV light from blue creates mitochondrial diseases now?
Your brain wakes up when you look at your computer or phone screen. It’s alert. Because it hears, “It’s daytime! Time to be focused and do human things!”
But guess when it’s terrible to hear that signal?
The other 14 hours of the day, the Sun wouldn’t usually send such a signal to the brain.
We need a break from the stimulus. Otherwise, we fry our circuits and get fatigued.
So take a break from the blue light our modern world worships. Stop the intravenous coffee to your SCN and allow yourself to relax.
WHY DO ALL HUMAN NEED THIS COMPUTER?
This computer builds your brain anabolically and does not destroy it catabolically as every other computer does.
WHY DOES ALAN (artificial light at night) or blue light cause melanoma?
Pyrimidine dimers are molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions. Ultraviolet light (UV) induces the formation of covalent linkages between consecutive bases along the nucleotide chain in the vicinity of their carbon–carbon double bonds. The dimerization reaction can also occur among pyrimidine bases in dsRNA (double-stranded RNA)—uracil or cytosine. Two everyday UV products are cyclobutane pyrimidine dimers (CPDs) and 6–4 photoproducts. Blue light causes these cyclobutane residues, which can lead to cancers like melanoma. Many people think UV light causes this, but blue light is way more potent in generating these melanoma-inducing chemicals, as shown below.
These pre-mutagenic lesions alter the structure and possibly the base-pairing in DNA. Up to 50–100 such reactions per second might occur in a skin cell during exposure to sunlight but are usually corrected within seconds by photolyase reactivation or nucleotide excision repair. Uncorrected lesions can inhibit polymerases, cause misreading during transcription or replication, or lead to arrest of replication.
Artificial man-made Blue Light “Enhances” Melatonin Suppression….via melanopsin damage………Imagine that?
🐭😱
I’m sorry, but we are still relatively close to the starting line when it comes to the amount of research into blue light and circadian rhythm so we kind of have to read what we have access to and do our best to be DIRECTIONALLY accurate in what we take from them and how they apply to humans.
This paper, however, is one of the best you’ll find anywhere.
They tested 24 humans. Some of whom, I’m told, actually look like mice.
They determined…
“Each fluence-response curve demonstrated that increasing corneal irradiances of light-evoked progressively increased nocturnal melatonin suppression. A comparison of these fluence-response curves supports the hypothesis that polychromatic fluorescent light is more potent for melatonin regulation when enriched in the short wavelength spectrum.”
Is there visual acuity flux in the human eyes due to variable factors in our light environment? Yes, there is. Black Swan MDs would be wise to recommend routine sunning the eyes to release stress in eye ciliary muscles to improve vision accommodation via dopamine modulation of the skeletal muscle fiber types in these eye muscles. Just knowing this data is true, one can’t help but wonder if prescription eyeglass wearers shouldn’t be evaluated in an eye doctor’s office over a series of days/times (diurnal exams) to account for these confounding lighting factors in determining overall average visual acuity. I’ve begun doing this for blue blockers. The results are quite interesting. It caused me to ask Anjan to build this computer. Blue locking glasses are not enough protection.
Based on my work with patients, a computer with zero blue light emission is the requirement. We will still need them for other things, but you won’t need them with Anjan’s computer.
There is a “revolution on the surface of the earth” called blue-lit technology, and it is causing a new evolution of free radical signals via nnEMF and magnetic fields from your environment, changing the internal terroir in your mitochondria, leading to diseases that appear to emerge from nowhere. Anjan’s computer puts a dent in this game plan hatched by Silicon Valley. This is why they want him to fail. The healthcare reality you obtain manifests from these collisions and creations.
SUMMARY
This conversation happened recently based on my work around decentralized medicine and anabolic computing in El Salvador.
Follow me closely with this, because this might be the most important post you read on Patreon in your entire life:
“I have known for years now that melatonin is anti-cancer. But every study I’ve read basically pegged it as such because of its antioxidant activities. This is true to an extent.
However, last night, a pretty brilliant neurosurgeon that I’ve been following for about five years now turned the light on in my mind and made it crystal clear to me precisely what the mechanism is that makes melatonin so crucial for cancer prevention and healing from cancer.
He made two statements:
1) blue (artificial) light, especially at night, causes cancer.
2) nnEMF (non-native electromagnetic fields – think cell phones, x-box, tablets, Wi-Fi routers, cell towers, smart meters, smart homes, Apple watches, Fitbit, Bluetooth, or anything that operates on wireless technology) causes cancer.
But here is the connection that he helped me make last night:
What is the hallmark trait of cancer? – dysfunctional cells that are like STEM CELLS that are multiplying and growing out of control in the body.
Here’s the rub: we ALL have cancer cells growing in our bodies. All of us. What makes it that one person doesn’t develop deadly cancers while others do?
One word: apoptosis. This describes the body’s innate ability to recognize a cell as dysfunctional and potentially cancerous and “orders” the cell to shut down and die.
The amount of melatonin controls apoptosis a mitochondrion can make, and our mitochondria make the most melatonin in our body. That amount is quantized to the light we live under.
If apoptosis works correctly in you, you will not develop cancer because your body can recognize those dysfunctional cells and neutralize them immediately. Problem solved.
Here’s the thing: MELATONIN, the hormone made in every mitochondria and found in our pineal gland created in the absence of LIGHT, regulates apoptosis. Let me make this plain as day for you (even if it is a crude description of a very complex biological process):
No melatonin = no apoptosis.
No apoptosis = dysfunctional cells growing out of control = CANCER.
Artificial light at night and nnEMF BOTH individually signal to your colony of mitochondria that it is daytime. In response, your colony of mitochondria and your pineal gland will dramatically reduce melatonin synthesis and output.
The light bulb was invented in the last 100 years, and homes across America have permanently changed how they live. What do we do when the sun goes down? We flip on the light switch and turn the computer. We sit on our phones. On our TVs and tablets. We are using iPads as digital babysitters!
All of this lowers our melatonin and arrests the process of apoptosis.
We are literally handcuffing our body’s natural and brilliant defense mechanism against cancer!
THINK ABOUT THIS FOR A MOMENT!
In our lifetimes, research shows that 1 in 2 of us will develop cancer. This is a VERY sharp rise from even 50 years ago.
We give money to cancer research charities, who then give that money to cash-rich pharma companies who don’t need our money so they can create drugs that don’t cure cancer and make us go broke using them. We run, walk, and bike for the cure.
What if the cure for cancer was right under our noses?
What if it’s as simple as shutting off the damn lights when the sun goes down? Use a computer that has zero blue light. We can all agree on using low amber lighting, wearing blue-blocking glasses, shutting off your Wi-Fi router, turning off your wireless devices, and instead of watching TV, hanging out and talking with your family and then going to bed early.
If it’s that simple to prevent cancer for you and your children, would you do it?
Below is a study that shows how melatonin regulates the apoptosis of cancer cells.
There are hundreds, if not thousands, of studies and research papers that show how artificial light at night suppresses melatonin and several studies that show how nnEMF does this as well.”
“Jack and Anjan might have solved one of the biggest riddles in the world. ”
