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Your eye can be a clock or a camera. A blind man’s world is bounded by the limits of his touch and he relies on his timing; an ignorant man’s world by the limits of his wisdom; a successful man’s world by the limits of his vision and sense of timing. Man is the most complex eukaryote. Therefore he has the most sophisticated time piece in his eye that controls protein turnover. Protein turnover is a synonym for ubiquitin marking.
Eukaryotes spend 80% of their total energy budget on protein synthesis.That process is controlled by ubiquitination rates in cells. This is why you need to understand ubiquitin. Once you master ubiquitin you can use that recovered energy to reverse illnesses. Each peptide bond requires 5 ATP to seal the bond. That amount is 5 times as much that is needed to polymerize nucleotides into DNA!! Each protein is reproduced in thousands of copies, which are continuously turned over by ubiquitin to repair wear and tear. Elevations of ubiquitin marking are usually associated with higher blood glucose and ammonia levels.  This occurs because of damage in the urea and TCA cycles at Kreb’s bicycle.  Cell become unable to use beta-oxidation and protein cycles for biosynthesis.  Too many people are now blaming sugar and glutamine in cancer cases when it is clear the mitochondrial damage is making cancers have to use glycolysis and the PPP exclusively for bio-synthesis because of mitochondrial damage.  Cancer is a circadian disease in my opinion.

 

 

Medicine today treats the eye as a camera almost exclusively, when its most important physiologic role is as an optical clock. It turns out cataract formation and glaucoma are the best evidence that the timepiece in your eye is no longer working in concert with your gut, skin, or any of your cells properly. I believe all tissues contain time crystals that go awry because of a lack of sunlight during the day and a lack of darkness at night. When this occurs diseases usually follow.

 

 

 

Breast cancer patient usually has very abnormally low Vitamin D and melatonin levels when they are sampled. They rarely are because conventional oncologist DO NOT believe cancer is a circadian disease caused by mitochondrial dysfunction in the mitochondrial matrix. They also do not understand how glucose fits into this story. Most people today view elevated blood glucose as a pathologic condition related to a Warburg metabolism. That is another big error. When the clock in your eye is altered there is downstream collateral disarray in the peripheral clock genes. There is now another way to perceive an elevated blood glucose as a clinical sign of elevated ubiquitin ratios in all proteins because of a dysfunctional TCA and urea cycle.

 

 

Glucose is fully capable of braking ubiquitin cycling when ubiquitin is coupled to the cell cycle by normal solar light cycles as the picture above shows, but not when it is uncoupled and isolated due to altered solar cycles. The reason glucose has this ability because it contains a strong blue light signal in it for the SCN in the eye to provide negative feedback for the SCN. This ability is lost when light cycles are uncoupled from the nitrogen cycle in the eye or gut. When it is isolated, glucose levels go through the roof BY DESIGN to stop the PER 1 and PER 2 clock genes from turning over proteins by ubiquitin marking in cells. I believe eventually the narrative that cancer feeds on glucose will die a fiery death under the weight of new data about the PER gene products.  PROTEIN Turnover is the most energy costly activity a living thing does.

Most view the eye as a camera, but some of us see it as a optical lattice clock first.  HYPERLINK

In my recent webinar series for members on my site, (March through June 2015) I taught you about how the loss of negative feedback control in coupled biologic systems is the sentinel event for aging and disease generation. Moreover, I showed you what happens when you lose it on one side of the coupled event. There I used predator or prey to make the point. If you alter the balance of predator or prey the result is always the EXTINCTION of both animals. I have told you that in aging and neolithic disease generation that NAD+becomes altered in relation to NADH. This occurs because of defects in the TCA and urea cycles where the hydrogen is recycled from metabolic substrates to the electron carriers used in glucose metabolism at cytochrome 1.

The chronic loss of NAD+is the critical sign of a loss of negative feedback control of the ubiquitin cycle. This data scales directly to our molecular circadian clock and our peripheral clock genes (CCG’s). The LCHF cancer researchers are way off on their beliefs about the demonization of glucose in most cancers.  This same relationship also exists between the two coupled systems that control the eye clock protein timing mechanisms. When these proteins are drowned in blue light, it changes the molecular resonance coupling and this causes the extinction of the gears that control your timing mechanism in every system in your body. This is why blue light is associated with just about every neolithic disease known to man.  Where it occurs first is where diseases manifest soonest.

 

 

The current model of the mammalian circadian clock includes two interlocking transcription-translation feedback loops comprised of several so-called “clock” genes and their protein products, which ultimately regulate the transcription of “clock-controlled” genes. These feedback loops consist of positive and negative components. The positive components include the basic helix-loop-helix-PAS domain transcription factors, CLOCK, and BMAL1. These transcription factors heterodimerize, translocate from the cytosol to the nucleus, and bind to circadian E-box promoter elements that enhance the transcription of genes encoding the negative components PERIOD 1 & 2and CRYPTOCHROME 1 & 2.

This month in May 2018:  It appears my educated guess about PER1 and PER 2 in breast cancer was spot on.  Read this hyperlink.

The CRYPTOCHROME and PERIOD proteins feedback inhibit the transcription of the Cryptochrome and Period genes by blocking CLOCK/BMAL1-mediated trans-activation. The second feedback loop involves the trans-activation of the Rev-Erbα and Rora genes by CLOCK/BMAL1. The protein products of these genes compete for binding to RRE elements in the Bmal1 promoter, driving a daily rhythm of Bmal1 transcription and closing the second feedback loop. Rhythmic expression of these clock gene products produces circadian clock outputs by regulating transcription of clock-controlled genes (CCGs). At least some of these CCGs, including aanat, the gene encoding the penultimate enzyme in the melatonin biosynthetic pathway, contain circadian E boxes, which have a core nucleotide sequence of CACGTG and are activated rhythmically by CLOCK/BMAL1. Post-translational regulation, including phosphorylation, acetylation, ubiquitination, sumoylation and proteasomal degradation is also important in the regulatory mechanisms generating the circadian oscillation. All of these coupled processes become unhinged from light signaling to affect nitrogen, water, and carbon flows in cells to cause many neolithic diseases because of mitochondrial dysfunction.

 

 

SUMMARY:

Once your SCN timing mechanism goes haywire it is a matter of time before your circadian clock genes in tissues the SCN controls also goes haywire and result in diseases. What will be the ultimate result? EXTINCTION of both sides of the circadian timing mechanism and cancer is the ultimate result. Mitochondrial are self-regulated by just programs in humans.  Those programs are autophagy and apoptosis.  Melatonin helps augment autophagy by repairing mtDNA and acting as an antioxidant in darkness.  Interestingly enough, it is made first in the eye by an aromatic amino acid by sunlight.  Apoptosis is controlled by UV-A light because it releases nitric oxide which inhibits ECT at cytochrome 4 to increase cell suicide.  Cancer cannot exist with intact apoptosis.  This makes me believe sunlight is the ultimate vaccine for cancer.  The key is your skin and eye have to sense the full spectrum of the sun’s light to get the benefit.   It should be interesting to you that plants do not get cancer in nature. There is a deep reason for this that will be covered in this series. Cataracts, glaucoma, and many autoimmune conditions are earlier appearing neolithic diseases that often predate oncogenesis because of an elevated ubiquitin rate which is a MARKER for matrix dysfunction that cause abnormalities in NAD+.

CITES:
1. Herzog ED. Neurons and networks in daily rhythms. Nat Rev Neurosci. 2007;8:790–802.
2. Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, et al. Resetting central and peripheral circadian oscillators in transgenic rats. Science. 2000;288:682–685.
3. Ko CH, Takahashi JC. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;2:R271–277.
4. Munoz E, Baler R. The circadian E-box: when perfect is not good enough. Chronobiol Int. 2003;20:371–88.
5. Gatfield D, Schibler U. Proteasomes keep the circadian clock ticking. Science. 2007;316:1135–1136.

6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508210/

 

The title is provocative because contrary to popular belief a high fat diet can make you quite obese when a couple of variable are present that our modern environment favors today.

This blog fully explains why I knew I had to quit being on call and why I had to regain my time at night and weekends to remain well as I age and am afflicted by mitochondrial damage built into us by nature.  If I did not test my own biases I would have be facing different challenges then I do today.

THE BLOGS MAIN POINT UP FRONT:

Focusing in on food is losing proposition for the aging human.  This sound nuts when you first hear it but is very wise once it is fully explained so you can understand the perspective.

Black Swan mitochondriacs have learned this lesson the hard way.  They focus in on the engine and not the fuel to the engine.  The analogy is simple.  If you want your Ferrari to go 225mph constantly the main thermodynamic variable that will help you attain this goal is making sure the engine works perfectly.  If the engine is perfect it can consume 87, 90, or 93 octanes to get this goal at any one time.  If you use cheap gas over time it can affect the performance of the engine, IF YOU NEGLECT to maintain the engine maintenance. This brings up an interesting question to think about before I go full nuclear on the science.

Why do so many gurus recommend a high-fat diet to people who are aging, people with mitochondrial damage, or people with mitochondrial diseases?

Is ketosis supposed to be from the foods we eat of the liberation of fat from our own fat mass?

What good is a ketogenic diet from fat if you cannot use it because your matrix is defective? The only way to use fat is via beta-oxidation via the TCA cycle. Oxidative phosphorylation is made possible by the close association of the electron carriers with protein molecules along the inner mitochondrial membrane. The proteins on this membrane are unique, devoid of DHA (a special PUFA), and seem to guide the electrons along the respiratory chain so that the electrons move sequentially from one enzyme complex to another—with no short circuits in normal functioning.

 

 

This leads to a stable ROS signal in mitochondria that build complexity using information quanta in electron and proton quantum spin. The ROS signal is a function of oxygen content and the electrons within the inner mitochondrial membrane NOT experiencing any electrical short circuits. Does this situation persist in life?  No it does not, it varies as the distance between the proteins change and this is what aging really is. We call this heteroplasmy in biology. Short circuits become more likely and this changes the free radical signals possible while lowering oxygen levels which indirectly forces NAD+ at cytochrome 1 lower.

NAD+ stands for nicotinamide adenine dinucleotide.  It has two states, one with electrons and one without.  The electrons come from carbohydrates that grow in powerful light latitudes.

 

 

Moore circa 2010 sans “massive” technology diet

 

 

Moore (2017) on nutritional ketosis running his empire on social media

It has been widely assumed that a ketogenic diet using ketone bodies as a substrate can raise endogenous NAD+ to improve redox status but all these studies were done on nocturnal mammals who have scotopic retinas and skin. This is a very bad assumption considering that NAD+ is a FLUOROPHORE protein with a 340 nm spectral pattern. UVA light makes nitric oxide in our skin, blood vessels in our tissues to affect mitochondrial function.

 

 

This is why nature built it to handle excited electrons from foods that grow when UV light is present to a high degree.  This error has spilled over to the LCHF and ketogenic groups in humans.  For nutritional ketosis to work it has to be coupled with UVA exposure of the eye and skin because it lowers ECT and energy production in the mitochondrial matrix.

 

 

If it is done under the power of blue light, the ROS from melanopsin signaling destroys the quantization of NAD+ and NADH at cytochrome 1 to make is highly dysfunctional (picture above). This means mitochondrial damage changes the kinetics of how NAD+ can operate in HUMANS irresepctive of our dietary fuel choices. This means dietary fats can make us quite fat if cytochrome is damaged and IR-A and UVA light are absent from our life.

 

 

The recent research cited below in cite 1 (pic above) shows these assumptions might be dead wrong in humans because it appears that the ratio of NAD+ and NADH can vary independently because they are compartmentalized.  It turns out NAD+ and NADH are affected by the PHYSICAL location of certain metabolic pathways.  Different locations introduce timing and relativity to the equation, and no one seems to realize how this is affected by altered by the external lighting the animal is under to change the kinetic flux of the pathways mentioned in this blog.

 

 

For example, the TCA cycle is in the matrix, while the urea cycle is in the cytosol.  The place where they meet is called Kreb’s bicycle in research circles.  Higher quality research is needed to further identify where and when ketogenic therapy increases the NAD+/NADH ratio in humans.  The study needs to be done under both fake light and sunlight to see the real effect on human obesity because of the absorption spectrum in the inflection point of the UVA and UVB part of the visible spectrum of light.

THE INCIDENT EMF CHANGE THE FREE RADICALS MADE IN THE MITOCHONDRIA.

 

 

UV-A light makes Nitric oxide (NO). Nitric oxide inhibits electrons motions from cytochrome 3 to 4. It is a breaking mechanism to keep us thin and if you do not get any UVA and replace it with blue light from technology you just gave your body the signal to FATTEN.

These ideas will be critical in delineating specific downstream effects. This implies that a ketogenic diet could be highly fattening to humans who are blue light toxic. Blue light toxicity leads to ROS in the matrix.

 

 

There are two type of blue light Hazards known in humans. Noell et al. has described a rhodopsin mediated class 1 blue light hazard (BLH) and Ham et al. categorized a class 2 blue light hazard mediated by lipofuscin. Each cause different collateral effects because of the metabolic pathways they destroy.

Right now I believe the observation of modern humans supports this position fully and this 2018 paper from UT tells me the things I wrote in the Ubiquitination 4 and 5 blogs has even more wind in those sails than I realized when I wrote them years ago. The last cite below shows you how long I have believed that something else beside insulin was behind fattening of humans in technology 24/7.

 

 

It will be critically important in future studies to optimize the methodology carefully to ascertain if changes in the NAD+/NADH ratio are caused by changes in NAD+ or NADH solely (unlikely), or as levels of these two redox molecules can also vary independently.   This is more likely because of the circadian mechanism at play at cytochrome 1.  Supplement makers are now heavily pushing NAD+ supplements because they are betting that raising NAD+ alone varies by its concentration. That is unlikely because its effect is now known to be compartmentalized and is subject to pathway kinetic effects and flux.

 

 

Many low carb researchers/gurus have proposed that the decreased reduction rate of NAD+ to NADH during ketone-based metabolism increases the availability of NAD+ and thus alters the NAD+/NADH ratio.  There are several problems with this assumption.  The first one is that NAD+ is reduced by the addition of hydrogen to make NADH. This happens in the matrix which is a tightly regulated organelle.  The hydrogen in this location must come from the hydrogen pool in the matrix.  This is not true in all tissues in humans as the picture below shows.

 

 

For example, the heart and kidney can use alternative pathways to create NAD+. For example, the de novo synthesis (the deamidated pathway) uses the amino acid tryptophan, which is metabolized to form biosynthetic intermediates. These intermediates ultimately generate nicotinamide (the pyridine moiety of NAD+) and then form NAD+. Another pathway to NAD+ is the use of dietary vitamin B3 compounds, including nicotinic acid, nicotinamide and nicotinamide riboside, serve as NAD+ biosynthetic precursors and are salvaged from the diet (the amidated pathway) to generate cellular NAD+.

Tryptophan works with UV light from 260nm-290nm as the picture below shows. This is big time short wave UV light close to the UVC range. Why doesn’t anyone see these connections?

 

 

NAD+ is a hydride acceptor from the TCA cycle that forms the reduced dinucleotide NADH. The NAD+/NADH nucleotide pair is vital for driving reduction-oxidation (redox) reactions in energy production to oxygen in human mitochondria. Furthermore, NAD+ is a precursor for the phosphorylated dinucleotide pair NADP+/NADPH, which is required for several cellular biosynthetic pathways (Pentose phosphate pathway =PPP) and to protect cells from reactive oxygen species (ROS) made in the mitochondrial matrix.  So when NAD+ is lowered for any reason, the quantum clinician knows that the matrix is making more ROS/RNS than it should be while liberating more ELF-UV as a result.

This raises another question, where does the ELF-UV light come from?

That answer will be covered soon the QT series here and in my Vermont 2018 talk on June 1.

 

 

NAD+ is the oxidized version of cytochrome 1 meaning it is lacking an electron from dietary carbohydrate breakdown.  NADH is its reduced form of this chemical, meaning it has these electrons from carbohydrates.  Together both make up the thermodynamic couple that carries electrons from carbohydrates in humans.  NAD+ is part of the cytochrome 1 couple that carries carbohydrate electrons to oxygen in normal mitochondrial function.  It is a fluorophore-proteinthat has an absorption spectrum of 340nm which is also deep in the UV range.

KEY BLOG POINT:

The team of researchers at the University of Texas from cite 1 below has found NAD+ synthesis and consumption integrate glucose metabolism and adipogenic transcription during adipocyte differentiation. In their paper published in the journal Science, the group described their research into how glucose is converted into fat in the body.  As obesity rates continue to climb around the globe, these scientists wanted to explore why obesity is rising as NAD+/NADH couple in mitochondria is defective.  None of them realize that nnEMF cause AMPk amplification and more glucose to be spilled in the blood because cytochrome 1 is destroyed by the frequencies of light used by modern communications.  The defect can be enhanced by blue light toxicity in the skin and eye because as melanopsin is ruined, melatonin is lowered and we cannot maintain our mtDNA to keep the cytochromes in ECT working well or replace them.  UV sunlight helps us eat less by the design in our mitochondria.

 

 

They do not seem to realize that UVA light from the sun has to excite these electrons to get the effect.  Just eating tremendous amounts of them does nothing but cause them to go to storage via the NAD+ PPP pathways.  They also do not seem to be aware that the H+ need to make NADH whole again must come from the mitochondrial matrix.  It cannot be in any other isoform of hydrogen.  The May 2018 webinar laid the foundations out for you.

 

 

If these light conditions are NOT met on the skin and eye,  NAD+ will remain abnormal.  This is why blood glucose rises.  The electrons cannot be fed in if cytochrome 1 is nonfunctional.   As blood glucose rises, insulin secretion increases as a collateral issue from beta cells and this causes the fat mass to expand.  The cause of diabetes is really mitochondrial dysfunction and not an insulin driven mechanism.  This is why the UT researchers remain confused.  They do not realize where the pieces fit.

 

 

NAD+ synthesis is compartmentalized and within several membrane-bound organelles associated with the outer mitochondrial membrane via the Tensegrity system.  It is synthesized in distinct subcellular compartments by three different synthases called NMNAT-1, -2, and -3 as the picture shows.

 

 

KETOSIS IS SUPPOSED TO BE USED FOR OUR OWN FAT OR  IN WINTER, NOT 24/7.

We are designed to use our OWN fat in the subcutaneous space in autumn and winter to run these programs when UVA and UVB light are absent.  Eating fat is not the same idea.

Eating a high-fat diet is one way to raise NAD+, but eating this way poses a risk if the mitochondrial colony in that person’s tissues cannot effectively use beta-oxidation of the TCA cycle.  In this case,  the nutritional ketosis drives an increased adipogenesis via adipogenic signaling that is rapidly induced by the cytoplasmic NMNAT-2.

This isoform of the synthetase competes with a nuclear version called  NMNAT-1 for the common substrate, nicotinamide mononucleotide.  This chain of events leads to a precipitous reduction in nuclear NAD+ levels.  This signal inhibits the catalytic activity of poly-adenosine diphosphate (ADP)–ribose] polymerase–1 (PARP-1).  This is an NAD+-dependent enzyme that represses adipogenic transcription by ADP-ribosylating the adipogenic transcription factor C/EBPβ. So when somebody advocating a high-fat diet in the face of mitochondrial damage due to a chronic non-operational cytochrome one, you can get quite fat from eating fat. 

 

 

This is especially true when the TCA cycle is dysfunctional for any reason.  Blue light toxicity cause breakdown of the outer mitochondrial membrane and this allows deuterium to enter the TCA and urea cycle.  This destroys the kinetics of the NAD+/NADH couple.  It has many more collateral effects.   Most people in the LCHF community have no clue this mechanism exists because they do not read mitochondrial papers carefully.  In fact, the reversal of PARP-1–mediated repression by NMNAT-2–mediated nuclear NAD+ depletion occurs in response to adipogenic signals which drives adipogenesis in humans.

This is the dominant way technology use causes obesity via the melanopsin signaling in the eye, skin, and fat.  I call this the Jimmy Moore effect.  Why?

As NAD+ drops because of its own metabolic consumption, there is a serious loss of information transfer in mitochondria.  This is why low NAD+ levels are associated with aging and obesity and many other chronic diseases.   If your TCA and urea cycle are broken, oxygen levels also drop.  This drop in oxygen means the cell CAN ONLY use glycolysis and the PPP to drive biosynthesis.  

IS NAD+ AFFECTED BY THE PPP?

Yes it is.

NAD+ is broken down into nicotinamides and ADP-ribose that feed into the PPP.  Glycolysis and the PPP are older metabolic pathways involved in cell biosynthesis that operate in lowered oxygen environments with poorer redox capability.  These two pathways also get pulled into double duty when the TCA or urea cycle are non-functional because of the blockade at fumerase.  Fumerase is where both of these cycles meet at the cell membrane.  This situation is usually caused by cell membrane damage in the mitochondria which unleashes deuterium in the matrix where these two pathways meet one another.  These two pathways were favored by the first two kingdoms of life prior to the Cambrian explosion and early after the Cambrian explosion before atmospheric oxygen spiked for mitochondria to take full advantage of the electron negativity to pull electrons with some force toward oxygen. This means that NAD+ must be resynthesized in some fashion FAST enough for a normal cellular function to continue. Many researchers have noted that some prior papers have suggested that lower-than-normal levels of NAD+ can alter metabolism, leading to higher disease susceptibility.

 

 

Is there another way to help NAD+ levels when the TCA and urea cycle are functioning poorly?  Yes.  We can use polyphenols that affect the sirtuin axis.  This is why I am fond of high polyphenol wines from high altitudes.  They have two beneficial effects on hydrogen for the NAD+/NADH couple.  The second way they operate is that these grapes are grown with deuterium depleted rainwater at higher altitudes and latitudes.  I have found some coffees can do this as well and will be talking about them in the future.  In particular, NAD+ functions as a co-substrate in deacylation reactions which are carried out by the sirtuin family of enzymes. These NAD+-dependent deacylases control several aspects of metabolism and a wealth of data suggests that boosting sirtuin intake may affect the endogenous activity NAD+.  The mitochondrial sirtuins control metabolism and information transfer in the matrix by coupling NAD+ consumption with deacylation on critical lysine residues of metabolic proteins in the mitochondria, thereby regulating flux through cellular metabolism  This requires the use of some salt and a higher saturated fat diet regimen loaded with seafood and pork.  Soon you’ll find out why this is the case here on Patreon.

 

 

CITES:

1. Keun Woo Ryu et al. Metabolic regulation of transcription through compartmentalized NAD+biosynthesis, Science (2018). DOI: 10.1126/science.aan5780

2. Achanta L. B., Rae C. D. (2017). β-Hydroxybutyrate in the brain: one molecule, multiple mechanisms. Neurochem. Res. 42, 35–49. 10.1007/s11064-016-2099-2

3. Ahn Y., Narous M., Tobias R., Rho J. M., Mychasiuk R. (2014). The ketogenic diet modifies social and metabolic alterations identified in the prenatal valproic acid model of autism spectrum disorder. Dev. Neurosci. 36, 371–380. 10.1159/000362645

4. Belenky P., Bogan K. L., Brenner C. (2007). NAD+ metabolism in health and disease. Trends Biochem. Sci. 32, 12–19. 10.1016/j.tibs.2006.11.006

5. Boison D. (2017). New insights into the mechanisms of the ketogenic diet. Curr. Opin. Neurol. 30, 187–192. 10.1097/wco.0000000000000432

6. Bough K. J., Rho J. M. (2007). Anticonvulsant mechanisms of the ketogenic diet. Epilepsia 48, 43–58. 10.1111/j.1528-1167.2007.00915.x

7. Bough K. J., Wetherington J., Hassel B., Pare J. F., Gawryluk J. W., Greene J. G., et al. . (2006). Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann. Neurol. 60, 223–235. 10.1002/ana.20899

8. Braak H., Braak E. (1998). Evolution of neuronal changes in the course of Alzheimer’s disease. J. Neural Transm. Suppl. 53, 127–140. 10.1007/978-3-7091-6467-9_11

9. Branco A. F., Ferreira A., Simões R. F., Magalhães-Novais S., Zehowski C., Cope E., et al. . (2016). Ketogenic diets: from cancer to mitochondrial diseases and beyond. Eur. J. Clin. Invest. 46, 285–298. 10.1111/eci.12591

10. Brownlow M. L., Benner L., D’Agostino D., Gordon M. N., Morgan D. (2013). Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer’s pathology. PLoS One 8:e75713. 10.1371/journal.pone.0075713

11. Brownlow M. L., Jung S. H., Moore R. J., Bechmann N., Jankord R. (2017). Nutritional ketosis affects metabolism and behavior in Sprague-Dawley rats in both control and chronic stress environments. Front. Mol. Neurosci. 10:129. 10.3389/fnmol.2017.00129

12.  https://forum.jackkruse.com/index.php?threads/question-reversing-aging-by-restoring-nad-levels.11588/#post-138939

 

Can A Cocktail Of Vitamins And Steroids Cure A Major Killer In Hospitals?

Sure it can because that cocktail mimics the ketogenic diet.  In a 5 G world this might be the most common serious cause of death I expect to see spike in the next 5-7 years.  

Both ideas cause a recycling of cell water in the cytoplasm. I don’t believe keto is a weight loss Rx at its core either. It is something rather different that mimics the effect of Vitamin C in cleaning the TCA and urea cycle of deuterium at Kreb’s bicycle. Because of the shape of our teeth and the shortening of our gut humans lost their requirements for Vitamin C but it raised our needs for marine fats, iodine, and animal fat.  This fostered a seasonal ketosis that turned over the cell water in the matrix.

 

 

Ketosis is a novel seasonal way to drive matrix water replacement while autophagy can control cell membrane turnover and the movements of deuterium. In sepsis, both autophagy and apoptosis are uncoupled because of defective enzyme kinetics at fumerase, so this acutely lead to multiple organ failures quickly and causes a quick death.

 

 

 

It would be wise for hospitals to use red light in these patients rooms at the same time but they do not appear to understand that the 4th and 5th cytochrome react briskly to red light even when ECT is broken. This could be extended if windows were opened in an ICU to allow UV-A light in to patient room to help re-establish apoptosis. Another helpful adjunct would be the use of IV DDW. To date no one has tried this in the literature as far as I can tell.

 

 

This is so powerful, that in some cancers ketosis can exhibit synergistic antitumor activity and preferentially kill tumor cells by autoschizis, a novel type of necrosis characterized by exaggerated membrane damage and progressive loss of organelle-free cytoplasm through a series of self-excisions. During this process, the nucleus becomes smaller, cell size decreases one-half to one-third of its original size, and most organelles surround an intact nucleus in a narrow rim of cytoplasm. This narrow rim is the key marker for extreme turnover of cell water.

 

 

The key in sepsis and cancer is to change the fractionation of hydrogen in the cytosol. In sepsis, the cytoplasm becomes acutely overloaded with deuterium, but in cancer, it is a chronic change. In both cases, the cytoplasm is loaded with the wrong type of hydrogen isotope used in the urea and TCA cycle. While the mitochondria are condensed, tumor cell death does not result from ATP depletion.

 

 

CITES

https://www.npr.org/sections/health-shots/2018/05/11/609149556/can-a-cocktail-of-vitamins-and-steroids-cure-a-major-killer-in-hospitals

 

Many people have heard me use the term zip code in discussing quantum biology, but no one has ask me what I mean by it. What is “zip code” to you? I believe our zip code is the quantum fingerprint in nature we resonate with PROPERLY. Each hour of every day at every location has its own distinctive color, a family of frequencies, and a particular odor. Some of the smallest details inside of cells pay attention to these things. Nature always provides a solution, and our mitochondria was built how to solve the cipher. Our senses have to be blinded to the mystery. We can overcome that haze of understanding only if we know where to look for the answers. Life provides a myriad of vibrations but some resonant with us more than others. That is our connection to the whole. If we only live through the eyes of the others and don’t try to capture the vibration of our own individual experience, we may miss out the beam and brilliance of authenticity that is essential to move forward in nature. Allow no one and no thing to cause a schism between you and your intuition. Disorder creates connections──and that is the resonance life is built on.

 

 

ENTROPY = disorder.  Resonance creates an order from the disorder.  The probabilty of things in us and things in the sun and Earth cause a connective coupling called a correlative novelty.  ‘Correlated novelties’: are  a big thesis in how entropy drives the arrow of time in quantum thermodynamics. The more entropy we dissipate the more time become irreversible.  This is why we perceive life as we do.

HOW DOES THIS HAPPEN?

In life, as everywhere in the cosmos there exists a struggle between in matter, both biotic and abiotic. Chaos is entropy in abiotic systems and it turns out entropy appears to organize biotic systems without energy either. (represented by fear in biotic systems) Entropy appears to lead to an order which can organize into a zero entropy state of matter than keeps life far from equilibrium. If there’s a kind of physics behind biological teleology and agency, it must have something to do with the same concept that seems to have become installed at the heart of fundamental physics itself: information. Biophysics is as much about how mitochondrial create the energy flux as it is about how it processes environmental information accurately. To extract meaning from information or from energy something has to know how to do it. How does this happen? It appears this information in cells is harnessed using water’s shape shifting liquid crystalline abilities under solar powers direction.  According to thermodynamics, the capacity to extract useful work from the energy resources of the universe is always diminishing.

A mitochondria is ‘demon’ who deals in information and heat processing and energy flux. First, for the demon to dominant, it always must have more information than we do about the environment. The organism housing this colony of mitochondria must be blinded to this information and energy. This is just another facet of the quantum Zeno effect we see in the retina and skin with respect to UV and IR light. Humans cannot see either of them, because if they could they could not use either frequency family to regenerate their tissues via autophagy.

Our colony of mitochondrial demons must be able to see or sense all of the molecules individually, rather than just statistical averages of H+, deuterium content, and excitied electrons on the inner mitochondrial membrane. And second, the colony of demons within us has intention: a plan to separate the hot from the cold using uncoupling proteins to make water liquid crystalline. By exploiting its knowledge with intent, mitochondrial demons can defy the classical laws of thermodynamics by usng quantum thermodynamics

There is a deep connection between thermodynamics and the processing of information — or in other words, is related to the computations that mitochondria must make using the quantum spin state of electrons and protons.  Mitochondria make free radicals that have unpaired electrons with a unique quantum spin state.  The matrix excludes deuterium while the blood plasma is filled with it.  There seems to be an organizing process present because of the spin state of subatomic particles that is a hidden variable that limits biologic understanding.

Mitochondria are electron and proton ciphers and accountants for these things. This happens to be why the leptin receptors in the hypothalamus are loaded with mitochondria. Rolf Landauer showed that even if the computational aspects of an information demon can gather information and move a frictionless door with no seeming energy cost in his experiments.  He proved Maxwell’s ideas about the second law was correct.

Landauer also pointed out a penalty must eventually be paid back to nature. He showed that no mitochondrial demon can have unlimited memory of every molecular motion, unless it wipes its memory clean every so often. This raises the question, is this why sleep and mitochondrial function are ubiquitous in living things? 

The best two ways to improve sleep are to observe the sunrise and block our eyes and skin from man made light once the sun sets.  

 

 

 Is this why poor sleep and mitochondrial diseases are linked?  I believe it is. All quantum computational demons must occasionally wipe its memory clean — forget what it has seen and start again — before it can continue harvesting energy and information simulataneously. This night day on off switch is likely why most of the biologic cycles are feed by the sun’s energy and information of night and day.  This act of information erasure has an unavoidable price: It dissipates energy, and therefore increases entropy. And that increase of energy does not go to waste in living systems.  We use the increasing entropy to ORGANIZE information we collect.

It seems to me living quantum systems are expert in the information sharing side of the equation to organize and minimize chaos using biomolecules from the mitochondria to other parts of the cell, while extracting massive amounts of information about the universe they exist in.  Two groups of researchers found in 2017 that the quantum information describing the particles’ energy and quantum spin states can act as a kind of currency that enables trading between the reservoir’s energy and angular momentum supplies. 

This has a big implication for mitochondriacs because this organelle deals in deciphering and creating the quantum spin of electrons and protons and the information and energy they contain. The deciphering and creation of spin varies as the power densities of seasons changes as the planet moves around the sun. Electrons have quantum spin and they have information about the seasons in the power of photons that excite them. The spins of electrons can be altered in mitochondria to make free radical signals which can be used to drive decision making processes inside of cells. This will alter biochemistry within the cell. The quantum spins of protons also can be sensed by the mitochondria because the mitochondria generates a magnetic field and H+and D have two separate magnetic moments that will act differently within the same magnetic field. This difference is like a binary change in a computer that can be used quantum computation to decipher the information contained within the message.

More over, protons spin is also sensed by the mitochondria because all the channels in the mitochondrial matrix are quantum nanomachines that are built exclusively for H+ and not for the larger atom of deuterium. The level of deuterium in the matrix therefore also simulates the season inside the matrix of the mitochondria.  This alters the metabolic rate of the mitochondria as well.  All of this is programmed by light and is how ZIP CODE is coded for inside of us.

The more deuterium that is present, the more swelling one should expect. This shows you why thermodynamics and size and shape changes within the colony of mitochondria in tissues can be sensed macroscopically by our sensory systems in our thalamus. This alters the Tensegrity of the system. The human thalamus also has normal resonant frequencies it is tuned too.  That frquency is the Schumann frequency of the Earth.  Think of it as the electric and magnetic heart of Earth that is communicating with your thalamus.

Living quantum systems achieve a non equillibrium state, by capturing and storing information in our subatomic particles through the entrie system. Mitochondria are the key part of cells that are capable of doing these computations using free radical creation and the movements of hydrogen to build organization in a cell. The nucleus cannot do these computations in eukaryotes. Mitochondria offload most of the information to the nucleus by changing small poteins made by mitochondria carrying data to change the activity of the nuclear genome.  This information is encoded and stored magnetically in their nuclear genes and passed on from one generation to the next via the germline. 

 

 

This is a set of instructions for reaping a non equilibrium state by using the negative entropy built around the quantum spin states of electrons and protons. This is why most repicative structures in nature offload deuterium to their seeds and offspring. It can be used to anchor points in the organism like a thumb tack to align the body plan in the immature state in space and time using magnetic energy as the glue. Deuterium has a stronger magnetic moment and it also has a stong kinetic isotope effect to act as a buttress and trusses in body plan construction in cell membranes. The added mass allows the blueprint to drive all growth and metabolism into the adult form as excited electrons are pumped into the system and trapped by mitochondrial mechanism to build complexity. Mitochondria and DNA are examples of aperiodic crystals that go by another name called liquid crystalline quasicrystal. These are more time crystals in us that resonate with the sun and Earth vibrations. How they vibrate changes as the environment changes. Cells are designed to keep the nuclear genes tightly coiled and this changes what they can sense. This is akin to how the fret board works on a guitar. As fingers compress a string the frequency changes. This change alters signaling throught the time crystals. All of this is transferred over protons in water to all parts of the organism. The exclusion zone of water is life’s main crystal. This crystal has a different physical characteristics when light hits water made in a mitochondria (DDW).

 

 

AM sunlight has a specific resonance for EZ water. It is blue and red light vibrating together that programs water. Artificial blue light from tech screens changes the resonance in water. This results in a changing free radical signal in the central retinal pathways of the retina and can lead to mitochondrial damage in the pathways that lead to the central clock mechanism in the SCN. It is called the blue light hazard and well known. There are two types of blue hazard caused by different frequencies of blue light which changes proteins in the retina. Blue light also lowers ocular melatonin in the central retinal pathways and this lowers the efficiency of autophagy and apoptosis.

UVA increases melatonin and nitric oxide (NO) in blood vessels in skin and retina. NO inhibits ECT of mitochondria and this increases apoptosis to get rid of pre-cancerous cells with poor time crystals at Kreb’s bicycle. How? NO inhibits the flow of electrons in ECT and this is the signal that cytochrome 4/cardiolipin complex need to allow apoptosis. Cancer cells must inactivate apoptosis so they can become immortal as I laid out in the May 2018 webinar. Blue light thins the retina because of the altered free radical signals generated in the damaged mitochondria and this does not allow a normal NO signal to make other signaling molecules. To get NO and melatonin you need AM UV-A and IR-A from the sun. These frequencies improves autophagy and apoptosis via resonance.

Examine this graph. The sun hasn’t changed much in 4 billion years but screen use and blue light exposure certainly has. This is how a change in light zip code can ruin your ability to see.

 

 

It turns out discrete time crystals (DTC) have another characteristic that will interest you. In physics they are forbidden to occur in equilibrium situation. Life is built far from equilibrium.

The discovery of time crystals might sound pretty abstract, but it heralds in a whole new era in physics – this is going to help quantum biology supplant the old guard in biology. Darwinian evolution is now on a death watch. For decades we’ve been studying matter that’s defined as being ‘in equilibrium’, such as metals and insulators. But it’s been predicted that there are many more strange types of matter out there in the Universe that aren’t in equilibrium that humans haven’t even begun to look into, including time crystals. It turns out all living systems are made of these things. And now we know they’re real. The fact that we now have the first example of non-equilibrium matter will change perspectives on what is possible in biology. It will lead to breakthroughs in our understanding of the world around us, and the quantum process biology inside of us, as well as new technology such as quantum computing. Mitochondriacs will be on this leading edge.

 

 

The current definition of a crystal is based on the currently known catalogue of periodic and aperiodic crystals. Scientists currently do not know of any materials that have aperiodically ordered structures beyond incommensurate crystals and quasicrystals. The definition of a crystal also reflects the lack of understanding of what constitutes order in matter, and in this sense should be seen as a working definition that may well need to be revised in the future. In crystallography, order is linked to diffraction, which makes sense because diffraction is the method of choice to experimentally determine the structure of a solid.

The human brain is very skilled at detecting patterns and recognizing order in a structure, and ordered structures permeate cultural achievements of human civilizations, be it in the arts, architecture or music. The ability to detect and describe patterns is also at the basis of all scientific inquiry.

In 2009, Sharon Glotzer and her group at Michigan discovered that entropy, a concept commonly conflated with disorder, can actually organize things!!!  Her group’s simulations showed that entropy drives simple pyramidal shapes called tetrahedra to spontaneously assemble into a quasicrystal — a spatial pattern so complex that it never exactly repeats.

Water also uses these rearrangments when sunlight hits water in our tissues like blood via our skin.

It appears life’s time crystals is built from disorder to give all living things its arrow of time.  Our eyes, skin, and gut are examples of time crystals.  How ironic, but fitting, considering the counterintuitive nature of nature’s use of quantum processes.

It appears that cells have figured out how to utilize these queer processes close to 4 million years ago.  It looks like water was the stage the show was built upon.  The vibration of proteins stable on early Earth then began to vibrate with water and sunlight and the process of evolution began.  It wa smillions of years before all the kinks were worked out in DNA and RNA mechanisms to select the proteins that resonated with the light that fell from the sun.

 

 

This discovery was the first indication of the powerful, paradoxical role that entropy plays in the emergence of complexity and order in all forms of matter. This principle is not just isolated in abiotic atoms. It appears in biotic systems too. Hemoglobin and porphyrins are well known biologic liquid crystals.  Crystals are paradigms of ordered structures. Crystals are capable of doing amazing things to light rays from the sun or re-radiated light rays from other crystals in cells. While order was once seen as synonymous with lattice periodic arrangements, the discoveries of incommensurate crystals and quasicrystals has led to a more general perception of crystalline order, encompassing both periodic and aperiodic crystals. The current definition of crystals rest on their essentially point-like diffraction.

 

 

Cells use biophysical levers contained in light frequencies to control biochemical circuits using photo-electronic circuits. Life has used photonics for 3.8 billion years.  Humans have been toying with this process for 6-8 thousand years.  The remnants of those hacks can be seen in monuments man left scattered across the globe.  Photonics can overcome the high-speed electronic interconnect bottlenecks common in electronic circuits. Direct optical connections between processing elements provided many advantages to Mother Nature in building living systems. These include low signal loss, minimal power requirements, high efficiency, and data transfer over fiberoptic cables that provide massive connects to all parts of the system with minimal energy or information losses.  Is there an example we can use in a cell to make the point?

Single tubulin proteins, for example, follow precise rules of chemistry and physics to spontaneously self-assemble, or polymerize, into the microtubules essential for cell transport and motility. The proteins’ binding interactions effect rules that specify how the pieces fit together to form the resulting structure. They also specify when and how tubulins assemble from a nucleation complex—a molecular algorithm governing the logic of polymerization. Mother Nature created an culture of connectiveness in tissues linking to the colony of mitochondria in our tissues. No cell is untouched in photonic circuitry. Tubulins form microtubules in the brain. Inside of them water is found confinded at small scales.  Water confined at 30 nm reacts very differently than water does at 1.4 nm.  Life wants the water a mitochondria makes confined at small scale.  This is another reason this water has little deuterium present in it.   At one end of the tubulins the openings are larger and at the other end the spaces is smaller by design. This is designed to confine water to harness its optical abilities when it becomes a special liquid crystalline structure where the quantum thermodynamics is allowed to occur.

These complex structures self-assemble with remarkably few mistakes. Though considered quite simple, little is understood about the principles that govern programmable structural order underlying this type of spontaneous self-assembly. We now have clues it does not require energy to occur. Darwinian evolution should no longer be a special state or case of matter, but thought of as a more general phenomenon of how biophysical processes naturally organize matter using the operational laws of quantum mechanics on a planet. 

The local star of that planet provides most or all of the power, but the thermodynamic state of the planet set the floor and ceiling of what kind and type of living systems can be built. The fundamental principles that govern how macroscopic properties emerge from microscopic interactions and arrangements really should be the cornerstones of biologic sciences. Today it is not because we are ignore the hidden variables in nature.  It appears the inherent entropy in the system is useful to self assembly. Microtubules are just another example of aperiodic crystals themselves. This mimics the picture I showed you of my rhubarb earlier in the series.

 

 

In crystals, the simplest example of spontaneous self-assembly, subunits of the whole are arranged in a repeating pattern that extends indefinitely in all directions. If you know the position of one unit in the pattern, you can tell the exact position of every other unit. Life appears to depends in large part on storing and processing information in this way.

For genetic material to carry the diverse instructions required for living processes, Schroedinger initially proposed, it must be stored in an “aperiodic crystal”. Just nine years later, it was clear that DNA is indeed an aperiodic crystal, when another physicist Francis Crick showed us that genetic information in DNA/RNA is conveyed through this irregular pattern in its matter. Much like computers, biological systems are programmed to follow a precise set of rules, or algorithms, to store information and solve problems. These biological algorithms direct actions biophysically in a myriad of ways to biochemical processes to create complex patterns and structures by chemically modifying and assembling individual components. We have to realize that biophysics and biochemical arms work in entangled fashion. If we do not teach our clinicians about these connections and patients suffer as a result.  This is what quantum thermodynamics does.  It extends the classical laws of thermodynamics to explain what life really is.

SUMMARY: 

The water your mitochondria makes, that surround your proteins is a time crystal.  Your entire brain is floating in it.  Your mindset and th eability to think is directly related to the crystalline formation possible or impossible that is developed by the water in the CSF that sits on top of your neocortex.  That is the crystal that your eye communicates with via electromagnetic pulses it senses via the retina.

 

 

All time crystals are a form of matter that “ticks” when exposed to an electromagnetic pulse—from sunlight via our eyes, skin, or gut.

 

 

Time crystals, first identified in 2016, are quite different than the crystal above. Their atoms spin periodically, first in one direction and then in another, as a pulsating force is used to flip them. You should remember that mezmorizing gif from QT#6 as an example of how this happens. That’s the “ticking of the clock mechanism.” In addition, the ticking in a time crystal is locked at a particular frequency, a specific resonance even when the pulse flips are imperfect because of the changing diurnal aspects of the sun.

 

 

This implies all of biology is applied chemistry from how light interacts with electrons and protons inside of us. Chemistry is applied physics, so every living thing on this planet runs a “resonance software program” built by hydrated proteins. These proteins are conserved magnetically in DNA. These proteins are changed by the addition of electrons, protons, and light. Proteins respond only to specific frequencies of light. They have their own ‘zip code’.

That zip code is more important than the genetic code because it is changes every second of every day we live. Our proteins are surrounded in a sea of water our mitochondria makes from substrates from food and the atmosphere which all become programmed by the sun at our current location. Proteins are quantum Garmin GPS devices fundamentally. The action of water around proteins helps quantize the electrons and protons in us to change the matter that makes us up minute to minute. Our species is constantly changing because of these unseen variations.

Evolution is not some static process that occurs slowly. It is ruthless and rapid. We just do not see or understand how the addition and subtraction of electrons orders and disorders us. Blue light and purple light change how our time crystals resonate. The change in that pattern alters what frequencies we connect to because free radicals are changed. This change, cause our resonance to change instantly. Who we were yesterday is not who we are now. That is how fast evolution is operating in us. Darwin’s version of the process leaves much of that detail out.

 

 

What we once use to respond to  at one point in our life, we remain limp too, as the light we surround ourselves changes.  What once was an abyss becomes a new echo chamber that dominates our life.  This is how electromagnetic pollution is reprogramming our us constantly.  This is how people develop tinnitus and electrohypersensitivity.   This quantized process occurs by the varying kinetic energy buried in frequencies of sunlight.  What happens if we bury the sun and build neon God’s?  This entropy causes the melody of life to change.  The beats our hearts and brains used to march to can be changed by light when we get right down to it. Light is an electromagnetic wave that gets changed to an electro-mechanical vibration by proteins and water around the protein-capture the sound blast for signaling. Changing your light environment changes your inner terrain and the dis-ease train will not be able to thrive at your station of life.  That is what “zip code” is to a mitochondriac.

What on the surface seemed ludicrous when I began this blog now suggests entropy drives order.  This now opens more questions for biology and medicine. You’ve got to question beliefs to understand nature’ innovation using the physics we know is possible. Just because something is unlikely does not mean it cannot happen. This is why I reject Occam’s razor arguments in science. What nature does not forbid will happen given enough time for the environment to sculpt the change using non-coding DNA, light, water, and mtDNA.

Photons of light come to Earth and to humans in a timeless state.  Electrons and protons in proteins in living systems pay attention and resonate with that light to absorb the energy and information light contains.  Our cells then transmute that into other waves, light and sound, which start our internal clock ticking to create time from light.  The next time you listen to a human heart beat, feel a pulse, or listen to breath, you are sensing someone else’s zip code. There is information in those waves.  You will be drawn to them or recoil from them.  This is how you connect with other living systems to build your network.

 CITES:

1. Marjorie Senechal. Structures beyond superspace. Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2015; 71 (3): 250 DOI: 10.1107/S2052520615009907

2. Uwe Grimm. Aperiodic crystals and beyond. Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2015; 71 (3): 258 DOI: 10.1107/S2052520615008409

3. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0020448

4. https://phys.org/news/2018-05-physicists-crystal.html#jCp

 

Here is a present for my Patrons and members. I told you you would all get the benefits of reading snipets from my future works if you remain a Patron. This is the “early” realease of my own biohack from 2003-2005 of my own EHS reversal from my Operating room lights and Wifi.

I have told this story to many of my patients with EHS.

After hearing it, many have made the tough decision to relocate, mitigate and rebuild their redox potential with sunlight using information quanta mechanisms that nature provides cells to relearn using light. It sound bizarre until you understand how sunlight passes information from quantum spin to orbital angular momentum properly. (Stay tuned for QT #7) Many do not do enough and they remain on their way to getting severe EHS as their immune cells lose massive amounts of information quanta from the AC power grid.

I’ve been asked my opinion if EHS can begin as a transient mild headache while in the proximity of a 50Hz or 60Hz Magnetic field (fan or transformer) and progresses as the bodies learn from the information quanta in the man-made fields of the electric power grid via the mechanism in the QT series on Patreon? The answer is yes that is precisly how EHS goes from bad stimulus to learned behavior. This can manifest as a sign of transient mild PTC by destructuration of HDW in the coherent domains of the EZ. It can cause changes or inflammation of the pia of the brain where our main SQUID is located.

In 2003 I found I was getting tuned to the things in my OR when we went to papers EMR’s. The number one offender for me was LED lights and the Wifi from anesthesia machines. I found in my hacks after they showed up in my work environment my sleep was degraded quickly so I went searching. I began concentrating transition metals because of the OR EMF and blue light the hospital added to the OR. So I started to change my OR start times and I went outside between each case to get the sun to teach my system with solar EMF’s. Therefore I knew I had to use CT when I got home in the sun with a higher fat diet to get my redox potential back in my inner mitochondrial membrane to lose weight and reduce the EHS symptoms causing my cognitive haze. I realized I had to get my ATPase spinning faster without using excess food (ECT flows) to do it. This is when I realize this is what UV-A light does for cytochrome c oxidase via its release of nitric oxide from the skin and arterioles in the skin that come to the surface when UV-a light is sensed. I also realized the”pressure wave it made was the key to making the soliton in the blood to cause the NO release.

 

 

The addition of the sun and fat increased my ability to change the water made in my matrix that was attuned to the OR nnEMF’s. I found doing this also to supercharged my P450 system via the PPP. This was an unexpected result of the hack.

 

 

This is how I learned to always choose redox over detox. The PPP gives us back the major reducing element, NADPH. I realized the H in NADPH had to be light hydrogen to properly make intracellular glutathione in cells. This is why I no longer will use the new version of IV tylenol that hospitals are psuhing for patients in surgery. I have found it reduces glutathione the most of any drug in our surgical toolbox. In fact, if one uses oral tylenol often you should drink DDW to reduce the chance of getting EHS in an altered magnetic field. The NADPH acts to recycle glutathione and the glutathione links directly to the melatonin cycle in the brain. It is also when I found out that saturated fat diets and DDW increases endogenous glutathione production. Then I found evidence for this in the literature.

That is when my life really changed its focus. When glutathione is low, we must add back UVA light to increase apoptosis and this help raises melatonin at the same time. Often EHS destroys melatonin cycles in the brain with the Vitamin A cycle. All opsins use Vitamin A to work with light. This is how I found the LED lights in my OR were making me sick. It is also when I made the prediction that melanopsin would be found in the skin. This is why skin problems develop in our patients before they get really sick from electro pollution. It is also why my profession uses Vitamin A, in retin A, to try to improve these issues. Is the redox is bad it makes on worse? If the redox is decent it can help. The smarter move for EHS people is getting AM sun when the UVA IRA transition occurs. It dawned on me then that that artificial light was fully capable of altering people to make them more electrosensitive and this change would lead to poor cogntive function that made it harder for them to think, learn, and adapt. It was why I was losing my edge in surgery for something I truly liked to do. It all occured because of the light hospitals adapted too to save money in the 2000’s.

 

 

 

Water puts the “magnetic” back in “electromagnetic.” In nature’s schematic above, a standing light wave with magnetic (blue) and electric (red) field peaks is generated in an optical photonic cavity, it acts as a resonator. As the light bounces between two reflection points that act like mirrors it transfers information from the quantum spin of particles to orbital angular momentum. This is how lasers can be tuned and how we can increase the base quantum spin number of photons. Normally photons have a quantum spin number of one.

Most people have no idea that light appears to be able to have unlimited storage capacity for OAM when we use an optical resonator. What does this physically in us? Water does this. Not the water from your tap, or the water you drink. It is done by the water your mitochondrial makes. I will be talking about this process in three weeks in Vermont at Shelburne Farms. you might want to get some tickets. You can review my talk on photosynthesis from 2016 and my talk on the retina from 2017 on Youtube. This year there won’t be a YouTube video so attendance will be helpful.

 

 

Once water is physically changed by sunlight it obtains new physical properties that give it unlimited nonlinear potential.  Researchers have now proven this to be true in several sub-disciplines of physics.  How much do you know about aquaphotomics?  If you do not, you might want to join my tribe of misfits at https://jackkruse.com/become-a-member/

If you cannot swing that join me here at Patreon.  For in-depth blogs on the coming age of quantum, biology becomes a Patron and I will teach you and answer your questions directly for the cost of a coffee a month. https://www.patreon.com/DrJackKruse

ARE YOU READY TO BECOME A BLACK SWAN MITOCHONDRIAC?

 

 

Magnetism is everywhere if you look for it. In biology, few look for magnetism and that is why they do not understand it. Most biologists know oxygen is critical for life, and since it is paramagnetic and drawn to magnetic fields you’d think this would make them understand why oxygen is drawn to the terminus of the respiratory proteins where the ATPase spins at a fantastic rate to generate a magnetic field. That one observation should change all of what we believe, but so far it has not made its proper mark. Any place life has mitochondria we are able to measure huge magnetic fields with SQUID’s, MEG, and EEG’s. We know this, but we don’t know what it means.

We detect magnetic fields everywhere, even in the “empty” depths of intergalactic space too. Magnetic fields cannot exist without causative electric currents. We learned this from Faraday and Ampere experiments. In fact, as you will soon in this series certain diets have topologic effects related to their topologic charge. This is why the vegan diet does not operate well at high latitudes. It ruins the topology of the semiconductors in our cells. This means less information can be stored in our tissues when we make poor choices. SERIOUS? Yep.

 

 

The study below in the cite shows omega-3 levels are better predictors of risk for death than serum cholesterol

A recent study published in the Journal of Clinical Lipidology looked at the value of measuring blood levels of EPA and DHA omega-3 fatty acids to assess an individual’s risk for developing certain diseases. In this new report from Harris and colleagues, the “Omega-3 Index” (the EPA+DHA content of red blood cell membranes) was measured in 2500 participants in the Offspring cohort of the Framingham Heart Study. (This group is largely made up of the children of the original Framingham study which began in 1948.) The results showed that the risk for death from any cause was reduced by about 33% comparing the lowest Omega-3 Index participants to the highest.

An update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids.

 

Review article:  Stanley WC, et al. Curr Opin Clin Nutr Metab Care. 2012.

PURPOSE OF REVIEW: Recent evidence has linked n-3 polyunsaturated fatty acid (PUFA) supplementation with dramatic alterations of mitochondrial phospholipid membranes and favorable changes in mitochondrial function. In the present review, we examine the novel effects of n-3 PUFA on mitochondria, with an emphasis on cardiac mitochondrial phospholipids.

RECENT FINDINGS: There is growing evidence that dietary n-3 PUFA, particularly docosahexaenoic acid (DHA), has profound effects on mitochondrial membrane phospholipid composition and mitochondrial function. Supplementation with n-3 PUFA increases membrane phospholipid DHA and depletes arachidonic acid, and can increase cardiolipin, a tetra-acyl phospholipid that is unique to mitochondrial and essential for optimal mitochondrial function. Recent studies show that supplementation with DHA decreases propensity for cardiac mitochondria to undergo permeability transition, a catastrophic event often leading to cell death. This finding provides a potential mechanism for the cardioprotective effect of DHA. Interestingly, other n-3 PUFAs that modify membrane composition to a lesser extent have substantially less of an effect on mitochondria and do not appear to directly protect the heart.

SUMMARY: Current data support a role for n-3 PUFA supplementation, particularly DHA, on mitochondria that are strongly associated with changes in mitochondrial phospholipid composition

CITES:

Harris WS, Tintle N, Etherton MR, Vasan RS, The Omega-3 Index can serve as a marker of overall health in older Americans. Erythrocyte Long-Chain Omega-3 Fatty Acid Levels are Inversely Associated with Mortality and with Incident Cardiovascular Disease: the Framingham Heart Study, Journal of Clinical Lipidology (2018), doi: 10.1016/j.jacl.2018.02.010.

 

Even when the experts all agree, they may well be mistaken.  This is the case with photosynthesis.  How energy and information flows is not equal.

IS OUR ZIP CODE MORE IMPORTANT THAN OUR GENETIC CODE BECAUSE OF OUR ATPase design?

Is this why I drag my members to the Yucatan yearly?  yep.

What makes Yucatan special is the Chicxulub crater?  Information and energy transfer is optimized in the ATPase at this location even in a plasma filled with nnEMF.

I need to go back and retell you the story most of your forgot.  It is incredibly important to the black swan mitochondriac to fully comprehend why it is critical.

The Chicxulub crater  links humans to their ancient ATPase and may allow them to navigate the modern 5G ecosystem well.   What connects their ATPase to the crater is the biophysics of their matrix in their mitochondria.  I spoke about this deep connection in my book, The Epi-Paleo Rx.  I still do not believe most people understand how incredibly powerful this connection is for the mitochondriac.  The picture above is the skull of the dominant animal on Earth prior to that asteroid impact.  Go back above and take a look at the picture carefully.  Without that asteroid, nothing human would have ever been present on Earth.  Dinosaurs and humans are a mismatch of species.  When you see the power of the picture above it makes you realize that a single environmental change can take out the most powerful species at any time on Earth.  Today, modern humans are now facing their asteroid in technology.

You might have missed how this crater directly coupled life on Earth today with a huge environmental shift that occurred 65 million years ago.  The two major groups of life that survived this environmental event had excessive mitochondrial capacity in their body plans.  This was the key requirement for life to survive post-event.  Photosynthesis has two prongs.  It provided energy and information to living systems via electron, proton, and photon spin, as you have learned in this series.

Photosynthesis was disrupted for a long period of time so it meant that life had to live on the edge, predominantly using information, using this capacity to survive in some way.  Light normally flows from the sun to living things on Earth.  This flow of energy and direction can be altered by many factors.  Interestingly, information flow might differ. How so?  65 million years ago it was an out of this world factor that limited energy and infromation flows that change the trajectory of ALL evolution on Earth.  Today, it is a manmade factor that is disrupting energy and information flows from nature to living systems on Earth. Much like the unbelievable sotry fo the first sailing of the Titanic, modern people have no idea that technology is biology’s iceberg.  How could this be, you ask?

The Titanic sunk in 1912.  This is what our inner cities began to look like at the same time.

 

 

These wires are located between the Earth and sun and create their own waveforms. Are waves the keys to understanding information loss?

Remember from the earlier blogs in this series I showed you as we extract more information from a system more physiologic work can be done. The flip side of the coin is that if any information is lost, less physiologic work can be done and life becomes less complex and must adapt. That is the essence of what an extinction event is all about. This is why observing humans from 1900 with normal cognitive function being rapidly altered by our environments over the last 120 years to be more afflicted by things like Alzheimer’s and autism at different times of their life is a canary in the coalmine for the black swan mitochondriac. In 1912, Alzheimers was considered a disease of the older population. Today it is not. In 1912, autism was not even discovered. It took 3 more decades of nnEMF to show up in the medical literature in 1940. This disease afflicts the youngest humans from birth to their first few birthdays.

 

 

Technology is not always progressive leading to cutting-edge change in society. It is sold to us this way by the sellers of technology gear. This is how marketing work. As I showed in the last paragraph, long periods of stability in homo sapiens is now being interrupted by Black Swan occurrences in our environment that are now leading to a branching evolution and new trajectory in our species. This is evolution in motion by causing a change in information and energy flows in nature. The collateral effects can lead to a punctuated evolution in living systems by placing limitations of wisdom in our society and our valuation of information over understanding.

 

 

DOES PHOTOSYNTHESIS HAVE TO TRAVERSE THE IONOSPHERE IN A SPECIFIC WAY TO OPERATE IN OUR CELLS?

Yep.

Do modern communications affect the information transfers in some way from the sun and Earth?  Yes they do.  How? They interrupt vibrations between the sun and Earth.  Remember all living systems are between those two thermodynamic objects.

Researchers have discovered a new role for protein vibrations in controlling the transformation of sunshine into useful energy and information in our cells.

Plants on land and algae in the sea soak up sunlight and transfer the energy using proteins holding colored pigments in cells. A pigment energized by a photon can pass that excitation energy and information in the light photon to another nearby pigment—like passing the baton between runners in a relay. By repeating this process the photon’s energy and information is carried to the reaction center where the energy can be used to produce oxygen and power plant growth.  The information can be transferred from the light photon to the orbital angular momentum of electrons, protons, and other light waves trapped within the organization of things in cells.  This is why cells are built to work far from equilibrium.  They can capture the information in light during the process of transferring energy.  Energy, charge, quantum spin, and orbital angular momentum are all conserved quantities in nature.  Your cells use each one in specific ways to harness the energy and information with high efficiency.

Scientists have long wondered how plants move this energy and information so quickly and efficiently across the large collections of pigments surrounding each reaction center.

In the study cited below, researchers focused on one photosynthetic protein known as PC645. Using computer simulations and experimental data, they found that PC645 controls where energy goes by tuning the vibrations of pigments to enhance energy transport along specific routes.  What they did not realize is that information transfer is the key controller of how that energy is transported and dissipated in a specific and sensitive way.

All proteins and lipids in you have a bar code built into their atomic arrangement that allow them to work with specific and sensitive vibrations.  This means the incoming light can offload its information in its orbital angular momentum to the quantum spin of electrons and protons in you without any time delay.  They key to the download speed is the atomic arrangement of the things in your cell.  That is the information your nucleic  acids provide to your cellular design.  That design varies within tissues.  Each tissues has a different zip code to work with information quanta transfers in cells.  The paper below only is dealing with energy transfer.  They do not realize that energy transfer is directed by information download first.   You can imagine these proteins using the vibrations of different pigments like traffic signals in your tissues that send excitations in one direction or another.  This mechanism has a name.  It is called anisotropy.

For example, when a ‘blue’ pigment is excited it could pass the excitation to a number of different neighboring pigments with similar energies. By controlling the vibrations, proteins can direct the ‘blue’ pigment to pass the excitation to a specific ‘red’ pigment thereby skipping over pigments with intermediate colors.

The unusual thing that occurs when you run the experiments in a lab, the excitation doesn’t step down an energy ladder. It jumps from the very highest rung to the very lowest rung and never touches anything in between. It makes you wonder—why does life do this? And more importantly, how does it happen?   It happens because information quanta is being transferred before energy is moved.  The ability to transfer information between quantum spin and OAM occurs faster than the transfer or energy on excitons between proteins.  The issue is the researchers never realized it because they never controlled for this effect.  Because they never control for it, they have no idea what is controlling the process.  Fodo researchers are making the same error in their papers when they fail to control for light frequencies when they perform studies on diets and biochemical pathways in a lab.  What occurs in a lab is not equivalent to what happens between the Earth and the sun.  This is why in Vermont in 2016 I said if Dr. Price was alive today he would be part of my misfits and not Sally Fallon’s tribe of food gurus.  Without understanding the details of biophysics you can never decipher the code of understanding of how nature operates.

BACK TO THE SUN

Previously, researchers thought this could only be explained by quantum effects like entanglement. It turns out we now know this is not true.  It is also why I spent so much time highlighting that the TCA and urea cycle can only operate to burn fat and protein when they inner mitochondrial membrane are vibrating at 100Hz.  Vibronic coherence—the entanglement between electron and vibrational motion—was thought to be necessary for the fast jumps between very different energy levels. However, the new research cited below suggests that what is needed is not vibronic coherence, but a large band of vibrations that bridge the energy gap between two pigments.  That is precisely what your cells are expert in producing from their DNA.

From a material perspective, this kind of classical mechanism is more useful because it’s robust to reasonable levels of disorder (entropy) that current synthetic techniques can achieve.  I warned you this entropy thing was going to be a big deal in quantum thermodynamics.  We’ll have a full blog on that soon in this series.

Researchers have to pursue further research into the quantum thermodynamic principles that form biophysical abilities of life. In my opinion, quantum thermodynamics will eventually fully explain how biologists need to begin to study how photosynthetic proteins to control and enhance the energy and information transport necessary for efficient photosynthesis. When they do tap QT ideas they can begin to use these natural design principles to help develop new technology and solar energy materials that will not harm man.

One of the key challenges is that we need better tools to study the changing interface of quantum spin to orbital angular momentum that ocurs in cells. I’ve got a sense the computer might help us get there.  How is that for irony!  Computer simulation required 10 million CPU hours and more than two years of human time to study one protein they studied.  Lesson suspended now.

BACK TO US

The atmosphere and water share a physical property by being anisotropic. You heard me use that term above.  What does this mean?  Anisotropy of an object or substance means it has a physical property that has a different value when measured in different directions. A simple example is wood, which is stronger along the grain than across it.

The atmosphere and water exhibit properties with different values when measured in different directions or perspectives.  Earth has an anisotropy at different zip codes. So does water all over the globe.  So does air in different locations.  This is what a geopathic stress zones are really all about.  The Yucatan peninsula, for mammals, is their “cradle of life” because of the biophysics of the ATPase built by our DNA.  These variances alone can alter the flow of energies and information quanta on Earth to living things.  That is what the property of anisotropy really is to the black swan.  This physical ability is born from the 3 D atomic relationships of the object in question to an energy source;  these arrangements can alter energy and information flows within and between living things.

Consider the ATPase in a mitochondria:

The Grotthuss mechanism occurs in humans  who use iodine from the marine food web to brings H+ closer together to transfer information rapidly.  This mechanism allows protons to tunnel from one water molecule to the next via hydrogen bonding.  It is the usual mechanism given for facilitated proton mobility. When hydrogen bonds are deuterated to high degree can information transfer occur from the quantum spin number of deuterium to its surrounding components in a cell?  No.  Chemical bonding slows infromation transfers.  This is why the KIE is an optical brake for information transfer.  H+ can freely move in an aqueous system like the matirx and it can rapidly transfer information in the TCA and urea cycles.

This process is very similar to that of auto-dissociation or electrolysis we see in photosynthesis; the mechanism causing the ions (H+, OH-) to initially separate because of sunlight.  People forget, charge separation of water happens as the first step in photosynthesis. Both processes increase with increasing temperature. This means that temperature favors the formation of H+ in an aqueous network. Isn’t it an interesting coincidence how mitochondria release heat by nature’s design to raise the temperature as we go away from the equator where sunlight is poor and deuterium depleted water is more common? The skeptics have left a lot on the bone for me to hammer them on this month on the Patreon blogs!!!!  I spoke about these concepts long ago without much detail here:  https://www.jackkruse.com/tensegrity-6-hydrogen-bonding-networks-water/

Why is DHA seafood H+ and sunlight all linked at the ATPase? BIOPHYSICS.

Matrix reality: One ton of ATP is turned over in 24 hours. In a marathon of 26 miles, you could turn over 60 kilograms of ATP as you run.  Running makes the ATPase Fo head spin faster.   When you consider that it takes a little over 3 hydrogen atoms (H+) to make one ATP in the ATPase, you can triple this number and then you can understand how important deuterium is to a living system. When you consider deuterium is designed to be plentiful in the blood plasma where RBC’s are, you begin to realize why RBC’s have NO mitochondria.  If they did they could not work with a deuterium fraction of 150 ppm around them.   The mammalian system in the matrix is designed to see a very much lower deuterium fractionation where an ATPase is located. Ask yourself why nature built us this way? Why is deuterium absent where mitochondria are plentiful? There is no paradox here. Where a mystery of nature exists,  a lack of human understanding persists.

Anisotropy enables for abrupt swings in the direction of flow of energy within its atomic lattice, in the atmosphere and in living tissue because of water.   Today, modern life and our atmosphere are changing rapidly in a similar situation.  Let us examine this queer physical ability.  After the KT event, the environment cooled tremendously for a long time because photosynthesis was disrupted.  This lead to massive changes in the flow of energy and information in the atmosphere to change our climate and killed off the dinosaurs.  Let us use a modern example to explain this further.

It is clear that most electromagnetic energies are capable of altered ubiquitin rates on Earth because of how the gases are changing in our atmosphere today.  C02 is rising as we use technology.  We have blamed the rise on many other things.  The thermodynamic process is linked to light’s power in quantized fashion.   The only way to increase light’s power is to increase its frequency.  We seem oblivious that light can increase its information power by just expanding its orbital angular momentum.  This is how a laser works.  It appears life is best adapted to the frequencies below the microwave range in the electromagnetic spectrum of light.  Might this be how cells build their own lasers to operate in cells?  I think so.  I will be talking about this in Vermont this year.  This is incredibly important concept.  Today, man is using the frequencies above visible light for communications without fully understanding the effect on ubiquitin marking. Anything distal to infrared rays seem to be a real problem of information transfer of sunlight to cells via photosynthesis.  It is clear to me now that the information quanta in the nnEMF photons is what is transferring the incorrect error messages to ubiquitin in our cells.  This leads to diseases.  When you visit the Yucatan, your ATPase can operate better, and over come many of the error messages that modern tech devices bring to our cells.  

CITES:

Samuel M. Blau et al, Local protein solvation drives direct down-conversion in phycobiliprotein PC645 via incoherent vibronic transport, Proceedings of the National Academy of Sciences (2018).  DOI: 10.1073/pnas.1800370115

https://jackkruse.com/ubiquitination-18-flow-and-energy-direction/