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When you watch the video above what thoughts are you left with?

Do you believe the narrative that is pushed with words, or did you pay close attention to the results you saw about particle spread in the computer test?

Do you believe they were equivalent?

Are Public Health experts now using the wearing of masks as a con man would use on the public playing three card monte?

Just being a master of public health expert, with a degree, (MPH) does not imply you are wise.  Intellect does not equal wisdom.

In the USA, OSHA controls the government regulations on what masks can and cannot do for employees.  What do their rules say?  Are they equivalent to what you’ve been force fed by the MPH ?

OSHA certification is an official certificate of competency issued in accordance with the Occupational Safety and Health Act of 1970 and represents the achievement of outcomes stipulated by the Occupational Safety and Health Administration.  Many jobs require an OSHA card before you can talk to employees about wearing of MASKS during employment.

Occupational Safety and Health Administration’s (OSHA) Outreach Training Program’s requires 10-hour and 30-hour safety courses.

I know many people who are OSHA 10 and 30 certified. I know some of you might be too reading this.

I don’t really know WHY OSHA hasn’t come forward and stopped the nonsense of mandatory mask wearing for employment but these three facts need to be considered.

• N95 masks and masks with exhale ports
• surgical masks
• filter or cloth masks

ARE THEY ALL EQUIVALENT?

No they are not.

If you dig deeper, OSHA says some masks are acceptable and some are not in certain situations.   What are those conditions?

If you’re working with fumes and aerosol chemicals and you give your employees the wrong masks and they get sick you can be sued.

• N95 masks: are designed for CONTAMINATED environments. That means when you exhale through N95 the design is that you are exhaling into contamination. The exhale from N95 masks are vented to breath straight out without filtration. They don’t filter the air on the way out. They filter it on the way in.  They don’t need to.  This means this mask does nothing to stop spread to others.  It protects you in a region where there is micron level contamination.  Is C-19 a contaminate at the micron level?  Do you know?

Conclusions: if you’re in Home Depot and a person with C-19 has N95 mask his covid breath is unfiltered being exhaled into Home Depot’s air space (because it was designed for already contaminated environments, it’s not filtering your air on the way out)

• Surgical Mask: these masks were designed and approved for STERILE environments in operating rooms.  I use them all the time. The amount of particles and contaminants in the outside and indoor environments where people are CLOG these masks very quickly. This is why they are changed often.  The moisture from your breath combined with the clogged mask with render it “useless” IF you come in contact with C-19 viral particles because this mask also blocks at the micron level.  Moreover, if the mask gets wet from breathing long periods of time you become a walking virus dispenser.  Everytime you put your mask on you are breathing the germs from EVERYWHERE you went. These masks are made for people standing at an operating table and not moving until they are done.  They should be changed or thrown out every “20-30 minutes in a non sterile environment” according to OSHA.  Have you heard that from anyone in the MEDIA?  On #medtwitter?

Cloth masks: today three people pointed to their masks as the walked by entering a store I was at.  I had no mask on. They said “Sir, you should be wearing a mask”.   I do not wear a mask without proper reasoning. I said very clearly “those masks you have one don’t work because of particle size of C-19, in fact they MAKE you higher risk for illness.

By now hopefully you all know CLOTH masks do not filter anything because of particle size.

You mean the American flag one my aunt made for me is worthless? Yes, it is.  When you where a mask like this it shows you’re OK being silenced by pseudoscience and people who are trying to alter your behavior to control you.

In fact on June 18th, 2020 what has California said on Twitter?  California will now require most of its nearly 40 million people to wear face coverings both inside and outside, when physical distancing is not possible.  HUH?

The one with sunflowers that looks so cute? Yes. The bandanna, the cut up t-shirt, the scarf ALL of them offer NO FILTERING whatsoever. As you exhale you are ridding your lungs of contaminants and carbon dioxide. Cloth masks trap this carbon dioxide the best. It actually increases risks to you health according to PEER reviewed science that OSHA offers in the courses. The moisture caught in these masks can become mildew ridden over night. Dry coughing, enhanced allergies, sore throat are all symptoms of a micro-mold in your mask.

TRUTH BOMB: N95 masks allows you to blow the virus into the air from a contaminated person as the video showed above.  But the researcher in the video never said that is what it was doing.  You’d have to know by watching carefully.

The surgical mask is not designed for the outside world and will not filter the virus upon inhaling through it. It’s filtration works on the exhale. (Like a vacuum bag it only works one way)

Cloth masks are WORSE than none.

The CDC wants us to keep wearing masks, yet the masks don’t work according to OSHA.

You can, wash your hands. Sanitize your hands. Don’t touch stuff. Wash your phone. Don’t touch people. And keep your distance. Why? Because your breath stinks, your deodorant is failing, your shoes are old and stink, that shirts not clean, I like my space. Trust me I can hear you from here. Lots of reasons. But trust me, OSHA is right, the masks do not work to prevent C-19 spread in healthy populations.

*Occupational Safety & Health Administration cited.

WHO ARE THEY?

The top American organization for safety.

They regulate and educate asbestos workers, surgical rooms, you name it.

If your mask gives you security wear it,  just know it is a false sense of security.

If stores stopped enforcing it no one would continue this nonsense.  Your employer might push you to do it until somebody throws an OSHA manual up at them and educates them.

When you are in an environment where healthy people dominate, you do not need a mask.  When you visit your elderly family at the nursing home or hospital then wearing a mask makes sense.

In mammals, hypercapnia IS CAPABLE of suppressing immune function through its inhibition of the NFκB pathway and this can set you up for higher infection risks.  Do you still think the CDC/NIH/WHO has your best interests at heart on this topic?

OR MIGHT OSHA be the one government agency who got it right it about masks?

You decide.  Do not let politicians or your employers decide for you.

WHAT IS THE SCIENCE AROUND C-19 and masks?

SUMMARY

Do the math for yourself: 1000 nanometers in 1 micron.

Viruses are measured in nanometers.

Masks filter at the level of microns.

Saying that a mask prevents C-19 is an epic fail.

Mandating mask wearing is now a form of tyranny.

CITES:

1. The 2020 OSHA manual

2.  https://www.jpost.com/health-science/could-wearing-a-mask-for-long-periods-be-detrimental-to-health-628400

Jeremy and I sat on the beach at Destin and began a discussion about happiness and wisdom as it pertains to a mitochondriac.   The audio file of the beginning of our discussion as it occurred is above.  It is pretty raw.  You can hear the surf and wind in the back round along with the music of the moment.

This is a contemplative blog……..about why so many struggle choosing nature over society’s comforts.

THE PREMISE:  When your mitochondria are hypoxic, seeking happiness is deadly because of what happens to NAD+ in mitochondria.  This implies, that constantly seeking happiness in any endevor is perilous.

WHAT ARE YOU CHASING, HAPPINESS OR WISDOM?

Humans evolved the attributes of a large brain, the ability to speak, and formed an intricate social networks that can use many aspects of technology. Our biggest attribute is the ability to think. This allows us to radically change the environment that we are ideally adapted to. It has allowed us to dominate all habitats and create havoc in most of them as well. The real human miracle of our mind is not that we can see the world as it is…but that we can see it as it is not and then change it. If we think and act incorrectly, we can quickly recalibrate and overcome it. Conversely, we seem to be a prisoner to our paleo-cortex (older, less evolved brain) and resist change even when we know it must occur. Many times we will subjugate the best interests of our survival to suit our emotional needs or desire. The real paradox of humanity is that often our reasons for the things we do are often weak but our sentiments to do them remain quite strong. Interestingly, we have overcome that liability as a species so far many times. Some of us even find comfort in that ability at times.  That comfort is dangerous to us longer term.

I believe today we are now mismatched in our environment because of our own doing.   We’ve created a world of man made light and culture and we have no Earthly idea why society is changing as rapidly as it is now.  It turns out the choices we’ve made around light and technology are sculpting our lives because of how it changes they way we think like never before.

Patients often take the longest possible paths; they digress onto numerous dead ends, and make all types of errors because of this artificial environment. Then some writer comes along and write summaries of this asymmetric, messy non-linear process.  Their writing cleans the mess and make it appear like a simple, clean symmetric straight line. Human history has been and always will be highly non-linear and unpredictable.  The use of artificial light has become a Black Swan event in evolution of life that has led us to poor thinking.  It is no longer survival of the fittest that matters, it is survival of the wisest that does.

The Black Swan asymmetry of our history allows us to be confident about what is wrong, not about what the majority believe is right.

As long as you are looking for permission for your thoughts you’ll always be behind the curve awaiting absolute proofs which don’t exist.  The truth is always an approximation of what we believe today based on the present state of data.  Few of us realize how light has ubiquitously changed our decisions around many things.

By utilizing marketable proverbs at every turn, society encourages people to “just be happy” without actually acknowledging or working through their issues.  The marketing cliches  confuses platitudes with actually doing the work to find wisdom that is buried in Nature.

When you focus on happiness as the goal you might be limiting real life wisdom.  

Every day before I die I want to do 5 key things each day to improve. Lead, grow, create, excel, serve. I lead myself and my business to fulfill my purpose of leading to changes I want in medicine, so I begin with me. I find a theme of the day and I live it that day. I try to become the change I want to see in my world. I become radioactive to the old paradigms. I try to grow myself and my business in some small way to achieve my potential. Potential is worthless without the action of kinetic energy. Daily creation of world-class leadership ideas in some way: resources, experiences, ideas. Chase excellence in all I do. I may not always be successful but I won’t allow stasis to hold my mission back. I want to serve my members, patients, clients, colleagues, and community. For too long I used to serve only myself.

The obstacle of daily accomplishment is implementation. What every starts well ends well. Sharing knowledge is easy. Implementing said knowledge is power. Behavior precedes belief. Belief precedes decisions and choice precedes action. Action precedes buy-in; it does not follow it. Are you ready for a change? Join my new tribe today. https://jackkruse.com/become-a-member/

DO LOVE/RELATIONSHIPS FOLLOW HAPPINESS OR WISDOM PATHWAYS? 

When someone loves you, the way they talk about you is different. You feel safe and comfortable and that comfort limits your actions to seek new data to obtain wisdom. Comfort breeds laziness and laziness limits action for the sake of happiness. This is why some relationships fail.  I believe an addiction to happiness has lead to our high divorce rate.

Recently a relationship guru announced their divorce on line and asked their followers not to pry into their lives.  This was an ironic statement since they made money selling the public the idea that having a good marriage was all linked to trying harder to be happy.  Here is their marketing cliches linked to happiness:

“You Have to Choose a Happy Marriage – Every morning you wake up and you get a choice. You get to choose your perspective. You get to choose how you’ll approach the day. You get to choose happiness. Every morning I want to wake up and choose to be a kind mother. I want to choose to be a good friend. I want to choose joy in my marriage. By choosing to have a happy marriage you’re more forgiving, more kind, more willing to laugh together and look for special moments to connect. Believe me, I don’t always get there but if I start the day with the intention I’m far happier than I am without it. Whether you’ve been married eleven years or fifty or a week and a half, you get to choose how to go through life together. Choose to be happy.”

Now these two guru announce they are divorcing………….and both say they are happy to do so!!!!  

Is this congruent to their marketing tag lines?   I thought the quest for happiness created marital bliss according to their logic?  

Time makes more converts than reason, it appears………….

My wisdom is different.  Love is not something you protect. It’s something you risk, always.  If you do not, you’ll settle for less than you deserve.

Our culture has been selling us happiness to the nth degree.  Marketing executives have based entire brands on telling it like it is, but when you look with a discerning eye, it looks like our culture has only been telling us what they think you need to hear.

Happiness has a time and place.  It is relative to the environment you find yourself in now.

Ralph Waldo Emerson once said, “For every minute you are angry you lose sixty seconds of happiness.”   Might anger be useful to the mitochondriac to put a limit on the quest for happiness?  I think so.

Everyone chases after happiness, but few understand where it comes from.  Even fewer realize what they have to give up to acquire it.

Happiness, without a braking mechanism leads to a life without wisdom.  Nature is all about wisdom.  Without wisdom, you become subject to marketing/media gurus.  Marketing is the art of getting the public’s mind to lie to itself using a fable.  It disconnects us from Nature and reality and builds a chasm to obtain true wisdom.  You will never be happy if you continue to search for what happiness consists of. You will never live if you are looking for the meaning of life.  All failures in Nature can be summarized as the failure to adapt.  Moreover, all success in Nature is based around successful adaptation.  The wisdom of Nature finds success using resilience in the face of adversity, not the comfort of happiness.

GENIUS IS CREATED BY OUR THINKING, NOT OUR BIRTH

I believe the quest of happiness subtracts us from the wisdom of Nature. 

I save my wisdom for my friends I value, because Nature appears to reserve her wisdom for those who follow her recipes.

I need to constantly remind people that science is the process that takes us from confusion to understanding. In this sense science is the communication path man should be using to study how nature shapes us. We have to remind ourselves that the path is fallible because of the process of nature and the nature of man.

Man always creates errors and often he fails to understand why his methodologies can create many scientific fallacies believed to be fact. Much of what man has learned and come to believe is not true in nature, it just happens to bring us closer to the truths that nature weaves. This occurs because Mother Nature’s hand is capable of erasing while she simultaneously write’s more wisdom that builds things around us.

You begin to realize in every experiment and theory there’s no such thing as a complete lie or complete truth. There’s always some truth in there and that is what science is trying to squeeze out from the pulp. Man’s duty is to distill the juice of nature with experiment, but how something is studied effects the results and this can create new knowledge or dogmatic fallacy. Realizing what was once believed to be true, but no longer is true, is what creates man’s wisdom.

Experience never errs.  it is only our judgement that errs in promising itself results as are not caused by our experiments.

Great minds ask great questions.   If the government, mainstream media, or your supplement maker can get you asking the wrong questions, these entities never have to worry about the answers you find, because they will always be immaterial.

My experiments on happiness have shown me the more happy I am, the less wise I become.  Happiness and comfort are one of modern society’s greatest half truths.

Happiness is life’s mirage.

Discuss this idea below…………….I always enjoy feedback.

We’re having a family open house day 7/4/20 for members. Details coming via email. Guest MD speakers, glass blowing, and FIRE works by Jeremy Thomley.

What is the Real Cause of Influenza Epidemics?

Influenza does not follow the predicted patterns for infectious diseases. In fact, there are several conundrums associated with influenza epidemics, such as:

1. Why is influenza both seasonal and ubiquitous — and where is the virus between epidemics?

2. Why are influenza epidemics so explosive?

3. Why do epidemics end so abruptly?

4. What explains the frequent coincidental timing of epidemics in countries of similar latitudes?

5. Why did epidemics in previous ages spread so rapidly, despite the lack of modern transport?

A theory gaining weight in the scientific community explains influenza epidemics as a result of a dormant disease, which become active in response to vitamin D deficiency secondary to a lack of terrestrial sunlight. This theory provides answers for many of the above questions. A disease that remains dormant until vitamin D-producing sunlight exposure is reduced by a winter or rainy season would explain a widespread seasonal disease with a rapid onset and decline.

There is compelling epidemiological evidence that indicates vitamin D deficiency is just such a “seasonal stimulus.” Recent evidence confirms that lower respiratory tract infections are more frequent, sometimes dramatically so, in those with low levels of vitamin D. Researchers have also found that 2,000 IU of vitamin D per day abolished the seasonality of influenza, and dramatically reduced its self-reported incidence.

The vitamin D levels in your blood fall to their lowest point during flu season, which generally coincide with low-sunlight seasons.  Low Vitamin D levels alter mitochondrial function and response.  This leads to tissue level damage in those with medical co-moribidities.  Most people with diseases have sub-optimal vitamin D levels.   Less than optimal vitamin D levels will significantly impair both arms of the immune response and make you far more susceptible to contracting colds, influenza, and other respiratory infections.  Innate system needs high levels of Vitamin D to prevent the virus from entering the cell.  The adaptive immune system is immunosurpressed by terrestrial sunlight to limit the cytotoxic storms that are associated with ICU admission and mechanical ventilator needs.

Dr. John Cannell and colleagues introduced the hypothesis that influenza is merely a symptom of vitamin D deficiency in their paper Epidemic Influenza and Vitamin D, published in the journal Epidemiology and Infection several years ago, which adds even more weight to this latest research in the Virology Journal on the effect of sunlight on coronaviruses.

Unfortunately, conventional medicine’s answer to preventing the flu is not to increase vitamin D levels via terrestrial sunlight exposure, but rather to encourage, or even mandate, flu shots. What they don’t tell you is that flu shots, at best don’t work, and at worst, can make your health worse. There is PEER reviewed papers that show that flu shots make soldiers more susceptible to future coronavirus infections.

A recent study published in the October issue of the Archives of Pediatric & Adolescent Medicine found that vaccinating young children against the flu had no impact on flu-related hospitalizations or doctor visits during two recent flu seasons.

Additionally, no studies have conclusively proven that flu shots prevent flu-related deaths among the elderly, even though this is one of the key groups to which they’re pushed.

Yet despite these findings, physicians like Dr. Danuta Skowronski, epidemiologist at the B.C. Centre for Disease Control, keep insisting that the benefits of the flu vaccine outweigh the risks for most people. That is a belief that support the grant money and salary of academics.

I wholeheartedly disagree that assessment.

If you actually weigh the benefits found by these studies (no apparent benefits) against the reported risks (fever, malaise, the flu, allergic reactions and Guillain-Barré syndrome, just to name a few), you’d have to employ some fairly odd math to come to that conclusion. When you realize the response is tied to salary and grant money only then does it make sense.

In the CBC News article here, a man who contracted Guillain-Barré syndrome and was paralyzed for almost five months after receiving his flu shot wants to warn others of the risks inherent in this widely pushed vaccine.

Guillain-Barré syndrome is an autoimmune disease that attacks your nervous system – similar to muscular sclerosis. The B.C. Centre for Disease Control estimate your chances of developing that particular disease from the flu shot as one in a million. However, if you get it, the consequences can be severe.

Research Shows Optimal Vitamin D Levels Protect You From the Flu, using Nature

In the United States, the late winter average vitamin D is only about 15-18 ng/ml, which is considered a very serious deficiency state. It’s estimated that over 95 percent of U.S. senior citizens may be deficient, along with 85 percent of the American public. No wonder the flu runs rampant each year.

Remarkably, researchers have found that 2,000 IU of vitamin D per day abolished the seasonality of influenza!  Most of you I am no fan of supplementation for Vitamin D, but during a pandemic this might have a place for those humans who want to avoid ICU admission and intubation.

Please note that this is far higher than the recommended daily allowance (RDA) spouted by public health agencies like the American Academy of Pediatrics, which just announced that they’re doubling the RDA of vitamin D for children to 400 IU. This new guidance still falls absurdly short of what’s needed to keep kids healthy, especially during flu season.  Kids deficient in Vitamin D have serious risks of a COVID-19 Kawaski like disease.

In order to prevent the flu, children need 2,000 IU a day of vitamin D, while adults need anywhere between 4,000 to 5,000 IU per day.   Solar exposure depends on many factors such as haplotype, Fitzpatrick skin type, and SNP and SAP’s.  The key is to make sure you monitor your vitamin D levels by blood testing, to make sure your levels are therapeutic and not toxic.  The toxic levels of Vitamin D are a lot higher than public health experts spout off.

If you want more info on terrestrial sunlight please my Patreon blog on how to build your solar callus nature’s way.

Vitamin D Can Also TREAT the hypoxia associated with RNA viruses!

If you are taking the above doses of vitamin D the odds of you getting the flu are very remote. However, if you do come down with the flu, keep in mind that you can also use vitamin D therapeutically to TREAT the flu.

The therapeutic dose of vitamin D is 2,000 units per kilogram of body weight (one pound is 0.45 kg). The dose would be taken once a day for three days. (This could be a very large dose if you are very heavy – as high as 2-300,000 units per day).

This is the dose that Dr. John Cannell, founder of the Vitamin D Council, has been using very successfully for a number of years.

If you start this program early on in the illness, it should be able to completely wipe out the flu in short order. This is rarely done in the hospital setting. You need to have a clinician who understands the literature and can pack your parachute.

Another useful supplement you could try, should you come down with a case of the flu, is olive leaf extract, which you can find in most any health food store. I prefer to eat olive leaf stuff with meat and seafood.  Olive leaf extract has been found to be a potent broad-spectrum antiviral agent, active against all viruses tested, including numerous strains of influenza and para-influenza viruses.

Bottom line is stick with nature.  Sunlight raises your venous O2 saturation.  Nothing on planet Earth I know can do that but sunlight to venous blood.

The thin layer of Earth’s atmosphere hasn’t always contained oxygen. An experiment that used lasers to zap carbon dioxide suggests ultraviolet light from the sun might have helped boost oxygen gas levels in Earth’s ancient atmosphere.

In a new experiment, researchers used a laser to decouple a molecule of carbon dioxide, or CO2. It yielded both carbon and oxygen gas, also known as O2.

Air hasn’t always been rich in oxygen. Billions of years ago, other gases dominated. Carbon dioxide was one of them. At some point, algae and plants developed photosynthesis. This allowed them to make food from sunlight, water and carbon dioxide. One byproduct of this process is oxygen gas. And that’s why many scientists had argued photosynthesis must have been behind the buildup of oxygen in Earth’s early atmosphere.  But is the belief true?  No, it is not.

A new study suggests that ultraviolet light from the sun could have cleaved oxygen from carbon dioxide in the atmosphere. And this could have converted CO2 to carbon and O2 long before photosynthetic organisms evolved. The same process also may have produced oxygen on Venus and other lifeless planets rich in carbon dioxide.

CITES:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631809/pdf/11384511.pdf

B. Mole. “Lasers wrest oxygen from carbon dioxide.” Science News. Oct. 7, 2014.

S. Ornes. “The algae invasion.” Science News for Students. May 11, 2010.

S. McDonagh. “Earth’s early oxygen boost.” Science News for Students. Feb. 9, 2004.

U.S. Birthrates Fall to a Record Low (click here to read article)

Alchemist & Metaphysician = ancestral dogmatic beliefs are that biochemistry is definitive science.  Biochemistry is really a solid state story of how light alters valence electrons within hydrated semiconductive proteins. This light is capable of changing their physiologic ability as the electromagnetic signals on the surfaces of them changes geometry in their lattice.  This is why electromagnetic charge changes always involve shape shifting of proteins made by DNA surrounded by water made by mitochondria. Life runs on being able to harness the energy of an excited electron to the ground state. Life cannot do this well when pseudohypoxia exists at cytochrome one with lowered NAD+. Technology’s nnEMF and blue light cause this quickest today.

The cost of a high aerobic capacity is low fertility so that we can maintain our cortisol pathways from LDL and Vitamin A as I mentioned the Hormone 101 & 102 blogs ages ago. This is why the pregnenolone steal syndrome exists. Cortisol over sex steroids is due to the use of oxygen as the terminal electron acceptor in human mitochondria. So when cortisol drops chronically this tells you that your environment is not allowing you to effectively utilize oxygen in your mitochondria as a terminal electron acceptor. What does that mean in english? It means your ubiquitination levels are raised and your mitochondria are pseudohypoxic. This means you are using other gases to perform the tasks that oxygen used to when your environment was more optimized.

This causes us to use too much NO, H2S, and CO. These are sub-optimal choices and this leads to altered cortisol and overall hormone panels. All these changes lead to a lack of catalase in cells and altered UV light light release in cells (too much) and all these sequential changes fuel this low fertility and a low cortisol. When you begin to read all the details of the ubiquitin series you will see how pseudohypoxia plays into every mechanism of disease we have in biology and medicine and then you will see this is the huge problem our environment creates and it alters the optical non linear communication pathways between the mitochondria and nucleus.

The effect of tech on fertility is linked to the NAD+ ration to NADH.   Pseudohypoxia creates infertility.  American births down to their smallest total in 35 years: “The general fertility rate fell 2% to 58.2 births per 1,000 women aged 15 to 44, its lowest level since the government began tracking the figure in 1909.  Pseudohypoxia= leptin resistance = infertility = extinction is a synonym for infertility.

Is fecundity, fertility, and successful pregnancy all linked to circadian biology via melatonin control over apoptosis and autophagy in mitochondria? The answer appears to be a big YES. This has huge implications for extinction levels of events in anything that alters melatonin levels. It is now clear melanopsin function does this with blue light and nnEMF. I wonder how long it will take the non-Black Swans out there to get this rather simple, yet significant message?

Melatonin also appears to play an important role in modulating the immune system so a fertilized egg can be implanted. A fertilized egg has different DNA and cell markings than our own cells. In most cases, our tissues would recognize this forming embryo as an invader and the immune system would attack. Instead, our bodies welcome the rapidly dividing ball of cells as a welcome guest. What causes this unusual reaction?

Researchers are not sure exactly how this immune modulation happens but melatonin appears to play a crucial role. Melatonin is made by the placenta and appears to protect newly implanted pregnancies from immune attack while encouraging the growth of blood vessels and other changes needed to sustain a healthy pregnancy. In addition, melatonin made by the placenta is transferred to the fetus and may play an important role in the child’s prenatal development.

SUMMARY:  

You don’t need people’s expert opinions on a fact of nature, says Mother Nature. Understanding how light from the sun is tied energy and information transfers to support this idea. The modern paradigm has carefully crafted a meme that the sun is toxic for us and this is ludicrous when you consider we have massive data that the sun reduces all cause mortality.

Hormone panels are a reflection of the cells reaction to their light environment.  That is a choice you make before sex.

Adiposity and leptin resistance makes obesity a stem cell strategy rather than a disease pathology…….all driven by altered ubiquitin tied to the melanopsin and retinol mechanism.

Pregnancy is affected by electrification. If you are infertile you better join my tribe soon before you make some more incorrect choices. Infertility means you’re leptin resistant = melanopsin dysfunction due to electromagnetic interference.

Pseudohypoxia = low O2 = Low NAD+/NADH ratio = NAD+ = altered Pyruvate/lactate levels in the mitochondria = altered matrix functioning = altered thiamine dynamics = alterations in blood sugar and AMPk pathways = altered sex steroid hormone panels = evidence of melanopisn damage = higher serum retinol = photoreceptor damage = tryptophan break down begins = the neural toxicity of the selected breakdown pathway destroy tissue and stimulates HIF-1 alpha = alters fission and fusion rate in the mitochondria = size and shape changes in the mitochondria = oxphos slows = NAD+/oxygen levels drops further in people with blue light exposure = elevated ubiquitin rates = more need for methionine and thiamine = low levels of electrons in tissues = less electrons = less solar activiation of electrons = electron density in tissues is a function of the DHA concentrations and solar exposure = less UV/IRA light = low EZ size in cell water = dehydration = higher positive charges (protons) in proteins making them less hydrophilic = low intracellular pH = low redox potential = cell and mitochondrial swelling (cyto c release) = lowered magnetic and electric fields in mitochondria = low ATP levels = a lot of carbs and protein electrons on ECT = further destruction of thiamine stores = more hypoxia = altered local and regional melatonin, serotonin and dopamine levels in the retina and frontal lobes = NT release tied to calcium efflux = calcium controls voltage gated channels, NMDA, and glutamate excitotoxicity= low DC electric current = low tissue DHA = infertility = altered perceptions of reality and depression/anxiety and just about any other disease you want to understand.

There are 3 layers to how life organizes that parallel the 3 legged stool, light, magnetism, and water chemistry. Why have I talked about pseudohypoxia for so long in this series? This is what results when we have altered thiamine levels due to chronic blue light and nnEMF exposure in our environments.

Why have I told you to go back and read David Sinclair’s Dec 2013 paper on SIRT 1, HIF 1, and NAD+? They all link to every disease on this planet. Why? The liberation of oxygen from photosynthetic plants and bacteria also allowed more complex life forms to evolve using more complex energy transfers. These waste products of two kingdoms directly allowed DHA to form in the oceans 600 million years ago. The more complex things become morphologically in an organism as evolution has evolved, the more brain one needs to control all the circadian systems tied to the environmental signals. The more oxygen in seawater, meant the more electrons would be able to collect from our environment from many sources like food, the sun, water, and our magnetic field. It also meant we could create more electrons from the endogenous electric and magnetic fields created in each mitochondrial in our cells. This slowly allowed DHA to build up in sea plants like algae and phytoplankton. Fish began to eat these plants and use DHA to build their own neural systems. The more life that evolved within the sea, meant the world’s oceans would be more green, and not blue. Green seawater = increased DHA, Iron, and O2 content. Blue seawater = little DHA, no iron, and low O2 content. Low O2 content means less magnetic energies can be utilized. This is why hypoxia is toxic to eukaryotic life at a fundamental level.

CITES:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076149/

 

Most people are not interested in learning what truth is. They would sooner sit in front of a box that continuously spits out lies and misinformation and entertains them. If that box emits blue light or nnEMF it might exacerbate an illness you have.

Did you know that NAD+/NADH in cytochrome 1 is a fluorophore protein complex that transfers electrons in the electron transport chain of the inner mitochondrial membrane?

Fluorophores have particular importance in the field of biochemistry and protein studies. We use them in immunofluorescence studies. Fluorophores typically contain several combined aromatic groups, or plane or cyclic molecules with several π bonds. To understand them you need to know a bit of physics surrounding the photoelectric effect. The fluorophore absorbs light energy of a specific wavelength and re-emits light at a longer wavelength. The absorbed wavelengths, energy transfer efficiency, and time before emission depend on both the fluorophore structure and its chemical environment, as the molecule in its excited state interacts with surrounding molecules.

The best studied fluorophores in biology are nicotinamide adenine dinucleotides (NAD+/NADH). These proteins are small and all made out of nitrogen atoms. As I discussed in detail in Ubiquitination 17 blog post, NAD+ and sirtuins are designed to work together as a redox couple as well to create the eye’s clock timing mechanism.

Today’s humans have created a world and environment that is dominated by blue light emission and nnEMF night and day! Blue light and nnEMF destroys DHA presence in mammalian cell membranes everywhere in our tissues. Many other things also lower because of this effect. For example, Vitamin D levels go lower and this makes the Vitamin A levels in your blood to rise too. These two Vitamins are yoked to work.

When this happens we see a redox shift in the NAD+/NADH couple of mitochondria. The destruction of this process (melanopsin) in the retina/skin/arteries however is the most important, because the eye clock controls the flow of carbon in every cell of our body. The flows of carbon are directly tied to how well our mitochondrial respiratory proteins work in concert with nuclear DNA. As DHA levels decline, the inputs to the SCN from melanopsin photoreceptors also decline. This degrades the optics of the atomic lattice in the SCN that responds to 460-550 nm light. This is in the blue/green range. This causes cells to age faster by raising their ubiquitin rates. Simultaneously it lowers NAD+ levels in cells.

This is why I have told my clients that blueblocking glasses improve oxygenation and help boost immunity.  Most other experts have no idea how blue blockers are capable of this effect.  When oxygen tensions drop in the eye cataracts and acute macular degeneration are often the chronic effect.  This is how photoreceptor blindness occurs.

Melanopsin forms a functional photopigment capable of catalyzing G-protein activation in a light-dependent manner. This G-receptor needs DHA to function optimally. It is the melanopsin iRGC’s that generates melatonin rhythms in the pineal gland.

NAD+ causes a form of hypoxia. That hypoxia is seen in many diseases associated with acute and chronic mitochondrial failure. This is true in COVID 19, bacterial sepsis, diabetes, cancer.

You’ve all seen this picture above in this series as it links to thiamine, lactate and pyruvate levels.  Now I need to make sure you see how it links to cytochrome 1 of your inner mitochondrial membrane.  When NAD+ is lowered pseudohypoxia predominates in cells.

 

KEY POINT: As NAD+ lowers, so does the entire cell redox potential.  This selects for specific mitochondrial respiratory protein changes as they key factor in aging, heart disease, and oncogenesis. What are those changes? Normally the length of the respiratory chain in mitochondrial is 60 Angstroms. When NAD+ is lowered, the length increases. This alters how electrons can flow in electron chain transport and affect oxygen levels in cells.  Note below how this paper in the CITES wants to fool you into taking a supplement you don’t need if you just get natural terrestrial sunlight free daily.

Why did I tell members that Methylene blue might significantly help C-19 patients with hypoxia?   Methylene blue was once used to treat malaria.  This should peak your interests during this C-19 pandemic.  Methylene blue oxidizes NADH into NAD+, to replenish falling NAD+ levels due to the mitochondrial damage and increases the NAD+/NADH ratio as a result. They key most mitohacks using drugs and pills miss that it is not the ratio that matters most,  but the fact that the H in NADH comes from the TCA cycle intermediates  and it must be H+ form and not come from any trapped deuterium in the matrix.

There are 3 layers to how life organizes that parallel the 3 legged stool, light, magnetism, and water chemistry. Why have I talked about pseudohypoxia for so long? Why have I told you to go back and read David Sinclair’s Dec 2013 paper (CITES 2 below) on SIRT 1, HIF 1, and NAD+?

These chemicals all link to every disease on this planet. Why? The liberation of oxygen from photosynthetic plants and bacteria also allowed more complex life forms to evolve using more complex energy transfers. These waste products of two kingdoms directly allowed DHA to form in the oceans 650 million years ago at the Cambrian explosion. The more complex things become morphologically in an organism as evolution has evolved, the more brain one needs to control all the circadian systems tied to the environment signals.

SUMMARY

Hypoxia = low O2 = Low NAD+/NADH ratio = NAD+ drops in people with blue light exposure = elevated ubiquitin rates = low levels of electrons = electron density in tissues is a function of the DHA concentrations = low EZ size in cell water = dehydration = higher positive charges (protons) in proteins making them less hydrophilic = low intracellular pH = low redox potential = cell and mitochondrial swelling (cyto c release) = lowered magnetic and electric fields in mitochondria = low ATP levels = a lot of carbs and protein electrons on ECT = altered melatonin, serotonin and dopamine levels in the retina and frontal lobes = NT release tied to calcium efflux = calcium controls voltage gated channels, NMDA, and glutamate excitotoxicity= low DC electric current = low tissue DHA = altered perceptions of reality and depression/anxiety and just about any other disease you want to understand.

The data reveal the effects of lowered NAD + is due to loss of the circadian mechanism with aging and in most comorbid disease states through the spatiotemporal control of the molecular clock in cells. This is why the use of terrestrial sunlight is the best way to reset your molecular clock daily. Sunlight also decreases hypoxia risk in most diseases and this is why sunlight helps in all mitochondrial disease states. Today, we see the result of this in COVID-19 but the experts from the NIH still do not undertand the mechanism fully. That is why I decided to post this today.  It is also why using a supplement should be avoided as suggested in the paper below. This is why we should always seek the sunrise and sunset over manufactured pills. 

CITES: 

1. https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30236-7#.XrCAABE4n-I.twitter

2.  https://www.cell.com/cell/fulltext/S0092-8674(13)01521-3

Why is the WHO and the Chinese communist party facing the wrath of those who can think?

Both of them failed to utilize the precautionary principle with COVID-19.

What is this principle?

The precautionary principle places the burden of proof on the side that carries the uncontrolled risk…it is up to those who refuse the application of the treatment to demonstrate that it is more dangerous than the absence of treatment.

With that all said. He is the present reality:

Reported US coronavirus deaths:

Feb. 15: 0 deaths

Mar. 15: 65 deaths

Apr. 15: 30,844 deaths.

This rise defines what logrithmic growth is all about.

WHO ELSE HAS MASSIVE FAILED THE PEOPLE OF THE USA?  The entire media.  They have forgotten their role in the government.

The First Amendment to the U.S. Constitution protects the freedom of speech, religion and the press. It also protects the right to peaceful protest and to petition the government.

The MEDIA have forgotten that when they shirk their duties, and the first amendment fails the people, it makes it much more likely that the people will use their second amendment rights to take up arms against the tyranny of government.  We are now seeing aspects of tyranny.  Just look at what the governor of Michigan has done to the people who elected her.  They now want her recalled.  People do not realize how close America is to rising up.

The real reason Thomas Jefferson gave us the first  for freedom of speech in the first amendment of the constitution is this: Suppression of speech results in second and third-order problems (trust, authority, suspicion) that are far worse than first-order inconveniences from its freedom.  We all our standing on that precipice now.  All people of all ideologies.  This pandemic has forced everyone to take a road that they are not used to taking.  In non pandemic America, normally, precipices are the routine routes only that unroutine people take.   The reality of our situation, is that it’s only at the precipice that we evolve, only on the brink do we change.

Sadly our personal perceptions of the truth is only an approximation of what we believe based on the data we accept. What we accept then builds our cognitive biases.  The truth about the truth is that is never stops changing with new data.   This pandemic is causing many to see the fallacies in what they were taught.

If we really knew what to look for……most Americans are not good observers of their own government or their own ideology,  I have found.  This is why most people cannot see what was really going on around them in their lives before the pandemic.  None of them could put their finger on really why COVID-19 happened.  Most are blinded by their educational biases.   However, one thing should be clear to all now, this pandemic has taught everyone something is structurally wrong with our government.   This is true for the left or right leaning crowd.

WE”RE ADDICTED TO TECHNOLOGY AND ALIEN LIGHT AND IT LOWERS OUR DOPAMINE LEVEL.  THIS CAUSES US TO MISREAD THE TEA LEAVES.

We are all guilty of it.

We all need to remember the lessons from the past. Over-machined technocratic societies create environments that fail humans because they divorce us from our life force, Nature. We need to learn from this failure. The manufactured devices themselves condition the
users to employ each other the way they employ machines. They enslave us.
At its core the technocracy will always need a select few humans to keep the house of cards running. Technical people don’t make good slaves. Without their wholehearted cooperation, things will fall apart. That is how the slave trade the government allows to continue.  The FCC was given this power by CONGRESS and the military industrial complex now enforces it.  The NIH, CDC and CONGRESS try to keep us blind to it because they refuse to fund research that challenges the technocracy in this country.  Realize who did this to us.  Realize your role in allowing it to happen.   Realize your roll in how to stop it.

The customer can fire everybody in the company from the chairman on down, simply by spending his money somewhere else. We need to remind China’s CCP of this. Removing funding of the WHO is the first step in many that needs to be done.

By the time 5G is fully rolled out, the intellectual poverty of technocracy and the primacy of socialistic politics over it would be a well-established truth in need of no further defense.

Stopping your current ‘thought car’, and agreeing to look into the rear view mirror to see your real story clearly helps you re-navigate your life now, to change your future. That is truly what embracing nature does for black swans, in my opinion. You must embrace the suck. But embracing that first foul tasting step only does one thing. It stops you from living your life like your driving down a road just looking through the wind shield while your life- “time contracts” or you age faster and die sooner, like over 30,000 American have from this virus.

Medicine is fumbling the ball because it has no true epistemologic foundation to tie its biologic decisions too, like chemistry or physics has. The point is when we begin to use evolutionary biology to guide our decisions instead of our feelings and socially created beliefs, we get better permanently. We need to use evolutionary thinking to guide and master our thinking today. If you’re with me, I think you will get Optimal eventually. That is the modus operandi of my entire blog and it is the thesis of my life now.

Maybe I should stop calling my tribe “Black Swans” and instead refer to them as “Roosters”. People who exist among us to wake the rest of the sleeping awake with some truth.

o let us look at what we have all accepted due to COVID-19 and see if it marries to what our Constitution laid out for us 250 years ago.

Here are the official Coronavirus guidelines from our government:

1. Basically, you can’t leave the house for any reason, but if you have to, then you can.

2. Masks are useless, but maybe you have to wear one, it can save you, it is useless, but maybe it is mandatory as well.

3. Stores are closed, except those that are open.

4. You should not go to hospitals unless you have to go there. Same applies to doctors, you should only go there in case of emergency, provided you are not too sick.

5. This virus is deadly but still not too scary, except that sometimes it actually leads to a global disaster.

6. Gloves won’t help, but they can still help.

7. Everyone needs to stay HOME, but it’s important to GO OUT.

8. There is no shortage of groceries in the supermarket, but there are many things missing when you go there in the evening, but not in the morning. Sometimes.

9. The virus has no effect on children except those it affects.

10. Animals are not affected, but there is still a cat that tested positive in Belgium in February when no one had been tested, plus a few tigers here and there…

11. You will have many symptoms when you are sick, but you can also get sick without symptoms, have symptoms without being sick, or be contagious without having symptoms. Oh, my..

12. In order not to get sick, you have to eat well and exercise, but eat whatever you have on hand and it’s better not to go out, well, but no…

13. It’s better to get some fresh air, but you get looked at very wrong when you get some fresh air, and most importantly, you don’t go to parks or walk. But don’t sit down, except that you can do that now if you are old, but not for too long or if you are pregnant (but not too old).

14. You can’t go to retirement homes, but you have to take care of the elderly and bring food and medication.

15. If you are sick, you can’t go out, but you can go to the pharmacy.

16. You can get restaurant food delivered to the house, which may have been prepared by people who didn’t wear masks or gloves. But you have to have your groceries decontaminated outside for 3 hours. Pizza too?

17. Every disturbing article or disturbing interview starts with “I don’t want to trigger panic, but…”

18. You can’t see your older mother or grandmother, but you can take a taxi and meet an older taxi driver.

19. You can walk around with a friend but not with your family if they don’t live under the same roof.

20. You are safe if you maintain the appropriate social distance, but you can’t go out with friends or strangers at the safe social distance.

21. The virus remains active on different surfaces for two hours, no, four, no, six, no, we didn’t say hours, maybe days? But it takes a damp environment. Oh no, not necessarily.

22. The virus stays in the air – well no, or yes, maybe, especially in a closed room, in one hour a sick person can infect ten, so if it falls, all our children were already infected at school before it was closed. But remember, if you stay at the recommended social distance, however in certain circumstances you should maintain a greater distance, which, studies show, the virus can travel further, maybe.

23. We count the number of deaths but we don’t know how many people are infected as we have only tested so far those who were “almost dead” to find out if that’s what they will die of…

24. We have no treatment, except that there may be one that apparently is not dangerous unless you take too much (which is the case with all medications).

25. We should stay locked up until the virus disappears, but it will only disappear if we achieve collective immunity, so when it circulates… but we must no longer be locked up for that?

26. You wear a mask to protect others, not yourself.

Ask yourself, who are you really good for when you are not good enough for yourself?  Is this message our government is sending to us?  It is supposed to be for the people.  It was codified in “WE THE PEOPLE”.  Is this still true?

This is the reality of our modern tyranny.

SUMMARY

When your life stop’s pleasing you…..you’ve lost your randomness……change it with your new creations. Embrace the suck of the chaos we are all in now.  Chaos is what we’ve lost touch with when we gain comfort.

The reality we imprint upon our future is very often the idea of some lost, imagined past. This is unfortunate. The dream of past and future in our mind is akin to the contact of two chemical substances: if there is any reaction, both should be transformed before any reality is created.

Water and sunlight were the primordial matter on Earth to give life a start.  Light, water, and the electromagnetic force combined to give us the organizing elements on this planet.

How much more evidence do we need that ultra-processed man-made light are never good for us compared to sunlight?  The picture encompasses our entire problem.

All of us are maladaptive to the use of the light spectrum around us. The light bulbs are but one part of the technocracy, we’ve addicted ourselves too.

The irony here, our technocracy has blinded us to these facts. We have asked for more technology not less. Our govenment has given us exactly what we’ve asked it too. Are you satisfied on your precipice now? How is your current view?

The pandemic has caused me to pause and think about my past when I was awoken to Nature’s power. I was standing in Rome in the Sistine Chapel showing my son the center panel of Michelangelo’s masterpiece ceiling. What does let there be light really mean?

I realized that day I might want to know God’s thoughts about life.  What in the hell was he thinking in genesis?    I want to know God’s thoughts in a biologic way and I found the path to that way used an alphabet called evolution.

Evolution in my eyes is the following:

• It does not mean random
• It does not mean to improve
• It does not mean morphing during a lifetime
• It does not mean abiogenesis
• It does not mean the origins of the universe
• It does not mean social Darwinism
• It does not mean genetic determism
• It does not mean amoral
• It does not address theologic claims
• It does not mean atheism, communism, racism or any politcal ideology

Evolution means change over time brought about by environmental change in the Earth, pure and simple

How it happens is a natural truth based upon quantized science.  Quantum mechanism is the substance of nature and it is not based on cause and effect it is 100% based on probabilites of what can happen.  The thermodynamics of the environment is what causes reality to manifest.  What is happening to us now is due to our lack of insight of how our abuse of the electromagnetic spectrum is linked to this pandemic.

If you deny these things:  The universe, change over time, then, in my eyes,  you deny our current reality:

The theory of biological evolution attempts to explain the facts and connect the data that indicate that life on Earth is related through a common descent or process, and has been changing for close to 4 billion years. I am sure it will continue to evolve too.  We don’t have all the answers today, but we are getting better at finding some, and this post is foundational to evolution’s role, in life’s ascent at the ocean floor and eventually in Homo’s solution.

I told a friend parts of my new cognitive bias on this topic in a phone call in 2011, and told him when I was done with all this that I would leave no doubt in any one’s mind with what I found and why it altered my perception.  I told him about Factor X,  hoping he would see the was a bigger evolutionary story I was painting for people to see.

He explained that it might upset the ‘apple cart’ and I should expect some backlash.  I told him that people interested in ancestral living in Nature should be more interested in the truth of how our biology really works than what they believe.

Martin Luther King said it best, “Every time we witness an injustice of thought, and do not act, we train our character to become passive in its presence, and thereby eventually lose the ability to to defend ourselves and the one’s we love to create the life we need.”  I feel I need to write about this because our species survival is tied to these thoughts.  My hypoxia #8 webinar reminds me of MLK’s words daily.  This is the passion that drives me now.

My message, on my blog and book, was to be a true voice and not an echo chamber for the technocracy or the government that supports it.

It is time for you to change how you think about this pandemic.  It might be the thing that causes you to survive and thrive in the New World order that is being forced down our throat by the government we elected.

If you are struggling you might need to find your voice. Your inner voice is the amplifier of your heart and soul. We all have two kind of voices within us: One that is always encouraging. The one that says, “Yes, you can do it” and…..Another that is always discouraging. That one always throws negatives at us. How we view the world is often how we see it. The result is in the voice we project. Vincent Van Gogh remarked, “If you hear a voice within you say ‘you cannot paint,’ then by all means paint, and that voice will be silenced.”

Stop blocking your abilities to dominate. As human beings, we are blessed with a choice to silence one of those voices and encourage the other. Negative, being automatic is easy to adapt. But it is always a choice to make – consciously! Today, begin to use your voice powerfully. It has creative power to shape your world and those you touch.

Share this…………become a ROOSTER and wake up the sleeping.

Sarah Elizabeth Stewart, PhD, MD (1905–1976 pictured below), whose discoveries involving the murine polyomavirus with Bernice Eddy, PhD, propelled the then-reluctant field of oncology to pursue viral etiologies of cancer.  They worked together at University of Chicago for three years which lead to her being recruited by Alton Ochsner for the New Orleans project to find a cure/solution to the contamination of the poliovirus by SV-40 in a secret lab at a US Public Service Hospital in New Orleans with Dr. Mary Sherman.

From my initial post mortem of data I have gathered from my contacts on the front line in New Orleans this virus is hijacking hemoglobin’s ability to carry oxygen to tissues.  The lung tissue then responds to this in a reactive way via imaging studies.

HYPERLINK

I don’t think this paper above is getting enough publicity right now in this pandemic. It helps explain why the COVID 19 hypoxia is unique in its presentation.  

The paper theorizes how and why coronavirus reduces blood O2 and causes “crushed glass” lung imagery. This happens because the virus attacks the beta chains of hemoglobin and this binding appears to kick out heme from RBCs rendering them unable to deliver oxygen to mitochondria. The risk factors of high A1C, blood sugar, high LDH and ferritin, and why certain treatments work. (Hydroxychlorquine)

One clinical pearl I have heard from all my MD friends on the front line in NOLA is “Very often, extreme fatigue hits first.” PEEP and blood transfusions are not helpful. My bet is RBC transfusion won’t work well in patients who are actively shedding virus because the virus will immediately attack the new transfused RBC mimicking graft versus host disease response. COVID viral genes 1 and 8 have been predicted to interfere with heme synthesis.

Heme synthesis first step occurs in the mitochondria. So if it is disrupted this virus compounds the situation. Heme is the red compound in blood and in cytochrome C oxidase, and catalase that carries oxygen and CO2.   When mitochondrial oxygen consumption slows more dissolved oxygen in the cell rises and this excess oxygen become substrate to make free radicals that further destroy the lipid membranes of mitochondria and RBCs to lead to the early fever, and cytokine storm seen in COVID19 via the NFLR3 inflammasome.

This destroys ATP formation by the ATPase and this causes extreme hypoxia that mimics suffocation or high altitude pulmonary exposure (HAPE). It appears once the virus attacks it acts by kicking out the iron and this gives a specific phenotype in the blood that mimics malaria. This explains why chloroquine seems effective as a treatment. Why would azithromycin help augment hydroxychloroquine? Azithromycin appears to be effective in the treatment of COPD through its suppression of inflammatory processes.  Azithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thus inhibiting translation of mRNA. Nucleic acid synthesis is not affected.

During a viral sepsis acid base balance is altered and most people become very acidotic. Azithromycin is an acid-stable antibiotic so its efficacy would not be altered in the face of metabolic or respiratory acidosis. This is why it has efficacy in COVID 19. It is one of the few antibiotics that can work in low pH environments. Due to its high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma due to ion trapping and its high lipid solubility.

The damage to the beta chains of hemoglobin by COVID mimics malaria. Malaria also causes an inactivation of RBC to carry oxygen to mitochondria.  Malaria is an acute form of hemolytic anemia.  These types of anemia have symptoms that are similar to other forms of anemia (fatigue and shortness of breath), but in addition, the acute breakdown of red cells leads to jaundice and increases the risk of particular long-term complications, such as gallstones and pulmonary hypertension.

It appears COVID 19 happens so fast jaundice and gallstone do not have enough time to form but the pulmonary hypertension manifests as the key feature of the disease acutely.  The hemolysis can occur inside the vessels or outside the vessels.  I believe in COVID 19 it is an extravascular hemolysis that is operational.  Extravascular hemolysis refers to hemolysis taking place in the liver, spleen, bone marrow, and lymph nodes.  In this case very little hemoglobin escapes into blood plasma.

This is why no one is reporting jaundice in COVID 19 patients.

Pulmonary hypertension is a condition of increased blood pressure within the arteries of the lungs.  Symptoms include shortness of breath, syncope, tiredness, chest pain, swelling of the legs, and a fast heartbeat.

All of these symptoms are found in COVID 19 patients.

Extreme fatigue is a sign of HYPOXIA = HIF-alpha-1 = serious over use of thiamine which is a beacon of a loss of mitochondrial redox power no TCA use = lack of delta psi.  Without delta psi no new heme can be to replace hemoglobin or cytochrome C oxidase or catalase.  This explains why people present the way they do in the ER.

Here is a report from a NOLA ER doc who graduated LSU in 1998.

Clinical course is predictable.

“2-11 days after exposure (day 5 on average) flu like symptoms start. Common are fever, headache, dry cough, myalgias(back pain), nausea without vomiting, abdominal discomfort with some diarrhea, loss of smell, anorexia, fatigue.

Day 5 of symptoms- increased SOB, and bilateral viral pneumonia from direct viral damage to lung parenchyma.

Day 10- Cytokine storm leading to acute ARDS and multiorgan failure. You can literally watch it happen in a matter of hours.

81% mild symptoms, 14% severe symptoms requiring hospitalization, 5% critical.

Patient presentation is varied. Patients are coming in hypoxic (even 75%) without dyspnea. I have seen Covid patients present with encephalopathy, renal failure from dehydration, DKA. I have seen the bilateral interstitial pneumonia on the xray of the asymptomatic shoulder dislocation or on the CT’s of the (respiratory) asymptomatic polytrauma patient. Essentially if they are in my ER, they have it. Seen three positive flu swabs in 2 weeks and all three had Covid 19 as well. Somehow this VIRUS has told all other disease processes to get out of town. This shows you how the virus is causing a loss of medical capacity inside the hospital.

China reported 15% cardiac involvement. I have seen covid 19 patients present with myocarditis, pericarditis, new onset CHF and new onset atrial fibrillation. I still order a troponin, but no cardiologist will treat these heart attacks (STEMI) no matter what the number in a suspected Covid 19 patient. Even our non covid 19 STEMIs at all of our facilities are getting TPA in the ED and rescue PCI at 60 minutes only if TPA fails.

Diagnostic

CXR- bilateral interstitial pneumonia (anecdotally starts most often in the RLL so bilateral on CXR is not required). The hypoxia does not correlate with the CXR findings. Their lungs do not sound bad. Keep your stethoscope in your pocket and evaluate with your eyes and pulse ox.

Labs- WBC low, Lymphocytes low, platelets lower then their normal, Procalcitonin normal in 95%

CRP and Ferritin elevated most often. CPK, D-Dimer, LDH, Alk Phos/AST/ALT commonly elevated.

Notice D-Dimer- I would be very careful about CT PE these patients for their hypoxia. The patients receiving IV contrast are going into renal failure and on the vent sooner.

Basically, if you have a bilateral pneumonia with normal to low WBC, lymphopenia, normal procalcitonin, elevated CRP and ferritin- you have covid-19 and do not need a nasal swab to tell you that.

A ratio of absolute neutrophil count to absolute lymphocyte count greater than 3.5 may be the highest predictor of poor outcome. the UK is automatically intubating these patients for expected outcomes regardless of their clinical presentation.

An elevated Interleukin-6 (IL6) is an indicator of their cytokine storm. If this is elevated watch these patients closely with both eyes.

Other factors that appear to be predictive of poor outcomes are thrombocytopenia and LFTs 5x upper limit of normal.

Disposition

I had never discharged multifocal pneumonia before. Now I personally do it 12-15 times a shift. 2 weeks ago we were admitting anyone who needed supplemental oxygen. Now we are discharging with oxygen if the patient is comfortable and oxygenating above 92% on nasal cannula. We have contracted with a company that sends a paramedic to their home twice daily to check on them and record a pulse ox. We know many of these patients will bounce back but if it saves a bed for a day we have accomplished something. Obviously we are fearful some won’t make it back.

We are a small community hospital. Our 22 bed ICU and now a 4 bed Endoscopy suite are all Covid 19. All of these patients are intubated except one. 75% of our floor beds have been cohorted into covid 19 wards and are full. We are averaging 4 rescue intubations a day on the floor. We now have 9 vented patients in our ER transferred down from the floor after intubation.

Luckily we are part of a larger hospital group. Our main teaching hospital repurposed space to open 50 new Covid 19 ICU beds this past Sunday so these numbers are with significant decompression. Today those 50 beds are full. They are opening 30 more by Friday. But even with the “lockdown”, our AI models are expecting a 200-400% increase in covid 19 patients by 4/4/2020. “

That is the clinical view from New Orleans now.

If the patient isn’t showing signs of respiratory difficulty but has extreme fatigue, one thing to question is whether the oxygen is getting from lungs to body tissues.

This would lead to organ and tissue death, roughly in the same way as if a patient were being suffocated.

Even when a patient can breath (fill lungs with air), the oxygen isn’t getting to the colony of mitochondria in the cells in their body.

Similiarities between COVID 19 and High Altitude Pulmonary Edema

HAPE symptoms similar to covid: “HAPE was misdiagnosed for centuries, as evidenced by frequent reports of young, vigorous men suddenly dying of “pneumonia” within days of arriving at high altitude.”

HAPE’s mechanism results from low amounts of ambient atmospheric oxygen, so the subject’s blood is unable to bring enough oxygen to the body.

Nothing is “attacking” the lungs, but the lungs show similar inflammatory symptoms to COVID, because O2 in blood is low. Remember UV light exposure increases venous O2.

This would lead to organ and tissue death, roughly in the same way as if a patient were being suffocated.

Even when a patient can breath (fill lungs with air), the oxygen isn’t getting to the cells in their body.

The inflammation in the lungs results from the lungs not being able to perform the oxygen/CO2 exchange, and would therefore appear to be a SECONDARY result of the hijacking of the blood.

The lungs not working is a result of lack of O2 in blood, not the cause of it.  It might be a disease of heme.  

The reason why technology use exacerbates the disease because it also causes defects in RBC synthesis by blocking heme formation by causing mitochondrial damage. (pic below)

Several paper reviewed on drug models the behavior of chloroquine and faviparavir as well, which appear to bind to the non-structural viral proteins that hijack the heme groups, thus inhibiting them from knocking out the iron and wrecking the O2-carrying ability of the red blood cells.

This also explains the observation made by various ER docs that patients tend to have elevated ferritin: ferritin is used to store excess iron released from the RBC damage. If a lot of iron is knocked out of heme groups and floating around, the body produces more ferritin.

In humans, it acts as a buffer against iron deficiency and iron overload. This overlaod happens hyperacutely in COVID19.   Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia. This anemia can happen acutely or chronically.

If this mechanism of damage is true, this implies we need to think a lot differently than we are now:

1. Starting drug treatment while symptoms are mild keeps virus from hijacking too much of the RBC and cytochrome C oxidase, or catalase, enabling a still-healthy body to mount an immune response. Plasma therapies should be done before RBC transfusions.

This explains why early drug treatment (first week of symptoms) is often successful. It stabilizes iron metabolism and stabilzes CO2/O2 delivery early on and maintains mitochondrial function via cytochrome C oxidase. This preserves ATP function. Red light therapy would augment this affect.  Nitric oxide mimicry might save cytochrome c oxidase.  This might be why UV light helps limit COVID 19 cases.  UV light increases the production of nitric oxide and this shuts down the use of cytochrome c oxidase.

This would explain why all coronavirus seem to be inactive in summer months.

2. Drug treatment and intubation once patient is critical these option will rarely work because tissues/organs are already damaged by viral destruction of the beta chain of hemoglobin; therefore, blood can’t carry O2, and the body is too weak to produce new red blood cells able to carry iron (and thus oxygen/CO2) even if drugs inhibit more hijacking.

3. Thus: start severe patients on drug treatment upon hospital intake to suppress further hijacking of blood by the virus, then give them a blood transfusion of new red blood cells immediately that are unhijacked.

4. If heme/hemoglobin is involved, a higher hemoglobin count may be protective to the disease process.  This may explain why nicotine helps.  It maybe that’s why smokers are so underrepresented in the data.  Their chronic hypoxia from smoking increases their hemoglobin counts.   This also would also predict less severe acute mitochondrial failure from COVID 19 disease in high altitude populations.  The Johns Hopkins map supports this.  Nairobi is untouched. 

5. Hypoxia explains the loss of taste and smell too.  We know that the human olfactory receptor becomes less sensitive under hypoxic hypoxia.  HYPERLINK

CONCLUSIONS:

If all this is true, we would see rapid patient improvement with the use of plasma first. The reason for many cases of recrashing with COVID might be due to an inability to recovery the ability to make new heme because of the mitochondrial damage. People forget heme synthesis begins in the mitochondrial matrix. This implies we should consider RBC transfusion later in the disease during recovery.

These ideas should be very testable in the hospital environment now.

Also, if it’s true, we’re gonna need a lot of blood donations after the acute phase of viral attack.

So far as I know, there are no studies where we’ve tried transfusing blood from a patient who HASN’T had or recovered from COVID-19.

We can verify/disprove this by comparing outcomes between plasma-only and full blood transfusion (and control), or just between blood transfusion vs control (both should be given hydroxychloroquine. It appears the hydroxychloroquin is a heme salvage operation before acute infection and beta chain destruction.

So for ER/ICU/hospitalists MD’s handling incoming severe patients with multi-organ system failure that we consider early plasma therapies to protect all heme proteins and later blood transfusion with supportive care to deliver oxygen to mitochondria in tissues that are undergoing acute mitochondrial colony failure.  

CITES:

1. https://www.click2houston.com/news/local/2020/03/29/houston-methodist-first-in-nation-to-be-approved-by-fda-to-transfuse-donated-plasma-from-recovered-covid-19-patient/

2. https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

3. https://jamanetwork.com/journals/jama/fullarticle/2763983

4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617508/