If you listened to the beginning of part two of the podcast, I mentioned the large band gap needed to charge separate water.  This single issue sent me looking at the periodic table.  I found that answer there, but in reality, I stumbled into a bigger reality.  I finally realized how we humans evolved.  Here are the details of that POMC story.

LIGHT AND WATER BECAME THE FIRST TWO LEGS OF THE STOOL OF LIFE

Water is made from two atoms so I began with hydrogen on the periodic table because water has 2 H in its chemical formula.  As soon as I went deep I found some interesting trends about hydrogen.  Science depends on compelling narratives, and few people seem to know the real story behind hydrogen. This really explains why even today biology ignores water’s role in a cell.  In fact, in a cell Nature has shown us that hydrogen can act as a metal or non-metal.  Hydrogen makes life a cooperative quantum dance and it can make other elements do things they normally would not do.

It turns out how hydrogen acts chemically,  depends wholly on the environment it is within.  Does this means hydrogen can take different forms in our body if the environment of that region is controlled by information in some way? Is it a donor or a collector of electrons? Is it a metal or a gas?  The answer is yes.

This is why on Earth hydrogen always seems to hang out exclusively with carbon and oxygen in life. The hydrogen ion (proton = H+) and electrons go to reduce (or fix) carbon dioxide into the carbohydrates and biomass of photosynthetic organisms using both the C3 or C4 pathways, which feed herbivores, and down the food web, the vast majority of animal species. The air-breathers break down carbohydrates by oxidizing them (with oxygen) in the mitochondria of cells to obtain energy for growth and reproduction, regenerating carbon dioxide and water. This completes the living dynamo of photosynthesis and respiration that turns inanimate substances into living organisms.

The measured ionization energy of H2 is 1488 kJ mol-1. This number is primarily important in comparison to the ionization energy of a hydrogen atom, which is 1312 kJ mol-1. Therefore, it requires more energy to remove an electron from the hydrogen molecule than from the hydrogen atom; the electron, therefore, has lower energy in the molecule. To pull the atoms apart, the energy of the electron must be increased.  I knew electrons can only be powered by light because of Einstein’s photoelectric law of the universe.  So I looked up how much power by light was needed to break this bond. I began to understand why we needed over 12 electron volts of light power to split water into its substrates.  Hence, a lot of energy is required to break this bond. So I went looking for an answer on how photosynthesis did it.

MAGNETISM THEN BECOMES THE THIRD LEG OF THE STOOL OF LIFE

Next, I looked at oxygen.

The oxygen molecule is a particularly interesting case, O2, to study.  This study was detailed in my 2014 conference talk at Dave Asprey’s event that you heard Rick Rubin talk about in the podcast.  Asprey banned the talk because essentially it told everyone who heard the talk everything Dave was selling was snake oil.  Props to Rick for telling that story.  I would have died with it.

When I looked at oxygen I drew out its complete molecular orbital energy level diagram, and I noticed that the last two electrons must either be paired in the same 2p π* orbital or separated into different 2p π* orbitals. To determine which, it is important to note that oxygen molecules are paramagnetic—meaning they are strongly attracted to a magnetic field. I did not know that prior to this moment.  It turns out that moment was going to change my life.  To account for this paramagnetism, I recalled from my high school chemistry class that electron spin is a magnetic property. In most molecules, all electrons are paired, so for each “spin up” electron there is a “spin down” electron and their magnetic fields cancel out. If all electrons are paired, the molecule is diamagnetic, meaning that it responds only weakly to a magnetic field.  then I thought about the Earth.  We have a magnetic field and so does the sun.  Then I thought about the ATPase in mitochondria and knew it had one from the spinning Fo head where ATP was made.  Immediately I realized oxygen was being drawn to mitochondria because of magnetism.

If the electrons are not paired, they can adopt the same spin in the presence of a magnetic field. This accounts for the attraction of the paramagnetic molecule to the magnetic field. Therefore, for a molecule to be paramagnetic, it must have unpaired electrons.  This thought stopped me dead in my tracks because I knew we had some chemicals in us that had unpaired electrons called free radicals.

Are all free radicals created in human biology paramagnetic because they have unpaired electrons?

It turned out in my research of organic chemistry, all radicals are paramagnetic, but all paramagnetic species are not radicals. Take for example the metal Nickel. Nickel is paramagnetic, and therefore has unpaired electrons, but at the same time is not a radical because it is a stable atom and does not react with other elements. Radicals are unstable by nature and they react by donating their electrons.  I thought to myself, is this donation of electrons how a semiconductor operates.  I looked into it and found that is exactly how a semiconductor works.  That created an idea and I wrote this down on a piece of paper that became this slide below.

I left the normal periodic table of elements and then looked up the magnetic table of elements.  Here I found, Ca2+, Mg2+, K+, and Na+ are also paramagnetic. Mo is used on the inner mitochondrial membrane and is also paramagnetic. The thought crossed my mind that it seemed biology was specializing in using atoms in biochemistry that might dope semiconductors.  I knew collagen was a wide band gap semiconductor from Becker’s bone work.  I began to realize atoms doped to carbon and surrounded by water are all wide band gapped semiconductors.

Then I looked at other atoms used in cells.

H, C, N, P, S. Se, Cu, I are all dimagnetic.

It seemed immediately that H and O differ in their magnetic powers. What about water that acts as a semiconductor in cells? Water is not paramagnetic even though oxygen is, due to the absence of unpaired electron (s) in its molecule. Here is hydrogen pulling its magic tricks again on another atom. Water is reported as a diamagnetic substance with a susceptibility of − 9 × 10 ^− 6. This implies that when it is submitted to a magnetic field, it will tend to repel the field lines.

Then I thought about iron and hemoglobin and all the heme based proteins in cells like the P450 system, catalase, and peroxides in mitochondria.

Fe, Co, are ferromagnetic

Oxygen is paramagnetic.

All free radicals are paramagnetic.

Anything paramagnetic is drawn to magnetic fields and inside cells this draws them to mitochondria.

Then I thought about Mammals. What did I know about them? I knew about the asteroid event.

The rocks found at the K-T boundary, whether they are found in Europe, Canada, or the United States, all show a very high level of the element iridium. This iridium layer has been located in over 100 different spots on Earth, both on land and under the ocean. Iridium, which defines the KT boundary is also paramagnetic.

Does anyone see a trend here that I found in hacking the periodic table?

HYPERLINK

Most of the key atoms were paramagnetic and this told me semiconduction was the key to understanding how cells work.  I then looked at proteins differently and remembered about Szent Gylogi’s talk in 1941 where he said all proteins were semiconductors and Becker proved him right 25 years later.

I went back to hydrogen and proteins to see a link.  I found it in chlorophyll, hemoglobin, and melanin.

What thoughts filled my head that day?  The retina has melanin in its RPE and it creates massive amounts of ROS at the choriocapillaris.  I thought to myself……..is melanin creating a stream of electrons in the eye to electrify the brain?

When electrons are not paired, as they are in ROS/RNS they can adopt the same spin in the presence of a magnetic field around them.  The brain is filled with mitochondria that creates magnetic fields. Might this accounts for the attraction of the paramagnetic molecule to the a mitochondria’s magnetic field? Might these free radicals be key to explain how tissues are sculpted and changed?  I knew for a molecule to be paramagnetic, it must have unpaired electrons.  I went looking for a protein that was paramagnetic and could transform light into chemical energy in the form of free radicals and I found melanin.

Melanin is a paramagnetic bio-polymer that has revealed in testing to exhibit strong and stable paramagnetism.  It is loaded in mammals skin and in their eyes.  I also found out that melanin synthesis is an oxygen-dependent process that acts as a potential source of reactive oxygen species (ROS) inside pigment-forming cells.  I knew I was onto something.  Melanin was able to transform light energy into chemical energy, and this has been accepted by the countries of the first world patent offices.  I wondered it melanin could create hydrogen and oxygen in a cell. I found that it can.

Hydrogen is the rogue element in the periodic table that breaks all the rules we expect, and this is why life uses it in her designs. When a hydrogen bond forms between two water molecules, the redistribution of electrons changes the ability for further hydrogen bonding. In this sense, a hydrogen bond can be electrostatic. Hydrogen bonds, however, can become covalent as well.  Iodine’s addition to hydrogen favors the formation of covalent bonding in water.  You heard about this in the podcast.  This is a fancy way of saying hydrogen makes other atoms do things they normally might not want to do. Hydrogen’s will is strong because of the closeness of its one electron to its nucleus. This gives hydrogen lots of differentisotopes. This is when I found out the addition of deuterium, a heavier isotpe of hydrogen changes how water absorbs light.  I did not know this.

Water with deuterium in it absorbs less IR-A light and hardly any UV light at all.

These facts meant something more interesting.  It meant hydrogen had to invoke Einstein’s relativity theory more than any other element on the periodic table! You might not understand why now just yet, but more on this aspect shortly to fill in your gaps.

Magnetic Type for all the elements in the Periodic Table

Hydrogen normally has one proton that is encircled by one electron that buzzes in its electron shell.  Its valence shell is designed to hold two electrons. So you need to ask yourself is the shell half filled or half empty?  Other atoms want to know this too because this is how they decide how they react with hydrogen. This is why hydrogen can be a chameleon. Most elements either gain or lose their electrons in chemical reactions. The pathways that hydrogen electron takes determines the chemical abilities of the atoms in this dance. Hydrogen swings, either way, depending upon the environment it finds itself in.   This makes it a very interesting player in biochemistry. It’s no wonder hydrogen is an integral part of life’s plan. Hydrogen is found in all amino acids and semiconductive protein polymers.  It also makes up 2/3 of water.  Imagine that.  Without water depleted of deuterium, you cannot convert sulfated cholesterol to Vitamin D 25 D (OH) because the photoisomerization step needs it.

When hydrogen is ionized or charge separated………however, what can happen in life at the cell level changes in a big way……….hydrogen becomes the superman of flow.  When hydrogen is ionized and loses its only electron it becomes a proton cation.

This makes H+ the lightest cation in chemistry and given the small size of the proton, explains the unusually high diffusion rate of the proton relative to that of other common cations like potassium (K+).  When hydrogen loses its electron it becomes an ionic plasma that acts like a liquid metal.

Ionic plasmas have special abilities.  One ability is called proton jump conduction or protonicity.  These rules are governed by something called the Grotthuss mechanism.   Hydrogen is a chemist’s conundrum, a biologist’s enigma, and a physicist’s dream because it can lose or gain this single electron. I have always been of the belief that hydrogen did not really belong to any group in the periodic table based on this ability. Remember all that talk about the periodic table I did to Rick and Andrew.  Do you think that work was wasted now that you see the details in the story they missed?

After many thoughts on this topic,  I realized under some environments it can be placed into group 7 or group one in the periodic table. All known elements of group 7 are halogens. The group 1 elements compromise the alkali metals. Hydrogen is often placed in group one of the periodic table by convention due to its electron configuration,  but it is not considered by many to be an alkali metal.  Why?

Hydrogen rarely exhibits behavior comparable to that of alkali metals. For example, all the alkali metals react with water, with the heavier alkali metals reacting more vigorously than the lighter ones. The word “alkali” received its name from the Arabic word “al qali,” meaning “from ashes”. These particular elements were given the name “alkali” because they react with water to form hydroxide ions, creating very basic solutions (with pH > 7), which are also called alkaline solutions.

Hydrogen forms water with oxygen directly and does not form a basic solution. Adding more hydrogen to it does not cause a special reaction at all, as it does with the other metals in group 1.

Why is hydrogen fundamentally different? Water is most famous for forming hydrogen bonds with other water molecules and with other ions dissolved in it. A hydrogen bond consists of hydrogen shared between two electronegative atoms like oxygen or sulfur. The compound that donates the hydrogen to the chemical reaction is the hydrogen donor, and the acceptor atoms is the hydrogen acceptor.

Water is unique because it can be both an acceptor and a donor of hydrogen. It means water can be a switch hitter in many biochemical reactions.  This is why water is the universal solvent on Earth.  In fact, water can even donate two of its hydrogen’s if need be! This makes the water molecule take on the tetrahedral structure in its frozen form linked in a crystalline hexagonal array in crystal ice.  When I realized water had a crystalline structure I knew immediately it had to be part of the cells construction plan for its own wide based semiconductors.

All of a sudden biology took on a new meaning to me with this new perspective.

I told you in the podcast that hydrogen can also act as a group 7 halogen.  It can mimic iodine element 53.  It means it can gain electrons to become a nonmetal.  Non-metals can become semiconductors.  It was here that I realized the water was acting as a semiconductor between sulfated cholesterol and Vitamin D in our skin to change the structure of matter.  When hydrogen does this in water when it is associated with iodine it forms an ionic liquid.

Ionic liquids are now receiving special attention in science, owing to their unique properties such as high ionic conductivity, non-volatility, and non-flammability.  This ability makes these fluids versatile alternatives to conventional solvent-based systems used to make batteries, fuel cells, and supercapacitors that hold large charges.  They are also quite helpful as heat-transfer fluids to move infrared energies within a system.  This is when I realized why iodine was being used in the breast, brain, and thyroid gland with melanin and tyrosine.  Iodine and water create another semiconductor that is transferring energy from the sun to us.

Iodine addition to iodide-based ionic liquids leads to extraordinarily efficient charge transport, vastly exceeding that expected for a standard viscous system.  Hydrogen and iodine form an ionic plasma within the CSF of the human brain. The choroid plexus of the human brain is designed to add iodine to CSF.  CSF, you will recall is an ultra-filtrate of blood plasma and is made up of 99.9% water.  When iodine meets water that has been charged separated by IR light or by the hydrophilic proteins within the dura matter a massive amount of H+ is made in the CSF of the brain.  H+ is equivalent to a proton.  Using the Grotthuss mechanism, iodine is able to move protons closer together than we would normally expect,  to alter their hydrogen bonding network to allow them to form superconducting proton cables that act like a positive charge electric current.  The mechanism allows for charges to be transported not by the movement of particles, but by the breaking and reformation of chemical bonds. As water is charge separated by IR light or by hydrophilic substances, many excess H+ ions are made adjacent to the exclusion zone of water. Gerald Pollack’s experiments have shown this exquisitely.  The excess protons can then diffuse through the hydrogen bond network of water molecules or other hydrogen-bonded liquids (iodized CSF)  through the formation or cleavage of covalent bonds.  Iodine helps UV light get from the sun and our skin to the brain.

A biological cell is a dissipative system by its very nature. You heard this in the podcast when Rick said, “I don’t know what that means.”  I said I will tell you.  Now I am retelling it to you here.  This implies it has the role or purpose to break symmetry and create a metastable system to react to all environmental possibilities that the cell may face. Breaking symmetry tells biology something about Noether’s theorem.  A cell uses hydrogen and oxygen to un-condense our protein polymers, ever so slightly, to allow life to exist.  It changes the size and shape by moving charges, of electrons and H+.  Gilbert Ling tripped over this in the 1950s.  I mentioned him in the podcast.

When we sleep our semiconductive proteins are designed to be fully condensed and small.  This implies that life can only exist when our protein polymers are slightly unfolded during wakefulness.  Ling is the guy who brought the idea of unfolded proteins to centralized science.  This unfolding of protein semiconductors happens when electrons are withdrawn from proteins.  Free radicals add electrons to the holes that ATP creates to create a current.  In fact, any paramagnetic atoms can add their electrons to the semiconductor to operate it.  UV light creates hormones and hormones are tides of electrons controlled by our star.

Cortisol from ACTH in POMC do this and so does ATP made in the matrix.  Cortisol and ATP are both electron-withdrawing semiconductive biochemicals.  Gilbert Ling was the first scientist to realize what ATP did to proteins.  ATP allows for amino acids to unfold to allow for water binding sites to open to the water hydration shells around proteins.  Water is also a semiconductive protein because of the action of hydrogen bonds in water.

Ling had no idea what he found but the guys at FONAR did because they made an MRI machine from the idea.  When I read Ling’s books I realized what he was saying.  Water is a semiconductor in human’s and it needs specific proteins adjacent to it to operate and unleash solar energy in the electronic state.  Again, when I met Ling I asked him questions to see if he really knew what he found. He did not, and if he did I think he’d have Peter Mitchell’s Nobel Prize now.  He deserved it.

WIDE BAND GAPPED SEMICONDUCTORS ARE SPECIAL BECAUSE THEY CAN SENSE UV LIGHT AND USE IT TO TRANSFER ENERGY AND INFORMATION.

When we are awake our proteins have to be somewhat unfolded and un-condensed (larger).  This means during the day we are less thermodynamically efficient.  The sun’s light has to bridge the gap and this is why we evolved wakefulness from sleep.  This is why I told you in Cold Thermogenesis 2 that I believed that life’s primordial condition was sleep. I believed we evolved wakefulness when we gained the ability to unfold our protein polymers and engage in semiconduction.

Within this sliver of semiconductive protein unfolding is where the magic of life happens.  Similarly, a cell is designed to break symmetries by using hydrogen and oxygen to its advantage.   This ability must be associated with a specific molecule capable of breaking symmetry.  H20 can “unfold” or ‘charge separate’ into H+ and -OH with the addition of infrared heat from the sun or when it lies adjacent to hydrophilic substances.

Proteins are made more hydrophilic with the addition of electrons to them.  They are made more hydrophobic when electrons are removed.   It turns out all proteins are hydrated in life.  Our proteins are the first smart device ever built by nature.  This might be why DNA only codes for proteins using specific amino acids.  Those amino acids work with the visible spectrum of our star.

When we die we lose that ability and our muscles get hard in stiff in rigor mortis.  Liquid water is the perfect chemical to break symmetry with all the protein polymers in all life forms. The reason is found in water’s molecular 3 D molecular arrangements. Liquid water has perfect symmetry in that no matter from which direction you look at the molecules, the view is the same from a molecular standpoint. But water, can and does, lose its symmetry in nature naturally.

During my 18 months of unlearning to relearn, I found out that symmetry in crystals is key.  When symmetry is broken by any phase transition in chemistry (water) energy and information transfers must occur by nature’s laws.  This was how sunlight info and energy entered our bodies.  I realized melanin, Vitamin D, T3, T4, RBCs, etc…..all were semiconductive crystals transferring data from the sun.

This data informs the biomolecules in biochemistry how to act because all of them have hydrogen the chemical chameleon I mentioned above.  This occurs many times in the biochemical reaction pathways of cells. And as such, all breaks of symmetry require a transfer of energy by the laws of physics to satisfy the Second Law of Thermodynamics. Symmetry is also broken any time temperature rises or falls or when electrons or protons are moving in any biochemical reaction. Any transfer of energy/information has the potential to break symmetry and therefore to give rise to emergent properties in the protein polymers or products of these reactions.  This explained why Cold thermogenesis worked to create new stronger light inside of us: VUV using melanin water and these elements on the periodic table.

The line between metal and non-metal status in any element has become quite blurred because of hydrogen. Physics is now awakened to this issue.  This is a new problem for modern chemistry. Its implications have not yet been appreciated by biology.  When you consider that hydrogen is involved in most biologic reactions, this has massive implications for the biology of you and for life in general.  I am no longer in the biochemical silo of belief and I make fun of those who are toying in that cesspool of misunderstanding:  Ray Peat and the food gurus.

When I was a student growing up, hydrogen had a clear distinction in chemistry.  Sodium and hydrogen are group 1 elements.  Not only is hydrogen capable of switching teams but so is sodium its neighbor. Sodium is also used by life in a big way in extra and intracellular ionic fluids.  Now we know that hydrogen and sodium “switch teams” based on their local environment.  When the conditions of existence in these atoms’ environments are altered, they can change their chemical abilities. This action seems very counterintuitive, yet it has been proven by experiment.  This makes them “metastable atoms”. Life appears to like to use atoms that are cationic, small, and metastable. Ling realized this too.  Ling was a smart cookie.

I went back to the periodic table.

We all think hydrogen is a clear gas. But on Jupiter, hydrogen is under so much pressure with an altered temperature, it becomes an extraordinary superconducting metal. In mitochondria, H+ becomes a metal-like plasma as well.  MEG data shows that the two tissues with the highest mitochondrial densities have large magnetic fields, namely the brain, and heart.

This is why Jupiter is believed to have a stronger magnetic field than the sun. Hydrogen gas is diamagnetic on Earth while its dance partner gas oxygen is paramagnetic.  One repels a magnetic field while the other is drawn to one.  So hydrogen acts differently on both planets because each planet fosters a different environment.  In space, hydrogen also acts differently magnetically. Hydrogen is a plasma in space. When air or gas is ionized, it loses its electrons, and plasma forms with conductive properties similar to those of metals. We see this in our ionosphere with aurora.

Plasma is the most abundant form of matter in the Universe because most stars are in a plasma state. Heating a gas may ionize its molecules or atoms by reducing or increasing the number of electrons in them, thus turning it into a plasma.  A plasma contains charged particles: positive ions and negative electrons or ions.  I’d like to remind you here that your mitochondrial matrix is filled with H+.  This is a hydrogen proton missing its electrons.  Mitochondria also liberate light in the form of infrared light or heat.  They also create WATER!  That water is needed to fabricate our wide bandgapped semiconductors.   It too acts as an ionic plasma in you.

These were all the connections I was making that fateful day in the library of the medical school.

Here is how cells bury the sun’s magnetic flux in cells.  It uses H+ to do it.   Magnetism is the essential force that determines the form of plasma or ionized matter taken in an environment. The hydrogen regions around galaxies are also considered plasmas, despite their degree of ionization being small. The degree of ionization in interplanetary space varies between unionized states or can morph into fully ionized states in other regions of space.

In space, however, even the weakly-ionized plasma in the hydrogen region reacts strongly to electromagnetic fields.  Magnetized plasma, such as that contained in the hydrogen region, is the dominating state in the universe as a whole.  Our sun produces massive amounts of plasma it spits out at us into the solar system as the solar wind or a coronal mass ejection.  The sun’s plasma is contained by the high electric and magnetic fields of the sun.

So is the H+ in our mitochondria.  This makes your colony of mitochondria an antenna for the sun’s photons.  To decipher the electric and magnetic codes you need wide-band gapped semiconductors to get Nature’s recipes to run your cells far from equilibrium to satisfy the second law of thermodynamics.  Not too hard to understand once you see it.

SUMMARY

Modern semiconductor technologies are only 70 years old but have already transformed human society. At the heart of the technologies are the physical characteristics of the semiconductor materials themselves: their fundamental electronic and optical properties that enable electrons, holes, and photons to interact and control each other in a wide variety of device architectures and operating environments. For the first 40 years of semiconductor technology, through the late 1980s, the major semiconductor materials were Ge, Si and the “conventional” III-Vs elements of non-metals. The Ge- and Si-based technologies were spawned in 1947 by the demonstration of the first transistor. The early devices were discrete and modest, but further development enabled the replacement of bulky, inefficient, and slow-turn-on vacuum tubes in applications that began with civilian radios and walkie-talkies but quickly expanded to police radios and later military communications satellites. Shortly thereafter, these devices were followed by integrated microelectronics, enabling the rise and spread of computer technology. By 2015, Si technology, dominated by Si complementary metal-oxide semiconductor (CMOS) architectures. The “conventional” III-Vs refer to the narrower-band gap subset of compound semiconductors composed of elements from columns III and V of the periodic table. None of them were paramagnetic.

In electronics, the discovery in the 1970s that the AlGaAs/GaAs heterojunction could give rise to a two-dimensional electron gas (2DEG) was pivotal, enabling the first high-electron-mobility transistors (HEMTs) in GaAs5 and thin pseudomorphic strained InGaAs6 channels. In the 1980s, these devices and their cousins, GaAs- and InGaAs-based heterojunction bipolar transistors (HBTs), quickly began setting records for unity-current-gain frequency (fT) and output power above 10 GHz. In 1989, recognizing these benefits, the U.S. Defense Advanced Research Projects Agency (DARPA) launched its GaAs-based monolithic microwave integrated circuits (MIMIC) program. In optoelectronics, the invention in the 1960s of the laser diode was just as pivotal. A long chain of progress led, among other devices, to the single-mode InP-based laser diodes that now power the broadband dense-wavelength-division-multiplexed (DWDM) optical fiber networks, and which in turn are the backbone of the modern Internet.

By hacking the periodic table I found out in the late 1980s and early 1990s, a series of pivotal materials breakthroughs were made by Isamu Akasaki, Hiroshi Amano, and Shuji Nakamura, for which they were awarded the 2014 Nobel Prize in Physics. Their breakthroughs, built upon the efforts of many earlier researchers, were completely unexpected: seemingly “magic” AlN and GaN buffer layers on sapphire that dramatically reduced dislocation densities; methods to activate p-type Mg doping of GaN; and the remarkable resilience of InGaN quantum well luminescence against structural defects. Magnesium doping was the key to my hacking eureka. Magnesium also doped chlorophyll. My search for other atoms to dope carbon was open full bore.

The KT event caused a brownout on Earth with respect to photosynthesis. This meant less food for the big dinosaurs but it also meant less oxygen for all life. Why did mammals do so well in this environment?

Mammals began to specialize in using paramagnetic atoms with unpaired electrons to control their cellular circuitry. This helped make them more hydrogen, oxygen, and electrons instead of having to rely on their ATPase. Melanin crystals they absorbed from their surface were their innovative event to give them superpowers.

Oxygen is considered critical to nearly all life on earth, as the end electron acceptor in mitochondria that makes, theoretically, mitochondrial oxidative phosphorylation possible, and thereby energy production. This is modern centralized dogma. Is there another pathway to oxygen that mammals specialize in? Anaerobic energy sources can only temporarily supply ATP and maintain cellular function before substrate depletion, energy shortfall, or end-product poisoning that threatens survival. In most vertebrates, the limits of anoxia tolerance are short, on the order of minutes, because of the urgent dependence of the heart and central nervous system on a continuous supply of O2. Modern humans can only handle 4 minutes of anoxia before neuronal cell death occurs. What happened 65 million years ago with mammals is interesting because their hearts and brains were small organs and not energy dense. Today that is not true.

This brings up the key question, what did early mammals look like and how were they sculpted by melanin moving in their bodies from their surfaces to their interior organs?

That story continues in the next blogs.

CITES:

My cerebral cortex.

The question was good and it is still a POMC story whether you know it or not.

As melanin degrades so does melatonin and this correlates with low mitochondria redox power and a drop in delta psi. As melatonin breaks down it liberates tryptophan. Tryptophan has two catabolic pathways it can travel. As the time crystal blog on methionine and tryptophan said this AA metabolism is linked to the presence or absence of UV light. Quinolinic acid (QUIN), a neuroactive metabolite of the kynurenine pathway, is normally presented in nanomolar concentrations in the human brain and cerebrospinal fluid (CSF). QUIN is often implicated in the pathogenesis of a variety of human neurological diseases and melanin degradation due to heteroplasmy is one such cause. QA is produced following the metabolic breakdown of the amino acid tryptophan, via the kynurenine pathway. Quinolinate (Quin) is a classic example of a biochemical double-edged sword that needs light programming from our environment, allowing Quin to act as both an essential metabolite and potent neurotoxin. With proper mTOR signaling, Quin is an important metabolite in the kynurenine pathway and tryptophan catabolism leads to the de novo synthesis of nicotinamide adenine dinucleotide (NAD+). When mTOR is screwed up or redox is bad or you use the other pathway for tryptophan catabolism NAD+ is not recycled.

WHAT IS PROPER mTOR SIGNALING? 

Dr. David Sabatini discovered the mTOR pathway 28 years ago. What is that pathway about?  Look at the picture above.

mTOR = Mammalian target of rapamycin. This semiconductive protein regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in tissues in the body. The way it operates in different tissues has confounded Sabatini for 3 decades. There is a reason for that. He has stayed in his centralized biochemical silo and refused to see the light. To understand mTOR fully, you have to understand the physics of organisms first.

Wide-band gapped semiconductors make the light that controls the entire mTOR pathway. This light, stronger than the sun, alters glucose, oxygen, and phosphorous metabolism rostral to mTOR protein.  This changes the light in cells to activate POMC, tryptophan, and methionine biology. Sabatini’s eureka came 28 years ago on Easter Island. He doesn’t know this info yet, but after my podcast with Rick and Andrew, you should. That endogenous light cells created from the mass in the wide-band gapped semiconductors is how mTOR protein does the things it can do. Alterations in light emission are controlled by dopants on these semiconductors. I have found light around 380 nm changes HUMAN metabolism from anabolic to catabolic. Summer is the time for anabolic living and winter time is the time for catabolic living.  This is why human muscle anabolism and catabolism are more active during the day and at night, respectively.  Light is transformed from atoms everywhere inside of us, but we cannot see it because of our atomic arrangement in cells (AMO physics).

380 nm light (UV-A) is the photonic switch between catabolism and anabolism in the mTOR pathway. That selection tells us something deep about what happened at the KT event.  Living in nature’s visible light spectra induces POMC translation on our surfaces. This, in turn, stimulates the semiconductive circuits deep inside cells to create VUV-IR-A endogenously where our colonies of mitochondria reside. The frequencies of light created endogenously below 380 nm is where mammalian longevity occurs in humans.  This reality exists because of what happens at small scales via the translation of the POMC gene.  This gene has been amplified and  is buried in the pathways of tissues inside of us. This explains why the human brain is littered with light chromophore proteins. That is where Noether’s theorem comes into the story of life. Centralized science does not know, much less accept, what I just told you about Noether’s theorem but they will soon.. That is fine. With time, you’ll remember this post and the picture below. Dr’s Sabatini and Attia have been staring at the answer for a long time in the literature but ignoring it at your peril.  Light alters metabolism in a big way.

Now how it happens is a bit mind boggling.  UV-A light stimulate both alpha MSH and ACTH but the translation of ACTH is frequency related.  Blue light is a more powerful stimulus to ACTH cleavage than UV-A light.  Ultraviolet B radiation stimulates increased expression of the proopiomelanocortin (POMC) gene which is accompanied by production and release of alpha melanocyte stimulating hormone (a-MSH) by both normal and malignant human melanocytes and keratinocytes.  This alone should have told centralized scientists the sun could not be the cause of melanoma.  It was not.  What differentiated the cleavage in mammals who survived the KT event? The production and release of both peptides are also stimulated by cyclic adenosine monophosphate (cAMP) the breakdown product of ATP and interleukin (IL-1) but not by endothelin-1 (ET-1) or tumor necrosis factor-a (TNF-a).

N-acetyl-cysteine (NAC), a precursor of glutathione (GSH), an intracellular free radical scavenger created , abolishes the UVB-stimulated POMC peptide production and secretion.

Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels—5 millimolar—concentrations in most cells. As can be seen in Figure 1, this is the same concentration in cells as glucose, potassium, and cholesterol! Considering the high level of metabolic activity required to produce glutathione, such a high level underlines its importance.

Did you know glutathione absorbs strongly from VUV light to 290nm with a strong peak at 280 nm.  That means endogenously created light raise glutathione levels which in turn, quenches melanin action, and acts to limit surface level melanin production from UV light we get from the sun.  This always keeps the balance of melanin creation on our insides compared to our exteriors as humans. 

Chalk one up for negative entropy again.  Now you know why I am no fan of exogenous use of NAC or glutathione.  I also hate acetaminophen use because it blocks the endogenous production of glutathione in humans.  I actually think people who use this drug maybe at higher risk of melanoma in the skin.

Glutathione exists in cells in 2 states: reduced (GSH) and oxidized (GSSG). As can be seen in Figure 2, oxidized glutathione is actually 2 reduced glutathiones bound together at the sulfur atoms.

GSH biosynthesis is also regulated post-translationally by changes in cellular oxidation.  This is important in understanding how light operates with GSH and POMC cleavage.  POMC has to have UV light to be translated first and then GSH can operate inside the cell if a lack of electrons develop. If electrons are deficient so will light in the system.  This is what a low redox state and is the MAIN pillar of morbity and mortality in the longevity of mammals. This is what oxidation is.  The redox homeostasis of a cell ensures that endogenous and exogenous stimuli are modulated by the redox homeostasis of a cell. However, altered mitochondrial redox homeostasis leads to cellular oxidative stress, which in turn may lead to aberrant cell death and contribute to disease development.  Glutathione synthesis is stimulated when UV light and IR-A light are scarce for mammals.

The GSH tripeptide is derived from Cys, Glu, and Gly and is synthesized exclusively in the cytosol in a cell.

GSH is critical for maintaining redox balance in cells at the mitochondrial level, so GSH biosynthesis is upregulated in response to oxidizing conditions that mtDNA sense. Animal tissues generally have a fairly high concentration of GSH (0.5–10 mM) in comparison to cysteine (10–100 µM).  This is another clue that mammals are designed to be in the sun to raise GSH and explains why POMC has beta endorphin in it from an evolutionary perspective (below).  Mammals get high by being the in the sun.  This keeps their motivation high to seek it.  There is also another reason this is important.  Mammals eye clock is directly wired to the retina in all species.  This became important in humans when they lost Vitamin C, expanded glutathione and melanin inside their heads with encephalization.  This system is highly attuned to light via the eye since mammals get most of their light sense via their pupil and the retinohypothalamic tract.  I think when humans began to encephalize and wear clothes this one thing alone kept the unbalance between surface melanin to melanin that was absorbed into the body over our 4 million years ago.

The ratio of GSH to GSSG determines cell redox status of cells. Healthy cells at rest have a GSH/GSSG ratio >100 while the ratio drops to 1 to 10 in cells exposed to oxidant stress.Glutathione is also recognized as a thiol buffer maintaining sulfhydryl groups of many proteins in their reduced form.

Glutathione is produced exclusively in the cytosol and actively pumped into mitochondria. GSH is made available in cells in 3 ways:

1. De novo synthesis via a 2-step process catalyzed by the enzymes glutamate cysteine ligase (GCL) and glutathione synthetase (requires ATP).
2. Regeneration of oxidized GSSG to reduced GSH by glutathione reductase (requires NADPH).
3. Recycling of cysteine from conjugated glutathione via GGTP (requires NADPH).

Notice that all 3 require energy. The rate of synthesis, regeneration, and recycling is determined primarily by 3 factors:

1. De novo glutathione synthesis is primarily controlled by the cellular level of the amino acid cysteine, the availability of which is the rate-limiting step.
2. GCL activity is in part regulated by GSH feedback inhibition.
3. If GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated primarily by increasing availability of cysteine through recycling of GSSG.

These 3 methods for producing glutathione can be seen in Figure 3.

Many people currently believe it is hard to overstate the importance of glutathione.  For me glutathione is Robin and melanin is Batman for mammals.  These systems co-evolved while we deleted Vitamin C genes from use.  Glutathione plays a role in shielding cellular macromolecules from endogenous and exogenous reactive oxygen and nitrogen species. Melanin’s role is far more important.  While GSH directly quenches some free radicals, it power pales in comparison to the capabilities of melanin in how free radicals and heavy metals are handled in mammals. Glutathione has a greater importance closer to the surfaces of mammals where light comes into the system because it deals directly with the causes of topological oxidative stress.  Melanin does the same deeper inside of our tissues with absolute power (Noether’s theorem) and this is critical in setting the stage for quantum coherence in a warm wet environment.  Glutathione limits quantum processes at our surfaces.  This is why GSH is synthesized exclusively in the cytosol of the cell.  This is why deuterium is so common in blood.

BACK TO THE KT EVENT that linked mTOR to tryptophan

Neuropsin is an opsin family member known to function as a solar UV-A light detector.   responsive to wavelengths in the near-UV (λ max = 380 nm). After my podcast with Mr. Rubin, you’ll know that neuropsin was linked to the KT event and the ascent of mammals because of an interruption of photosynthesis and UV light. Neuropsin is the afferent reflex arc and mTOR is the efferent reflex arc for metabolism of all mammals. All mammalian metabolism, like photosynthesis is controlled by solar frequencies. I’ve been saying it for a long time, but everyone else wanted to focus on Dr. Sabatini’s work and not photosynthesis.

I have thought for 25 years light had to be the major controller of metabolism in us. It makes too much sense, but the mechanism was difficult to explain for biology. Once you exit the biochemistry silo and enter the silo of physics the mechanism was not difficult to figure out in those 18 months.  Even the microbiome releases massive light in response to feeding. The melanin sheets of the enterochromaffin cells are their target in our gut.

How does mTOR link to the light story?   Tryptophan is the key.

Tryptophan metabolism occurs via the kynurenine pathway or the serotonin pathway to produce bioactive metabolites. The kynurenine pathway is responsible for metabolizing most of the free tryptophan in mammals. It is activated by infectious agents, inflammatory mediators, and stress (ACTH from POMC).  A small fraction of free L-tryptophan (Trp) is used for protein synthesis and the production of neurotransmitters such as serotonin and neuromodulators such as tryptamine (below middle panel) which is important for. Tryptamines act predominantly as hallucinogens (mental illness). Classic hallucinogens (psychedelics) mediate specific serotonin-receptor activities and produce hallucinations. Substances in these groups mimic the effects of traditional drugs such as 2C-B, LSD, and DMT but may also possess residual stimulant activity in non-mental illness states where the circadian mechanism is intact. 90% of kynurenine pathway degradation occurs in the liver via TDO conversion of TPH to kynurenine. The remaining kynurenine degradation occurs by IDO in the brain, GI tract, and liver.

There is a blog that tells you the rest of the linkage………read it sometime

When we can’t make water in the mitochondrial matrix our metabolic pathways (mTOR) are not surrounded by the water they need to operate like a wide band gapped semiconductive diode. This alters the VUV-IR-A light show around mTOR and it does not work like Sabatini’s papers say it should. Blue light antenna in our skin control melatonin levels. Those antennas are called melanopsin. The light antenna in us is blue and it is linked to Vitamin A in neuroectodermal tissues where POMC also resides. Vitamin A is linked to Vitamin D at the RXR receptor in the brain where both of them are linked back to the DHA receptor that controls the retinohypothalamic tract which is step one in the pathway. This is how the peripheral clock genes in tissues are linked to melatonin levels locally in tissues. They are also linked to tryptophan metabolism.

L-Tryptophan is an essential amino acid for mammals (all of them) that is obtained exclusively from diet. Trp and its metabolites have key roles in diverse physiological processes, ranging from cell growth and maintenance, in which Trp serves as a building block of proteins, to the coordination of organismal responses to environmental and dietary cues via photosynthetic signals (light), in which Trp metabolites serve as neurotransmitters and signaling molecules. Together, these functions suggest that, during evolution, Trp metabolism has become linked to the revolution of Earth around the sun and electromagnetic signals became programmed into the cellular pathways (mTOR & NAD+). This energy & information footprint has been codified in our AMO organization at a subcellular level. The cellular electronic and vibrational state is affected by this process. This is why tryptophan and methionine are time crystals. This is how cells know about the environment. No brain is necessary. This is the basis of the brain-gut axis too. Waking up yet? Told ya’ this POMC is a big deal. This is why tryptophan and methionine organismal communication strategies align food availability with physiology and behavior.

As Vitamin A drops in the plasma so does melatonin levels. Melatonin repairs the peripheral clock gene mechanism in humans at the local tissue level when things go awry. Tryptophan has to be metabolized when this happens. Our cells pay attention to this. How? Remember ubiquitin marking and all those blogs I wrote about them?

Maybe you’re beginning to see where they all fit.

As a result, our proteins become dehydrated and lose their topologic charge, this causes size and shape changes in many small signaling proteins in mitochondria that control apoptosis and autophagy. It also alters the light frequencies your endogenous semiconductive proteins make. This alters mTOR signaling. The defective protein in these self-regulatory programs then gets marked for a turnover by ubiquitin. The protein that does this is ubiquitin. I have written an entire series on this protein.  This protein is also controlled by the peripheral circadian mechanism hardwired from the retina to the SCN.

The circle of life is controlled by life below your ability to see it much less understand it.

CITES

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699458/

2. https://pdf.sciencedirectassets.com/271024/1-s2.0-S0167488900X00213/1-s2.0-0167488996000638/main.pdf

What hit the cutting floor?

What do centralized healthcare providers need to know?  History of their profession so they can make better adaptations for patients.  If you listened to the Huberman/Rubin podcast I just did on Tetragrammaton you’ll want more of the details that lead me to POMC and melanin.  Here is the part of that story that EVERY MD needs to assimilate.

I wrote this blog last night after doing a consult for a centralized MD.  I hope it helps many of you.  Check out my latest article: HOW I GOT ON THE POMC/MELANIN TRACK AFTER MY MICHELANGELO EUREKA?  https://www.linkedin.com/pulse/how-i-got-pomcmelanin-track-after-my-michelangelo-eureka-jack-kruse

I made this public.

SHARE IT.  If you want your doctor to adapt you need to help them by pushing them.

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The “regressive evolution” of living a species on Earth has spawned interesting new ideas in new species.  The most interesting regression to me is now seen in humans on social media.  It is hiding right in plain sight and you can only see it if you maintain the wide band gapped semiconductors in your brain.  Improving them in your body no longer is operational.  Darwin is attributed to the quote that survival is linked to the survival of the fittest, but 20 years ago I realized his perspective was myopic.  I believe it should now be about the survival of the wisest.    INTELLECT IS NOT WISDOM.

Only wise humans who can see the loss of human superpower happening at breakneck speed will survive this “backward evolution“.  Wisdom for today’s mammals is born inside their melanin sheets inside their skulls.  Wisdom makes you the most adaptable creature in a rapidly changing environment.  What is changing fast?  Light is.

Light is the creative “Source” in the universe.  To some “backward evolution” may imply a loss of complexity, misleading you to believe, that evolution has a goal of creating more complex forms. It doesn’t However, evolution merely favors features that make a poster “more fit” for a particular current environment.

Consider cave-dwelling fish in Mexico below.

Look at the fish.  Implications of the picture?  What you do isn’t what you think. Let me explain the creative process buried at the core of life.  The evolutionary process doesn’t retrace its steps in “regressive evolution”.  It just appears it to those who do not carefully observe the process.  You have to go deeper than the facade.  Cave-dwelling creatures have frequently undergone “regressive evolution”,  due to their unique light environment.  Remember fish are not mammals, but they have lessons for mammals to learn.  These fish have lost many complex features, like eyes, that are not needed in dark environments. But eye loss in cavefish, for example, doesn’t mean an exact return to a primordial ancestor without these organs. The eye remnants remain.  They are atrophic and lie in wait until the light, the “Source code” returns.  Instead, processes that previously produced the eye stop partway through the process, leaving a vestigial eye overgrown with skin.

I believe the same process occurred in the primate clade of mammals in Africa 2-4 million years ago to explain our species.

To a surface thinker with low dopamine, due to degraded melanin sheets in their skulls, things can look like they’re going into reverse when they aren’t. The eye didn’t go in reverse. It just stopped going forward.  Might humans represent the same thing in the chimp family?

Might it even be more complex today compared to our own genesis?

I believe this is exactly what is happening to human mammals today.  They are no longer moving forward, and their epigenetic toolbox which relies on UV light to drive mitosis, is also regressing.  What does that imply?  The cavefish doesn’t face this now because it is not a mammal and it is protected fully from man’s use of artificial light.

What is happening to mammals that aren’t in Nature and are subject to man made light?

That is how it looks on the primate side who doesn’t talk, how does it look in their cousins who can speak?

What was perfection 520 years ago in stone?

As humans have degraded the melanin sheets inside their skulls with the use of clothing and indoor dwelling with fire use they have become more creative.  Creativity is a regressive evolutionary creation in my opinion of regressive changes in the frontal lobes.  This regressive change has had a positive connotation which can be seen in the Louve in Paris.  Melanin degradations created various levels of dopamine in our frontal lobes that lead to new things on Earth.  There is a lesson here.

Losses in biological complexity may accompany less-obvious increases in complexity in other areas of humanity.  This manifests in novel ways, such as the biochemistries parasites use to get inside hosts and sculpt changes in us by changing light frequencies in our cells.  How big a deal is this?  Men’s face change due to toxoplasmosis.

The sex of offspring change when women infected get pregnant.  What happens to the mitochondrial DNA of women with POMC deficiency over several generations since they control mtDNA inheritance.  Do you understand what “regressive evolution” really means?    I think autism is the first step in new speciation.

It’s very easy for people who do not understand science to think of evolution in terms of what you see; what the morphological features are in living things. But there are also lots of other features that we don’t perceive at the physiological and the biochemical level.  It turns out POMC is working at the biophysical level.  This is well below the classic world of reality.  It is well hidden by Nature.

In cavefish, lost eyes may similarly obscure alternative complexity. Organs responsive to vibrations appear in great quantities in these fish, providing another way to sense in dark environments. And in the already-overstuffed head, these organs found available real estate in the fish’s empty eye sockets.  Nature is efficient in how she operates even in regression.

When Alan Turing turned his mind to biology in 1952, he proposed a model for how biological patterns could stem from the interaction of just two molecules. New work hints that it’s what all vertebrates use to grow hair, feathers, and other skin structures that links to melanin biology.

In 1952, well before developmental biologists spoke in terms of Hox genes and transcription factors, or even understood DNA’s structure, Alan Turing had an heretical idea.

Turing wanted to understand the underlying mechanism that produces natural patterns. He proposed that patterns such as spots form as a result of the interactions between two chemicals that spread throughout a system much like gas atoms in a box do, with one crucial difference. Instead of diffusing evenly like a gas, the chemicals, which Turing called “morphogens,” diffuse at different rates. One serves as an activator to express a unique characteristic, like a tiger’s stripe, and the other acts as an inhibitor, kicking in periodically to shut down the activator’s expression.

How would this work?

Imagine a field of dry grass dotted with grasshoppers. If the grass were set on fire at several random points and no moisture were present to inhibit the flames.  The fires would char the entire field. If this scenario played out like a Turing mechanism, however, the heat from the encroaching flames would cause some of the fleeing grasshoppers to sweat, dampening the grass around them and thereby creating periodic unburned spots in the otherwise burned field.  A pattern would develop.  POMC operates the same way on the body plan genes to sculpt us.  This is where our new frontal lobes in the brain came from and where bipedalism came from.  It also explains why POMC is heavily expressed in our skin overlying our gut that shortened by 30 feet from our cousins.

Some centralized biologists remain skeptical that Turing mechanisms are sufficient to account for these periodic patterns, particularly because there are other viable models, including one proposed by Lewis Wolpert, an emeritus developmental biologist at University College London. In Wolpert’s model, cells interpret their position in space based on how much of each morphogen there is, resulting in stripes, spots or digits. Furthermore, Wolpert says, “no one has yet identified the molecules that work for a Turing mechanism in development.”

Uncle Jack thinks alpha MSH and ACTH/blood glucose are the morphogen and activator in the Turing mechanism of mammals and UV light from our environment and inside of our bodies powers the process of building the mammalian body plan to explain morphogensis.

Centralized biology ignored this paper for decades after Turing’s death.  Only mathematicians toyed with it.  In my 18 months of unlearning to relearn, I realized what Turing found.  He found a way to allow mathematics to bridge the gap between reality to the quantum world.  How?

POMC is a gene made out of atoms.  Since the beginning of the universe, we know one thing for sure.  There were quantum subatomic particles present at genesis.  First and foremost, this implies that a quantum evolution began as a by-product of some type of supernova blast.  All atoms come from these blasts.  This quantum mechanism evolved into a chemical evolution with the construction of atoms.  From this chemical evolution emerged biochemical evolution directed by light some 3.8 billion years ago.  No one is following these clues back to how all things began except Turing.

Atoms are in everything that makes us, especially proteins which come from genes like POMC.  Every part of you is made up by atoms right now.  All atoms are controlled by light at some level = they are quantized.  The laws of the universe scale from the quantum level to the macroscopic level.  Quantum mechanics is foundational to everything in this universe.  This implies that, in order to have a fundamental understanding of life, you must have a quantized molecular mechanism to prove your theory.

Darwin has nothing to prove anything with what he wrote in the Origin of Species. He provided us with observations that correlated to morphologic change.  This was correlative data, not causative data.  Lots of people forget that basic fault because of guys like Huxley and Dawkins.

When you are dealing with atoms, you are dealing with quantum mechanics.  This is an area where Dawkins will have to trick you to believe Darwin’s ideas.  Nothing in Darwin’s theory talks about nature’s basic quantum language because it was not discovered yet.  Darwin gets a pass on that but Dawkins does not from me.  Feynman famously said that if your theory does not match your experiment, no matter how elegant the theory,  it is wrong.  Well, I am going to show you Darwin was, in fact, wrong.  I am going to use quantum mechanics to show you why.  The key to understanding how evolution occurs is to understand the fundamentals of Einstein’s mass equivalence equation E =mc^2.

The mass equivalence equation shows us the wide reaching impacts of failing to understand how small changes in quantum mass can create widespread changes in energy.  How does math scale to the quantum world?   Avogadro’s constant is the only scaling factor we have that allows us to go between the macroscopic world to the quantum level (sub atomic scale).  This allows us to link observations we make in nature, with respect to atoms, directly to the mathematics of the quantum realm.

You heard me mention this relationship in the podcast I did with Max Gulhane, MD from Australia when I talked about how much water is created from Fats and carbohydrates and I mentioned that fats created double the amount of moles of water than sugar does.  One mole of a substance is equal to 6.022 × 10²³ units of that substance (such as atoms, molecules, or ions). The number 6.022 × 10²³ is known as Avogadro’s constant.

Just from common sense, quantum mechanics describes nature as absurd.  hen the quantum experiments have validated nature’s absurd behavior, we must accept Lady Evolution as she is; bizarre and  absurd.   QED seems counterintuitive to evolutionary biology because she asks you to read the mass equivalence equation right to left in order to understand her.  Life is fundamentally a thermodynamic problem to solve, not an evolutionary one.  E=mc^2 means that 2 x3 = 6 just like 3 x 2 = 6.  Few realize that is built into Einstein’s mass equivalence equation.

The key for quantum evolution is to know how the molecules of life, namely proteins, change over time.  Subatomic particles change the charge and change the size and shape of molecules and this leads to new emergent properties macroscopically in animals.  POMC is the mammalian gene that introduced charge variation and size and shape changes to proteins to cause them to act differently.

Biological diversity, across the board, is based on a fairly restricted set of principles that seem to work and are reused over and over again in evolution.  This seems especially true in the evolution or mammals and therapod dinosaurs/birds over the last 65 million years. Nature, in all its exuberant inventiveness, may be more conservative than we thought in creating changes in morphology.

SUMMARY

Part of the reason evolution doesn’t retrace its steps is that adaptations lead to other changes. That makes simply dialing back a specific change extremely complicated.

If you’ve made a change, you’re going to fine-tune that adaptation, and that adaptation will have to interact with other genes to sculpt out a solution with staying power.  Now, if you reverse that one change, all of the other genes are still going to have to be changed to reverse evolution.

In cavefish, for example, the original development of an eye may have come with changes not only to the semiconductive proteins needed for eyes but also to skull structures of an eye socket. A mutation affecting an eye protein wouldn’t cause an organism to revert to one without the socket.

Changes in the the environment always predates changes in the semiconductive fab plants in cells.  When thought of in this way, you can see why Nature never makes mistakes. Evolution is always progressive in that it’s selecting for features that improve the fitness of the individuals in which that variation is being expressed.

If DNA genes matter so much why is it that most, not all, circadian gene regulation occurs at a post transcriptional time frame?  Post-transcriptional regulation is the control of gene expression at the RNA level. It occurs AFTER the RNA polymerase has been attached to the gene’s promoter and is synthesizing the nucleotide sequence. This means the gene is not the key to change.  It means the process after gene expression are the key to how wide band gapped semiconductors in you sculpt tissues.  Therefore, as the name indicates, it occurs between the transcription phase and the translation phase of gene expression.

These controls are critical for the regulation of many genes across human tissues. It also plays a huge role in cell physiology, being implicated in pathologies such as cancer and neurodegenerative diseases in humans.  This tells us that these diseases are caused by environmental changes and not GENETIC ones.  This is why I told Dr. Huberman and Rick Darwin was wrong in his approach and the neo Darwinists like Dawkins are really wrong.  I can give Darwin a pass because quantum mechanics was not discovered until 50 years after his penned his theory.  I cannot absolve Dawkins of this.  His self gene book was penned over 50 years from the discovery of quantum mechanics.   The implications for you care clear.  Centralized science still acts like Darwin was correct.  This makes no sense from a scientific point of view does it?  Darwin said small changes in genes called mutations leads to variation of species.  This is a huge problem for neo-Darwinians. Why?  A post transcriptional protein results in a non-functional protein for life.  Proteins must have all four bends to work properly in cells.  So how could life’s stage be gene based?

Life is like a photograph; it develops from the negatives in the environment.  What is next for humans on Earth?

I now believe creativity, and most mental diseases, are a regressive evolutionary creation in my opinion of regressive changes in the frontal lobes.  Many modern diseases are evidence of proteins undergoing semiconductive engineering inside your tissues to change the frequencies of light in your tissues.  This leads to new and alien bends, charges, and alteration of atoms in your tissues that change the morphology of your body and the physiology of your tissues.  The most powerful changes are occurring in the POMC gene family and all the peptides it creates by light frequency cleavage.

CITES

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363033/

https://www.science.org/doi/10.1126/sciadv.aau5484

https://www.newscientist.com/article/mg25834344-900-the-shocking-decline-of-earths-microbiome-and-how-to-save-it/

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The video above was recorded before I ever released the story of POMC and the evolution of man from his cousins.  But if you listen closely, especially at the end of the podcast I opened those doors.  This series of interviews I thought would lead Cory and Robin to the story of melanin biology which is the ultimate battery for sunlight.  We never completed this series because Robin lost interest, and decided to go back to the UK when COVID ended and the tapes were lost.  Cory recovered some of them and tried to improve the audio but this is as good as good could get. The story, however, is intact.  This story is important to understand what evolution did with melanin and the POMC gene.  We capture light via electrons and we move them the same way.  When electrons are moved they have to be controlled.  What controls the flow of electrons?  Semiconductive circuits.  DHA is key to the retinohypothalamic tract that controls circadian biology.  DHA creation had to be made before melanin could be innovated.  DHA and mitochondria innovation at the same time created water for eukaryotes.  That is how the water story began for life.

Organisms are open thermodynamic systems dependent on energy flow. Energy flows in together with materials, & waste products are exported, along with the spent energy that goes to make up entropy. Entropy defines the flow of time.  Molecular clocks are flowmeters of entropy.  And that is how living systems can, in principle, escape from the second law of thermodynamics by staying on the edge of it.  Cells do this by creating order from chaos using cells as a dissipative structure. That structure is built around the AMO physics of atoms in cells.  Their molecular arrangement inside the cell is the key life uses to do the things it does.

Cyanobacteria came sometime between 3.8 – 2.0 billion years ago and they possessed for the first time on Earth the machinery to utilize water as a fuel source by oxidizing it. THEY BURNED WATER TO MAKE ENERGY.  More significantly, the by-product of photosynthesis happened to be oxygen. for the planet.  That creation stimulated the evolution of mitochondria. This event, known as the “Great Oxidation Event,” occurred sometime between 2.4 – 2.1 billion years ago.

Life remained simple with just bacteria and archaea dominating the planet mostly in the oceans where electrons dominated.  Then environmental change happened again on Earth because the light of the sun changed at the Cambrian explosion. This event changed how life began to use water.  It brought water from outside of bacterial walls to the inside of cells to make water do things to light to build complex life.

Mitochondria created a sea of water for life to innovate upon. Water (H2O) is the third most common molecule in the Universe (following the H2 and CO molecule), and its standard chemical structure, based on the hydrogen bond, is actually confined by a simple scheme of charges interacting via static Coulomb forces; that is, liquid water as most humans experience it on Earth is totally reliant on electrostatics and omits all mention of electrodynamics and the consequent radiation field.

Cells have a different experience of liquid water than humans do because cells eliminate the Coulomb force at their scale.  Human cells do not burn water as cyanobacteria did.  We use it as a superconductive highway to move electrons and protons around our tissues to ferry solar light our proteins collect. It has been speculated that a large percentage of effects in condensed matter physics make use of the radiation field in one way or another but it still doesn’t seem to have found a place in much of the basic chemistry of life because it negates water from its understanding.

The POMC gene is the most innovative gene in all of life because it is the most complex condensed matter protein currently on Earth.  In biological systems almost all water is within a fraction of a micron or less from a surface or molecular backbone and so is interfacial water.  In humans, water inside a cell is never too far from coherent water in our cells by design.

This interfascial water behaves in a quantum way, where the Coulomb law of electrostatics does not apply. In these circumstances, charges attract and they do not repel each other.  This is why your mitochondrial matrix is filled with H+.  All of the biology itself depends on this scenario, so as to allow the accumulation of tissues from negatively charged cell bodies.  When you separate charges, you are creating the means to store energy from the sun.  You are creating a mini-sun in your cells to run your life.

SUMMARY

According to the domain system in evolution, the Tree of Life consists of three domains such as Archaea, Bacteria, and Eukaryotes.  The first two are all prokaryotes, single-celled microorganisms without a membrane-bound nucleus. All organisms that have a cell nucleus and other membrane-bound organelles are included in Eukaryotes.  Every domain of life emits light from its cells.  Prokaryotes emit 5000 times more light than eukaryotes do.

The frequency of light from the sun has changed for life many times in our evolutionary history.  The most recent change came from human frontal lobes via our imagination and innovation.  That innovation however is harmful to our POMC biology.

Because of POMC biology, humans need to go on a tech diet more than they need to go on a food diet.

Current versions of mammals are filled with mitochondria that are acclimatized to the specific amount of oxygen on Earth, that we take it for granted. However, oxygen was absent from the Earth’s atmosphere for close to half of its lifespan.  This is when we used other atoms as our terminal electron acceptors.  Their use was the best thermodynamic option in those epochs, but they were not the best choices on the periodic table.   When the earth was formed around 4.5 billion years ago, it had vastly different conditions in the environment. At that time, the earth had a reducing atmosphere, consisting of carbon dioxide, methane, and water vapor, as opposed to the present-day atmosphere which consists primarily of nitrogen (71%) and oxygen (21%).

Though sunlight split the water vapor in the atmosphere into oxygen and hydrogen, the oxygen quickly reacted with methane and got locked into the earth’s crust, barely leaving any traces in the atmosphere. A silent, mysterious force worked to release oxygen steadily until the very composition of the atmosphere changed. That mysterious entity happened to be a microbe: Cyanobacteria.

The earliest onset of life on our planet occurred around 3.8 billion years ago.  This video above begins to explore the history of Earth.   Since oxygen was projected to be absent from the earth at that time, metabolism in living organisms would have been anaerobic, involving the use of minerals present in the ocean to generate energy. This is how energy was transformed at ocean vents for billions of years.

There is also isotopic evidence for autotrophic carbon fixation at 3.7 to 3.8 billion years ago, although there is nothing that indicates that these organisms were photosynthetic. All of these claims for early photosynthesis are highly controversial and have engendered a great deal of spirited discussion in the literature (Buick, 2008).

However, around 2.7 billion years ago, a peculiar group of microbes, known as cyanobacteria, evolved in our seas. Phylogenetic analyses based on 16S and 23s rRNA, genome reconstructions, and fossil evidence have been used to understand the evolutionary characteristics of these early living organisms. These microbes possessed the remarkable ability to perform a different type of photosynthesis than the one we know today. This newfound ability allowed them to generate energy directly from sunlight.

Mammals used the same game plan when they innovated the POMC gene 220 million years ago and this innovation was refined and then amplified 65 million years ago to create man.

This is fractal biology 101.

CITES

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949000/

Morning Rays Keep Off the Pounds

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The butterfly effect from my weekend…..with Rick Rubin and Dr. Huberman continues.  Start the video at the 16:00 mark

Huberman wants to come and visit me in my lab and do a podcast mano y mano with me.  In “light” of this I want Andrew to be aware of the butterfly effects of what I said to him so he is ready for the next round of inquiry on light

KEY BLOG POINT: CLIP = Corticotropin-like intermediate lobe peptide and blue light without the protection of IR-A and UV light in the eye cause ACTH release from cells with POMC and as ACTH rises so does CLIP.  HOW?

Implications of this slide above?  In humans, this is how blue light raises blood glucose and insulin.  CLIP cleavage is the major cause of diabetes in modern man.  A big statement backed up by the picture. CLIP raises insulin in response to blue light exposure without any food exposed to the organism. (see below)  I have posted this picture a thousand times and no one asked me the right question.  How in the hell do the papers listed below explain it?  They couldn’t.  Read on, because I can.  It is all linked to POMC cleavage and retinal anatomy.

CLIP raises insulin in response to blue light exposure without any food exposed to the organism.  This peptide has massive effects on the exocrine pancreas.  CLIP’s physiological role has been investigated in various tissues specifically in the central nervous system.

Big Pharma has been trying to keep a lid on this for a long time.  So beware of where our discussion will go.  What cells specifically make POMC in humans?

Look at the tissues where POMC is located and think about what we teach doctors about the symptoms of diabetes.

Polydipsia

Polyuria

Polyphagia

All are caused by a lack of POMC in the hypothalamus where the central retinal pathways converge before radiating to the rest of the body.  Polydipsia is due to a lack of ADH in the posterior pituitary.  Polyuria is caused at the kidney tubules because there is very little vasopressin in the system to control water balance.  Polyphagia is due to the destruction of the leptin-melanocortin pathways that begin in the retina.

Diabetics carry unusually high risks of retinopathy, nephropathy, and neuropathy.  Do you understand why they do?  The retina anatomy is destroyed by chronic blue light exposure.  The basement membranes of the kidney are destroyed by the chronic elevated blood glucose and insulin related to POMC cleavage due to blue light and neuropathy is caused by a chronic lack of the creation of T3 in peripheral nerves.

THERE ARE MANY MORE IMPLICATIONS ANDREW

Andrew based on our 10 hours of discussion on light/water/magnetism if you look at that list and remember what I told you about in 1923 about mitogenic radiation and NaCl in the CSF you might begin to understand these slides below with new eyes.

^^^^^Please recall Dr. Huberman that the choroid in the eye is where melanin sheets of the RPE and Bruch’s membrane are adjacent to POMC in the retina.   We can do an OCT on the retina to see it before the disease begins!!!!  The white arrows below show the choroid vessels and the highly reflective RPE and Bruch’s membrane is immediately above them.

The entire substructure of the retina is made of collagen and DHA. Both these biomolecules are wide-band gapped semiconductors because of the quantum chemistry of carbon.

Do you see a new reality developing here in front of your eyes yet Andrew???

Dr. Huberman, do you remember during the podcast when I asked you if you knew what part of the visible spectrum bends the most in the eye and you said you did not know?  Remember when I reminded you that melanopsin and POMC are in very specific locations of the retina and I told you Nature does not make mistakes in where she puts things on our semiconductors?  Ya’ know, the AMO physics thing I went on about for ten hours……….

Do you know POMC is also located inside of the ring of POMC too……just not as much of it.  Do you know what light bends the next most?  Blue light does.  It is the reason why so many humans today suffer from visual blur because blue light does not fall on the fovea/macula region of the retina.  The macula is normally yellow to acts as the complementary color to blue to absorb stray blue light to preserve central vision sharpness.  It causes another bigger problem in the development of diabetes.  It destroys the blood vessels in this middle region of the retina.  This is why retinopathy is a diabetic problem.  The waste products of this area of the retinal photoreceptors and semiconductors collect just as we see in arterial disease.

The blue light hazard destroys blood vessels in that region around the fovea that I can see as a neurosurgeon with my ophthalmoscope in my clinic when I am looking for it in all the patients I treat (see picture below).  The last two slides show you how the bending of light links to the anatomy of how melanin, ACTH, POMC, RPE, and blood vessels really work in a quantum fashion. (picture below)

Modern ophthalmology is still in the dark on this linkage of light bending to retinal anatomy and this is why they have no idea the blue light hazard really causes diabetes in humans.

They also have no idea that light is activating POMC via molecular resonance to cleave the POMC peptides from the gene.  This can be studied easily today but no one in diabetes research wants a cure when treating the disease fuels a trillion dollars a year profit center for Big Pharma Andrew.  Many of your labs sponsors and your University are kept afloat by these corporations.

Fluorescence resonance energy transfer (FRET) measurements can be done between single pairs of acceptor and donor fluorophore semiconductive proteins to yield information about structural relationships and distance fluctuations between regions of a single biomolecule or between components of an interacting system of biomolecules.  Someone needs to study this in ophthalmologic research after they read this blog.

Blue light causes a machine gun effect of palor in the retina and blood vessels all around the fovea (below).  Diabetics also show an altered response of pupillary response to blue LED vs red LED if they use both.  I have been doing that in my TBI patients for years now because I understand how this system was built to work.  This blue light toxicity is what causes photophobia in brain injuries. Anything that causes acute hypoxia in the retina can cause these effects due to the change in melanin light emission from the RPE in the periphery of the retina.  This is why POMC and the choriocapillaris have the most interesting relationship to oxygen tensions in the human retina.  More on that coming later in the series.

What else does this all imply Andrew?  Most fat diabetics will also have hypothyroidism because of the quantum arrangements in the retina.  This is how we know their diabetes comes from the eye and the leptin-melanocortin destruction at the hypothalamic level at the paraventricular nucleus. Note below the down and up arrows for the paraventricular nucleus which houses most of the thyroid releasing hormone neurons in humans (TRH).

Thyrotropic-releasing hormone (TRH) released from neurons in the paraventricular nucleus of the hypothalamus is stimulated directly by the hormone, leptin and alpha-MSH as the up arrow shows.  This is why American tend to be fat diabetics with hypothyroidism because they are addicted to their tech screens and iPhones.

As the picture above shows multiple factors, either directly or indirectly, regulate TRH neuron activity. Thyroid hormones (T3/T4) are the most potent negative regulators of TRH. T4, efficiently taken up by epithelial cells of the choroid system in the lateral ventricle, binds to transthyretin (T4-binding prealbumin) and is secreted across the blood–brain barrier into the CSF.  Note the top part of the slide below.  Visualize the retina at the left side adjacent to phenylalanine and the basal ganglia and thalamus adjacent to melanin and dopamine next to dopa.  Realize the pituitary and the PVN at the level where T3 & T4 are in the slide.  This defines the distal end of the semiconductive circuits in the central retinal pathways as we enter the brain substance.

Almost 80% of T3 at the paraventricular nucleus originates from the peripheral conversion of T4 in cells outside the brain. Only 20% of hypothalamic T3 crosses the blood–brain barrier directly from the periphery.  This makes T3 much more important in the human brain.  Melanin and DOPA can be used to stimulate T3 production in the brain even when the thyroid is defective or missing.

The more one can tan the better this ability is.  Most hypothyroid/diabetic patients are horrible at tanning because their skin is atrophic due to a lack of alpha, beta, and gamma MSH. Regular exposure to solar UV light via your eyes and skin stimulates your thyroid and brain to make T3, which balances your body’s metabolism. Tanning increases your metabolism, which in turn helps you maintain a healthier weight. This is all done via POMC biophysics.  Anything that blocks it fattens you and ruins your thyroid function.  T3 is the biophysical manna of longevity for mammals.  T3 function is the best predictor of longevity for the human myocardium and CNS/PNS.  These are the two tissues that kill humans the most.  You won’t hear that from Peter Attia in his new book on longevity.  This completes the lessons I gave you about thyroid function in the cold thermogenesis series of blogs.

The type II deiodinase (Zn/Se), is mainly expressed in third ventricle tanycytes.  You should be asking me what is a tanycyte.  It is an important regulator of TRH neuron activity and plays a major role in T3 availability in the paraventricular nucleus.

Tanycytes are how leptin enters the hypothalamus at night at the median eminence.  They are the most common type of macroglia in the CNS of lower vertebrates. In adult mammals, tanycytes are restricted to certain brain regions where the tissue is rather thin and POMC gene is present. These regions are the wall of the diencephalic third ventricle.  Recall the optic bud and retina are all diencephalic derivatives in the human embryo.

Fasting and infection upregulate tanycyte type II deiodinase expression with Zn/Se atoms, resulting in local increases of hypothalamic T3 which may partially explain the reactive decrease in peripheral TSH observed during fasting or inflammatory diseases. T3 inhibits TRH gene transcription in a classic feedback loop and TSH synthesis. T3 also influences the processing of proTRH neurons adjacent to POMC neurons by altering paraventricular nucleus prohormone convertase (PC) levels. T4 also reduces TRH levels measured in the hypophyseal portal circulation.  This is a very complex dance that few understand because of its optical physics. Understanding biochemistry is not enough.

OUTSIDE THE BRAIN:  TRH has effects

Thyrotropin-releasing hormone (TRH) is expressed throughout the gastrointestinal tract in humans in gastric G cells, in pancreatic islet beta cells, and in neurons constituting the myenteric plexus of the esophagus, stomach, and intestine. In the stomach.  If you are a human and you have a gut problem you have a melanin problem via POMC.  TRH, T3, and T4 are linked back to this story.   TRH modulates pentagastrin-stimulated gastric acid secretion and may attenuate acid secretion in subjects with acid secretory disorders. This is why GERD is fundamentally a nnEMF/blue light story.

In the pancreas, TRH is expressed during perinatal development, and TRH administration in mammals induces pancreatic hyperplasia and inhibits amylase release. TRH also reduces CCK-induced gallbladder smooth muscle contraction and inhibits cholesterol synthesis within the intestinal mucosa but is not trophic to the intestinal mucosa.  Yes, you can get gallbladder pain when you are LACKING SUNLIGHT.  I have a farm member who had this issue and I helped her overcome it using sunlight and the circadian mechanism linked to POMC actions.

Today’s diabetes is a result of mammalian innovation that was used to survive the KT event.  How?  Look closely are POMC and what it does.

Light can be transformed when it hits matter like a semiconductive protein.  (see below all the ways light can be changed)  When looking at the POMC rabbit hole you’ll notice that the central melanin system is hodologically linked to every sensory pathway in mammals whose neural tracts end in the thalamus.  All 5 senses end in the thalamus and then the thalamus projects to the hemispheric lobes of the brain.

The thalamus is the end station of the diencephalon where the optic bud ends in the embryo.  It is obvious to see the connection when you follow it back embryological (above).

Light frequencies and varies changes in amperage in currents are capable of cleave POMC via molecular resonance into action in the retina.

What if I told you that ACTH is cleaved more from its parent protein POMC based upon the frequency of the light most likely to be there?  Recall in the podcast I asked Huberman did he know which part of visible light bends the most and he was stumped by the question.  Blue light bends second most in the retina’s periphery in a circular format.  Would you believe it?  You should.  Might this relationship be present in every mammal retina to bright blue-laden light because blue light was used to stimulate ACTH to create glucocorticoids like cortisol to raise blood glucose when food was sparse and light frequencies changed and the environment got cold?

Well, you should.  Because that is exactly what happened when mammals took over the world and left their holes in the ground and the sun came back. The retina is somatotopically organized to light frequencies.

This exact mechanism was used by ancient mammals and therapod dinosaurs to raise their own blood sugar when photosynthesis was disrupted by an asteroid crash. ACTH was and is upregulated by blue light.  The blue light was present 65 million years ago at the surface level of Earth.  Light created glucose for life to survive.

Today the same effect is causing diabetes in a modern man who has built a world of blue-lit bulbs that has very little UV light to regenerate melanin at the same time this occurs in the retina.  Oh! So you see that now.  Good.  Alpha-MSH and its cousin peptides cannot be liberated or cleaved from POMC unless UV light is present in the anterior chamber of the eye because it is more peripheral to the ipGCRs and melanopsin.

Why is melanopsin the most common opsin in the human brain when blue light cannot pentrate the skull?

Dr. Huberman, do you realize what this also explains?  If explains why modern humans who have the blue light hazard through their eyes are more likely to be obese with diabetes because the leptin-melanocortin pathways from the retina to the hypothalamus are also damaged in this scenario.

Diabetics have melanopsin damage in the peripheral retina (nnEMF/blue light) more in the integument than their eyes will be skinny diabetics.  What else does this imply Andrew?    It means people who have had cataract surgery and get blue light intraocular lenses but have blue light stress on their skin will be skinny diabetics.  Centralized medicine has never been able to explain this difference in the literature.  I gave it to you for 5 bucks.  Do you still think this knowledge is worthless?

MORE NUANCE WITH POMC CLEAVAGE

Do you know that ACTH, cortisol, blood glucose, and insulin all act to decrease melanin’s ability to be renovated on our surface because there was no UV light present?  So, Andrew, this means under blue light conditions mitosis would have been stopped on the skin of mammals and feathers of therapod dinosaurs.  They would have lost their colors and tans as they migrated their melanosomes interiorly.

The bending of light should also now fully explain the anatomy of the retinal blood supply in the mammal eye, don’t you think Dr. Huberman?  Note how in the center of the retina there are no blood vessels that normally have hemoglobin.  RBCs are also devoid of mitochondria as well.  Hemoglobin is a heme porphyrin that has absorption spectra that spans the entire UV spectrum of terrestrial sunlight but also extend deep into the UVC range = 250nm-600nm light.  Hemoglobin has a sharp cut-off at the IR-A region at 600nm.  Do you see how the pieces fit yet with POMC?  The anatomy of the mammalian eyes is 100% a story of how melanin works in us.

Now let us look at what blue light is doing at the same time in the eye in relation to POMC.  You should recall that from my Vermont 2017 talk we found melanopsin is now in blood vessels.  This means modern lighting destroys photoreceptors just around the fovea when it is mostly blue light.  We can see this effect below.  It looks like a machine gun took out everything around the macula.  In most hypothyroid diabetics the macula also loses its yellow pigment and this tells me the blue light hazard is chronic in their eyes.  Yellow pigments come from lutein and zeaxanthin of the xanthophyll family of carotenoids that are loaded in my survivor soup Patreon post.  They are yellow to preserve the sharp central vision of the macula and absorb any stray blue light as a complementary color.  Blue light causes visual blur when your macula is damaged.  Many diabetics have this before they get diagnosed.

On the left below, you see the control where the red specks are mitochondrial and in the center, the mitochondria vanish under the blue light hazard.  On the right, you can see where IR-A light with blue is protective of some of the photoreceptors.

Hey Andrew do you remember what Rick told us in the podcast when was using my advice to mito-hack himself back to health he told you he noticed when he flew in planes from Costa Rica to California he would always lose his tan quickly and he could not figure out why?  Are you connecting any dots yet Andrew?  You know when you disconnect from the Earth and are not grounded to Earth to close the circuit so this would act to speed up the migration of cells not sensing UV light on the surface.  This would cause melanosomes to migrate inside of you following their embryonic neurulation tract.  This is why people lose their tans.

Remember Gurwitsch’s work on mitosis here.  What did Gurwitsch find Andrew about UV light in onion roots in 1923?  The video above shows that at the 16:00 mark.

Now let us have a look back in the eye where POMC and DHA are at the highest level in the human brain.

When you look at this and see “mitosis” and death and you realize those are migrating cells from within that only migrated to the surface skin to deep inside the skull to get to the UV light and when they got there then mitosis showed up on the surface = “neuroectoderm psyops“.

Now for the big bow on the present I gave you during the podcast @hubermanlab

LET’S REVIEW THE LESSON:  Thyrotropic-releasing hormone (TRH) released from neurons in the paraventricular nucleus of the hypothalamus is stimulated directly by the hormone, LEPTIN via the leptin-melanocortin pathways.

MASSIVE BLOG POINT: Leptin normally increases melanocortin (α-MSH) and it is required for TRH expression!   This means people with hypothyroidism cannot make POMC or melanin well!!  This means their longevity will be cut.  This is why hypothyroidism is a gateway disease to many others and leads to an earlier demise.  Those with hypothyroidism need massive solar exposure to change this outcomes.  This also implies that hypothyroid patients should have worse outcomes from melanin-related diseases, and they DO!

This makes their skin pale, and these people will also seem to burn more and not know why.  Many will develop autoimmune conditions in the skin and gut and their docs will remain impotent to know why.  Many will tell you they are allergic to the sun.  I just laugh at these comments.  When you know better you do better.

And this makes their tissues atrophic for sunlight = why so many humans have sun hypersensitivity.  Think of lupus, diabetics, fibromyalgia.  Look at the teeth of diabetics/hypothyroidism and you’ll notice they are more yellow than translucent white.  This is from POMC defects in dentin.  People using Big pharma drugs like phenothiazine, erythromycin, or tetracycline all mimic this sunsentivity because the drugs alter POMC cleavage.

SUMMARY

The melanocortin system anterior to the braincase in the eye where POMC begins is activated by UV light and by blue light in the sun.  It activates the TRH promoter on DNA through the phosphorylation (dopant atom of the wide band gapped semiconductive melanin protein) of the signal transducer and activator of transcription (Stat3). The Stat response element in the TRH promoter is required for the effects of leptin to occur = Leptin-melanocortin tract wisdom

LOOK AT THE TOP ROW OF THE SLIDE BELOW

TRH is present in virtually all parts of the human brain: cerebral cortex, circumventricular structures, neurohypophysis, pineal gland, and spinal cord.  TRH is also found in pancreatic islet cells and in the gastrointestinal tract. Although it exists in low concentration, the total amount in extra hypothalamic tissues exceeds the amount in the hypothalamus!

The extensive extrahypothalamic distribution of TRH, its localization in nerve endings, and the presence of TRH receptors in brain tissue suggest that TRH serves as a neurotransmitter or neuromodulator outside the hypothalamus.  TRH is a general stimulant and induces hyperthermia on intracerebroventricular injection, suggesting a role in central thermoregulation.

Aromatic amino acids that makeup melanin are all linked to this inside your skull and outside your skull.  The system is ubiquitous in humans.  How do you like me now Andrew?

CITES

1. Neuroendocrinology chapter in

Malcolm J. Low, in Williams Textbook of Endocrinology (Thirteenth Edition), 2016

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC377492/

3. Ronald M. Lechan, … Csaba Fekete, in Reference Module in Neuroscience and Biobehavioral Psychology, 2018

4. The Hypothalamic pituitary thyroid axis.  Marco Bonomi, … Luca Persani, in Encyclopedia of Endocrine Diseases (Second Edition), 2019

Finsen figured out long ago the light in the sun was the key to healing many diseases.  In 1893 he showed IR-A light cured smallpox.  No vaccine was needed.

Kellogg, or cereal fame, followed this science and found that the sun truly was miraculous.  Since the 1890’s centralized medicine has tried to demonize the sun & Finsen’s work.  Kellogg knew back at the end of the 19th century that part of the sun was good for us he and his rich friends decided to bury that truth to build an industry around food and drugs to take advantage of this knowledge.

The paper below is over 20 years old.  It says that with repeated UV exposure skin with more melanin is associated with FASTER DNA repair.    This is 180 degrees to the dermatology opinion that the sun is toxic.  This says the more melanin you have in your skin the faster you heal.

Note the color of type 2 skin to type four skin that was mentioned in the paper.  Do you notice that darker skin is a huge advantage?  Most African Americans fall into types 5 and 6 six types and many of them still get sunburn when they go out in the sun as modern humans. Do you know what sunburn means in their case?

Did you know that skin cancer rates in Type 5 & 6 skin are reduced?  Can you venture a guess why now?

People of color have a lower risk of developing skin cancer than people with fair skin tones.  Imagine that.

The paper below shows avoidance of the sun is a risk for death on a par with cigarette smoking.  You cannot make this stuff up.

OVERVIEW OF GURWITSCH’S 1923 ONION ROOT EXPERIMENT FOR REVIEW

To test the hypothesis of the “non-chemical external impulse,” Gurwitsch performed his famous “onion root experiment”. Two onion roots as even and smooth as possible were located perpendicular to each other and mutually centered, so that the tip of root No1 (acting as the “emitter” of the “impulse”) was directed toward the division zone of root No 2 (acting as the “recipient”). The authors made histological sections of the “recipient” root, and calculated the number of mitotic figures in the exposed and non-exposed halves of the root. The exposed side possessed significantly higher proportion of cells in mitosis than the non-exposed side. This phenomenon was called “mitogenetic effect” (MGE).

MGE was also detected, if a quartz plate was fixed between the two roots, and was not detected, if the roots were separated with glass or nontransparent materials ( confirmed by Gurwitsch, 1924; Reiter and Gabor, 1928a). Chemical isolation of the roots did not affect the results. Based on these and other data, the acting factor was concluded to be UV light of very low intensity, and was called “mitogenetic radiation.”

Back to the blog……………..

What are the skin and eye doctors missing?  Neither one knows about Gurwitsch’s work on mitosis and UV light, neither know that cells that can’t divide travel in our body to look for UV light release, and fewer have realized that modern lighting has totally subtracted out all UV light and most of the IR-A light leaving behind mostly blue light which causes massive ACTH release which drives blood glucose and insulin levels through the roof while also causing melanin degradation on our skin.  High blood glucose and insulin make the melanin in your skin atrophy and the lack of environmental UV light allows melanocytes to become mobile in the neuroectoderm migration patterns.  This means you cannot absorb UV light well via your skin even if you were on the equator naked.

Why?

Answer:https://twitter.com/DrJackKruse/status/1636019966947348480

As result what happens? If you cannot absorb UV light because your melanin sheets are disrupted or dysfunctional due to a lack of UV-IR-A light on your surfaces,  the melanosomes deep inside your skull and viscera begin to migrate toward your surface to find UV light at the surface.  Here is where Einstein’s relativity bites you in the ass.  Without UV light created endogenously, you lose the ability to slow electron flow on the inner mitochondrial membrane.  This is why Mother Nature put the VDR receptor there.

When this occurs in mitochondria, we lose the ability to create melatonin in mitochondria deep inside our body, and slowly over time apoptosis becomes defective.  Mitochondria and immune cells take our defective engines.  Without endogenous VUV production, these organelles and cells cannot work well.  What are the acute symptoms we see in our patients that this is ongoing slowly?  Women tend to get melasma and hypothyroidism.  Melanosomes migrate to the surface of their faces from deep in their skulls because of the surface’s use of makeup, sunglasses, and sunscreen.  A lack of UV light and extreme use of blue light drive this process.  This is why I wrote this blog below long ago.

Cancer states all have one thing in common and it links directly back to melanin biology:  Apoptosis physiologically doesn’t operate as designed because the VDR gets redacted on the inner mitochondrial membrane.  You can finally understand the Warburg effect when you understand how POMC biology and a lack of UV light are driving this process. Cancer cells have to keep bringing electrons to ECT, and this process happens because of ACTH from POMC.  65 million years ago this allowed mammals to survive without food.  Today, because UV light has been deleted for longer time periods in humans than it was 65 million years ago, new collateral effects have occurred.  A chronic cleavage of POMC – high levels of ACTH release to drive glucose and insulin levels.  POMc mimics what photosynthesis does, it creates glucose directly from light.  Mammals use blue light frequencies to cleave ACTH directly from POMc to do it when UV light is absent from the environment of the mammal.

This tells us that endogenous UV light has to be liberated in an uncontrolled fashion when this process is present in mitochondria to create a constant source of blood glucose and insulin to maintain the pace.  We know from Pritz Popp’s work when eukaryotic cells have defective mitochondria they emit more UV light.  They are designed not to release light.  Prokaryotes release 5000 times more light than eukaryotic cells by design.  This is a big clue we are using non-linear optics to signal.  It is the control arm of all biochemistry.  65 million years ago this mechanism saved mammals with a disrupted food chain on Earth.  This implies that the acute state of a lack of UV light control helps mammals survive for short periods of time. This situation told me the sun was not disrupted very long because if it was, mammals all would have died from cancer and they clearly did not.  On a chronic basis, the lack of UV light controls on POMC will drive cancer diagnosis and growth.  That is the modern burden of mammals today because this subtraction has gone on since 1893.

Blue light and nnEMF drive this process due to the products in POMC and how they operate with melanin and melatonin production.  I hinted at this in a big way in the Time 9 blog.

A lack of UV light creates chronic diseases in the mammalian system because of POMC biology. Most of what we call today’s mammalian chronic diseases really are just adaptations built into our cells.  The chronic maladaptation of light builds a facade that we call diseases.  A lack of UV light drives insulin, blood glucose, and precocious puberty on an acute basis.  Chronic UV blockade means mammalian cells on their skin cannot get into mitosis.  This makes the grow due to the insulin and growth signals and allows them to migrate.  This is why cancer is exploding in mammals in the 20-21st century.

Only electrons can capture photons.  So what makes cancer worse?  A lack of UV light or a lack of electrons in key spots is a real problem.  Another issue could be too many protons in water, which changes its dielectric constant and refractive index.  This means we cannot absorb enough UV light in water.  These biophysical factors are present in our blood, if you know what to look for, those changes will be in cells bathing in this water.  Once a clinician sees the cellular changes they know by definition what is happening on the quantum levels in hydrogen bonds in water: namely the thickness of the coherent domains in water made inside a cell from mitochondria.

This is why every patient who hires me at my clinic gets a peripheral blood smear.

This may sound tough to figure out until you realize what POMC is really doing.  Once this perspective is in your head, you can never go back to a centralized medicine mindset.  It is a game changer at the larger scales of practice. It fully explains why the Warburg shift works with glucose and glutamine to maintain ECT function while inhibiting apoptosis because UVA and UVB light cannot stop ECT flow before the ATPase.  It is wise for the mitochondriac to remember that the first step in heme synthesis also begins in the mitochondrial matrix.  So it is affected, so will your RBC and hemoglobin.  If they are the melanin renovation Rx will not work.

Anytime intracellular water production is lowered from mitochondrial respiration or physically changed in ways below your perception, proteins are less hydrated and this affects the physical chemistry of divalent ions like calcium and magnesium that work with mitochondria in stressful situations. The velocity and chemical activity of ions is determined by the degree of their hydration and the atomic mass of things in that WATER. This is why dehydration is devastating to cellular metabolism in the cytosol and in the mitochondria.  Both of these ions are paramagnetic and drawn to organelles with inherent magnetic fields.  When mitochondria are stressed their ATPase cannot spin as fast and as such their rotating heads spin less fast.  As a result, these local mitochondria begin to sense time differently, and that effect is seen in the size and shape changes in mitochondria, the formation of IMJ (pic above), and the space between cytochromes.  These are the telltale signs of cellular information loss.

MELANIN RENOVATION Rx

It begins with AM sunlight because this light is loaded with IR-A light.  This pre-conditions your skin to absorb more UV light at the transition at your particular latitude. (more on this topic later in the series)

The effectiveness of UV to induce erythema declines rapidly with longer wavelengths as we get closer to 400nm. To produce the same erythemal response, approximately 1000 times more UVA dose is needed compared with UVB. UVB-induced erythema occurs approximately 4 hr after exposure, peaks around 8 to 24 hr, and fades over a day or so; in fair-skinned and older individuals, UVB erythema may be persistent, sometimes lasting for weeks. The time courses for UVA-induced erythema and tanning are biphasic. Erythema is often evidenced immediately at the end of the irradiation period; it fades in several hr, followed by delayed erythema starting at 6 hr and reaching its peak at 24 hr. Erythema is associated with a wide variety of changes at the cell and molecular levels, but especially with the appearance of apoptotic keratinocytes (sunburn cells). The action spectrum for UV-induced tanning and erythema are almost identical, but UVA is more efficient in inducing tanning whereas UVB is more efficient in inducing erythema. The observation that the action spectrum for erythema is very similar to that for CPD induction suggests that DNA damage is an important trigger for erythema.  You will be shocked to find out that DNA damage induces ROS/RNS that melanin absorbs to charge separate water to liberate 2 electrons.  This mimics the first step in photosynthesis in plants.  This means ROS/RNS are GOOD THINGS, and they are only bad things when melanin is absent.

The story in the literature is filled with papers to fight against the dermatologist’s opinions.  Sunburns won’t give you skin cancer and they certainly not kill you.  They actually may be life-saving as the paper below shows from 1980.

SUNBURNS DO NOT MATTER. Another bad meme people spread is because they are ignorant of the effect of melanin from UV light exposure via POMC.

And the flip side of this argument is sun exposure actually leads to an all-cause drop in mortality. Burn away. I do and I’ll never change that opinion because I am a mammal and I understand my clades genesis and why we flourished when UV went missing.
****All-cause mortality: http://ar.iiarjournals.org/content/38/2/1173.full

Best time to put your Junk in the sun?

UV-B light is the off switch for sex steroids as laid out in the Vermont talk and talked about in blogs. UV-B light inactivates sex steroid creation from sterols to maximize Vitamin D production.

CRITICAL Brain-Gut POINT ALERT: When this chemical effect is CHRONICALLY present, the decision in the cell always has to be made between survival or reproduction based upon how the cell signals using its nuclear hormones.  When we are oxidized we are consuming our hormones. UV light actually inactivates our sex steroid hormones. This is another form of natural childbirth in the summer months when UV light dominates.

When we are reduced we are resupplying them in the great pharmacy in our brains by using melanin to restore pituitary POMC hormones. This means that all the LDL cholesterol that is normally made into pregnenolone will either go into cortisol OR to the progesterone pathway. If all the pregnenolone shunts cortisol’s path, it helps you survive life’s oxidation. The shunting signal that determines that choice is the level of cellular inflammation that oxidizes the cell.

Lipid POINT:  Sunlight reduces cholesterol, LDL, Lpa, and APO B too.  No drugs are needed.  Eumelanin is used to step down UV power to create a small amperage ferroelectric current that lines the surfaces of all mammals.  When that current is interrupted this is where you will see lipid accumulation, endothelial disruption, lack of NO production, and damage to melanopsin chromophores.  POMC will also be destroyed.

When we measure cortisol in the plasma, saliva, or urine, it is often low when we are oxidized chronically. That is a sign the PVN nucleus in our brain is working overtime because melanin there needs renovation, and this is a sign you are oxidizing your cells. You are aging faster than normal.

UV light exposure is the key to reducing a tissue in mammals because electrons are moved into the tissue and protons are moved out and the pH change improves the VUV light power made in the tissues. This stimulates POMC production while renovating the melanin in your cells to regenerate from stem cell depots.  The movement of electrons occurs by inducing Becker’s injury current using ferroelectricity.  The same mechanisms work in the adrenal medulla as well.

This is measured clinically by an adrenal stress index test and really accurate in a low salivary melatonin level and flatlined cortisol curve. The result is all the hormones going the “other way” in the hormone synthesis chain are very low……..that is the “reduction path”. Reduction means you are staying younger because melanin renovation is progressing.

This explains why human babies are supposed to be born during the late spring and summer.  Nature uses sunlight to lower the father’s testosterone and this fits nature’s plans on many levels in the family unit.

Sunlight increases melanin by way of POMC cleavage of the endogenous release of cellular UV light, Vitamin D3, histamine, and sulfhydryl groups while lowering (photolysis) adrenalin, steroids, testosterone, estrogen, thyroid hormone, DNA, and RNA. This is the feedback loop.  Other chemical liberated adjacent to POMC acts to lower the sex steroid hormones.

Secretion of hormones by the anterior pituitary gland can be stimulated or inhibited by paracrine factors that are produced during solar reactions.  While UV stimulates all the things in POMC including ACTH, the product of ACTH is ultimately glucose and glucose provides feedback control to decrease POMC signaling and this stops melanin production via alpha MSH.  The elevated blood glucose continues due to this feedback loop allowing all mammals to survive long periods of time without food.  This is the pathway mammals use to hibernate.  It turns out that elevated glucose acts like antifreeze in mammals and keeps their blood from freezing and it also stimulates another subpopulation of neurons that link to reproduction fitness and thermoregulation.

Kisspeptin, Neurokinin B, and Dynorphin regulate reproduction.

KNDy neurons are located in the hypothalamus region of human brains due to conservation across ALL mammalian species. Other roles of KNDy neurons include influences on prolactin production; puberty; stress’ effects on reproduction; and the control of thermoregulation.

The mature male testis has two primary functions: sex steroid hormone production and spermatogenesis both of which are needed for mammalian survival

The roles of testosterone and 5-alpha-dihydrotestosterone (DHT) in male sexual differentiation are not germane to this blog.

THE HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS

This axis is controlled by a classic feedback loop. The major endocrine stimulators of human testes are luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are made by the anterior pituitary via light coming through and energizing the central retinal pathways and secreted into the systemic circulation. LH stimulates the testicular synthesis of testosterone and its two major active metabolites, estradiol and 5-alpha-dihydrotestosterone (DHT). LH is secreted in a pulsatile pattern with peaks approximately every 90 to 120 minutes. FSH has a subtler pattern of pulsatility. LH and FSH secretion is stimulated by the pulsatile release of gonadotropin-releasing hormone (GnRH) from neurons in the hypothalamus; GnRH reaches the gonadotroph cells of the anterior pituitary via a portal vascular system.

The hypothalamus GnRH pulse generator reacts to light — The medial basal region of the hypothalamus (particularly the arcuate nucleus) contains neurons that secrete a gonadotropin-releasing hormone (GnRH) from axon terminals in the median eminence (has no BBB) into the hypothalamic-pituitary portal system. These neurons constitute the GnRH pulse generator and act as the metronome of the axis. Because serum concentrations of GnRH in the portal system are normally low, peripheral circulating GnRH concentrations are very low and not measurable in humans. Several hormones, neuropeptides, neurotransmitters, and cytokines modulate GnRH secretion.

Kisspeptin and its hypothalamic receptor, KISS1R (formerly called GPR54), play a major role in stimulating GnRH secretion, and it is likely that a synchronized interaction between the secretion of kisspeptin and the coexpressed neuropeptides, neurokinin B and dynorphin (from KNDy neurons of the arcuate nucleus), regulate the pulsatility of GnRH secretion. A number of neurotransmitters and hormones regulate GnRH secretion, including gamma-aminobutyric acid (GABA), glutamate, and leptin (stimulatory) and sex steroid hormones, corticosteroids, and opioids (inhibitory).

Kp does not work alone.  DYN A is an endogenous opioid that inhibits GnRH.

Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive functions, recent data described its action in the control of metabolism. Of particular interest for the review is the population of Kp neurons localized in the arcuate nucleus (ARC) of the hypothalamus, the site of the brain where reproductive and metabolic cross-talk occurs.

Sunlight induces biochemical reactions via photolysis and it induces coordinated endocrine adaptation effects in the eye and the skin surfaces where melanin and leptin dominate in mammalian physiology. It affects the sympathetic and parasympathetic systems where POMC dominates in these neurons.

It is the stimulus for the circadian timing mechanism of the body clock via the central retinal pathways. All these effects are built into the electronic state of your semiconductive proteins under solar power and magnetic flux.

If you re-read Brain Gut 11 you will see what a chronic low cortisol level buys us. Poor solar exposure chronically = chronic Low cortisol = low mitochondrial melatonin = epithelial cancers = Leptin Resistance = a lack of melanin in that tissue. These are the chronic effects.

Acute light stress with blue light will stimulate glucose and insulin production and precocious puberty in mammals.  Mammals used this on an acute basis to survive the interruption of sunlight and still procreate.

We tend to get cancer as we age. It follows then that oxidation = Leptin Resistance and LR = aging. Low cortisol is not a good thing for a human long term, but short term it could be adaptive.

When the process first begins……ACUTELY, you will have hypercortisolism for a time, until you fatigue the output of your PVN nucleus in the hypothalamus. That PVN nucleus is just one of the major pharmacies that function in your brain. Oxidation occurs when you cannot use the TCA or urea cycle optimally. If you do that long enough, you oxidize (age) your body, while simultaneously destroying your sleep, causing your body to slowly begin to fail while your body composition declines.

For example, Hashimoto’s disease is a disease of chronic oxidation with melanin degradation throughout the human nervous system. It depletes you of the life-giving chemicals in the pharmacy that resides in your brain. This is why it is associated with so many other neolithic diseases.  These are all due to a lack of melanin where T3 and T4 are made.  The slide below shows you melanin can be used to restore thyroid hormones.  These are reversible reactions in all mammals.

SUMMARY

Realize that the number of genes an organism has in its genome is linked to the amount of energy the organism can transform.  This means the gene expression is also directly correlated by probabilities to how it is expressed.  POMC in mammals is critical in this energy linkage.  This is a function of the energy/information flow from their environment to their skin/eyes/guts, and not the anatomy of the genome itself.  It is also related to the redox potential of the organism in question.  Ultimately, All energy in life ultimately comes from sunlight.  It is stored in every cell membrane and in the electronic state of cells.  Most of these stores of energy available to cells are not accounted for in any biochemistry book.  Get some sun today to give your genome the day off to rest once in a while.  Your health will benefit if you do.

The POMC system was built in animals before the age of mammals 210 million years ago but mammals refined and now define this ancient light system (controls their entire epigenome) and brought it to prominence in their clade when dinosaurs were dying due to an asteroid collision.

The change in light frequency from this impact is what sculpted mammals to amplify this system.  The POMC system in the mammalian skin and fur was key to their survival.  From this point in their history, they amplified POMC in all neuroectodermal derivatives and this meant they did not need more genes to advance from an evolutionary perspective as all other animals had in the past.

Fast forward 65 million years, and now humans are the trophy “mammal” on Earth.  They are at the top of the food chain of all mammals because of how they have used the POMC system to sculpt their neuroectoderm compared to any other member of the family.  This idea explains a paradox from the human genome project as well.

Scientists were shocked to find humans and primates are almost genetic equivalents.  This goes from primitive primates to humans.  POMC biology explains fully why humans (mammals) have virtually the same number of genes as their recent ancestors.  In the last 2-4 million years homo-sapiens primates have used melanin to sculpt their nervous system using a light-saber from the heavens.  Melanin biology links directly to mitochondrial redox power and this is why the energy power laws still exist in mammals.

At this point, embracing technology and nnEMF is like booking a ticket on the Titanic or getting in the car with Thelma and Louise.   The reality is this: As a result of your awesome internet connection, you’ll get an awesome connection with the hospital too!

Unless humans can make their original adaptations to our environment as rapidly as their science can alter Earth, our culture and society will continue to drive our species to extinction.  The development of a bio-physics understanding of mammalian biology is a critical prescription for the protection of the species requiring the experimental spirit of the modernist vanguard.

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I decided to share Chapter one of my new book with you this AM.  I hope you enjoy it.

All these thoughts in this book came about from starlight.

CHAPTER ONE

“THE SILENCE”

Your family defines you and what you will become.

Mammals crawled out of their underground holes and heard the silence for the first time in their lives.  That is how the scene in this chapter begins.

What is a chapter to you? In a novel, a chapter is defined as a section, or division, in a book, and it is usually separated by a chapter number or chapter title. Chapters often break the overall book topic into sections.

In reference books, chapters are still used in much the same way. They form part of an overall indexing and organizing system that makes the book more useful as a store of information. You can see how the last group of thoughts links to the present ideas getting presented so to speak.

However, in novels and narrative non-fiction, book chapters serve a different purpose.

Chapters and scenes are related, as they are both parts of a book, but they are not the same thing:

• A scene is a part of your narrative, where characters experience certain events in a particular time and place.
• A chapter is a division of your book, marked by a number or title.

In some novels, chapters contain one scene each. Sometimes that scene is so dramatic it seems like it dominates the rest of the book.  So it is with our family, the mammals.  How the began was non-descript.  They found an underground niche and because of that, they had to script a life that worked without sunlight for much of their life cycle.  As they evolved and found it safe in the world, they rapidly changed and became creates who could thrive without sunlight.

More often, each chapter of a book will contain several related scenes. In this case, the scenes are usually divided from one another by whitespace, by a typographic ornament, or by using a transition phrase in the text itself—but not by a number or title. In our family, the jump from our cousins, the chimps, to use is another stunning development in the narrative.  One that is so counterintuitive that when you hear about the process that drove it you are in stunned disbelief.  But in that disbelief, the story becomes compelling.  You can no longer look away from it.  And when you dive deep into, the details of this epoch on Earth has fueled my curiosity and kept me entertained for my entire life.  It really is why I became a brain surgeon.  I get to operate on two lobes in the front of our head which is the key difference between our species and the rest of our family.  Those two lobes are another chapter that just does not appear to fit into the story of life either.  They represent a quantum leap of change in our family and this very day, have confused most of the experts in science.  There is seemingly no good plausible explanation of how they came to be.

That story is defined by this paragraph. The living system in mammals, especially your frontal lobes are nests of abiotic carbon, hydrogen, oxygen, and nitrogen, organized together with traces of a few other elements, yet of a complexity of structure that has hitherto resisted all attempts at complete analysis because our species of biological experts do not understand how light and water bind and weave the process of atoms in things.  This makes our protoplasm the most enduring and the most easily destroyed of substances we know; its molecules are constantly programmed electronically by light to break down constantly, yet reorganize under solar power to furnish the power for the manifestations of many vital phenomena.  Yet, through its remarkable property of assimilation of light, a power possessed by few other things on earth, it constantly builds up its substance anew from the surrounding medium and it avoids our perception of its recipe.

Well, I wrote that chapter down now on a bunch of napkins on a Delta flight coming home from Italy in 2003.  You can find the details on those napkins in the Quantum Engineering series of blogs on my Patreon series of blogs.  Recalling that story makes tears come to my eyes every time I think about it.  I have tears in my eyes just writing this.  The music I put above is playing as I type this.  You’ll hear those tears in my podcast with Rick Rubin.  This chapter of my life changed me forever.  It is when I became fully decentralized.   It is where I rejected my past education and began my journey, to tell the truth about our species.

It is my favorite chapter of science I have ever written. Parts of this story have traveled with me for large segments of my life.  But how they were all tied together in the story of humans occurred for me close to 20 years ago at the foot of a statue in Florence when a few key elements in the environment came together to put the final touches of this silence reverberating in my head into a scene.  To date, that day has been the most impactful of my life.  I cannot wait to share that story with some of you with science subtracted out when my podcast with Mr. Rubin comes out.  Right now, I am unfolding the science in that scene in the chapter of my book with you now on Patreon.  It is spectacularly bold, not because of my ideas, but because of what happened to our family, the mammals.

For me, a chapter is an era of life.  I have recently realized that my own life is unfolding in the same way as the mammalian family.  Chapters that should have come earlier in my own story did not.  An asteroid interrupted my own life and caused its trajectory to change too.  I never gave it much thought until I started writing about how POMC sculpted everything that created a silly talking monkey with sunlight.  Much like the family of animals I come from, the mammals, the key chapters in my life seem to have come out of order too.  How is that for irony?  Mammals’ time in the sun on Earth, was created by an extraterrestrial event.  An event so unlikely, that the collateral effects of that impact changed the plot of life forever in a moment.  When you understand where it is in the history of life it sticks out like a sore thumb.  When you dive into this chapter, it is stunning how different it is from the rest of the story of how life unfolded on Earth before it. Modern humans love stories about who we replaced as a family.  I think we like it because when we see the carnivore bones in museums of the T-Rex it gives our species a boost of confidence that we replaced them.

That is a myopic viewpoint for sure, but it explains why we continue to see so many Jurrasic Park movies.  Hollywood scenes have tried to usurp this chapter of the book of life to boost our dopamine levels.  If silly talking monkeys were wise, they’d realize that those killing machines were taken out by something they never saw coming and the same thing is happening to us right now of our own design.  The dinosaurs, in that way, are superior to us.  They had no design flaws.  The natural environment took them out.  We come from a group of animals who seems to be an afterthought of Nature.  Her favorite mistake was designed on a rainy day when there was no sun.  Yet, in that darkness, came a recipe for future success.  It is as if this group of animals so non-discript got a boost from the heavens.  Almost like hitting the jackpot in a slot machine.  It is even more ironic when you considered who mammals replaced.

A plot twist few in this biological novel would have ever thought of. We are a biological implausibility when you get down to the brass tacks.  And this one chapter in my life for me has always transfixed me.  No matter what other chapter I am in my life, or no matter what other chapter of life I am studying from the Novel Earth has written, is more compelling than this one.   I hope you someday find a chapter in your life that energizes you every day as this one has for me.  This song above seems to resonate with how mammals came to take over Earth.

Transformational change in mammals is a state of bold total annihilation or what we were to something Nature envisioned us to be without a ton of sunlight. Her original design was optimized for a lack of sunlight.  So what happens when your main nemesis gets taken out and sunlight returns to your life, but your family is designed for long stretches of darkness sans sunlight?  This chain event is a game changer for your cells.  The adaptation to this set of circumstances can not simply be a better version of the business-as-usual approach found in every other chapter of evolutionary history.  Yes, this chapter stands out like a sore thumb demanding an explanation.  That explanation will be your transformational learning moment; it will be a shift in your context of reality and your point of view about yourself…………of that I am sure.  Why?  It has changed my entire life already.  Now it is your turn.

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In my recent weekend in Maliibu with Mr. Rubin and Dr. Huberman, many of you thought I went after Dr. Huberman centralized science.  I did not.  I went there to educate and teach.  Instead, I really went there to expose a longevity expert who was involved in the Mr. Rubin’s care.  He has been selling a lot of bad ideas around longevity, in my opinion.  I am waging a war against centralized ideas in biology.  I am not waging war against people.  I want to use centralized gurus as the “oral historians” of bad modern information to the public so the public becomes wise to call bull shit on bad ideas around their centralized beliefs in biology.  I bet this was a plot twist few of you saw coming.

I gave many examples of why that was the case but it all began with a lesson on water chemistry I gave Rick and Andrew in Malibu.  I will recount for you exactly why I said what I did in those master tapes.

Recently, Dr. Huberman did a podcast with that physician and you should watch it above.  Then I’d suggest you follow my critique below here in this Twitter thread I made this week.  Dr. Huberman warned me in early March of 2023 he was soon releasing a podcast with this expert physician because he has a book tour upcoming about longevity.

https://twitter.com/DrJackKruse/status/1638334680599613440

On March 22, 2017, I posted something on my Facebook wall that was meant to call out the bad science of Dr. Attia.  I never mentioned him in the post because of my friendship with Mr. Rubin but at the end of the post was Cite number 1 you can read it later.  I was pissed that Dr. Attia told Rick that methylene blue was nonsense and the advice of a madman because he did not know shit about the physics of cells. Actually, I was quite infuriated about it back then but I stayed quiet.  Today, you’ll get to hear who got the last laugh in this.  When Rick agreed to speak about his surgery at Stanford I knew this was my chance to set the record straight.

Now how does this all link to Mr, Rubin’s medical problem and to POMc biochemistry?

A hydrogen fuel cell converts chemical energy stored by hydrogen fuel and transforms it into electricity. Hydrogen is not an energy source. It is an energy carrier like electricity. Plants and animals both use DC electric current to regenerate. This means hydrogen recycling is the key to understanding the energy that life uses. Similar to a battery, a fuel cell with a supply of hydrogen and oxygen can be used to power devices that use electricity. While both batteries and fuel cells convert chemical energy into electrical energy, batteries store this chemical energy inside the battery itself. This means that a battery will run down, or need recharging when there is no longer enough stored chemical energy available to produce sufficient electricity to power the device connected to the battery. Rather than storing chemical energy inside itself, a hydrogen fuel cell receives a supply of chemical energy from the outside.

This chemical energy is stored in the hydrogen that is supplied to the anode of the fuel cell. A hydrogen fuel cell essentially consumes hydrogen and oxygen. When a fuel cell is continuously supplied with hydrogen and oxygen, and the product water is removed, the fuel cell can generate electricity. I just described EXACTLY what a mitochondrion does.

How can we reduce the two phosphate enzymes in POMC, as mentioned in the article I posted earlier today (3/22/2017) in the White Adipose Tissue to Brown Adipose Tissue transition? Most people think brown fat is brown because it has more mitochondria.  While that is true, the real reason it is brown is because it contains neuromelanin in it.  That is the darkest semiconductive protein humans have.  Do you know why it is there?   It is there to promote the sensitivity of leptin & insulin in fat to increase BAT transformations.  You need the DC electric current to regenerate the WAT to BAT.  Melanin is critical in that energy transformation = leptin melanocortin pathway wisdom.

Will some kind of supplements help you ask?

Answer:

No supplements work, but sunlight and cold do. Experts who push supplements should be avoided.  The sun is your best supplement for Cold thermogenesis because it creates more melanin via POMc biochemistry.  the sun also lower blood glucose because it limits ACTH release and sunlight causes us to eat less because of its actions on the innermitochondrial membrane.  This is why the VDR receptor is there.  It is also why DHA is not on this membrane.   The physics of light and water explain this atomic pecularity.

Phosphorus and the melanin family of proteins in our cells and proteins and enzymes work with the sun to charge separate water into H2 to fuel us. The sun also activates melanin in many tissues of our body to fuel us using another pathway that simulates “animal-like photosynthetic pathways”. Remember the first step in photosynthesis is also to charge separate water to get to H2. Six hundred million years ago, the fossil record displays the sudden appearance of intracellular detail and the 32 phyla. The “Cambrian Explosion” marks the onset of dominant aerobic life and when mitochondria began to be usurped by eukaryotic cells for oxidative PHOSPHORylation of fats.

KEY POINT DR. ATTIA DOES NOT REALIZE YET:  Most people do not know that POMC neurons and cleavage products control the conversion of white fat cells to brown fat cells.  Fewer people know that cold increases all by-products of the POMc/melanin system in mammals because cold induces more endogenous VUV-IR-A light inside of cells.  That light is captured by melanin and it is used to create more hydrogen, oxygen, and electrons in the first step of energy creation in mammalian cells.  It mimics photosynthesis completely.  Moreover, fewer people realize that POMc also creates glucose from ACTH cleavage just as photosynthesis does.  ACTH cleavage increases most when UV light is absent and it is replaced by blue light to create blood glucose.  Mammals used this pathway to create a fuel source for underground life, nocturnal life, and for hibernation.

Fossil intracellular structures are so similar to extant organisms that they were made with similar membrane lipids and proteins, which together provided for organization and specialization. We know life had the capability to synthesize amino acids could over 4 billion years ago, but what few people still realize is that only oxidative metabolism allows for the synthesis of highly unsaturated fatty acids like DHA, thus producing novel, specific, and highly sensitive cytosocial power to choose lipid molecular species for specialized cell membranes.

DHA (in the SN-2 position) actually controls the insertion and cytosocial behavior of all lipids in eukaryotes and uses phosphorus atoms in concert with melanin as its partners in many tissues to create H2 and two electrons. Hydrogen is not an energy source but is an energy vector or carrier for humans.  Because H+ is the lightest isotope of this atom it is least reactive to electric and magnetic fields and this makes it most likely to become a coherent energy source that will have the innate ability to undergo entanglement in quantum processing in cells.  This is why evolution chose it to be the ideal fuel source for mitochondria.   <——-Don’t forget this nugget I gave you.  

This means that hydrogen in its lightest isotopic form has to be produced from one of the primary energy sources: fossil fuels, nuclear, solar, wind, biomass, hydro, geothermal, and urban waste resources. All the energy we use, including hydrogen, must be produced from one of these three primary energy resources.

On earth, hydrogen is found combined with other elements. For example, in water, hydrogen is combined with oxygen. This is the one that chloroplasts and mitochondria concern themselves with. Nature solved its water problem when it figured out how to charge separate water that has its first ionization energy of 12.06 eV.  It is clear from this value that natural sunlight is not capable of doing it.  So Nature built an intermediary protein that was capable of increasing the power of sunlight to break the bonds in water to unlock the power of hydrogen power.

The terrestrial light conundrum for central biology to answer: How did I start my conversation with Rick Rubin and Dr. Huberman? I asked a question Dr. Attia has never asked himself.  This is how centralized half-truths in biochemistry become full lies in clinical decnetralized practice and highlights why it is so important to get things right to get people longevity.

KEY BLOG POINT INCOMING

Science knows for sure that the first step of the entire food web is to charge separated water into hydrogen oxygen and 2 electrons. What biology still cannot account for is this: The first ionization energy of water on Earth is 12.06 eV. When you look at the wavelengths of TERRESTRIAL solar light reaching the Earth you realize biology has a fundamental problem to explain using their paradigm of belief, namely that terrestrial sunlight photon energy pie chart in electron volts (eV) is: VISIBLE LIGHT: 1.65 to 3.1, UV-A = 3.10 to 3.94, UV-B = 3.94 to 4.43 and UVC = 4.43 to 12.4 eV. This indicates that magnitude of biological response has to be defined by the quantum mechanical nature of the chromophore and the quantum mechanics of electron excitation to make up this gap. Everyone knows UVC/soft Xrays of 12.0-12.4 eV isn’t building our food webs, so how do they account for this with the hydrolysis of ATP or chemiosmosis theory?

Oil is a molecule carrying solar energy.  It is made via photosynthesis.

In fossil fuels, hydrogen is combined with carbon as in petroleum, natural gas, or coal. The challenge is to separate hydrogen from other naturally occurring compounds in an efficient and economic manner. Life is all about charge separation in plants and animals. In photosynthesis, we use sunlight to separate charges. Animals use phosphorus and melanin-like compounds to do it. In animals, we use hydrophilic semiconductors (P and melanin) to do the same thing. What is the fluid of charge separation? Water.

Researchers have for years known that the thermodynamics of the TCA cycle breaks the second law of thermodynamics by a large amount.  This sent many a researcher looking for the solution to how cells create the majority of their energy.  After years of unsuccessful results, these researchers finally realized that the chemical energy released through the dissociation of a water molecule by the solid-state actions of wide-band gapped (WBG) atoms and melanin represents over 90% of cell energy requirements. These findings reveal a new aspect of cell biology, as glucose and ATP have biological functions related mainly to biomass and not so much for energy transformation. Researchers have woken up about the unexpected intrinsic property of melanin to transform photon energy into chemical energy through the dissociation of water molecules.  This role was performed supposedly only by chlorophyll in plants according to centralized textbooks. This single finding seriously questions the sacrosanct role of glucose in biochemistry as the primary source of energy and power for the cells.  Someone should inform Dr. Attia of this.

Water next to a hydrophilic semiconductor acts like an N-type semiconductor in cellular design. This makes the water adjacent next to the semiconductor carry a large negative charge.  This explains why cells have this charge.  Biochemistry dogma to this very day has no idea why the charge is so negative in a cell.  The further you go away from it the more charge is positive. What helps energize this simple battery? More sunlight does.  But it still raises the issue of how cells get to 12.06 eV to get the hydrogen and freed electrons to use.  Sunlight does change the dielectric properties of water from 78-160; this changes the refractive index in water and can alter water’s battery function positively or negatively depending on how it moves due to light in our environment.

In the zone next to the semiconductors that Robert O. Becker found in his papers on bone in the 1960s he found something he called the DC current.  This current had some interesting abilities in wound healing and regeneration, especially in bone. Becker found that this current was negatively charged. He had no idea where it came from.

Pauling, Ling, and Szent Georgyi did have a pretty good idea of where it came from based on their writings. So I followed their clues to me.  It came from the separation of water into hydrogen oxygen and electrons. In the coherent domains of water, physicists like Del Guidice, Preparta, & Mae Wan Ho have shown the water is filled with a large net negative charge inside of cells. It also turns out these electrons reside in oxygen molecules in the water.

They are usually distributed throughout the water lattice adjacent to the hydrophilic semiconductor proteins in cells. The number of oxygen atoms in dissolution seems to dictate the amperage of the DC current. The larger the amount of oxygen content dissolved in the cell, the larger the electron density present in the water.  It seems to me that a variation in oxygen will also change the emission frequencies in the LED of this semiconductive unit. This also explains why cooler water carries more oxygen.  Cooler temperatures also cause unusual actions in semiconductive currents. As temperature drops, water becomes more electron-dense, and because cold water has more dissolved O2 in it there has to be a reason why cells are using this solid-state process that is not published in biochemistry textbooks.  There is (pick above).

Wide band gap semiconductors function better as they are cooled. This means they make lower frequency UV light than even the sun can inside of your cells.  Yes, you read that correctly. This is why the pic above exists.  Fritz Popp 101.   This is at the core of why CT is powerful in all mammals. It allows for more electrons to be dissolved in the major fluid of your cellular matrix to deliver more energy by liberation of these electrons when charge separation occurs via WBG semiconductive solid state physics in melanin biology.  This is where temperature sculpts cells to do things that thge biochemistry textbooks Dr. Attia read, and why anyone who read them remain ignorant of. This is a story of how non-linear physics and physical chemistry can be explained simply for you to begin to understand why classical chemistry and biology cannot explain life fully.  Those textbooks left quite a few lessons out of the bags of tricks Nature uses.

Dr. Attia is a representative of centralized medicine, and this blog is pointing out why centralized MDs do not have a full understanding of how life really operates below the cell level.  When you understand this, how can you take their advice on longevity seriously?

Rick had enough sense before his heart surgery to ask his surgeon about my advice before his surgery because he valued my opinion.  I made this case clear to Dr. Huberman during my weekend in Malibu. Solid state actions around water chemistry are the big factor for how biochemistry works and the purveyors of centralized biochemical ideas have nothing to account for it.

Because of this simple fact, they should lose their expert status in my opinion.  I believe Mr. Rubin knew this and that is why he sought my counsel before his heart surgery and I mentioned to him he should consider methylene blue use while he was on cardiopulmonary bypass.  In the podcast, Mr. Rubin mentions that Dr. Attia had no clue about the use of methylene blue for this impending heart surgery. and did not recommend it.  I will give Dr. Attia some credit.  He looked it up after he was told I recommended it to Rick.  MDs seem to react best when they know another guy knows something they do not.  Unfortunately, that still has not got Dr. Attia to the point of change by upgrading his advice.  He is ready to assault the public with some more bad ideas in a new book.

Once Mr. Rubin’s surgery was done, Dr. Attia came back to Rick and told him that the ideas I gave him were wiser than he iniitally thought.  He saw things about methylene blue’s uses he did not know.  To date, he still has no idea how this works and no one has held him accountable for his persistent lack of curiosity until this blog.  I did this in the podcast with Dr. Huberman and Mr. Rubin, but I have a sense that part of the interview might be editted out due to friendships.

This paper below, CITES 1, shows you just how much-centralized medicine is missing about how energy from the sun is transformed in our cells.  When you know better you do better.  As a physician I want my tribe to get the best I can offer them.  I will not be advocating to anyone in my tribe about buying Dr. Attia’s new book, Outlive.

I know it will be a myopic view of the real story in cells. I can predict what he will tell you.  He will tell you that you need to exercise a lot to live long to lower glucose and insulin signaling.  He still has no idea all mammals make sugar naturally when they are in UV poor environment.  This implies centralized MDs will continue to blame food and lack of exercise as a source of longevity subtraction.  This is why they argue to hypertrophy muscles to metabolize the glucose.  That is DEAD wrong advice.

What his book cannot and will not explain is why Dr. Nir Barzilai’s supercentenarians at Albert Einstein Medical Center do not look like Dr. Attia’s advice.

Dr. Nir Barzilai, MD, is a Professor in the Department of Endocrinology Medicine and the Department of Genetics at the Albert Einstein College of Medicine.

He studies people who live over 100 years old.  Many of the things these people  have done in their lives DO NOT SQUARE WITH Dr. Attia’s advice in his DRIVE podcast.  You would think that alone would get Dr. Attia to become curious what else he has missed but to date it hasn’t.  I know Dr. Attia respects Dr. Barzilai because he has had him on his podcast a few times.  Apparently, just talking about science is not ennough to get you asking the most fundamental questions about food and exercise.  How do cells charge separate water.  Once you go down that rabbit hole your life as a centralized MD will change.

These old men and women all are chubby and have amazing cognitive abilities in their old age.  How you look is a facade.  Humans are the one mammal in the primate tree that did not bury theur mitochondrial capacity in their muscles.  they buried it in their brains and hearts.  This is why humans are dying of those diseases.  Having hypertrophied muscles won’t make you live longer.  It actually will harm you.  Why?  Energy transformation is a zero sum game due to the conservation laws in light, Klieber’s power laws, and Wallace’s idea of heteroplasmy rate with aging.  These supercentanarians mere reality is incongruent with Dr. Attia’s advice.  I want you to know it and know why it is.  I can explain exactly how it happens because I understand how POMc biochemistry works with solar power by way of solid state physics.  I can say that definitively because of the story in this blog and what happened to Mr. Rubin 5 years ago.

SUMMARY

You have to remain hostile to centralized half-truths to remain well in the decentralized framework Nature gives cells.   This is a mitochondriac credo.  Mitochondriacs are ‘illness martyrs’ in disguise.  An ‘illness martyr’ does not go against the grain, they create their own grain using the miracle called the truth. When you accept the fact that your true identity includes being an ‘illness martyr’, you will never settle for less than the natural truth. Don’t ever settle for less than you deserve, because once you begin to settle you will always default to it.  Marketers and paradigms always will push you to settle and be satisfied with their offerings. This benefits their answers for illness. They are incentivized to peddle bullshit.   Know what you deserve.  Know your worth. Know the difference between what you’re getting from the paradigm and what you deserve.  You are the most valuable asset Nature builds.  An ‘illness martyr’ is someone who feels shame in believing conventional centralized wisdom. Mitochondriacs will not settle for bullshit. When an “A” is available they have no use for the B,C, or D nonsense the supplement maker or pill pusher sells.  Those shills want the public to remain undereducated about light.  They know if you knew better you’d want the best for themselves.  Mitochondriacs always dig deeper because they have hostility for propaganda & bullshit.  Half-truths and the people who peddle them will emotionally decapitate you in your journey to optimal.   Sometimes nature requires the ‘mitochondriac’ to be overtly hostile to succeed.  Often times you’ll find being hostile for the truth is exactly the right amount of harshness you need to develop wellness.  Make no apologies when you are fighting for the truth to become the best version of you.

GAME, SET, MATCH.

Choose your experts wisely.

CITES

https://www.ncbi.nlm.nih.gov/pubmed/25645910/

https://twitter.com/DrJackKruse/status/1638334680599613440