Circadian biology is so fundamental to sleep and metabolism but few people realize just how important it really is. It is more important than your macro or micronutrients. Most of you reading this really do not buy this because of the questions I get asked and all the comments I have seen made on FB, twitter, blogs, and internet forums. The blogosphere is tied to macronutrient ratios. It is a fact that our neolithic mind has burned into our conscious beliefs. This post is about showing you why you might want to consider changing your perspective on things related to what you eat. What we are designed to eat is the answer to where our ultimate health really lies. When we choose to eat in spite of our biologic directives this is when illness, disease, or bad feelings tend to crop up and cause confusion to the patient. The best way for you to solve this situation is to think. I want you to think about the message your neolithic mind is capable of delivering to your paleolithic genome on a daily basis. The reason we screw it up is that we fail to account for the effect of the mitochondrial genome’s effect on the rapidly changing epigenetic program that really is the master sculptor in biology. Most of us are completely unaware of this biologic mismatch. It is my belief that it underlies much of what currently ails most of mankind today. The reason is quite simple…….melatonin controls the efficiency of autophagy and apoptosis in the human mitochondrial genome. This gives the mechanism to just about every human chronic disease.
oday, in the face of rampant heart disease, osteoporosis, diabetes, and autoimmune diseases like celiac disease, multiple sclerosis, and thyroiditis, we have learned that America’s health crisis began with Tesla and the power grid in the during the last 19th century during the ‘Electric Power Wars’. Scientists are now uncovering that the electric power grid and things plugged into it increase blood glucose without any added food source of carbohydrate. This drives altered signaling in cells. Today Ph.D. researchers are blaming food for the etiology of mitochondrial disease, but the science of light is showing us this is a misplaced notion. The power grid and nnEMF increase blood sugar and need NO help from manmade foods to do so. It turns out technology and progress have raised blood sugar faster than Snickers bar or any fruit eaten out of season could. We are clueless to this reality and this is why no one is solving the diabetic mess. Carbohydrates only exacerbate the mitochondrial heteroplasmy problem……….they do not cause it and they cannot solve the quantum etiology.
The alteration of circadian rhythms is associated with a variety of mental and physical illnesses. Recent studies show a significant association between quantitative and qualitative sleep rhythm disturbances and increasing prevalence of obesity. Furthermore, reduced sleep quality and duration lead to decreased glucose tolerance and insulin sensitivity, thus increasing the risk of developing type 2 diabetes. This was from the January 2019 issue of issue of Internist from the article ‘Importance of Sleep and Circadian Rhythm for Energy Metabolism’. Even the paradigm is waking up to this science.
My Black Swans have gotten the code from me long ago. Now you are beginning to see where all the piees fit and why I have been very correct in saying light trumps food at all levels in all cases of human disease. No one fully understands how light controls the matter in cells and it all begins with the leptin-melanopsin chromophore loops in man. This idea is really the basis of most of the data in this book below.
When you read this book and re-read this blog you’ll see just how forward thinking my ideas have been for 15 years. I made sense of Hollowich by knowing where to look for the missing pieces. Melanopsin and leptin biology are two massive pieces.
We don’t have to go back very far in medical history to get to the time when rods and cones were believed to be the eye’s only photoreceptors. Not only do we now know of others, melanopsin included, but we are learning they have functions that go far beyond vision. For instance, the chief job of melanopsin is not to help us see images, but to act as a light sensor that provides ‘reflexive responses‘ to both the body and the brain, many of which have to do with circadian rhythms (melanopsin is the likely reason that I’ve suggested for 15 years sleeping in a room with zero light — not even a digital clock). CNRS International (The Many Roles of Melanopsin) had this to say about this photo-optic protein.
“It has been shown to regulate a wide range of non-visual functions, such as the synchronization of the circadian rhythms and the sleep-wake cycle with the light-dark cycle. Two main mechanisms regulate sleep: the circadian mechanism, which determines the optimal time for sleep, and the homeostatic system, which keeps track of how long the body is awake and asleep, and triggers ‘sleep pressure’ when the body suffers from sleep deprivation. Though light was known to influence the circadian mechanism via melanopsin, its effects on non-circadian processes were considered minor. Now, in a recent study, a team from CNRS reveals that light detection by melanopsin acts directly on non-circadian mechanisms and that circadian and non-circadian routes interact with one another.”
If you head over to my website or Patreon site and do a search on melanopsin, you’ll find articles like Reality #7: Blood & Chlorophyll Types and Food and Time #12: Is Adrenal Fatigue Due to an Altered Spectrum of Light? These blogs are so outside the box on how light is the driver to these diseases your head will hurt trying to make sense of all the concepts I’ve been trying to link together for you. REVIEW THEM! Listen to this statement I’ve made about melanopsin’s relationship between the brain (HYPOTHALAMUS), the eye, sunlight, leptin, and your body’s ability to heal.
Jack said, “The outer portion of the retina is where the photoreceptor melanopsin is loosely covalently bound to retinol. Melanopsin/retinol controls the neural signaling along the central retinohypothalamic tract. This tract connects the retina to the suprachiasmatic nucleus (SCN) which controls the circadian mechanism. This tract continues on and connects the retina and SCN to the leptin receptor in the hypothalamus. The leptin system, in turn, controls all growth and metabolism of the organism and this system controls the circadian release of hormones from the pituitary gland using specific light frequency changes present in AM sunlight. In December 2017 we have proof melanopsin/retinol are now in human skin, subcutaneous fat, and the arterioles of the skin. I will remind you that the subcutaneous fat mass links to the leptin receptor in the hypothalamus too using leptin and adiponectin as fat hormones. Melanopsin is the light chromophore for LEPTIN biology. He who controls the frequency of sunlight via the eye and skin, calls the shots for the anterior pituitary hormones and its effect on human behavior and illness.”
When one types “circadian” into the MeSH portion of PubMed, you’ll find (gulp) over 100,000 studies. To get an idea, however, of just how vast and important this field of study really is, allow me to show you some titles that were published within the beginnig of 2019:
- Integration of Melatonin Related Redox Homeostasis, Aging and Circadian Rhythm (Rejuvenation Research)
- Alterations of Circadian Rhythms and their Impact on Obesity, Metabolic Syndrome and Cardiovascular Diseases(Critical Reviews in Food Science and Nutrition)
- Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer’s Disease (Trends in Endocrinology & Metabolism)
- The Connection of Circadian Rhythm to Inflammatory Bowel Disease (Translational Research)
- Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer’s Disease (Frontiers in Cellular Neuroscience)
- Hypothesis: Ubiquitous Circadian Disruption can Cause Cancer (European Journal of Epidemiology)
- Circadian Oscillations of Cytosine Modification in Humans Contribute to Epigenetic Variability, Aging, and Complex Disease (Genome Biology)
- The Circadian Rhythm of Breakthrough Pain Episodes in Terminally-ill Cancer Patients (Cancers)
- Interplay Between Diet, Exercise and the Molecular Circadian Clock in Orchestrating Metabolic Adaptations of Adipose Tissue (Journal of Physiology)
- The Synchronized Clocks of the Host and Microbiota (Acta Physiologica: Oxford)
- The Role of Microbiome in Insomnia, Circadian Disturbance and Depression (Frontiers in Psychiatry)
- Calorie Restriction Reprograms Diurnal Rhythms in Protein Translation to Regulate Metabolism (The Official Journal of the Federation of American Societies of Experimental Biology)
- Circadian Rhythm Abnormalities in Parkinson’s Disease (International Journal of Molecular Sciences)
- Circadian Blueprint of Metabolic Pathways in the Brain (Nature Reviews: Neuroscience)
- Circadian Disruption and Human Health: A Bidirectional Relationship (European Journal of Neurosciences)
- Metabolic Rhythms: A Framework for Coordinating Cellular Function (European Journal of Neurosciences)
- The Arrival of Circadian Medicine (National Reviews: Endocrinology)
- Circadian Regulation of Endocrine Systems (Autonomic Neuroscience)
- Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology (Frontiers in Neurology)
SO AM I A MORON OR HAVE I PAID MORE ATTENTION TO WHAT REALLY MATTERS THAN MOST?
All the pieces of my thesis are coming to manifest folks.
NOW WE HAVE THIS MASTERPIECE CITE below from the literature:
DIABETES = MELANOPSIN DYSFUNCTION. EVERYONE’s RISK IS N=1 depending on the redox state of their melanopsin leptin axis. High sensitivity and interindividual variability in the response of the human circadian system to evening light are being elucidated in the literature. This will have some interesting collateral effects for blue blocker glass makers if they understand the physics of light going forward. It appears melanopsin is the reason why all of biology is N=1 game. This is why zip code trumps the genetic code in a blue light world.