RELATIONSHIP REDOX #8: DOES FRIENDSHIP AND LOVE PLAY A MAJOR ROLE IN YOUR REDOX STATE AND HEALTH?

I’d like this post to be dedicated to ideas around nurturing love long term.

I think I have done a poor job of exploring this aspect of relationships and how it relates to health and wellness and I think I need to improve this.

I believe relationships are built around three cornerstone pillars similar to life’s 3 legged stool of light water and magnetism.

They are:

  • Intimacy, which is characterized by warmth, support, communication, and understanding;
  • Passion, which is characterized by physical arousal and desire; and
  • Commitment, which involves the decision to actively work on, and sustain, a relationship.

I think all three are dynamic and lead to different types of love in relationships and they all build different lives.  This mimics the effects of light, water, and magnetism and its dynamism effect on mitochondria and cells to create an epigenetic program that sculpts the matter in our cells to build our tissues and the life we experience.

Currently, I believe the most important of this 3 legged stool is passion.
I believe today that holding “decay beliefs” about passion — in other words, believing a decline in passion is irreversible — is associated with lack of commitment, lowered investment, and pursuing romantic alternatives to one’s partner.  I think this belief is a function of the redox state of our colony of mitochondria as we age.  As such, I think the reason relationship struggle as time marches on is because each other redox state varies based upon the choices we have made in how we sustain the redox power in our own lives.

I believe total ‘complete’ love, is a possible result in life when all three variables of the stool of love are present and relatively strong.  However, this dynamic viewpoint of love brings up the possibility that there might be multiple possible combinations of this 3 legged stool, therefore, multiple resulting types of love can manifest based upon the variable strengths.

Romantic love:  For example, a couple who engage in a short-lived romance might demonstrate high levels of passion and intimacy, even though they lack commitment.  There is a strong link to dopamine creation here.
Fatuous love:  Some other couples who meet might marry quickly (and therefore commit to each other) on the basis of overwhelming passion but perhaps do so without truly understanding or getting to know one another deeply.
Such people are more likely to indulge in both commitment and passion in the absence of intimacy, which can be a risky move for obvious reasons. They might not like each other much once they become more familiar with each other’s quirks and proclivities!
Companionate love: In contrast, an experienced couple who have shared many experiences throughout their long, happy marriage might continue to enjoy significant intimacy and commitment to each other, even if their passion has progressively dissipated over the years.  Sometimes having a companion is the most powerful driver of a bond.
Consummate love: Consummate love is a synonym for total love or a love that appears to be an ALL IN type of relationship.  This happens when intimacy, passion, and commitment are all present in substantial degrees.  I believe this is what most people are looking for and want in their lives.

I believe it is the rarest because I believe it requires optimized levels of hormones made around light, like POMC, insulin, leptin, and melanopsin.  I think when a relationship has two people who experience two different light environments the redox power becomes more variable to one another on a relative basis and this threatens the balance of the type of love possible between the two people as time evolves.

Total love is difficult to sustain long term because it requires both people to heavily invest in behaviors that support redox power chronically as we age.
What variable do I think is most at risk with lowered redox power?
The most variable element in my opinion, — the one most at risk of decline with time— is passion.  I think this is why love in a relationship varies over time. 

Could a chemical give us a clue to a changing redox in our partner?  
Phenethylamine is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans and is made in the same areas dopamine is made in the brain.  PEA chemical formula is pictured below.

In humans, this is a VERY variable chemical and it is found in Substantia nigra pars compactaVentral tegmental areaLocus coeruleus where dopamine is found at high levels; many other places where amines with aromatic benzene rings are made to act as photon traps for sunlight.  This chemical is very similar to other potent exogenous stimulants known to alter human behavior.

It is made from phenylalanine and tyrosine in humans.
The creation of phenethylamine (PEA) varies greatly across species, and the human receptors of this stimulant chemical is called hTAAR1.  PEA is an endogenous neurotransmitter and neuroregulator that plays a key role in mood and cognition too.
This brings up an interesting point about PEA:  can it be harnessed to improve your health and love life in ways that might surprise you?  Yep.
It has been found among 95 carbon and 95 nitrogen sources tested in foods, β-phenylethylamine (PEA) performed best at reducing bacterial cell counts and biofilm amounts, when supplemented to liquid beef broth medium.  PEA is a trace amine whose molecular mechanism of action differs from biogenic amines, such as serotonin or dopamine. Especially low or high concentrations of PEA may be associated with specific psychological disorders. For those disorders that are characterized by low PEA levels (e.g. attention deficit hyperactivity disorder).  Might it be able to modulate the other neurohormones we need to create a stable loving relationship over time?

I think it might.

PEA is strongly linked to bacterial metabolism and this makes me think it might be a serious modulator of mitochondrial redox power in humans as well because the inner mitochondrial membrane is the source of redox power and it retains its mitochondrial evolutionary lineage.
In several bacterial species, the above reaction is catalyzed by the enzyme tyrosine decarboxylase, which also converts tyrosine to another trace amine, tyramine (Marcobal et al., 2012Pessione et al., 2009). Intriguingly, PEA synthesized by fungi and bacteria can also be found in food products (Onal et al., 2013), where it serves an indicator of food quality and freshness.

This includes the Korean natto (Kim et al., 2012) and commercial eggs (Figueiredo et al., 2013). Another food that contains PEA is chocolate, where it is not produced by bacteria, but during the thermal processing of cocoa (Granvogl et al., 2006).
PEA has also been found in the brains of humans and other mammals (Paterson et al., 1990Philips et al., 1978), which is facilitated by its high solubility in plasma and its ability to cross the blood-brain barrier (Oldendorf, 1971).

Like its α-methylated derivative, amphetamine, PEA has stimulant effects which lead to the release of so called biogenic amines, including dopamine and serotonin (Bailey et al., 1987Rothman & Baumann, 2006). This can help it modulate their diurnal controls in our cells and affect our behavior with our partners.

Unlike amphetamine, PEA has difficulties maintaining high concentrations in the human body, due to its oxidative deamination to phenylacetic acid by the enzyme B monoamine oxidase (MAO) (Yang & Neff, 1973). Phenylacetic acid,has an effect that is similar to the activity of the natural endorphins (POMC), an effect that is known as a “runner’s high”.

I’ve started to look deeper into this connection in people with relationship issues and the results have been eye opening to say the least.

RELATIONSHIP REDOX #7: “Life is the dancer and we are the dance.”

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So they died, they left your, you left them………bottom line is that you are alone. What is your game plan now?

We all have limits. Almost no one reaches theirs. You definitely haven’t but I am ready to teach you how to go deeper than you ever thought you could. Bravery means finding something more important than fear. I’ll be waiting for you inside the bottom of my deep blue sea. We do things differently there. It’s OK to reinvent the wheel, but only after you know how the current wheel works. Never assume you know better when you don’t really know anything about the process of recovery……….Courage without meaning is just recklessness. Brave people aren’t fearless; they’ve simply found something that matters more to them than the fear they’re facing.

Say you’re scared to start your life over from scratch when you’re 55. Your friends and family think you are having an existential crisis. You know you haven’t, you just got sick of settling for less than you deserve. You decided to use chaos and discomfort to fill your gas tank to get to places you never could get to ever before. Eventually, you find a reason that has greater meaning than the fear: your future, your new partner, your desire to make a difference, or your dream of a more fulfilling life.

When you find greater meaning in your life, you’ll find the courage to overcome your fear. Today’s pain is tomorrow’s power. The more you suffer today, the stronger you are tomorrow.

SO YOUR SOLO AGAIN………. 

Success is all about taking your shot, over and over again until you win.

You’ll never create the perfect business plan, never find the perfect partners, the perfect market, the perfect location, but you can find the perfect time to start.

That time is now

Stop waiting for the ‘right time.’ Success is a numbers game: the number of times you take a shot.

If your sick of being single do something about it right now.

When you meet the right someone, they will undress you.  I’m not talking about getting naked to get laid.  Nothing makes you feel more naked than someone identifying a desire in yourself, you never knew you possessed.  This spark will lit that pilot light.  It might illuminate a passion in you, you never saw in yourself.  You have to allow people to move in those spaces in you if you want to move forward with your best life.

MY LATEST LESSON:   LEARNING THE TANGO

Never invest in any kind of relationship with anyone who is not willing to work on themselves just a little every day. You have to chose better today than you did before.  A person who takes no interest in any form of self-improvement, personal development or spiritual growth will also not be inclined to make much of an effort building a truly meaningful connection with you. A relationship with only one partner willing to do the work ceases to be a relationship.  This is called bondage or a prison.  Never allow anyone to put you in a cage and slip handcuffs on you and tell you that they’ll love your forever.  That is insanity.   And as anyone who has been there will tell you – it’s pointless to try and dance the tango solo.

‘Life is the dancer and we are the dance.

When you realize you could actually choose the type of dance in life, and actually take the lead, your life begins to dance it naturally. Ask yourself now, ‘What type of dance have you been asking the Universe to dance with you?  Might this be why you are failing?’

I have slowly realized after 55 years that my choices are what  determine what dance will the Universe chose to play for me.  Did I go with that flow or break the harmony?  It turns out, the music life is playing in the now…happiness, fear, rage, passion etc. Embracing and dancing to it as music… you stop the struggle and learn to move with the flow of life.

Just because you failed again in building a relationship have the courage to persist.  “Courage is forward movement while embracing fear. Thinking for yourself is courage. What’s rare is the courage to follow it to the dark places where it leads. One person with courage is the only majority you need to succeed in life.”

Take enough shots, and over time you’ll grow more skilled, more experienced, and more connected. You will become entangled. And that will mean a greater percentage of your efforts will succeed. Take enough shots, learn from what didn’t work, and in time, you’ll have all the skills, experience, and connections you need in your relationships. Relationships fail because we did not have the right tools, or enough tools in our love tool box to create success.

Ultimately, success is all about taking your shot, over and over again. Sometimes you may win, sometimes you will definitely lose, but the more things you try, the more chances you have of succeeding. Put the power of numbers on your side. Take as many shots as you can. There’s no guarantee of success, but when you don’t take a shot, there’s a definite guarantee of failure.

Being single is not a state of failure. Solo is a unique place. It is a place that requires embracing the suck in relationships and in life. Do not recoil from tripping up and being solo again. Accepting each reality of being single head-on almost always loosens the knot of despair, and frees up your energy to accept what you can’t change, and change what you can about your and your situation.

Single means you are brave enough to face the glorious unknown of the unaccompanied journey in your life with some zest. You’ve become ready to try to do it better this time. You take more shots, because now your blade is sharper. This is why the last cut is the deepest………just because your old does not mean this part of your life should be dead on arrival.

When you find your path, person, or passion in this life you must not be afraid to jump again. You need to have sufficient courage to make mistakes. Disappointment, defeat, and despair are the tools Mother Nature uses to show us the way to Optimal.

In 2019 what I learned in editing my own life is that when you stop expecting people to be perfect, you can like them for who they are. Then some interesting shit can happen………..

RELATIONSHIP REDOX #6: SHOES

In about four hours from now my life is going to change. I am not sure if it will be for the better or not…………but it reminds me of an old pair of shoes I wore to my first ever job interview in NYC with the Sterling National Bank CEO. After talking with me, the CEO of the bank sent me to Barney’s of New York to see his tailor. There I got a new pair of shoes and a brand new suit courtesy of my new boss.

He told me I like you and your passion. I want you on my team and I want you to represent my brand but you need to look the part. Go see “my guy” and adapt and you have a job.

With that……….my life changed on the spot that day in 1981.

Above is a picture of the newest Chapter of my life that began today on 10/5/19.  I have purchased an entanglement shack on the beach on the panhandle of Florida where my misfits can come and change their lives, if they chose too.  My first ever VIP will be held there on 12/27/19 for 4 people who will possibily have their lives altered.  As the initial guest they will have special sculpted signs created for them by Jeremy who keeps his art sculpture business at JeremyThomley.com

 

On 10/5/19 one of my dearest friends is going through a similar change that I mentioned above, and that change is quite uncomfortable for them right now.  What follows is their words that describe their current plight.

“I have absorbed some of that discomfort on their behalf because that is what good friends do when the storms in your life rise up. They walk in and shed some of their light on you to let you know better days ahead are coming. I have had a few of these friends recently come into my own life and do the same thing for me when the people who were around me could not understand what I was doing and why I wanted their chaos around me in my darkest hours. Now it is time for me to put some new soles on their shoes as they did for me.

I would like to apologize to the universe… Life has happened all around me lately. So many times in the past 4 years I have found myself questioning what is next for my family, my farm and business. I have pulled some people close and pushed others away… some for no reason, others for treason. My circle of friends once at my side are now mostly remote. They continue to live a life we agreed was most free, I chose a goal that meant I’d spend a lot of time saying no to other goals. I was not likely to become a better professional without a lot more work, I am not opposed to the idea in the future but I needed to run down this dream if it was ever to be my life. I am a new man, somedays a new father filled with new wisdoms. I also invested my heart in my new clinic and building a community of people who some would call employees or customers but truly they are my friends. I have watched this dream grow and be pruned by fear, grow again and be chopped down by what I can only name as jealousy.

So many raw nerves had to be cut, amputees that feel weak till the tree grows new roots. I’m grateful for my wounds. I know this discomfort is necessary even when those in my rearview mirror do not understand what I am doing to my life now. This chapter is closing now. I might need to burn this passage after reading it, but I like how the wound makes me see the future more clear.”

 

FURTHER ENTANGLEMENT OCCURS TODAY…………..

The following is a story by a nurse Jenelle, I have become fond of lately. This story isn’t really about shoes at all. Neither was our stories above……………

I have an old pair of shoes …

They aren’t really that old.

It was my first pair of shoes for my first nursing job.

I thought they were a great pair of shoes … until my toes started hurting.

I bought a new pair of shoes ~ and WOW! Now, I thought to myself, those are a great pair of shoes.

I realized when I got these new shoes, that I don’t even have to use insoles in them. My back doesn’t hurt, no matter how long I’m on my feet. My toes never hurt. I do untie them when I get in my car … loosen them up for the drive home. But all day long — up until that point — I don’t even think about my shoes.

Sometimes, I still look at that old pair of shoes, and I think, “Man, those shoes are so cool! I wish I could still wear them.”

Then I remember: There’s a reason I stopped wearing that old pair of shoes. And I’ve tried those old shoes on since I bought my new shoes … thought I could just wear them at home for a day, and see how they feel. NOPE. Those old shoes had to come right back off.

I can hold them in my hands, turn them over, and see the places where the bottoms are worn … a sign of every hustle-bustle, stressed-out moment I spent, walking MILES and MILES around that building, at my first job. And I can smile ~ and love those shoes, for what they once were to me. I can keep them as a reminder of where I’ve been, and what I’ve done.

But then I will put them back down, and walk away. In my new shoes. My new shoes are the newst chapter I am writing in my novel.

Sometimes I wonder when my new shoes will become my old shoes? Then I realize when the soles wear out, I’ll know when to adapt and change my life again. Discomfort is the signal to my feet that I need to adapt. What will the next pair look like? And I keep an eye out for them.

But for today ~ I’m really happy in my new shoes and the chapter I am currently living out in my life. And that is good enough for me, right here and now.

To get the relationships with humans you want, you often have to burn the old ones to the ground to make enough room for the roots to take hold before you add in the water and nutrients.

RELATIONSHIP REDOX #5: PROTON GRADIENTS ARE FOUNDATIONAL TO YOUR LIFE

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What don’t they know about protons and how they relate to our relationships?

The way we think and feels about people in our life comes down to the redox state in our central nervous system.

The base of redox state is built by proton gradients and in humans newer systems in mitochondria and cells set the ceiling of the redox state to -400mV.

That system is built around glutathione which replaced the melatonin and Vitamin C system in lower eukaryotes as seen below. -200mV defines cytochrome C oxidase and the ATPase redox potential and this is the BASE that cells need to survive on Earth. I mentioned this in the video above. After 3.8 billion years we added other systems to build the redox potential of our cells to -400 mV to form complex life as the picture shows below.

The centerpiece of Nature’s conceptual idea for life lies in the novel use of natural proton gradients created in the ancient seas on Earth and they surround the story of water and light from the sun to do something remarkable around protons. Four billion years ago, alkaline fluids bubbled into what would then have been mildly acidic oceans (CO2 levels were about a thousand times higher than they are today, and CO2 forms carbonic acid in solution, rendering the oceans mildly acidic). Acidity is just a measure of proton concentration, which was about four orders of magnitude (four pH units) higher in the oceans than in vent fluids. That difference gave rise to a natural proton gradient across the vent membranes that had the same polarity (outside positive) and a similar electrochemical potential (about 200 millivolts [mV] across the membrane) as modern cells have. This is where the base of the redox potential of modern human cells come from. It is remarkable that no food guru understands the basic biophysics of this planet well enough to see why food is not the driver of health. An optimized proton gradient, however, is critical to it because it forms the base of the redox potential of cells.

The equation that defines this idea behind proton movements with IR-A light from the sun is below.

The H+ in NADH must be a proton and never a deuteron (deuterium isotope of hydrogen). When this substitution occurs life cannot be maintained far from equilibrium over a long time span. This is when illness enters and when your partners redox drops and your relationships begin to fail as you grow apart.

Drinking high pH water does nothing for your health or your relationships when you have functional kidneys.

When your redox drops in your body your ability to make the chemicals that bond us together as humans also drop.  Those major chemicals are dopamine, melatonin, oxytocin.

Dopamine is a catecholamine.

The catecholamines, of which dopamine and adrenalin is the best known example, and the aminochromes, of which adrenochrome is the best known example, are intimately involved in stress reactions. Stress is well known to DESTROY relationships.  What is not well known is how stress does it by ZAPPING your redox in the process of destroying the neurochemicals that bonds us as humans and that control our behaviors and emotions.

Therefore to moderate the influence of stress or to negate it, the orthomolecular belief is that we must use compounds which prevent these substances from damaging the body. THAT IS 180 degrees oposite of my belief.  We need the sun and rebuild the redox before we need any substrates.  The orthomolecular idea that  Vitamin B-3 is a specific antidote to NAD+, dopamine, or adrenalin is old and a half truth.  The reason for this opinion is it only takes the substrate biochemical view point and never considers the affect of light on these substrates in how their electrons get programmed by light to create their proper physiologic effect.  This is what I was hinting at above in the video with Luke Storey.

The ortho molecular belief that exogenous antioxidants with the use of exogenous catecholamines is wise is just not supported.  We see the effect in people with Parkinson’s diseease who use exogenous L-DOPA get tachyphyllaxis from the drug.  Adding antioxidants such as vitamin C, Vitamin E, beta carotene, selenium and others DO NOT protect the body against the effect of the free radicals just by removing them more rapidly from the body is not a well thought out plan because it has no biophysical supports.

Any disease or condition which is stress related ought therefore to respond to the combined use of vitamin B-3 and these antioxidants, but the literature is filled with papers that show they do not.  None of these papers have been repeated when using these drugs with solar redox strategies and this may show a huge change in outcome if it does get studied.  I can tell you in my life and my practice experience it makes all the difference in the world.

Why do I think this orthomolecular supplement based strategy fails us so often?

Is this the same reason why adovcating a ketogenic diet for low NAD+ states is pure lunacy?

Yep.  Why Uncle Jack?

When you eat a ketogenic diet guess what else happens? It is believed we bypass complex one at the inner mitochondrial membrane and enter FADH2. I used to believe this but I no longer do because of technology light. You heard about this in the Quantum electron blog post at JackKruse.com………but what did not I tell you in that POST?

Why does a ketogenic diet work in T1D, T2D, and help us lose weight, but does not help all metrics in health? When you lose water conduction at the inner mitochondrial membrane (cytochrome c oxidase due to deuterium) you lose the ability of proper nanoscopic protein folding of cytochrome 1 (NAD+). This throws off the nanoscopic precision (size and shape) required for quantum tunneling and this cause increased ROS and metabolic syndrome……..This is also why exogenous niacin can work in these diseases because it is a ketone mimic drug (sans artificial blue light). Why?

Niacin also known as vitamin B3 (above), nicotinic acid and vitamin PP, is an organic compound with the formula C6H5NO2 and one of the 40 to 80 essential human nutrients. In fact, when niacin deficiency is present it is one of 5 vitamins that causes a pandemic disease condition called pellagra.

But it can be used to bypass a “broken” cytochrome 1 when misfolding (due to a chronic ATP deficiency think EMF 7 blog post now). But why ? Why am I tormenting you with this science?…….because you need to think about things you are missing……..and you will see where QED takes us……….Vitamin B3 can help activate PPP when we are broken for some reason when we are ketotic from a dietary standpoint using vast amounts of coherent water as I laid out in the quantum electron blog post. Yes, niacin is a precursor to NAD+/NADH (cytochrome 1) and NADP+/NADPH (the magic of the PPP), which play essential metabolic roles in all living cells as I showed in EMF 4. What most people do not know is tryptophan the aromatic amino acid that absorbs UV light forms the base of all these chemicals. Without UV light to program them all none of them work as they should in cells.

Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to NAD+ and NADP+ in vivo PROVIDED THE REDOX POTENTIAL IS GREATER THAN -200mV and this information is very valuable when you have liver leptin resistance, metabolic syndrome, or epilepsy.  Your food gurus never tell you this.  I do.

In 2010  Leonid Sazanov deciphered the crystalline structure of NAD+/NADH which is complex 1 respiratory complex in mitochondria. It is an the enormous protein in physical size and quite complex.   You can read about it in Efremov et al .2010.  Again, the atomic structure betrays the biophysical mechanism at play in NAD+ — in this case not a rotary motor as it is in the ATPase but, even more surprisingly, it uses a lever mechanism not unlike the piston of a steam engine.  This is why I have told people that mitochondria really mimic Carnot Theorem in thermodynamics.

Red light stimulates cells to replace defective mitochondrial engines.  Blue light damages them as the slide shows below.

When cytochrome 1 has misfolded electron transport proteins due to poor redox (ie:quinolone issue of CoEnQ10) you need to bypass it MOST of the time by eating fats that feed into FADH2 predominately because if you don’t, your mitochondria begin to make massive ROS that overwhelms the cells redox potentia dropping it from -400mV and this raises blood retinal levels while lowering vitamin D levels.  It also causes pregnenolone steal syndrome which lowers all hormones.  This is one of a myriad of ways your relationship can fail as your hormone panels crash.

Chronic pregnenolone steal syndrome will eventually shorten our telomeres to cause cellular signaling problems that lead to either senescence or advanced early aging.  This also destroys our relationships.

The chronic loss of NAD+is the critical sign of a loss of negative feedback control of the ubiquitin cycle. This data scales directly to our molecular circadian clock and our peripheral clock genes (CCG’s).  So this implies a loss of relationships is also related to poor circadian biology.  All things lead back to the light we chose to live under.  Few can fathom these links because they never look deeply into the life and how we work.

As our redox drops NAD+ builds up in relation to NADH levels on a per unit basis. There is a special case for blue light where a ketogenic diet can fatten you if you are chronically destroying cytochrome 1 because your REDOX is below -200mV.   When redox drops below this threshold it tells us there is a proton problem and that problem is usually related to having too much deuterium leaking into the matrix via the UCP-2 mechanism I laid out in my webinars for members in the past 18 months.

Then a fat-laden diet during spring and summer can make you very obese when this situation occurs.  See Jimmy Moore as a classic example.

Increasing the NAD+ endogenously (not via a supplement) in comparison to NADH changes a most of the mechanistic downstream signaling in protein kinase B pathways of cells. Why is that big issue? The AKT pathway is also known as protein kinase B (PKB). It is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes.  This is how the brain shrinks in PD, AD, ALS, FTD, and in diabetes.  It also is a huge problem in TBI’s which are concussions.

Akt1 is also able to induce protein synthesis pathways (urea cycle), and is, therefore, a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth.

Since it can block apoptosis (mitochondrial disease risks and cancer risk), and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8. UVA light can help restore apoptosis. In a mouse (nocturnal) which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth.

In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance/ T2D), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. It has been reported that mice lacking Akt3 have small brains. This is what causes brain shrinkage in all the neurodegenerative disorders I mentioned above that are linked to cytochrome 1 size and shape issues. PCOS is tied to this early one before the more chronic diseases come to the forefront.  This will also change you moods, alertness, your cognitive ability, and your behavior.

Akt2 is an important signaling molecule in the Insulin signaling pathway and you do not need food inputs to effect it.  Alien light in your environment can do it without any food stimulus. It is required to induce glucose transport.  TBI induces AMpK pathways and increase blood glucose because of the lack of circadian control of this process.

The follow through? AKT1 is involved in the PI3K/AKT/mTOR pathway and other signaling pathways. These all cause massive changes in cell cycle signaling and in cellular communication. mTOR is huge in longevity and in cancer progression via the dys-regulation of the p53 gene. If the high oxygen pathways are defective for any reason metabolic mitochondrial diseases are likely. (TCA/urea cycle)

What else is more likely to occur in your life when all this hard core biochemistry and biophysics fail in your cells?

YOUR RELATIONSHIPS WITH OTHER HUMANS WON’T BE AS GOOD AS THEY USED TO BE EITHER.

This might be a tough swallow for some of you, but it is the truth according to what Nature is telegraphing us.

Now you can see why when this pathway is activated many bad things can happen that are common to T1D, T2D, most cases of leptin resistance with elevations in hs-CRP. These steps are stops on the way to either final pathway and we call them neolithic diseases due to chronic mitochondrial failure and collapse.

Why do relationships really fail?  What is the foundational science problem?  

A LACK OF CELLULAR REDOX POTENTIAL IS THE ANSWER.

Relationships are not about passive agreements and merely spending time together: they are living, breathing entities, and if you don’t actively take care of them, they will suffer and die. If you want your relationship to be strong, you can’t just hope for it — you need to put in the work.    The work you need to put in is below in PICTURE FORM.

We often wonder why couples fight, lose interest or seem to lose the ability to communicate even when they love each other as redox drops. Why do dirty dishes or apparently innocuous words become triggers for such heated arguments?

Relationship conflict is a result of one or both partners feeling that their attachment is threatened and that psychologic issues is underpinned by how our stress hormones are acting under the direction of mitochondria in cells.  

Most of us don’t see this connection because the symptoms have purely emotional roots and those emotions are built by the light that control our mitochondria to make chemicals in neurons.

This is why anxienty and mood changes are linked to poor mitochondrial function as laid out in CITE 1 below.

So, why do we need secure attachment so much?

According to research, it’s because the lack of it can actually be a literal threat to our survival.

Researchers at Case Western Reserve University asked men with a history of angina and high blood pressure whether their wives “showed their love.” The ones who said no, suffered twice as many angina episodes during the next five years.

Another study found that women who had had a heart attack showed a 3x higher risk of having another if there was conflict in their marriage.

Being able to trust and be trusted (dopamine/melatonin/oxytocin), to love and be loved in your relationship is not just helpful: it’s crucial for you and your partner’s health, happiness, and overall quality of life.

Trust is a function of the neuro-chemicals built in these stress pathways by the redox power in your cells.  This is why relationships fail fundamentally.  If we trace the steps back it always comes back to couples who have differing redox states compared to one another.  Its shocking, but the links are laid out here in this blog for you to examine for yourself.

CITES:

1. https://medicalxpress.com/news/2019-09-anxiety-disorders-linked-disturbances-cells.html