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Free radicals and reactive oxygen species (ROS) in particular play an important part in aging because they direct repair and regeneration and taking antioxidants ruins this endogenous signal. Free radicals are (usually small) molecules lacking an electron needed for stability; they will steal an electron from the first thing they bump into. Like pulling a cog out from clockwork, stealing an electron from a protein or enzyme is usually not good for the finely-tuned biochemical machinery of our cells. The free radical might be rendered safe in the process, but it has left some form of chaos and damage in its wake.

Free radicals are sufficiently dangerous to biochemical machinery that some of our body’s defenders use bursts of free radicals as a kill mechanism. That is why Denham’s belief has died too slowly. Science changes though as data comes in.

Scientists now generally concur that accumulated damage throughout the body due to free radicals is one important root cause of age-related degeneration – but the devil is in the details. The vast, overwhelming majority of those free radicals are generated by your own metabolism as an unavoidable byproduct. The rate of free radical generation increases greatly with age as the basic mechanisms of your metabolism are themselves damaged by the free radicals they created. This is not a one-step process, however. I’ve tried to walk through it at a high level at my blog, cribbing from the mitochondrial free radical theory of aging that was proposed by Wallace and working its way into general acceptance because of new data

Within each of your cells are many mitochondria, tiny biochemical power plants that convert chemicals from food to ATP, the basic fuel molecule used by your cells to provide energy for life.

You have to beware of people who take advantage of the antioxidant theory of aging and have no earthly idea of how mitochondrial creation of free radicals really works. This is why supplement makers and coffee makers are pushing the false narrative that antioxidant use is wise. Marketing is legalized lying.

Mitochondria were once a separate organism that came to live in symbiosis with ancestral cells. As such, they brought their own DNA to the party; some of it still remains within our mitochondria, separate from the DNA we carry in chromosomes in the cell nucleus.

Mitochondria have a couple of ways of generating ATP. The more efficient of these methods – oxidative phosphorylation (OXPHOS) – generates some amount of free radicals as a natural byproduct, and requires the proteins coded in the mitochondrial DNA to function. It is the predominant way by which healthy cells generate their power.

Free radicals created through OXPHOS within a mitochondrion are most likely to damage that mitochondrion; they’re very reactive, so they won’t get far before sabotaging something. The components that really matter are (a) a membrane that helps organize the movement of various chemicals in the process of generating ATP, and (b) the mitochondrial DNA.

Sufficient free radical damage to mitochondrial DNA shuts down OXPHOS within that mitochondrion, as the necessary proteins can no longer be produced. The mitochondrion switches over to using a less efficient method of producing power, one that doesn’t produce free radicals but has to run at a much higher rate to produce the same level of ATP.

Mitochondria, like most cellular components, are recycled on a regular basis. Components called lysosomes are directed around the cell in response to various signals, engulfing and breaking down damaged or worn components. After the herd has been culled, surviving mitochondria within a cell divide and replicate, much like bacteria, to make up the numbers.

The signal to break down a mitochondrion is triggered by sufficient damage to its membrane: a sign that it’s old, leaky, inefficient and needs to be replaced with a shiny new power plant.

BUT: if a mitochondrion has had its DNA damaged to the point of stopping OXPHOS/beta-oxidation/alpha-oxidation, it will no longer be producing NORMAL free radicals that can damage its membrane. So it will never get broken down by a lysosome. When the time comes to divide and replicate, it will replicate its damaged DNA into new mitochondria and disease is spread like a bacterial infection in your tissues. None of those new mitochondria will be producing free radicals via OXPHOS, and so will not be recycled either (autophagy).

One DNA-damaged, non-OXPHOS mitochondrion will eventually take over the entire mitochondrial population of a cell in this way. At that point, the trouble really gets started.

By the time you hit late life, perhaps 1% of your cells are in this state of being taken over by non-OXPHOS mitochondria. As for any neighborhood or city, it only takes a small proportion of dangerous criminals to make life really unpleasant for the rest of us. Same true here at the tissue level.

Non-OXPHOS mitochondria have the unfortunate effect of depleting a needed molecule used in many cellular processes, NAD+. This is a carrier molecule in the OXPHOS process, given an electron (and turned into NADH in the process) to port between point A and point B within the mitochondria. Once the electron is delivered, the NADH becomes NAD+ again. But without a working OXPHOS process to return NAD+ into circulation, the cell would quickly build up a deadly excess of NADH, run out of NAD+ and hypoxia occurs and cells die. (Sinclair, 2013)

Fortunately for the cell, and unfortunately for us, there is another way to recycle NADH into NAD+. Since NADH is just NAD+ with [amongst other things] an electron stuck to it, all the cell has to do is export those unwanted electrons to other proteins via the Jablonski diagram I have posted over and over.

In the points above, I omitted details of the reaction that transforms NAD+ to NADH in order to focus on the electron that is ported around. Wikipedia gives an introduction to the full picture, which also involves an extra hydrogen atom (non-deuterium) – NADH is NAD+ with the addition of a hydrogen atom (one proton, one electron), and an additional electron. Nonetheless, it is the shuttling and exchange of electrons that is important here.

In a form of chemical waste dumping, this is just what the cell does. Structures on the cell membrane known as the plasma membrane redox system (PMRS) export electrons from NADH, recycling it into NAD+. This process is only very active in cells that have been taken over by DNA-damaged, non-OXPHOS mitochondria, but their outer surfaces are little hotspots of electron dumping.

What do these electrons do? Well, for one, they combine with oxygen molecules – which are abundant in any of our living tissue – to create reactive oxygen species (ROS): more free radicals. Sick cells have pseudohypoxia to limit the damage and try to survive as autophagy is defective. This causes organ failure. So you have the Rube Goldberg system outlined above whereby a few free radicals have caused a cell to become an ongoing, major exporter of free radicals into the surrounding environment. These will make life unpleasant for surrounding cells, but that is most likely not the real problem. ROS just can’t travel far enough to explain how a corrupt 1% of our cells can cause a large fraction of the difference between being young and being old.

A more likely target for all the newly created ROS is cholesterol. Cholesterols, such as low-density lipoproteins (LDL) are used everywhere in the body and travel widely. If ROS reacts with nearby LDL – and there will always be nearby LDL – to form damaged, oxidized cholesterol, that damaged cholesterol can then be incorporated into and further damage biochemical processes throughout the body. For example, its effects on our arteries is well known: What is not well known is how the light that excites that electron damages cholesterol rings by how it is programmed. If the right frequency of light is on the electron cholesterol works well……if not you get a disease.

In conditions with elevated concentrations of oxidized LDL particles, especially small LDL particles, cholesterol promotes atheroma formation in the walls of arteries, a condition known as atherosclerosis, which is the principal cause of coronary heart disease and other forms of cardiovascular disease.

There are many other ways in which accumulations of oxidized cholesterol can send biochemical processes awry. This, then, seems to be a good candidate for the plausible, systematic method by which a small number of cells can work such varied damage upon your entire body.  Mitochondrial damage acts just like an infection does at the tissue level.  Aging does the same.  This is why health is the slowest form of death we chose by using the right light that excites electrons.  Mitochondria deal the right electrons to the right tissues to build health.

Do you only value something if you know it’ll end?

So what do you do with your significant other when it is over? Ponder the question before you pull out a piece of paper and answer this question.

What would a Black Swan do?

Would they sacrifice themselves and leave what is left for the person they are cutting out of their life?

Do you believe there is addition by subtraction?  Many people talk a big game but are they capable of writing a goodbye letter to a spouse who ruined your life?

I think Neil Young had it right when he said, ” “It’s better to burn out than to fade away.”

Sometimes we need to look past the chemistry and the butterflies to what is really going on at the base of it all. Who is the person you’re looking at in this moment? Do they match the idealized figure you’ve built up in your mind? What behaviors are confirming or denying that belief?

Will you end your relationship quickly or will you bleed it slowly?  Most people will go for the slow death of a relationship because they have little experience with death.  This is a grave error.

How many lost days are you willing to sacrifice before you give up?

For those who value time the answer will be different than the rest of you reading this.

Do you believe there’s a beginning in an end ? It’s true that you can’t reclaim what you had, but you can lock it up behind you. You can start fresh if you cut the head off the snake soon.

Are our relationship’s just a bunch of accidents, connected by one perfect end?

Does the end of your relationship  justifies the means. Might it be true that sometimes you have to do the wrong thing to get the right result?

Have you considered unusual mechanisms to solve your relationship dilemma?

How much do you know about discernment counseling?

Discernment counseling is not couples counseling. It doesn’t aim to fix any problems. Instead, in just a handful of sessions (both joint and individual), it helps couples on the verge of relationship breakdown understand why their problems have become so intractable, helping them trace the downward spiral and examine their patterns from a different perspective. In a sense, it’s an exit interview for a relationship, but one that leaves the door open to reconciliation.

And in an instant it all changed.

When I decided to get divorced I did discernment counseling before I signed my divorce papers………..I wanted to make sure my decision tree was plumb with my reasoning before I ended my relationship.

In this therapy I found out 50% of people who hire this type of therapist save their relationship before they transition into more traditional therapy. I found out many people who do this have even backed out of divorces. This peaked my interest. This why I did it. I did it on my own. I beleive many couples are unhappy for a long stretches, but many feel they can’t just leave. because they haven’t really done any work to address the problems in the relationship in any meaningful way.

Before my final exit I had to know I covered all my bases. So I jumped and did it.

When our partners aren’t right for us, they have a funny way of showing us that truth, but it takes a dose of radical honesty to see these warnings for what they are. To see these red flags for what they are and accept them, we have to start loving ourselves and setting boundaries both inside and out. Only when we learn how to love ourselves can we truly start loving others and receiving the love we deserve.When we love, we love deeply and that can often cause us to overlook critical red flags and warning signs that are best faced head-on and in the moment. Part of forming happy and lasting relationships is learning how to confront issues in those relationships as they happen, something that takes both time and understanding to carefully manage.

Most of the couples who sign on for discernment counseling are “mixed agenda,” meaning one is eager to walk (me), and the other wants to make things work (her).

I did it because I was sure I was done……..but I wanted exogenous validation that my feelings where solid before i dropped the hammer on my partner.

I suffered deeply from relationship ambivalence—this is the agonizing process of feeling uncertain about a romantic partner even while going through the daily motions of a relationship.

I think I had hoped I’d find an answer to why I felt why it was worth while staying, or maybe that I may conclude that I shouldn’t stay at all.

With either conclusion, the mark of successful discernment counseling is when a person can step outside themselves to view the relationship — and its dissolution — more objectively.  You have to remove your cognitive biases about the other person before you decide to stay or go.

Research suggests that couples struggle with relationship difficulties for an average of six years before seeking help. When you’re nursing a deepening hurt over that amount of time, it’s easy to become a bit solipsistic, favoring acts of self-preservation over generosity. It’s harder to see past old and recent wounds to adopt another perspective on the problem, even when doing so might provide a solution.

We confuse feelings with the stories we make up about those feelings.

My suggestion is to avoid couples counseling and try discernment counseling solo for yourself to figure things out for you before you call an attorney.

Discernment counseling made me feel like I did my homework, regardless of the outcome.  I felt that  this is the Black Swan thing to do before burning a relationship bridge down and trying to start over.

CITES

1. https://www.gottman.com/about/research/couples/

Harmony makes small things grow. properly in nature…… Lack of it makes big things decay around and in us.  Factor Y is a term I use for the sixth extinction that has begun about 120 years ago.  The political left, in my opinion is using climate change narrative to hide the real fact that the electromgnetic force is behind the 6th extinction.  Why do I believe this?  C02 thermodynamically cannot act fast enough to explain the Permian extinction or the current one ongoing.  The electromagnetic force can.  It is the strongest of the 4 forces and it has unlimited range and power so this means it can cause quick changes that will often be hidden for a time because many of the effects will be non-linear in nature.  5G from above courtesy of Elon Musk is one such non-linear change.

Technology use and abuse cause the capricious cohabitation of the human’s mind. Nature’s harmony makes small things grow. Lack of it makes big things decay. Technology ruins biologic coherence and induces degeneration of the mind and a lapse into cancer as the US National Toxicology Program’s final release is warning us.

Human behavior is fascinating. We like to think of ourselves as intelligent, rational beings. But we regularly fail to recognize basic logical fallacies. Our hedonistic propensities propel us to accept correlation as causation when it appears to validate behaviors we like to engage in, like abusing light technology under the guise of “progress” and crafting the narrative the sun is toxic. It is pure insanity.

Give me some examples of a non-linear effects Jack.

A small stimulus leads to massive amplification = a non-linear effect

1. A nuclear weapon can be thought of as non-linear action. It is the size fo a small car yet it can level a city.

2. A star like the sun can be thought of the same way. It is relatively small yet it can warm 9 planets over billions of miles.

3. Small amounts of UV light from the sun can leach into the eye (1%-3%) yet they have the greatest effect on the RPE dense core granules to drive the central retinal pathway that connects to the SCN and leptin receptor to control the growth and metabolism of every human on Earth.

4. The change in networking power used on the internet went from 0G in 1995 to 5G today. That is only 23 years.  That small change in the electromagnetic force  is fully capable of leading living things to the sixth extinction level event on Earth.

Those are some examples of non-linear effects.

All epigenetic effects are also non-linear. Blue light and nnEMF cause HYPERMETHYLATION of DNA and RNA. <——- That is the major change agent of the epigenome and we saw how Scott Kelly went up into space for 340 days and sustained massive epignetic genome changes compared to his identical brother left on Earth.

I think the increase in network power is now speeding up Factor Y among us but I think few realize it because the sands of time appear to move slower when you are in the mid of the 6th extinction.  The evidence is all around us if your dopamine level is high enough to sense the trend.   That assumes of course youre capable of looking for it by deciding to look for evidence of it.

Human and animal infertility are now at unbelievable levels inside of cities.

What is the mitochondrial reality of this event?

Do we have any historical evidence for the mechanism and how it might be devloping ?  We do.

Smog affects oxygen tensions, and oxygen tensions affect the NAD+/NADH ratio’s in your mitochondria.  Some anniversaries pass with little notice. Herewith a reminder that 70 years ago people dropped dead from air pollution in the Monongahela Valley town of Donora. Unfortunately throughout India and China today, similar conditions can be found with levels of particulate sometimes averaging more than 1000 ppm.  This explains where China and India fertility rates are dropping rather dramatically in the 21st century.  Introducing and industrial and tech economy to an agrarian lifestyle built over the last 5000 years will have a non-linear effect on mitochondria.  Light and oxygen always have nonlinear effects in biology and this trips up most conventional thinkers in biology.  This is why we have historical anecdotes that matter a great deal to the Black Swan in training.

MITOCHONDRIAL OXYGEN

For example: Another interesting link between the air and life is found in the Andes of South America. When the Spanish came to conquered the Indians who lived up at their altitude and settled with them there were no Spanish couples able to have children there for 53 years. It was only when they began having intercourse with the native people that they were able to have children at these altitudes. The reason was simple In Spain has oxygen tensions at 21% but in the Andes where the Indians were at serious altitude the oxygen levels were only 12.5%. This decrease in consumption in th emitochondria means that more oxygen is dissolved in the cell and this fosters more free radicals that make DNA more unstable. The Indians offset this risk by altering their epigenomic marks with methyl groups and histone acetylation.

Generally at sealevel, where the Spainards came from, and most people are, you need oxygen to act as the terminal electron acceptor and not be dissolved in the cell. This supports conversion of pregnenolone to the sex steroid hormones and for leptin to allow fecundity.

This basic mitochondrial fact should wake up modern humans who have demolished their hormone panel and need fertility docs to have a kid. This is huge evidence you are a TECHNOLOGY abuser. Technology use induces pseudohypoxia and upregualtion of AMPk pathways and sets the tone for mitochondrial diseases by lowering the matrix redox power from NAD+/NADH to oxygen as the picture below shows.

This lowers the electrical power difference between the beginning and end of electron transport. Taking NAD+ or using HBO to increase oxygen cannot fix this situation either. If you do this you will INCREASE free radicals that will damage your colony of mitochondria further by destroying heme proteins in the cytochromes and this will reduce the water that cytochrome 4 can make. So vet your expert advice well before buying their solutions for your infertility problems. A repair of your technology diet is more wise than clomid is for your offspring. forcing nature to do something with bad mitochondria in your germline is not a wise move if you want to have a healthy kid.

So there is a deep link of air pollution to a lack of sun and lowered fertility……but air pollution also brings low oxygen tensions and the two phenomena involve different mechanisms both acting on different parts of the mitochondrial biologic programs. This is an interesting Black Swan lesson contained here about the Andes and native Europeans.

HOW DOES THIS WORK MECHANISTICALLY?

According to mitochondrial data, when the pH of water drops (acidic = more H+ or D), so does it’s ability to absorb oxygen.

Therefore, a life or germline without sun or ground should result in a dynamic state of hypoxia, assuming the above is true.

If the mitochondrial respiratory processes are compromised and water is not able to absorb oxygen effectively from the lungs, where does this excess oxygen go? It goes to the broken mitochondrial engines where free radicals are made by the cytochrome proteins. How do mitochondria make free radicals to signal? ELF-UV bio-photons and oxygen must be present. Is this why oxygen levels are quantized precisely with mitochondrial damage in cells? YES INDEED.

If the mitochondrial respiratory processes are compromised and water is not able to absorb oxygen effectively from the lungs, where does this excess oxygen go? It goes to the broken mitochondrial engines where free radicals are made by the cytochrome proteins. How do mitochondria make free radicals to signal? ELF-UV biophotons and oxygen must be present. Is this why oxygen levels are quantized precisely with mitochondrial damage in cells? YES INDEED. As biophotons are released from the cell and NAD+ drops at cytochrome one. Why? Freed vitamin A destroys the heme protein at this cytochrome. There is no catalase, another heme chromophore to control it. We call this the pseudohypoxia state that David Sinclair found in Dec 2013 study published in Cell on this very topic. Even he has not put it all together. When all these things occur heteroplasmy is rising and cell volumes rising and ubiquitin marking increasing how aging really occurs in a quantum fashion. So do aging old people have kids? No………this is why when this state happens in young people they are infertile.

Let us go further……..What does pseudohypoxia (low NAD+) mean to our hormone panel in the sex steroids region? The cost of a high aerobic capacity is low fertility. This is why the pregnenolone steal syndrome exists and why males suffer low testosterone and females have an upside down PG/E2 ratio in menopause. their mitochondria can no longer make water well at cytochrome 4 and this is why infertile and aging people have markers of dehydration on labs. It is not what the anti-aging or functional medicine docs think or believe. This is quantum biology 101 for a Black Swan.

This formula above goes hand and hand with what I said in the November 2018 webinar about the 5G risks humans all face. If you think taking NAD+ analogs are wise you clearly are no Black Swan.

Producing cortisol over sex steroid production is survival mode for the cell and it is due to the use of oxygen as the terminal electron acceptor in human mitochondria in a really bad light environment (blue or nnEMF). As this occurs in a women’s gut at menopause their lower esophageal sphincter (LES) allows more O2 into the gut lumen because its myoglobin (another heme photoreceptor protein) is destroyed by the freed Vitamin A and this simplifies the gut flora changing the microbiomes biophoton light release to the enterocytes. This alters its circadian biology and affect activation of the GALT and the liver. This allows too much deuterium into the liver = fatty liver.

The liver is where most catalase is located in humans. This raises more free radicals in the liver making its deuterium load greater and lowering hormone production further. Remember the liver controls the long loop of the Bazan effect.

This cause global reduction of DHA in cell membranes ruining circadian control in many organs. The mitochondria also make thyroid hormone, specifically T2. This lowers thyroid hormones T2 and T3 and women cannot absorb the sun’s light even if they are naked at the equator. Lack of catalase ( increasing H2O2) and lack of AM UV/IR light fuel this low fertility. Catalase is most commonly found in the liver of humans.

Artificial light, with a lack of sunlight makes fertility doctors rich and busy. It’s not our abilities that show what we truly are, it’s our choices of light we live under that determine our fate when it comes to fertility. This is why people are infertile in a blue-lit microwaved world.

CITES:

1. https://www.telegraph.co.uk/news/2018/10/31/italys-populist-government-plans-reward-fertile-families-state/?fbclid=IwAR2C7qzb3JzD4H-jk9-9pz2tqgBR98im5fWUx_YbJZoj3AOrjI0l-C48-yc

2. Elizabeth Kolbert: The Sixth Extinction.

3.   https://www.smithsonianmag.com/history/deadly-donora-smog-1948-spurred-environmental-protection-have-we-forgotten-lesson-180970533

How do you process death? Most people struggle with death but what happens when you see somebody you love dying before your eyes while they are still living? How do you approaching the living dead about the choices that brought them to this place in your life?

How do you process their choices that have imprisoned their thinking and their mindset?

The causes of death are many and varied. It might be due to a mood disorder or depression because of life of night shift work. That chronic depression might lead to a suicide attempt. The very same scenario might not ever get to suicide but it could lead to dementia after 20 years of decline. The mood disorder might be caused by indoor office work that eventually lead to obesity, diabetes, stroke, that eventually lead to heart disease and an early death. On the way to any of these diagnosis, your relationship with that person might be radically affected by their choices. If you love them, do you ignore their choices and let them do what they want as you suffer and watch them die?

How do you salvage a relationship with a friend or partner who is hell bent on continuing to make choices that will ultimately cost them time……time in their life.

In survivor training they teach us how to not die when you’re helping rescue a drowning person who is anxious and fighting to survive.  If we get this decision wrong, you both drown.  Is this a wise choice?  I think there is a way to help a friend or partner when they are in dying mode while they are actively living and breathing.

The mode of how they are dying is the key to understanding what your best choice might be.  I don’t believe there is any correct answer for any relationship on life support.

THE GOODBYE CHECKLIST

1. You’d be wise to enlist the help of your cicle of six when trying to help another

2. Write them a goodbye love letter

3. Look them in the eyes while handing them an appointment to see a doctor to get a term life insurance policy you as the beneficiary.

4. Ask the dying while living what you can do to help.

What happens if the continue to ignore you? Are you prepared to force them to see a life without you in it?

Can you walk away to teach them how much you really care?  In relationships, people often get complacent with time because they become imprisoned by comfort and luxury.  They begin to avoid the discomfort of thinking.  This is how “comfortable thinking” creates cognitive biases.  Sometimes those biases can harm you and lead to illness or death.

Have you ever cared so much that you were willing to create a perfect dismount scenario for your significant other?  Dying while your living comes with many contexts in life.  It is a very tough situation to navigate.  There is no one recipe for all.

You have to try to got others who pack your parachute help you navigate these rough seas.  These people often can help you help the dying person see their self worth to once again love themselves again.  Without this love they will never be capable of loving you or anyone else.  Don’t we have to try help others see the value of time?

Nothing is harder than seeing your best friend kill themselves while they are alive, in my opinion.

Are you prepared to follow them to their grave?  Are you prepared to dig yourself in deeper into redox hell for them?  Is their a time limit that you’ll impose on them?  Or will you continue to give them a pass for their choices?  How long will you give them this pass?  How many of your body parts are willing to sacrifice?

When you love someone there are a few key questions to consider.  Do you love them unconditionally?  Are you in love with them now after their choices have changed the relationship between both of you?

Do you believe you can love someone, yet let them go completely for their own good?  Do you accept that it might be regal to release a person you love or loved, when their end is near?  Isn’t it true that real love is like a boomerang; it should be expected to come back if it was true?   Cutting your love loose is a wicked game.  Would you gamble this big if it was your only option left?

People only focus on your wisdoms, until they see the depth of how much you care.  I believe you can love deeply, without being in love, because love does not operate like a light switch.  Once the switch is flipped off, it cannot be easily turned back on.

Would you still be willing to help as choices continue to be made that will extinguish their light?  What happens when you finally realize the choices of others are the hinges of destiny in our relationships?

The differences in the stumbling blocks in relationships and stepping stones is in how we use them.

Are you ready to make them see you are willing to do the hard things to make the blind see again?  Can your actions put windex on the glass eyes of the dying?

You cannot make progress without making decisions in relationships. I have found a peacefulness follows any decision, even the wrong one.  It’s not hard to make decisions when you know what your values are.  How do you value your life?  How do you value time?   When one bases his life on principle, 99 percent of your decisions are already made.  They are made by the choices we make.

How all in are you really?  for you or for them?

Are you waiting for someone to put flowers on your casket or are you willing to plant your own garden to decorate your life right now?

We don’t heal anyone’s past by dwindling there with them and allowing them to remain imprisoned there by old choices.   We can only fully heal them by teaching them to live fully in the present even it that present no longer includes them any longer.

As a surgeon I am addicted to helping and saving the person dying an acute death.  It is what I am trained to do.  As a man in a relationship on life support, I found out that saving someone I love, is a lot more like trying to save a person drowning in the sea.

You have to be careful of how you attempt to save them, because you might go down with them.  This serves neither person or your family.  This is why living fully, while being solo might be the toughest goodbye that contains the best long term Rx.

In realtionships, actions prove who you really are. Words are just who you pretend to be…………..

I’d like this post to be dedicated to ideas around nurturing love long term.

I think I have done a poor job of exploring this aspect of relationships and how it relates to health and wellness and I think I need to improve this.

I believe relationships are built around three cornerstone pillars similar to life’s 3 legged stool of light water and magnetism.

They are:

• Intimacy, which is characterized by warmth, support, communication, and understanding;
• Passion, which is characterized by physical arousal and desire; and
• Commitment, which involves the decision to actively work on, and sustain, a relationship.

I think all three are dynamic and lead to different types of love in relationships and they all build different lives.  This mimics the effects of light, water, and magnetism and its dynamism effect on mitochondria and cells to create an epigenetic program that sculpts the matter in our cells to build our tissues and the life we experience.

Currently, I believe the most important of this 3 legged stool is passion.
I believe today that holding “decay beliefs” about passion — in other words, believing a decline in passion is irreversible — is associated with lack of commitment, lowered investment, and pursuing romantic alternatives to one’s partner.  I think this belief is a function of the redox state of our colony of mitochondria as we age.  As such, I think the reason relationship struggle as time marches on is because each other redox state varies based upon the choices we have made in how we sustain the redox power in our own lives.

I believe total ‘complete’ love, is a possible result in life when all three variables of the stool of love are present and relatively strong.  However, this dynamic viewpoint of love brings up the possibility that there might be multiple possible combinations of this 3 legged stool, therefore, multiple resulting types of love can manifest based upon the variable strengths.

Romantic love:  For example, a couple who engage in a short-lived romance might demonstrate high levels of passion and intimacy, even though they lack commitment.  There is a strong link to dopamine creation here.
Fatuous love:  Some other couples who meet might marry quickly (and therefore commit to each other) on the basis of overwhelming passion but perhaps do so without truly understanding or getting to know one another deeply.
Such people are more likely to indulge in both commitment and passion in the absence of intimacy, which can be a risky move for obvious reasons. They might not like each other much once they become more familiar with each other’s quirks and proclivities!
Companionate love: In contrast, an experienced couple who have shared many experiences throughout their long, happy marriage might continue to enjoy significant intimacy and commitment to each other, even if their passion has progressively dissipated over the years.  Sometimes having a companion is the most powerful driver of a bond.
Consummate love: Consummate love is a synonym for total love or a love that appears to be an ALL IN type of relationship.  This happens when intimacy, passion, and commitment are all present in substantial degrees.  I believe this is what most people are looking for and want in their lives.

I believe it is the rarest because I believe it requires optimized levels of hormones made around light, like POMC, insulin, leptin, and melanopsin.  I think when a relationship has two people who experience two different light environments the redox power becomes more variable to one another on a relative basis and this threatens the balance of the type of love possible between the two people as time evolves.

Total love is difficult to sustain long term because it requires both people to heavily invest in behaviors that support redox power chronically as we age.
What variable do I think is most at risk with lowered redox power?
The most variable element in my opinion, — the one most at risk of decline with time— is passion.  I think this is why love in a relationship varies over time. 

Could a chemical give us a clue to a changing redox in our partner?  
Phenethylamine is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans and is made in the same areas dopamine is made in the brain.  PEA chemical formula is pictured below.

In humans, this is a VERY variable chemical and it is found in Substantia nigra pars compacta; Ventral tegmental area; Locus coeruleus where dopamine is found at high levels; many other places where amines with aromatic benzene rings are made to act as photon traps for sunlight.  This chemical is very similar to other potent exogenous stimulants known to alter human behavior.

It is made from phenylalanine and tyrosine in humans.
The creation of phenethylamine (PEA) varies greatly across species, and the human receptors of this stimulant chemical is called hTAAR1.  PEA is an endogenous neurotransmitter and neuroregulator that plays a key role in mood and cognition too.
This brings up an interesting point about PEA:  can it be harnessed to improve your health and love life in ways that might surprise you?  Yep.
It has been found among 95 carbon and 95 nitrogen sources tested in foods, β-phenylethylamine (PEA) performed best at reducing bacterial cell counts and biofilm amounts, when supplemented to liquid beef broth medium.  PEA is a trace amine whose molecular mechanism of action differs from biogenic amines, such as serotonin or dopamine. Especially low or high concentrations of PEA may be associated with specific psychological disorders. For those disorders that are characterized by low PEA levels (e.g. attention deficit hyperactivity disorder).  Might it be able to modulate the other neurohormones we need to create a stable loving relationship over time?

I think it might.

PEA is strongly linked to bacterial metabolism and this makes me think it might be a serious modulator of mitochondrial redox power in humans as well because the inner mitochondrial membrane is the source of redox power and it retains its mitochondrial evolutionary lineage.
In several bacterial species, the above reaction is catalyzed by the enzyme tyrosine decarboxylase, which also converts tyrosine to another trace amine, tyramine (Marcobal et al., 2012; Pessione et al., 2009). Intriguingly, PEA synthesized by fungi and bacteria can also be found in food products (Onal et al., 2013), where it serves an indicator of food quality and freshness.

This includes the Korean natto (Kim et al., 2012) and commercial eggs (Figueiredo et al., 2013). Another food that contains PEA is chocolate, where it is not produced by bacteria, but during the thermal processing of cocoa (Granvogl et al., 2006).
PEA has also been found in the brains of humans and other mammals (Paterson et al., 1990; Philips et al., 1978), which is facilitated by its high solubility in plasma and its ability to cross the blood-brain barrier (Oldendorf, 1971).

Like its α-methylated derivative, amphetamine, PEA has stimulant effects which lead to the release of so called biogenic amines, including dopamine and serotonin (Bailey et al., 1987; Rothman & Baumann, 2006). This can help it modulate their diurnal controls in our cells and affect our behavior with our partners.

Unlike amphetamine, PEA has difficulties maintaining high concentrations in the human body, due to its oxidative deamination to phenylacetic acid by the enzyme B monoamine oxidase (MAO) (Yang & Neff, 1973). Phenylacetic acid,has an effect that is similar to the activity of the natural endorphins (POMC), an effect that is known as a “runner’s high”.

I’ve started to look deeper into this connection in people with relationship issues and the results have been eye opening to say the least.

So they died, they left your, you left them………bottom line is that you are alone. What is your game plan now?

We all have limits. Almost no one reaches theirs. You definitely haven’t but I am ready to teach you how to go deeper than you ever thought you could. Bravery means finding something more important than fear. I’ll be waiting for you inside the bottom of my deep blue sea. We do things differently there. It’s OK to reinvent the wheel, but only after you know how the current wheel works. Never assume you know better when you don’t really know anything about the process of recovery……….Courage without meaning is just recklessness. Brave people aren’t fearless; they’ve simply found something that matters more to them than the fear they’re facing.

Say you’re scared to start your life over from scratch when you’re 55. Your friends and family think you are having an existential crisis. You know you haven’t, you just got sick of settling for less than you deserve. You decided to use chaos and discomfort to fill your gas tank to get to places you never could get to ever before. Eventually, you find a reason that has greater meaning than the fear: your future, your new partner, your desire to make a difference, or your dream of a more fulfilling life.

When you find greater meaning in your life, you’ll find the courage to overcome your fear. Today’s pain is tomorrow’s power. The more you suffer today, the stronger you are tomorrow.

SO YOUR SOLO AGAIN………. 

Success is all about taking your shot, over and over again until you win.

You’ll never create the perfect business plan, never find the perfect partners, the perfect market, the perfect location, but you can find the perfect time to start.

That time is now

Stop waiting for the ‘right time.’ Success is a numbers game: the number of times you take a shot.

If your sick of being single do something about it right now.

When you meet the right someone, they will undress you.  I’m not talking about getting naked to get laid.  Nothing makes you feel more naked than someone identifying a desire in yourself, you never knew you possessed.  This spark will lit that pilot light.  It might illuminate a passion in you, you never saw in yourself.  You have to allow people to move in those spaces in you if you want to move forward with your best life.

MY LATEST LESSON:   LEARNING THE TANGO

Never invest in any kind of relationship with anyone who is not willing to work on themselves just a little every day. You have to chose better today than you did before.  A person who takes no interest in any form of self-improvement, personal development or spiritual growth will also not be inclined to make much of an effort building a truly meaningful connection with you. A relationship with only one partner willing to do the work ceases to be a relationship.  This is called bondage or a prison.  Never allow anyone to put you in a cage and slip handcuffs on you and tell you that they’ll love your forever.  That is insanity.   And as anyone who has been there will tell you – it’s pointless to try and dance the tango solo.

‘Life is the dancer and we are the dance.

When you realize you could actually choose the type of dance in life, and actually take the lead, your life begins to dance it naturally. Ask yourself now, ‘What type of dance have you been asking the Universe to dance with you?  Might this be why you are failing?’

I have slowly realized after 55 years that my choices are what  determine what dance will the Universe chose to play for me.  Did I go with that flow or break the harmony?  It turns out, the music life is playing in the now…happiness, fear, rage, passion etc. Embracing and dancing to it as music… you stop the struggle and learn to move with the flow of life.

Just because you failed again in building a relationship have the courage to persist.  “Courage is forward movement while embracing fear. Thinking for yourself is courage. What’s rare is the courage to follow it to the dark places where it leads. One person with courage is the only majority you need to succeed in life.”

Take enough shots, and over time you’ll grow more skilled, more experienced, and more connected. You will become entangled. And that will mean a greater percentage of your efforts will succeed. Take enough shots, learn from what didn’t work, and in time, you’ll have all the skills, experience, and connections you need in your relationships. Relationships fail because we did not have the right tools, or enough tools in our love tool box to create success.

Ultimately, success is all about taking your shot, over and over again. Sometimes you may win, sometimes you will definitely lose, but the more things you try, the more chances you have of succeeding. Put the power of numbers on your side. Take as many shots as you can. There’s no guarantee of success, but when you don’t take a shot, there’s a definite guarantee of failure.

Being single is not a state of failure. Solo is a unique place. It is a place that requires embracing the suck in relationships and in life. Do not recoil from tripping up and being solo again. Accepting each reality of being single head-on almost always loosens the knot of despair, and frees up your energy to accept what you can’t change, and change what you can about your and your situation.

Single means you are brave enough to face the glorious unknown of the unaccompanied journey in your life with some zest. You’ve become ready to try to do it better this time. You take more shots, because now your blade is sharper. This is why the last cut is the deepest………just because your old does not mean this part of your life should be dead on arrival.

When you find your path, person, or passion in this life you must not be afraid to jump again. You need to have sufficient courage to make mistakes. Disappointment, defeat, and despair are the tools Mother Nature uses to show us the way to Optimal.

In 2019 what I learned in editing my own life is that when you stop expecting people to be perfect, you can like them for who they are. Then some interesting shit can happen………..

In about four hours from now my life is going to change. I am not sure if it will be for the better or not…………but it reminds me of an old pair of shoes I wore to my first ever job interview in NYC with the Sterling National Bank CEO. After talking with me, the CEO of the bank sent me to Barney’s of New York to see his tailor. There I got a new pair of shoes and a brand new suit courtesy of my new boss.

He told me I like you and your passion. I want you on my team and I want you to represent my brand but you need to look the part. Go see “my guy” and adapt and you have a job.

With that……….my life changed on the spot that day in 1981.

Above is a picture of the newest Chapter of my life that began today on 10/5/19.  I have purchased an entanglement shack on the beach on the panhandle of Florida where my misfits can come and change their lives, if they chose too.  My first ever VIP will be held there on 12/27/19 for 4 people who will possibily have their lives altered.  As the initial guest they will have special sculpted signs created for them by Jeremy who keeps his art sculpture business at JeremyThomley.com

 

On 10/5/19 one of my dearest friends is going through a similar change that I mentioned above, and that change is quite uncomfortable for them right now.  What follows is their words that describe their current plight.

“I have absorbed some of that discomfort on their behalf because that is what good friends do when the storms in your life rise up. They walk in and shed some of their light on you to let you know better days ahead are coming. I have had a few of these friends recently come into my own life and do the same thing for me when the people who were around me could not understand what I was doing and why I wanted their chaos around me in my darkest hours. Now it is time for me to put some new soles on their shoes as they did for me.

I would like to apologize to the universe… Life has happened all around me lately. So many times in the past 4 years I have found myself questioning what is next for my family, my farm and business. I have pulled some people close and pushed others away… some for no reason, others for treason. My circle of friends once at my side are now mostly remote. They continue to live a life we agreed was most free, I chose a goal that meant I’d spend a lot of time saying no to other goals. I was not likely to become a better professional without a lot more work, I am not opposed to the idea in the future but I needed to run down this dream if it was ever to be my life. I am a new man, somedays a new father filled with new wisdoms. I also invested my heart in my new clinic and building a community of people who some would call employees or customers but truly they are my friends. I have watched this dream grow and be pruned by fear, grow again and be chopped down by what I can only name as jealousy.

So many raw nerves had to be cut, amputees that feel weak till the tree grows new roots. I’m grateful for my wounds. I know this discomfort is necessary even when those in my rearview mirror do not understand what I am doing to my life now. This chapter is closing now. I might need to burn this passage after reading it, but I like how the wound makes me see the future more clear.”

 

FURTHER ENTANGLEMENT OCCURS TODAY…………..

The following is a story by a nurse Jenelle, I have become fond of lately. This story isn’t really about shoes at all. Neither was our stories above……………

I have an old pair of shoes …

They aren’t really that old.

It was my first pair of shoes for my first nursing job.

I thought they were a great pair of shoes … until my toes started hurting.

I bought a new pair of shoes ~ and WOW! Now, I thought to myself, those are a great pair of shoes.

I realized when I got these new shoes, that I don’t even have to use insoles in them. My back doesn’t hurt, no matter how long I’m on my feet. My toes never hurt. I do untie them when I get in my car … loosen them up for the drive home. But all day long — up until that point — I don’t even think about my shoes.

Sometimes, I still look at that old pair of shoes, and I think, “Man, those shoes are so cool! I wish I could still wear them.”

Then I remember: There’s a reason I stopped wearing that old pair of shoes. And I’ve tried those old shoes on since I bought my new shoes … thought I could just wear them at home for a day, and see how they feel. NOPE. Those old shoes had to come right back off.

I can hold them in my hands, turn them over, and see the places where the bottoms are worn … a sign of every hustle-bustle, stressed-out moment I spent, walking MILES and MILES around that building, at my first job. And I can smile ~ and love those shoes, for what they once were to me. I can keep them as a reminder of where I’ve been, and what I’ve done.

But then I will put them back down, and walk away. In my new shoes. My new shoes are the newst chapter I am writing in my novel.

Sometimes I wonder when my new shoes will become my old shoes? Then I realize when the soles wear out, I’ll know when to adapt and change my life again. Discomfort is the signal to my feet that I need to adapt. What will the next pair look like? And I keep an eye out for them.

But for today ~ I’m really happy in my new shoes and the chapter I am currently living out in my life. And that is good enough for me, right here and now.

To get the relationships with humans you want, you often have to burn the old ones to the ground to make enough room for the roots to take hold before you add in the water and nutrients.

What don’t they know about protons and how they relate to our relationships?

The way we think and feels about people in our life comes down to the redox state in our central nervous system.

The base of redox state is built by proton gradients and in humans newer systems in mitochondria and cells set the ceiling of the redox state to -400mV.

That system is built around glutathione which replaced the melatonin and Vitamin C system in lower eukaryotes as seen below. -200mV defines cytochrome C oxidase and the ATPase redox potential and this is the BASE that cells need to survive on Earth. I mentioned this in the video above. After 3.8 billion years we added other systems to build the redox potential of our cells to -400 mV to form complex life as the picture shows below.

The centerpiece of Nature’s conceptual idea for life lies in the novel use of natural proton gradients created in the ancient seas on Earth and they surround the story of water and light from the sun to do something remarkable around protons. Four billion years ago, alkaline fluids bubbled into what would then have been mildly acidic oceans (CO2 levels were about a thousand times higher than they are today, and CO2 forms carbonic acid in solution, rendering the oceans mildly acidic). Acidity is just a measure of proton concentration, which was about four orders of magnitude (four pH units) higher in the oceans than in vent fluids. That difference gave rise to a natural proton gradient across the vent membranes that had the same polarity (outside positive) and a similar electrochemical potential (about 200 millivolts [mV] across the membrane) as modern cells have. This is where the base of the redox potential of modern human cells come from. It is remarkable that no food guru understands the basic biophysics of this planet well enough to see why food is not the driver of health. An optimized proton gradient, however, is critical to it because it forms the base of the redox potential of cells.

The equation that defines this idea behind proton movements with IR-A light from the sun is below.

The H+ in NADH must be a proton and never a deuteron (deuterium isotope of hydrogen). When this substitution occurs life cannot be maintained far from equilibrium over a long time span. This is when illness enters and when your partners redox drops and your relationships begin to fail as you grow apart.

Drinking high pH water does nothing for your health or your relationships when you have functional kidneys.

When your redox drops in your body your ability to make the chemicals that bond us together as humans also drop.  Those major chemicals are dopamine, melatonin, oxytocin.

Dopamine is a catecholamine.

The catecholamines, of which dopamine and adrenalin is the best known example, and the aminochromes, of which adrenochrome is the best known example, are intimately involved in stress reactions. Stress is well known to DESTROY relationships.  What is not well known is how stress does it by ZAPPING your redox in the process of destroying the neurochemicals that bonds us as humans and that control our behaviors and emotions.

Therefore to moderate the influence of stress or to negate it, the orthomolecular belief is that we must use compounds which prevent these substances from damaging the body. THAT IS 180 degrees oposite of my belief.  We need the sun and rebuild the redox before we need any substrates.  The orthomolecular idea that  Vitamin B-3 is a specific antidote to NAD+, dopamine, or adrenalin is old and a half truth.  The reason for this opinion is it only takes the substrate biochemical view point and never considers the affect of light on these substrates in how their electrons get programmed by light to create their proper physiologic effect.  This is what I was hinting at above in the video with Luke Storey.

The ortho molecular belief that exogenous antioxidants with the use of exogenous catecholamines is wise is just not supported.  We see the effect in people with Parkinson’s diseease who use exogenous L-DOPA get tachyphyllaxis from the drug.  Adding antioxidants such as vitamin C, Vitamin E, beta carotene, selenium and others DO NOT protect the body against the effect of the free radicals just by removing them more rapidly from the body is not a well thought out plan because it has no biophysical supports.

Any disease or condition which is stress related ought therefore to respond to the combined use of vitamin B-3 and these antioxidants, but the literature is filled with papers that show they do not.  None of these papers have been repeated when using these drugs with solar redox strategies and this may show a huge change in outcome if it does get studied.  I can tell you in my life and my practice experience it makes all the difference in the world.

Why do I think this orthomolecular supplement based strategy fails us so often?

Is this the same reason why adovcating a ketogenic diet for low NAD+ states is pure lunacy?

Yep.  Why Uncle Jack?

When you eat a ketogenic diet guess what else happens? It is believed we bypass complex one at the inner mitochondrial membrane and enter FADH2. I used to believe this but I no longer do because of technology light. You heard about this in the Quantum electron blog post at JackKruse.com………but what did not I tell you in that POST?

Why does a ketogenic diet work in T1D, T2D, and help us lose weight, but does not help all metrics in health? When you lose water conduction at the inner mitochondrial membrane (cytochrome c oxidase due to deuterium) you lose the ability of proper nanoscopic protein folding of cytochrome 1 (NAD+). This throws off the nanoscopic precision (size and shape) required for quantum tunneling and this cause increased ROS and metabolic syndrome……..This is also why exogenous niacin can work in these diseases because it is a ketone mimic drug (sans artificial blue light). Why?

Niacin also known as vitamin B3 (above), nicotinic acid and vitamin PP, is an organic compound with the formula C6H5NO2 and one of the 40 to 80 essential human nutrients. In fact, when niacin deficiency is present it is one of 5 vitamins that causes a pandemic disease condition called pellagra.

But it can be used to bypass a “broken” cytochrome 1 when misfolding (due to a chronic ATP deficiency think EMF 7 blog post now). But why ? Why am I tormenting you with this science?…….because you need to think about things you are missing……..and you will see where QED takes us……….Vitamin B3 can help activate PPP when we are broken for some reason when we are ketotic from a dietary standpoint using vast amounts of coherent water as I laid out in the quantum electron blog post. Yes, niacin is a precursor to NAD+/NADH (cytochrome 1) and NADP+/NADPH (the magic of the PPP), which play essential metabolic roles in all living cells as I showed in EMF 4. What most people do not know is tryptophan the aromatic amino acid that absorbs UV light forms the base of all these chemicals. Without UV light to program them all none of them work as they should in cells.

Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to NAD+ and NADP+ in vivo PROVIDED THE REDOX POTENTIAL IS GREATER THAN -200mV and this information is very valuable when you have liver leptin resistance, metabolic syndrome, or epilepsy.  Your food gurus never tell you this.  I do.

In 2010  Leonid Sazanov deciphered the crystalline structure of NAD+/NADH which is complex 1 respiratory complex in mitochondria. It is an the enormous protein in physical size and quite complex.   You can read about it in Efremov et al .2010.  Again, the atomic structure betrays the biophysical mechanism at play in NAD+ — in this case not a rotary motor as it is in the ATPase but, even more surprisingly, it uses a lever mechanism not unlike the piston of a steam engine.  This is why I have told people that mitochondria really mimic Carnot Theorem in thermodynamics.

Red light stimulates cells to replace defective mitochondrial engines.  Blue light damages them as the slide shows below.

When cytochrome 1 has misfolded electron transport proteins due to poor redox (ie:quinolone issue of CoEnQ10) you need to bypass it MOST of the time by eating fats that feed into FADH2 predominately because if you don’t, your mitochondria begin to make massive ROS that overwhelms the cells redox potentia dropping it from -400mV and this raises blood retinal levels while lowering vitamin D levels.  It also causes pregnenolone steal syndrome which lowers all hormones.  This is one of a myriad of ways your relationship can fail as your hormone panels crash.

Chronic pregnenolone steal syndrome will eventually shorten our telomeres to cause cellular signaling problems that lead to either senescence or advanced early aging.  This also destroys our relationships.

The chronic loss of NAD+is the critical sign of a loss of negative feedback control of the ubiquitin cycle. This data scales directly to our molecular circadian clock and our peripheral clock genes (CCG’s).  So this implies a loss of relationships is also related to poor circadian biology.  All things lead back to the light we chose to live under.  Few can fathom these links because they never look deeply into the life and how we work.

As our redox drops NAD+ builds up in relation to NADH levels on a per unit basis. There is a special case for blue light where a ketogenic diet can fatten you if you are chronically destroying cytochrome 1 because your REDOX is below -200mV.   When redox drops below this threshold it tells us there is a proton problem and that problem is usually related to having too much deuterium leaking into the matrix via the UCP-2 mechanism I laid out in my webinars for members in the past 18 months.

Then a fat-laden diet during spring and summer can make you very obese when this situation occurs.  See Jimmy Moore as a classic example.

Increasing the NAD+ endogenously (not via a supplement) in comparison to NADH changes a most of the mechanistic downstream signaling in protein kinase B pathways of cells. Why is that big issue? The AKT pathway is also known as protein kinase B (PKB). It is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes.  This is how the brain shrinks in PD, AD, ALS, FTD, and in diabetes.  It also is a huge problem in TBI’s which are concussions.

Akt1 is also able to induce protein synthesis pathways (urea cycle), and is, therefore, a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth.

Since it can block apoptosis (mitochondrial disease risks and cancer risk), and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8. UVA light can help restore apoptosis. In a mouse (nocturnal) which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth.

In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance/ T2D), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. It has been reported that mice lacking Akt3 have small brains. This is what causes brain shrinkage in all the neurodegenerative disorders I mentioned above that are linked to cytochrome 1 size and shape issues. PCOS is tied to this early one before the more chronic diseases come to the forefront.  This will also change you moods, alertness, your cognitive ability, and your behavior.

Akt2 is an important signaling molecule in the Insulin signaling pathway and you do not need food inputs to effect it.  Alien light in your environment can do it without any food stimulus. It is required to induce glucose transport.  TBI induces AMpK pathways and increase blood glucose because of the lack of circadian control of this process.

The follow through? AKT1 is involved in the PI3K/AKT/mTOR pathway and other signaling pathways. These all cause massive changes in cell cycle signaling and in cellular communication. mTOR is huge in longevity and in cancer progression via the dys-regulation of the p53 gene. If the high oxygen pathways are defective for any reason metabolic mitochondrial diseases are likely. (TCA/urea cycle)

What else is more likely to occur in your life when all this hard core biochemistry and biophysics fail in your cells?

YOUR RELATIONSHIPS WITH OTHER HUMANS WON’T BE AS GOOD AS THEY USED TO BE EITHER.

This might be a tough swallow for some of you, but it is the truth according to what Nature is telegraphing us.

Now you can see why when this pathway is activated many bad things can happen that are common to T1D, T2D, most cases of leptin resistance with elevations in hs-CRP. These steps are stops on the way to either final pathway and we call them neolithic diseases due to chronic mitochondrial failure and collapse.

Why do relationships really fail?  What is the foundational science problem?  

A LACK OF CELLULAR REDOX POTENTIAL IS THE ANSWER.

Relationships are not about passive agreements and merely spending time together: they are living, breathing entities, and if you don’t actively take care of them, they will suffer and die. If you want your relationship to be strong, you can’t just hope for it — you need to put in the work.    The work you need to put in is below in PICTURE FORM.

We often wonder why couples fight, lose interest or seem to lose the ability to communicate even when they love each other as redox drops. Why do dirty dishes or apparently innocuous words become triggers for such heated arguments?

Relationship conflict is a result of one or both partners feeling that their attachment is threatened and that psychologic issues is underpinned by how our stress hormones are acting under the direction of mitochondria in cells.  

Most of us don’t see this connection because the symptoms have purely emotional roots and those emotions are built by the light that control our mitochondria to make chemicals in neurons.

This is why anxienty and mood changes are linked to poor mitochondrial function as laid out in CITE 1 below.

So, why do we need secure attachment so much?

According to research, it’s because the lack of it can actually be a literal threat to our survival.

Researchers at Case Western Reserve University asked men with a history of angina and high blood pressure whether their wives “showed their love.” The ones who said no, suffered twice as many angina episodes during the next five years.

Another study found that women who had had a heart attack showed a 3x higher risk of having another if there was conflict in their marriage.

Being able to trust and be trusted (dopamine/melatonin/oxytocin), to love and be loved in your relationship is not just helpful: it’s crucial for you and your partner’s health, happiness, and overall quality of life.

Trust is a function of the neuro-chemicals built in these stress pathways by the redox power in your cells.  This is why relationships fail fundamentally.  If we trace the steps back it always comes back to couples who have differing redox states compared to one another.  Its shocking, but the links are laid out here in this blog for you to examine for yourself.

CITES:

1. https://medicalxpress.com/news/2019-09-anxiety-disorders-linked-disturbances-cells.html

In 2019, the update to the title slide of this post has become the biggest change in my life because of mitohacks I have done on 5G over the last 2 years.  The updated picture for 2019 is contained above too.  For the reasons why the change occured you’ll have to wait until my talk in Poland at the Polish Health Summit is released to the public.

7 Signs of a Genuine kinship is found in My Wisdom of the Circle of Six

How do you really value yourself? To say you have no choice in life is to relieve yourself of responsibility.

It is one thing to lose people you love as your journey unfolds. It is another to lose yourself in the very same process. There is a greater loss of time in the world. Realize that shit is the real talk your life needs daily.

Focus on those that listen…ignore the rest. Some will come around…some won’t

If you want extraordinary results, you need to narrow your focus on the things that matter and eliminate the unnecessary.

1. They stick with you NO MATTER WHAT.

True friends stick with you no matter what. I hear stories about friends falling out with one another because one doesn’t like the other’s new boyfriend and other trivial things.

That doesn’t matter to true friends. They stick with you through thick and thin.

2. They accept you and they NEVER JUDGE YOU.

True friends, like true lovers, won’t try to change the person you are. If you want to change, they have your back, and they’re sure to let you know their opinions, but they accept you for who you are. No strings attached.  A great friend can tell you things yo cannot tell yourself.

3. They celebrate you in good times and bad.

They aren’t jealous of you. Instead, they celebrate you. Big promotion at work? A new relationship?  Party! Third date went well? How about a glass of wine to celebrate? Your true friends won’t feel resentment for what you have going on for you when your winning and thriving.

4. They reinvigorate you and spark you to thrive.

Some “friends” we walk away from feeling totally drained. They’re negative Nancy types. True friends leave you feeling energized and invigorated, not tired and sapped of your energy.  You need to cut energy vampires and those who cannot reason well.

5. They reach out to you and this is why you’ll have them pack your parachute

This is a key factor. A true friend isn’t a friend you’re constantly having to track down. True friends seek you out year after year without prompting to sample your current awesomeness. They make time in their busy lives to hang out with you.  Nothing remains idle in life and thrives. This is double true with friends in your circle of six.  Life needs a moving force to prevent the devastating effects of stagnancy. You should become this forceas the gatekeeper of your domain.  That is why all life employs change and adaptability.  This is why my circle of six gateway has a revolving door at the entrance.  No one should feel comfortable with you too long.  Your waves should hit them chronically to force adaptability and they should crave it.

6. They don’t speak talk trash.  They speak at you.

True friends don’t talk about you behind your back. They don’t cattily gossip and spread rumors.

If they have something to say to you, they say it to your face. They won’t talk about you to anyone in a way that they wouldn’t talk directly to you.

Do you want to be in your own story or on the outside writing about it? Everyone battles fear and uncertainty every day. However, the only failure in life is believing that your value relies on other people’s approval or resources. The reality is this: When you are living your authentic self and not how people want you to act, then you are free to use the full spectrum of your creativity and gifts. People don’t need resources to get out of any life situation. They need creativity to create resources. When you realize that, becoming stuck is impossible.

If they want to talk shit about you, let them.  Never let anyone rent space in your head by caring one bit about their opinion.  Once they trash talk you cut them from your life and make them feel what life is like without you in it.

7. They don’t get possessive, they want you to thrive.

If you’ve got new friends and lovers in your life, they don’t get possessive. They always give the space you need and are there when you want to do stuff.  They want you to dominate and create your happiness and celebrate with you as you break glass ceilings..

SUMMARY OF HOW FRIENDS MAKE OR BREAK US IN RECOVERY 

Your circle is your chemotherapy.  Toxic relationships are just like any other disease.  The longer you tolerate it the worse the patient does.

Fill the circle with people who add to your life and do not subtract from it.   Every precious thing that you want out of life starts from believing that you possess an unstoppable drive to continuously strive and thrive.  That idea begins with your circle of six.

Build your circle of six with these ideas in mind to change your life.  Friends are the family you choose and they impact your health in tremendous ways.  Do not undervalue this reality in your own life and recovery.  Your spouse should be your best friend.  If they are not you must reevaluate your own strategies.  

I revalue myself daily by the music and artwork I put in my environment. This helps me trim my circle of six and cuting and pasting who should be in this position of my life. Many times only two seats in the counsel are filled at a time. I often joke with the people in my circle that my tribe has a revolving door. You cannot be good at everything so those other 12 eyes are huge in helping you thrive. Make sure those eyes are connected to people who you’d let pack your parachute before you jump out of a plane if you could not do it.

Ask yourself this today, “How do you experience value in your life?”

An elitist scientists might say, “ Creativity that satisfies and affirms your world view is entertainment and does not set a floor to your self worth. Creativity that challenges and disrupts your world view is art and it helps us see our value.” But then the creative will say, How one thinks work must challenge you to be considered art. I find Dali’s works satisfying because of the curiousity they create in me. It helps me revalue my character and my worth. That doesn’t make his work ”not art.” A fascinating aspect of art is how subjective it is. It turns out how we value ourselves is also wholly sunjective. What may challenge you may stimulate or relax another. Value, like time is also relative to th environment we allow around us. What resonates with you may produce the opposite or no effect for another because no two environments are equivalent.

Write like no one is reading your words or your work. When you do this, your authentic self will manifest and come to the surface. Whatever it takes to find the real you, don’t be daunted if the rest of the world looks on in shock when they read your work. Your words can be your art and they can be used to set your value.

When you fight yourself to discover the real you as you write, there is only one winner, YOU.

Value is always long-term proposition in life. I urge you to be so good at what you do and the services you provide to people that no other metric a human can think up will matter. You have to be all in for people to get them to the next level. Never settle yourself, and never let them settle. Try to teach people to avoid always seeking happiness or success on the road to optimal. I teach people that we create our happiness and success with choices we make about our life.  Teach them to become people who seek results. Your goal as a leader is to become a person of value to your flock. Being valuable does not mean you need to be perfect in any sense.  It is wise to be a diamond in the rough with a flaw than a pebble without any.  

My circle only has mitochondriacs in it.  Those are people who are “diamond like”.  They are made of specks of carbon and dirt who just have learned how to handle stress and chaos extraordinarily well become lustrous with many facets who shine brightly in any light.  

Value is premium you place on yourself and others. Value others and you value yourself. Valuing this way is self-replicating and will grow within you and emit from you. When you truly value others they will radiate value as well. Today, forget the prices of things and cherish the value of people.

Others value your time exactly as you do. If you value it, so will other people.

If you don’t have a plan for your week before it begins, you’ve planned to fail.

Leaders who value their time always start with a plan for the week before it begins.

Always have a plan for your week before other people plan it for you.

Spend 80% of your time with people who give you 80% of your results and stand back and be amazed at what happens. I use the filter of social media to figure out who that 20% is and I CUT THEM FAST.  I do this to focus on who matters to see if they are circle of six material.

Regardless, if you haven’t decided ahead of time the kinds of people you’ll meet with, you’re sunk.

Sometimes we don’t choose our path or the people on it. The path and the people often choose us.

Your reaction to “these misfits” becomes the next big thing in your life.  This has been an eye opening lesson I have pursued with a passion since 3/13/2019.  Relentless chaos drives my passion now.  You’ll come to realize sometimes you need a little chaos to get your adrenaline flowing and help you realize your potential.

What happened to me on that March day?  It was the day I listened for the call of my destiny, and when it came to me, I decided to release those past plans back to the universe and follow my new uncharted passions.  Mastery is the breeding ground of fresh, creative passion. Our greatest responsibility is to live a life that nourishes our highest truth.

I realized that day I was not my past. I am the warrior that rose above it to become the example of someone who didn’t just want to survive, but chose to thrive in creating the most beautiful last chapter of my life.  I decided to go all in for me.  I realized I really don’t have to subscribe to the life that had been written for me.

When you believe in yourself, in your innate abilities, and you LOVE YOURSELF, you begin to do and to think for yourself and your preservation.  You know implicitly that anything is possible. The impossible even becomes easy. This internal drive is the fire in your gut cannot be extinguished by the people who suck the energy and reason from life. Become fully invested and commit to these beliefs and you will most assuredly meet with success no matter the odds you currently face.

I want to be driven, motivated, filled with passion, for good things, worthwhile things, things that will make a positive difference, and add value to the lives of others. Your passion can ignite many others’ pilot lights as well. When our candle is lit, sharing it does not diminish our flame one bit………..Go light someone up today.