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Thiamine, also known as vitamin B1, is now known to play a fundamental role in energy metabolism.  When we are deficient in B1 the mitochondrial matrix suffers from pseudohypoxia.   Its discovery followed from the original early research on the ‘anti-beriberi factor’ found in rice polishings. After its synthesis in 1936, it led to many years of research to find its action in treating beriberi, a lethal scourge known for thousands of years, particularly in cultures dependent on rice as a staple.

Thiamine pyrophosphate (TPP) is the active co-enzyme form of thiamine and it is abundant in human RBC’s.  For this reason it is a reasonable marker that we can use in mitochondrial matrix failure associated with higher heteroplasmy states.  When we see abnormal peripheral smears in patients it signifies that we might want to clinically assess TPP activity and thiamine levels in our patients.  Some disease states associated with high mitochondrial density show these clinical features more often than not because certain organs have higher mitochondrial capacity.

When TPP is abnormal so is transketolase in RBC’s.  Transketolase is an enzyme of both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis.

When RBC transketolase is abnormal this is a beacon that RBC might not have a high fidelity signal connecting the sun to our colony of mitochondria.  This fosters the development of heteroplasmy in an insiduous way.  If one is not looking for it, a relative thiamine deficiency can manifest in many disease or non disease states.

In humans, transketolase connects the pentose phosphate pathway (EMF 4) to glycolysis, feeding excess sugar phosphates into the main carbohydrate metabolic pathways. Its presence is necessary for the production of NADPH (PPP), especially in tissues actively engaged in biosyntheses, such as fatty acid synthesis by the liver and mammary glands, and for steroid synthesis by the liver and adrenal glands. Thiamine diphosphate is an essential cofactor, along with calcium as a co-factor.

THE KEY LINK:

Thiamine Pyrophosphate (TPP) is the cofactor needed for the following reactions, Thiamine is required for only 4 biochemical reactions in the body  1. Pyruvate dehydrogenase 2. α ketoglutarate dehydrogenase  3. Branched-chain ketoacid dehydrogenase  4. Transketolase  TPP is involved in energy metabolism. Deficiency of TPP will affect the link reaction and TCA cycle. This leads to reduced ATP production and can alter function of the Pentose phosphate pathways I wrote about in EMF 4 blog post.  Red light from the sun can augment this ATP loss from thiamine deficiency.

Transketolase is an enzyme that uses a thiamine pyrophosphate (TPP) as its KEY cofactor to conduct a 2 carbon transfer from ketoses onto aldoses in humans. In the Pentose Phosphate Pathway (EMF 4 blog), it performs both a transfer of carbons from xylulose-5-P onto Ribose-5-P and onto Erythrose-4-P, setting them up for reaction with transaldolase.

Transketolase activity is decreased in deficiency of thiamine and can be used as a marker of heightened heteroplasmy by enlightened physicians.

RBC transketolase activity is reduced in deficiency of vitamin B1, and may be used in the diagnosis of Wernicke’s encephalopathy and other B1-deficiency syndromes if the diagnosis is in doubt. Apart from the baseline enzyme activity (which may be normal even in deficiency states), acceleration of enzyme activity after the addition of thiamine pyrophosphate may be diagnostic of relative thiamine deficiency from any causes.  This altered activity can be quantified as follows:

a. 0-15% normal

b. 15-25% deficiency

c. >25% severe deficiency

CENTRAL LEPTIN RESISTANCE:  LONG LOOP OF BAZAN

Liver disease is one such disease state that causes central leptin resistance (Leptin resistance Part Deux blog).  Most cases of liver disease have central leptin resistance associated with them due to damage of the long loop of Bazan (image below).  This limits the reincorporation of DHA into human cell membranes and fosters inflammation because the elvanoids cannot be made to curtail the inflammatory cascade.

 

Simultaneously, thiamine can be depleted because of altered matrix functioning.   There is brisk evidence that thiamine deficiency is found in many liver diseases.  The literature reports 58% of patients with chronic liver disease have B1 deficiency, moreover, the incidence is higher in alcoholic than in non-alcoholic hepatic patients. It has also been shown that daily supplementation with high doses of thiamine hydrochloride (200 mg/day) for one week can restores levels of thiamine pyrophosphate (TPP) in most cases.  Since TPP is the active co-enzyme form of thiamine, it also stimulates synthesis of the enzyme transketolase. Because of the essential role of TPP as a co-factor in intermediary metabolism of carbohydrates, lipids, and protein it can be a proxy marker for mitochondrial matrix dysfunction.  It maybe a NOVEL new way for us to indirectly measure heteroplasmy levels in humans.

THE LINK TO TECHNOLOGY:

Because thiamine is a major factor in the metabolism of glucose, it has long been known that ingestion of simple carbohydrates, processed in the body mainly to glucose, automatically increases the need for dietary thiamine. Since Frey and Volkow work, we know exposure to nnEMF also increase AMPK and glucose metabolism it should be clear that technology use and abuse can mimic nutritional problems historically associated with Vitamin B1.  Thus, high calorie malnutrition and technology abuse should be commonly associated with a chronic relative thiamine deficiency, irrespective of its fortification in food substances or the diet of any patient.  This relative deficit might lead to unusual presentations of disease linked to elevated heteroplasmy in humans.

QUICK SUMMARY:

Thiamine is normally present in pastured  lean pork and other meats, wheat germ, liver and other organ meats, poultry, eggs, fish, beans and peas, nuts, and whole grains. It is lower in foods like those mentioned above that have been altered by man’s input into food webs.  Blue light screens and nnEMF field deplete cells of thiamine because of how they affect AMPk pathways and glucose metabolism to mimic high calorie malnutrition.  Modern dairy products, fruit and vegetables are not good sources of B1.  In fact most of them deplete thiamine stores.  Humans only have the ability to store 14-18 days of this essential vitamin.  This storage ability is decreased by technology abuse and by vegan/vegetarian diets.   The RDA is 0.5 mg per 1000 kcal, adequate for a healthy individual consuming a healthy diet. Considerable losses occur during cooking or other heat-processing of food. Polyphenolic compounds in coffee and tea inactivate thiamine so that heavy use of these beverages could compromise thiamine stores in tissues.  

CITES:

http://jackkruse.com/emf-4-why-might-you-need-carbs-for-performance/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435462/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/

When a wise person speaks he understands fully the intent of the words, but what the ignorant person hears is subject to their present set of knowledge. There is an inherent disconnect. There is always a loss of information and energy transfer in this case which is why social media is not the ideal place to explain yourself in order to teach.

This requires the student having skin in the game to understand things well and it is best done in person. Where misunderstanding dwells, misuse will not be far behind in the under-educated mind. It is far safer and wiser for the quantum biologist to remain on the solid ground of the physics of light and eschew the shifting sands of philosophic extrapolations found in modern physics. The ignorant among us can know things, but the point of life is to understand how all things link back to the fabric of nature and life.

Life also has another surprise for those with natural wisdom: When we talk sense to a fool they often try to label you foolish only because of their own ignorance. If your audience is not wise this can lead to meme creation and control of many other lean minds. The goal is to make the curious wise with nature’s wisdom quickly to overcome the wasteful inertia of a paradigm’s core beliefs. This is why I am allergic to a closed mind who buries curiosity. What is the core message for a curious mind? Just because you don’t understand it, doesn’t mean or imply that the truth is not being delivered to you. Your wisdom myopia does not trump the deep truths buried in nature’s laws. There is a science of light out there to understand, and to bring it to biology is to brighten everyone’s perspectives. Today, biology is in the dark ages of understanding how light works with and within cells and innovates life from abiotic atoms.

This must change if medicine is to advance. An age in science is called dark, not because the light fails to shine, but because people refuse to see what is already published in the literature but still have yet to understand how it links back to life. Their educational myopia allows them to remain in the dark because they continue to misunderstand the implications of this data.

Your friends and family might not understand your new found ideas so this might help you help them to improve your relationships with in your circle of six.

I covered this in Levee 25 of the Quilt long ago and now this series will visit this in depth:

Hypoxia/pseudohypoxia.  Hypoxia is a cellular state that disrupts normal oxygen supply to the tissue (mitochondria), causing cellular dysfunction. Examples of t 25.his are altitude sickness at high elevations and clots in a blocked artery in an organ causing an organ to fail and die. Apoptosis and autophagy allow cells to adapt over their lifespan to many situations. Hypoxia is directly toxic to mitochondrial energy production. In humans, when oxygen is in short supply we can shift to anaerobic energy production, but it is not as efficient as mitochondrial energy production. Athletes with proper training can perform well in anaerobic conditions but it does appear that they pay a steep price for this adaptation by depleting their stem cell supply.  The gateway in mitochondria for hypoxia is pseudohypoxia by blockade of pyruvate which sits atop the TCA cycle inside the matrix.  The gatekeeper of the creation of Acetyl-CoA from pyruvate is thiamine.  It is the major controller of substate movements in the matrix.  As it drops we lose control of UCP-2 and this alters the matrix concentration of hydrogen isotopes.

Thiamine deficiency causes a relative pseudohypoxia and is closely linked to heteroplasmy rate elevation in aging.  Coffee and polyphenols destroy thiamine levels.  As this occurs there is massive signaling to the SIRT system to affect mitochondrial biology.

As a consequence of pseudohypoxia, NAD+ levels drop and this funnels all the way back to how the aromatic amino acid tryptophan is catabolized in cells.  It has multiple pathways it can travel and the pathway chosen will lead to the cell’s fate.

Hypoxia plays a role in aging because as one age the amount of blood to organs declines as the heart fails to deliver the same amount of blood through a stiffened arterial tree throughout the body. THIS IS A PROTECTIVE STATE FOR POOR MITOCHONDRIAL FUNCTION = higher heteroplasmy rate.

This causes cellular oxygen levels to fall and usually is a signal to mitochondrial biogenesis to offset the deficits. As one age, this signaling system is not as accurate in sensing changes to the oxygen level. This can be measured in the pyruvate/lactate levels. Low oxygen tension is a signal to autophagic pathways that normally help repair cells. If this gets impaired, signaling autophagy becomes less effective as we age and results in more organ failure and diseases of aging. Hypoxia is critical signaling in the cell for repair processes. This is disordered in heart disease and in sleep abnormalities such as sleep apnea. Hypoxia decreases cell mass and improves leptin resistance by forcing a calorie restriction via a relative thiamine deficiency state. This only operates well if the person remains in a strong solar environment.

This, below, is the deep lesson of levee 25.

Free radicals and reactive oxygen species (ROS) in particular play an important part in aging because they direct repair and regeneration and taking antioxidants ruins this endogenous signal. Free radicals are (usually small) molecules lacking an electron needed for stability; they will steal an electron from the first thing they bump into. Like pulling a cog out from clockwork, stealing an electron from a protein or enzyme is usually not good for the finely-tuned biochemical machinery of our cells. The free radical might be rendered safe in the process, but it has left some form of chaos and damage in its wake.

Free radicals are sufficiently dangerous to biochemical machinery that some of our body’s defenders use bursts of free radicals as a kill mechanism. That is why Denham’s belief has died too slowly. Science changes though as data comes in.

Scientists now generally concur that accumulated damage throughout the body due to free radicals is one important root cause of age-related degeneration – but the devil is in the details. The vast, overwhelming majority of those free radicals are generated by your own metabolism as an unavoidable byproduct. The rate of free radical generation increases greatly with age as the basic mechanisms of your metabolism are themselves damaged by the free radicals they created. This is not a one-step process, however. I’ve tried to walk through it at a high level at my blog, cribbing from the mitochondrial free radical theory of aging that was proposed by Wallace and working its way into general acceptance because of new data

Within each of your cells are many mitochondria, tiny biochemical power plants that convert chemicals from food to ATP, the basic fuel molecule used by your cells to provide energy for life.

You have to beware of people who take advantage of the antioxidant theory of aging and have no earthly idea of how mitochondrial creation of free radicals really works. This is why supplement makers and coffee makers are pushing the false narrative that antioxidant use is wise. Marketing is legalized lying.

Mitochondria were once a separate organism that came to live in symbiosis with ancestral cells. As such, they brought their own DNA to the party; some of it still remains within our mitochondria, separate from the DNA we carry in chromosomes in the cell nucleus.

Mitochondria have a couple of ways of generating ATP. The more efficient of these methods – oxidative phosphorylation (OXPHOS) – generates some amount of free radicals as a natural byproduct, and requires the proteins coded in the mitochondrial DNA to function. It is the predominant way by which healthy cells generate their power.

Free radicals created through OXPHOS within a mitochondrion are most likely to damage that mitochondrion; they’re very reactive, so they won’t get far before sabotaging something. The components that really matter are (a) a membrane that helps organize the movement of various chemicals in the process of generating ATP, and (b) the mitochondrial DNA.

Sufficient free radical damage to mitochondrial DNA shuts down OXPHOS within that mitochondrion, as the necessary proteins can no longer be produced. The mitochondrion switches over to using a less efficient method of producing power, one that doesn’t produce free radicals but has to run at a much higher rate to produce the same level of ATP.

Mitochondria, like most cellular components, are recycled on a regular basis. Components called lysosomes are directed around the cell in response to various signals, engulfing and breaking down damaged or worn components. After the herd has been culled, surviving mitochondria within a cell divide and replicate, much like bacteria, to make up the numbers.

The signal to break down a mitochondrion is triggered by sufficient damage to its membrane: a sign that it’s old, leaky, inefficient and needs to be replaced with a shiny new power plant.

BUT: if a mitochondrion has had its DNA damaged to the point of stopping OXPHOS/beta-oxidation/alpha-oxidation, it will no longer be producing NORMAL free radicals that can damage its membrane. So it will never get broken down by a lysosome. When the time comes to divide and replicate, it will replicate its damaged DNA into new mitochondria and disease is spread like a bacterial infection in your tissues. None of those new mitochondria will be producing free radicals via OXPHOS, and so will not be recycled either (autophagy).

One DNA-damaged, non-OXPHOS mitochondrion will eventually take over the entire mitochondrial population of a cell in this way. At that point, the trouble really gets started.

By the time you hit late life, perhaps 1% of your cells are in this state of being taken over by non-OXPHOS mitochondria. As for any neighborhood or city, it only takes a small proportion of dangerous criminals to make life really unpleasant for the rest of us. Same true here at the tissue level.

Non-OXPHOS mitochondria have the unfortunate effect of depleting a needed molecule used in many cellular processes, NAD+. This is a carrier molecule in the OXPHOS process, given an electron (and turned into NADH in the process) to port between point A and point B within the mitochondria. Once the electron is delivered, the NADH becomes NAD+ again. But without a working OXPHOS process to return NAD+ into circulation, the cell would quickly build up a deadly excess of NADH, run out of NAD+ and hypoxia occurs and cells die. (Sinclair, 2013)

Fortunately for the cell, and unfortunately for us, there is another way to recycle NADH into NAD+. Since NADH is just NAD+ with [amongst other things] an electron stuck to it, all the cell has to do is export those unwanted electrons to other proteins via the Jablonski diagram I have posted over and over.

In the points above, I omitted details of the reaction that transforms NAD+ to NADH in order to focus on the electron that is ported around. Wikipedia gives an introduction to the full picture, which also involves an extra hydrogen atom (non-deuterium) – NADH is NAD+ with the addition of a hydrogen atom (one proton, one electron), and an additional electron. Nonetheless, it is the shuttling and exchange of electrons that is important here.

In a form of chemical waste dumping, this is just what the cell does. Structures on the cell membrane known as the plasma membrane redox system (PMRS) export electrons from NADH, recycling it into NAD+. This process is only very active in cells that have been taken over by DNA-damaged, non-OXPHOS mitochondria, but their outer surfaces are little hotspots of electron dumping.

What do these electrons do? Well, for one, they combine with oxygen molecules – which are abundant in any of our living tissue – to create reactive oxygen species (ROS): more free radicals. Sick cells have pseudohypoxia to limit the damage and try to survive as autophagy is defective. This causes organ failure. So you have the Rube Goldberg system outlined above whereby a few free radicals have caused a cell to become an ongoing, major exporter of free radicals into the surrounding environment. These will make life unpleasant for surrounding cells, but that is most likely not the real problem. ROS just can’t travel far enough to explain how a corrupt 1% of our cells can cause a large fraction of the difference between being young and being old.

A more likely target for all the newly created ROS is cholesterol. Cholesterols, such as low-density lipoproteins (LDL) are used everywhere in the body and travel widely. If ROS reacts with nearby LDL – and there will always be nearby LDL – to form damaged, oxidized cholesterol, that damaged cholesterol can then be incorporated into and further damage biochemical processes throughout the body. For example, its effects on our arteries is well known: What is not well known is how the light that excites that electron damages cholesterol rings by how it is programmed. If the right frequency of light is on the electron cholesterol works well……if not you get a disease.

In conditions with elevated concentrations of oxidized LDL particles, especially small LDL particles, cholesterol promotes atheroma formation in the walls of arteries, a condition known as atherosclerosis, which is the principal cause of coronary heart disease and other forms of cardiovascular disease.

There are many other ways in which accumulations of oxidized cholesterol can send biochemical processes awry. This, then, seems to be a good candidate for the plausible, systematic method by which a small number of cells can work such varied damage upon your entire body.  Mitochondrial damage acts just like an infection does at the tissue level.  Aging does the same.  This is why health is the slowest form of death we chose by using the right light that excites electrons.  Mitochondria deal the right electrons to the right tissues to build health.

Do you only value something if you know it’ll end?

So what do you do with your significant other when it is over? Ponder the question before you pull out a piece of paper and answer this question.

What would a Black Swan do?

Would they sacrifice themselves and leave what is left for the person they are cutting out of their life?

Do you believe there is addition by subtraction?  Many people talk a big game but are they capable of writing a goodbye letter to a spouse who ruined your life?

I think Neil Young had it right when he said, ” “It’s better to burn out than to fade away.”

Sometimes we need to look past the chemistry and the butterflies to what is really going on at the base of it all. Who is the person you’re looking at in this moment? Do they match the idealized figure you’ve built up in your mind? What behaviors are confirming or denying that belief?

Will you end your relationship quickly or will you bleed it slowly?  Most people will go for the slow death of a relationship because they have little experience with death.  This is a grave error.

How many lost days are you willing to sacrifice before you give up?

For those who value time the answer will be different than the rest of you reading this.

Do you believe there’s a beginning in an end ? It’s true that you can’t reclaim what you had, but you can lock it up behind you. You can start fresh if you cut the head off the snake soon.

Are our relationship’s just a bunch of accidents, connected by one perfect end?

Does the end of your relationship  justifies the means. Might it be true that sometimes you have to do the wrong thing to get the right result?

Have you considered unusual mechanisms to solve your relationship dilemma?

How much do you know about discernment counseling?

Discernment counseling is not couples counseling. It doesn’t aim to fix any problems. Instead, in just a handful of sessions (both joint and individual), it helps couples on the verge of relationship breakdown understand why their problems have become so intractable, helping them trace the downward spiral and examine their patterns from a different perspective. In a sense, it’s an exit interview for a relationship, but one that leaves the door open to reconciliation.

And in an instant it all changed.

When I decided to get divorced I did discernment counseling before I signed my divorce papers………..I wanted to make sure my decision tree was plumb with my reasoning before I ended my relationship.

In this therapy I found out 50% of people who hire this type of therapist save their relationship before they transition into more traditional therapy. I found out many people who do this have even backed out of divorces. This peaked my interest. This why I did it. I did it on my own. I beleive many couples are unhappy for a long stretches, but many feel they can’t just leave. because they haven’t really done any work to address the problems in the relationship in any meaningful way.

Before my final exit I had to know I covered all my bases. So I jumped and did it.

When our partners aren’t right for us, they have a funny way of showing us that truth, but it takes a dose of radical honesty to see these warnings for what they are. To see these red flags for what they are and accept them, we have to start loving ourselves and setting boundaries both inside and out. Only when we learn how to love ourselves can we truly start loving others and receiving the love we deserve.When we love, we love deeply and that can often cause us to overlook critical red flags and warning signs that are best faced head-on and in the moment. Part of forming happy and lasting relationships is learning how to confront issues in those relationships as they happen, something that takes both time and understanding to carefully manage.

Most of the couples who sign on for discernment counseling are “mixed agenda,” meaning one is eager to walk (me), and the other wants to make things work (her).

I did it because I was sure I was done……..but I wanted exogenous validation that my feelings where solid before i dropped the hammer on my partner.

I suffered deeply from relationship ambivalence—this is the agonizing process of feeling uncertain about a romantic partner even while going through the daily motions of a relationship.

I think I had hoped I’d find an answer to why I felt why it was worth while staying, or maybe that I may conclude that I shouldn’t stay at all.

With either conclusion, the mark of successful discernment counseling is when a person can step outside themselves to view the relationship — and its dissolution — more objectively.  You have to remove your cognitive biases about the other person before you decide to stay or go.

Research suggests that couples struggle with relationship difficulties for an average of six years before seeking help. When you’re nursing a deepening hurt over that amount of time, it’s easy to become a bit solipsistic, favoring acts of self-preservation over generosity. It’s harder to see past old and recent wounds to adopt another perspective on the problem, even when doing so might provide a solution.

We confuse feelings with the stories we make up about those feelings.

My suggestion is to avoid couples counseling and try discernment counseling solo for yourself to figure things out for you before you call an attorney.

Discernment counseling made me feel like I did my homework, regardless of the outcome.  I felt that  this is the Black Swan thing to do before burning a relationship bridge down and trying to start over.

CITES

1. https://www.gottman.com/about/research/couples/

Harmony makes small things grow. properly in nature…… Lack of it makes big things decay around and in us.  Factor Y is a term I use for the sixth extinction that has begun about 120 years ago.  The political left, in my opinion is using climate change narrative to hide the real fact that the electromgnetic force is behind the 6th extinction.  Why do I believe this?  C02 thermodynamically cannot act fast enough to explain the Permian extinction or the current one ongoing.  The electromagnetic force can.  It is the strongest of the 4 forces and it has unlimited range and power so this means it can cause quick changes that will often be hidden for a time because many of the effects will be non-linear in nature.  5G from above courtesy of Elon Musk is one such non-linear change.

Technology use and abuse cause the capricious cohabitation of the human’s mind. Nature’s harmony makes small things grow. Lack of it makes big things decay. Technology ruins biologic coherence and induces degeneration of the mind and a lapse into cancer as the US National Toxicology Program’s final release is warning us.

Human behavior is fascinating. We like to think of ourselves as intelligent, rational beings. But we regularly fail to recognize basic logical fallacies. Our hedonistic propensities propel us to accept correlation as causation when it appears to validate behaviors we like to engage in, like abusing light technology under the guise of “progress” and crafting the narrative the sun is toxic. It is pure insanity.

Give me some examples of a non-linear effects Jack.

A small stimulus leads to massive amplification = a non-linear effect

1. A nuclear weapon can be thought of as non-linear action. It is the size fo a small car yet it can level a city.

2. A star like the sun can be thought of the same way. It is relatively small yet it can warm 9 planets over billions of miles.

3. Small amounts of UV light from the sun can leach into the eye (1%-3%) yet they have the greatest effect on the RPE dense core granules to drive the central retinal pathway that connects to the SCN and leptin receptor to control the growth and metabolism of every human on Earth.

4. The change in networking power used on the internet went from 0G in 1995 to 5G today. That is only 23 years.  That small change in the electromagnetic force  is fully capable of leading living things to the sixth extinction level event on Earth.

Those are some examples of non-linear effects.

All epigenetic effects are also non-linear. Blue light and nnEMF cause HYPERMETHYLATION of DNA and RNA. <——- That is the major change agent of the epigenome and we saw how Scott Kelly went up into space for 340 days and sustained massive epignetic genome changes compared to his identical brother left on Earth.

I think the increase in network power is now speeding up Factor Y among us but I think few realize it because the sands of time appear to move slower when you are in the mid of the 6th extinction.  The evidence is all around us if your dopamine level is high enough to sense the trend.   That assumes of course youre capable of looking for it by deciding to look for evidence of it.

Human and animal infertility are now at unbelievable levels inside of cities.

What is the mitochondrial reality of this event?

Do we have any historical evidence for the mechanism and how it might be devloping ?  We do.

Smog affects oxygen tensions, and oxygen tensions affect the NAD+/NADH ratio’s in your mitochondria.  Some anniversaries pass with little notice. Herewith a reminder that 70 years ago people dropped dead from air pollution in the Monongahela Valley town of Donora. Unfortunately throughout India and China today, similar conditions can be found with levels of particulate sometimes averaging more than 1000 ppm.  This explains where China and India fertility rates are dropping rather dramatically in the 21st century.  Introducing and industrial and tech economy to an agrarian lifestyle built over the last 5000 years will have a non-linear effect on mitochondria.  Light and oxygen always have nonlinear effects in biology and this trips up most conventional thinkers in biology.  This is why we have historical anecdotes that matter a great deal to the Black Swan in training.

MITOCHONDRIAL OXYGEN

For example: Another interesting link between the air and life is found in the Andes of South America. When the Spanish came to conquered the Indians who lived up at their altitude and settled with them there were no Spanish couples able to have children there for 53 years. It was only when they began having intercourse with the native people that they were able to have children at these altitudes. The reason was simple In Spain has oxygen tensions at 21% but in the Andes where the Indians were at serious altitude the oxygen levels were only 12.5%. This decrease in consumption in th emitochondria means that more oxygen is dissolved in the cell and this fosters more free radicals that make DNA more unstable. The Indians offset this risk by altering their epigenomic marks with methyl groups and histone acetylation.

Generally at sealevel, where the Spainards came from, and most people are, you need oxygen to act as the terminal electron acceptor and not be dissolved in the cell. This supports conversion of pregnenolone to the sex steroid hormones and for leptin to allow fecundity.

This basic mitochondrial fact should wake up modern humans who have demolished their hormone panel and need fertility docs to have a kid. This is huge evidence you are a TECHNOLOGY abuser. Technology use induces pseudohypoxia and upregualtion of AMPk pathways and sets the tone for mitochondrial diseases by lowering the matrix redox power from NAD+/NADH to oxygen as the picture below shows.

This lowers the electrical power difference between the beginning and end of electron transport. Taking NAD+ or using HBO to increase oxygen cannot fix this situation either. If you do this you will INCREASE free radicals that will damage your colony of mitochondria further by destroying heme proteins in the cytochromes and this will reduce the water that cytochrome 4 can make. So vet your expert advice well before buying their solutions for your infertility problems. A repair of your technology diet is more wise than clomid is for your offspring. forcing nature to do something with bad mitochondria in your germline is not a wise move if you want to have a healthy kid.

So there is a deep link of air pollution to a lack of sun and lowered fertility……but air pollution also brings low oxygen tensions and the two phenomena involve different mechanisms both acting on different parts of the mitochondrial biologic programs. This is an interesting Black Swan lesson contained here about the Andes and native Europeans.

HOW DOES THIS WORK MECHANISTICALLY?

According to mitochondrial data, when the pH of water drops (acidic = more H+ or D), so does it’s ability to absorb oxygen.

Therefore, a life or germline without sun or ground should result in a dynamic state of hypoxia, assuming the above is true.

If the mitochondrial respiratory processes are compromised and water is not able to absorb oxygen effectively from the lungs, where does this excess oxygen go? It goes to the broken mitochondrial engines where free radicals are made by the cytochrome proteins. How do mitochondria make free radicals to signal? ELF-UV bio-photons and oxygen must be present. Is this why oxygen levels are quantized precisely with mitochondrial damage in cells? YES INDEED.

If the mitochondrial respiratory processes are compromised and water is not able to absorb oxygen effectively from the lungs, where does this excess oxygen go? It goes to the broken mitochondrial engines where free radicals are made by the cytochrome proteins. How do mitochondria make free radicals to signal? ELF-UV biophotons and oxygen must be present. Is this why oxygen levels are quantized precisely with mitochondrial damage in cells? YES INDEED. As biophotons are released from the cell and NAD+ drops at cytochrome one. Why? Freed vitamin A destroys the heme protein at this cytochrome. There is no catalase, another heme chromophore to control it. We call this the pseudohypoxia state that David Sinclair found in Dec 2013 study published in Cell on this very topic. Even he has not put it all together. When all these things occur heteroplasmy is rising and cell volumes rising and ubiquitin marking increasing how aging really occurs in a quantum fashion. So do aging old people have kids? No………this is why when this state happens in young people they are infertile.

Let us go further……..What does pseudohypoxia (low NAD+) mean to our hormone panel in the sex steroids region? The cost of a high aerobic capacity is low fertility. This is why the pregnenolone steal syndrome exists and why males suffer low testosterone and females have an upside down PG/E2 ratio in menopause. their mitochondria can no longer make water well at cytochrome 4 and this is why infertile and aging people have markers of dehydration on labs. It is not what the anti-aging or functional medicine docs think or believe. This is quantum biology 101 for a Black Swan.

This formula above goes hand and hand with what I said in the November 2018 webinar about the 5G risks humans all face. If you think taking NAD+ analogs are wise you clearly are no Black Swan.

Producing cortisol over sex steroid production is survival mode for the cell and it is due to the use of oxygen as the terminal electron acceptor in human mitochondria in a really bad light environment (blue or nnEMF). As this occurs in a women’s gut at menopause their lower esophageal sphincter (LES) allows more O2 into the gut lumen because its myoglobin (another heme photoreceptor protein) is destroyed by the freed Vitamin A and this simplifies the gut flora changing the microbiomes biophoton light release to the enterocytes. This alters its circadian biology and affect activation of the GALT and the liver. This allows too much deuterium into the liver = fatty liver.

The liver is where most catalase is located in humans. This raises more free radicals in the liver making its deuterium load greater and lowering hormone production further. Remember the liver controls the long loop of the Bazan effect.

This cause global reduction of DHA in cell membranes ruining circadian control in many organs. The mitochondria also make thyroid hormone, specifically T2. This lowers thyroid hormones T2 and T3 and women cannot absorb the sun’s light even if they are naked at the equator. Lack of catalase ( increasing H2O2) and lack of AM UV/IR light fuel this low fertility. Catalase is most commonly found in the liver of humans.

Artificial light, with a lack of sunlight makes fertility doctors rich and busy. It’s not our abilities that show what we truly are, it’s our choices of light we live under that determine our fate when it comes to fertility. This is why people are infertile in a blue-lit microwaved world.

CITES:

1. https://www.telegraph.co.uk/news/2018/10/31/italys-populist-government-plans-reward-fertile-families-state/?fbclid=IwAR2C7qzb3JzD4H-jk9-9pz2tqgBR98im5fWUx_YbJZoj3AOrjI0l-C48-yc

2. Elizabeth Kolbert: The Sixth Extinction.

3.   https://www.smithsonianmag.com/history/deadly-donora-smog-1948-spurred-environmental-protection-have-we-forgotten-lesson-180970533

How do you process death? Most people struggle with death but what happens when you see somebody you love dying before your eyes while they are still living? How do you approaching the living dead about the choices that brought them to this place in your life?

How do you process their choices that have imprisoned their thinking and their mindset?

The causes of death are many and varied. It might be due to a mood disorder or depression because of life of night shift work. That chronic depression might lead to a suicide attempt. The very same scenario might not ever get to suicide but it could lead to dementia after 20 years of decline. The mood disorder might be caused by indoor office work that eventually lead to obesity, diabetes, stroke, that eventually lead to heart disease and an early death. On the way to any of these diagnosis, your relationship with that person might be radically affected by their choices. If you love them, do you ignore their choices and let them do what they want as you suffer and watch them die?

How do you salvage a relationship with a friend or partner who is hell bent on continuing to make choices that will ultimately cost them time……time in their life.

In survivor training they teach us how to not die when you’re helping rescue a drowning person who is anxious and fighting to survive.  If we get this decision wrong, you both drown.  Is this a wise choice?  I think there is a way to help a friend or partner when they are in dying mode while they are actively living and breathing.

The mode of how they are dying is the key to understanding what your best choice might be.  I don’t believe there is any correct answer for any relationship on life support.

THE GOODBYE CHECKLIST

1. You’d be wise to enlist the help of your cicle of six when trying to help another

2. Write them a goodbye love letter

3. Look them in the eyes while handing them an appointment to see a doctor to get a term life insurance policy you as the beneficiary.

4. Ask the dying while living what you can do to help.

What happens if the continue to ignore you? Are you prepared to force them to see a life without you in it?

Can you walk away to teach them how much you really care?  In relationships, people often get complacent with time because they become imprisoned by comfort and luxury.  They begin to avoid the discomfort of thinking.  This is how “comfortable thinking” creates cognitive biases.  Sometimes those biases can harm you and lead to illness or death.

Have you ever cared so much that you were willing to create a perfect dismount scenario for your significant other?  Dying while your living comes with many contexts in life.  It is a very tough situation to navigate.  There is no one recipe for all.

You have to try to got others who pack your parachute help you navigate these rough seas.  These people often can help you help the dying person see their self worth to once again love themselves again.  Without this love they will never be capable of loving you or anyone else.  Don’t we have to try help others see the value of time?

Nothing is harder than seeing your best friend kill themselves while they are alive, in my opinion.

Are you prepared to follow them to their grave?  Are you prepared to dig yourself in deeper into redox hell for them?  Is their a time limit that you’ll impose on them?  Or will you continue to give them a pass for their choices?  How long will you give them this pass?  How many of your body parts are willing to sacrifice?

When you love someone there are a few key questions to consider.  Do you love them unconditionally?  Are you in love with them now after their choices have changed the relationship between both of you?

Do you believe you can love someone, yet let them go completely for their own good?  Do you accept that it might be regal to release a person you love or loved, when their end is near?  Isn’t it true that real love is like a boomerang; it should be expected to come back if it was true?   Cutting your love loose is a wicked game.  Would you gamble this big if it was your only option left?

People only focus on your wisdoms, until they see the depth of how much you care.  I believe you can love deeply, without being in love, because love does not operate like a light switch.  Once the switch is flipped off, it cannot be easily turned back on.

Would you still be willing to help as choices continue to be made that will extinguish their light?  What happens when you finally realize the choices of others are the hinges of destiny in our relationships?

The differences in the stumbling blocks in relationships and stepping stones is in how we use them.

Are you ready to make them see you are willing to do the hard things to make the blind see again?  Can your actions put windex on the glass eyes of the dying?

You cannot make progress without making decisions in relationships. I have found a peacefulness follows any decision, even the wrong one.  It’s not hard to make decisions when you know what your values are.  How do you value your life?  How do you value time?   When one bases his life on principle, 99 percent of your decisions are already made.  They are made by the choices we make.

How all in are you really?  for you or for them?

Are you waiting for someone to put flowers on your casket or are you willing to plant your own garden to decorate your life right now?

We don’t heal anyone’s past by dwindling there with them and allowing them to remain imprisoned there by old choices.   We can only fully heal them by teaching them to live fully in the present even it that present no longer includes them any longer.

As a surgeon I am addicted to helping and saving the person dying an acute death.  It is what I am trained to do.  As a man in a relationship on life support, I found out that saving someone I love, is a lot more like trying to save a person drowning in the sea.

You have to be careful of how you attempt to save them, because you might go down with them.  This serves neither person or your family.  This is why living fully, while being solo might be the toughest goodbye that contains the best long term Rx.

In realtionships, actions prove who you really are. Words are just who you pretend to be…………..

I’d like this post to be dedicated to ideas around nurturing love long term.

I think I have done a poor job of exploring this aspect of relationships and how it relates to health and wellness and I think I need to improve this.

I believe relationships are built around three cornerstone pillars similar to life’s 3 legged stool of light water and magnetism.

They are:

• Intimacy, which is characterized by warmth, support, communication, and understanding;
• Passion, which is characterized by physical arousal and desire; and
• Commitment, which involves the decision to actively work on, and sustain, a relationship.

I think all three are dynamic and lead to different types of love in relationships and they all build different lives.  This mimics the effects of light, water, and magnetism and its dynamism effect on mitochondria and cells to create an epigenetic program that sculpts the matter in our cells to build our tissues and the life we experience.

Currently, I believe the most important of this 3 legged stool is passion.
I believe today that holding “decay beliefs” about passion — in other words, believing a decline in passion is irreversible — is associated with lack of commitment, lowered investment, and pursuing romantic alternatives to one’s partner.  I think this belief is a function of the redox state of our colony of mitochondria as we age.  As such, I think the reason relationship struggle as time marches on is because each other redox state varies based upon the choices we have made in how we sustain the redox power in our own lives.

I believe total ‘complete’ love, is a possible result in life when all three variables of the stool of love are present and relatively strong.  However, this dynamic viewpoint of love brings up the possibility that there might be multiple possible combinations of this 3 legged stool, therefore, multiple resulting types of love can manifest based upon the variable strengths.

Romantic love:  For example, a couple who engage in a short-lived romance might demonstrate high levels of passion and intimacy, even though they lack commitment.  There is a strong link to dopamine creation here.
Fatuous love:  Some other couples who meet might marry quickly (and therefore commit to each other) on the basis of overwhelming passion but perhaps do so without truly understanding or getting to know one another deeply.
Such people are more likely to indulge in both commitment and passion in the absence of intimacy, which can be a risky move for obvious reasons. They might not like each other much once they become more familiar with each other’s quirks and proclivities!
Companionate love: In contrast, an experienced couple who have shared many experiences throughout their long, happy marriage might continue to enjoy significant intimacy and commitment to each other, even if their passion has progressively dissipated over the years.  Sometimes having a companion is the most powerful driver of a bond.
Consummate love: Consummate love is a synonym for total love or a love that appears to be an ALL IN type of relationship.  This happens when intimacy, passion, and commitment are all present in substantial degrees.  I believe this is what most people are looking for and want in their lives.

I believe it is the rarest because I believe it requires optimized levels of hormones made around light, like POMC, insulin, leptin, and melanopsin.  I think when a relationship has two people who experience two different light environments the redox power becomes more variable to one another on a relative basis and this threatens the balance of the type of love possible between the two people as time evolves.

Total love is difficult to sustain long term because it requires both people to heavily invest in behaviors that support redox power chronically as we age.
What variable do I think is most at risk with lowered redox power?
The most variable element in my opinion, — the one most at risk of decline with time— is passion.  I think this is why love in a relationship varies over time. 

Could a chemical give us a clue to a changing redox in our partner?  
Phenethylamine is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans and is made in the same areas dopamine is made in the brain.  PEA chemical formula is pictured below.

In humans, this is a VERY variable chemical and it is found in Substantia nigra pars compacta; Ventral tegmental area; Locus coeruleus where dopamine is found at high levels; many other places where amines with aromatic benzene rings are made to act as photon traps for sunlight.  This chemical is very similar to other potent exogenous stimulants known to alter human behavior.

It is made from phenylalanine and tyrosine in humans.
The creation of phenethylamine (PEA) varies greatly across species, and the human receptors of this stimulant chemical is called hTAAR1.  PEA is an endogenous neurotransmitter and neuroregulator that plays a key role in mood and cognition too.
This brings up an interesting point about PEA:  can it be harnessed to improve your health and love life in ways that might surprise you?  Yep.
It has been found among 95 carbon and 95 nitrogen sources tested in foods, β-phenylethylamine (PEA) performed best at reducing bacterial cell counts and biofilm amounts, when supplemented to liquid beef broth medium.  PEA is a trace amine whose molecular mechanism of action differs from biogenic amines, such as serotonin or dopamine. Especially low or high concentrations of PEA may be associated with specific psychological disorders. For those disorders that are characterized by low PEA levels (e.g. attention deficit hyperactivity disorder).  Might it be able to modulate the other neurohormones we need to create a stable loving relationship over time?

I think it might.

PEA is strongly linked to bacterial metabolism and this makes me think it might be a serious modulator of mitochondrial redox power in humans as well because the inner mitochondrial membrane is the source of redox power and it retains its mitochondrial evolutionary lineage.
In several bacterial species, the above reaction is catalyzed by the enzyme tyrosine decarboxylase, which also converts tyrosine to another trace amine, tyramine (Marcobal et al., 2012; Pessione et al., 2009). Intriguingly, PEA synthesized by fungi and bacteria can also be found in food products (Onal et al., 2013), where it serves an indicator of food quality and freshness.

This includes the Korean natto (Kim et al., 2012) and commercial eggs (Figueiredo et al., 2013). Another food that contains PEA is chocolate, where it is not produced by bacteria, but during the thermal processing of cocoa (Granvogl et al., 2006).
PEA has also been found in the brains of humans and other mammals (Paterson et al., 1990; Philips et al., 1978), which is facilitated by its high solubility in plasma and its ability to cross the blood-brain barrier (Oldendorf, 1971).

Like its α-methylated derivative, amphetamine, PEA has stimulant effects which lead to the release of so called biogenic amines, including dopamine and serotonin (Bailey et al., 1987; Rothman & Baumann, 2006). This can help it modulate their diurnal controls in our cells and affect our behavior with our partners.

Unlike amphetamine, PEA has difficulties maintaining high concentrations in the human body, due to its oxidative deamination to phenylacetic acid by the enzyme B monoamine oxidase (MAO) (Yang & Neff, 1973). Phenylacetic acid,has an effect that is similar to the activity of the natural endorphins (POMC), an effect that is known as a “runner’s high”.

I’ve started to look deeper into this connection in people with relationship issues and the results have been eye opening to say the least.

So they died, they left your, you left them………bottom line is that you are alone. What is your game plan now?

We all have limits. Almost no one reaches theirs. You definitely haven’t but I am ready to teach you how to go deeper than you ever thought you could. Bravery means finding something more important than fear. I’ll be waiting for you inside the bottom of my deep blue sea. We do things differently there. It’s OK to reinvent the wheel, but only after you know how the current wheel works. Never assume you know better when you don’t really know anything about the process of recovery……….Courage without meaning is just recklessness. Brave people aren’t fearless; they’ve simply found something that matters more to them than the fear they’re facing.

Say you’re scared to start your life over from scratch when you’re 55. Your friends and family think you are having an existential crisis. You know you haven’t, you just got sick of settling for less than you deserve. You decided to use chaos and discomfort to fill your gas tank to get to places you never could get to ever before. Eventually, you find a reason that has greater meaning than the fear: your future, your new partner, your desire to make a difference, or your dream of a more fulfilling life.

When you find greater meaning in your life, you’ll find the courage to overcome your fear. Today’s pain is tomorrow’s power. The more you suffer today, the stronger you are tomorrow.

SO YOUR SOLO AGAIN………. 

Success is all about taking your shot, over and over again until you win.

You’ll never create the perfect business plan, never find the perfect partners, the perfect market, the perfect location, but you can find the perfect time to start.

That time is now

Stop waiting for the ‘right time.’ Success is a numbers game: the number of times you take a shot.

If your sick of being single do something about it right now.

When you meet the right someone, they will undress you.  I’m not talking about getting naked to get laid.  Nothing makes you feel more naked than someone identifying a desire in yourself, you never knew you possessed.  This spark will lit that pilot light.  It might illuminate a passion in you, you never saw in yourself.  You have to allow people to move in those spaces in you if you want to move forward with your best life.

MY LATEST LESSON:   LEARNING THE TANGO

Never invest in any kind of relationship with anyone who is not willing to work on themselves just a little every day. You have to chose better today than you did before.  A person who takes no interest in any form of self-improvement, personal development or spiritual growth will also not be inclined to make much of an effort building a truly meaningful connection with you. A relationship with only one partner willing to do the work ceases to be a relationship.  This is called bondage or a prison.  Never allow anyone to put you in a cage and slip handcuffs on you and tell you that they’ll love your forever.  That is insanity.   And as anyone who has been there will tell you – it’s pointless to try and dance the tango solo.

‘Life is the dancer and we are the dance.

When you realize you could actually choose the type of dance in life, and actually take the lead, your life begins to dance it naturally. Ask yourself now, ‘What type of dance have you been asking the Universe to dance with you?  Might this be why you are failing?’

I have slowly realized after 55 years that my choices are what  determine what dance will the Universe chose to play for me.  Did I go with that flow or break the harmony?  It turns out, the music life is playing in the now…happiness, fear, rage, passion etc. Embracing and dancing to it as music… you stop the struggle and learn to move with the flow of life.

Just because you failed again in building a relationship have the courage to persist.  “Courage is forward movement while embracing fear. Thinking for yourself is courage. What’s rare is the courage to follow it to the dark places where it leads. One person with courage is the only majority you need to succeed in life.”

Take enough shots, and over time you’ll grow more skilled, more experienced, and more connected. You will become entangled. And that will mean a greater percentage of your efforts will succeed. Take enough shots, learn from what didn’t work, and in time, you’ll have all the skills, experience, and connections you need in your relationships. Relationships fail because we did not have the right tools, or enough tools in our love tool box to create success.

Ultimately, success is all about taking your shot, over and over again. Sometimes you may win, sometimes you will definitely lose, but the more things you try, the more chances you have of succeeding. Put the power of numbers on your side. Take as many shots as you can. There’s no guarantee of success, but when you don’t take a shot, there’s a definite guarantee of failure.

Being single is not a state of failure. Solo is a unique place. It is a place that requires embracing the suck in relationships and in life. Do not recoil from tripping up and being solo again. Accepting each reality of being single head-on almost always loosens the knot of despair, and frees up your energy to accept what you can’t change, and change what you can about your and your situation.

Single means you are brave enough to face the glorious unknown of the unaccompanied journey in your life with some zest. You’ve become ready to try to do it better this time. You take more shots, because now your blade is sharper. This is why the last cut is the deepest………just because your old does not mean this part of your life should be dead on arrival.

When you find your path, person, or passion in this life you must not be afraid to jump again. You need to have sufficient courage to make mistakes. Disappointment, defeat, and despair are the tools Mother Nature uses to show us the way to Optimal.

In 2019 what I learned in editing my own life is that when you stop expecting people to be perfect, you can like them for who they are. Then some interesting shit can happen………..