Month: June 2024

For light to have a biological effect, photons must be absorbed by photoreceptors in the living body or there is no effect. ROS/RNS creation in mitochondria and oxygen begin this process.

H202 is a type of ROS made in mitochondria when we are healthy. When do we make ROS during the day? Daylight is associated with higher electric fields and lower magnetic fields and this correlates to mornings having higher ROS production. The morning AM ROS burst links to the PER2 gene in the mammalian clock mechanism. These effects are rooted in the spin selected ROS partitioning between peroxide and H202, known as the radical pair mechanism

When you add hydrogen perioxide to tissue heat is released and this heat is a clue that light is being liberated from the atoms in matter in your cells. I do this in almost every surgery I do but rarely tell people why I am doing it or how it works. My surgical team sees a lot of bubbles released and those bubbles are hydrogen gas being liberated at the same time. But there is more magic below the cell level to help my patients get better. I got the idea from radish roots.

This study below investigates the spontaneous emission of biophotons from radish root cells and the effects of various treatments on this biophysics phenomenon.

Key findings in the paper:

1. Freshly isolated radish root cells exhibit spontaneous biophoton emission at a rate of about 4 counts per second. This is an ultraweak photon release.

2. Addition of hydrogen peroxide (H2O2) to the cells from matter in cells significantly enhances biophoton emission from cells up to a rate of about 500 counts per second. When I read this I said I know how I can improve redox in the surgical site of my patients. This light has a specific spectra in the case of radish roots. This varies in eukaryotes like mammals.

3. The enhancement of biophoton emission by the addition of H2O2 is completely abolished when molecular oxygen is removed by using a glucose/glucose oxidase system or when reactive oxygen species (ROS) are scavenged using reducing agents such as sodium ascorbate and cysteine. This is a big clue glucose is not the real problem in cancer, unfettered light release to alter the nuclear genes is by excessive ROS. This tells you why cancers always are associated with their own brisk blood supply to keep oxygen humming to create light cells are missing to get through mitosis. That light is ultraweak UV light.

4. Spectral analysis of the H2O2-induced biophoton emission shows that biophotons are mainly emitted in the green-red region of the spectrum in radish.

5. The energy for this biophoton luminescence in cells is produced when an excited biological molecule drops to a lower energy state and the majority of the excited biological molecules are reactive oxygen species (ROS) Singlet oxygen, systematically named dioxygen and dioxidene, is a gaseous inorganic chemical with the formula O=O, which is in a quantum state where all electrons are spin paired. It is kinetically unstable at ambient temperature, but the rate of decay is slow.

Singlet oxygen (represented as 1ΔgO2, abbreviated as 1O2) is not a radical and represents an excited state of O2 in which the spin of one of the unpaired electrons is changed to yield two electrons with opposite spins. The terms ‘singlet oxygen’ and ‘triplet oxygen’ derive from each form’s number of electron spins. The singlet has only one possible arrangement of electron spins with a total quantum spin of 0, while the triplet has three possible arrangements of electron spins with a total quantum spin of 1, corresponding to three degenerate states. An excellent way to detect the presence of singlet oxygen is using steady-state or time-resolved measurements of its characteristic phosphorescence at around 1270 nm. Phosphorescence is a process in which energy is absorbed by matter in a cell and is released relatively slowly back into the cell in the form of light. This is in some cases the mechanism used for glow-in-the-dark materials which are “charged” by exposure to light. In mammals the amount of light is absorbed quickly by chromophore proteins to be used for signaling. This is why surgeons do not see what is clearly there during surgery. Plus, humans retina cannot see NIR light at 1270 nm . So how do we know this light is present? We use machines that can detect it.

Electron paramagnetic resonance (EPR) spin-trapping data shows that the formation of singlet oxygen is observed after addition of H2O2 and correlates with the enhancement in biophoton emission.

These findings in the paper below provide direct evidence that singlet oxygen is involved in biophoton emission from radish root cells. The results suggest that the biophotons are generated through a process involving the formation of singlet oxygen, which emits 1270nm light in the NIR range of the spectrum whose production can be enhanced by the addition of hydrogen peroxide.

 

SUMMARY

We know about how radish roots do it, but what about us when the solar cycle is awry?

Melatonin as a potent antioxidant and anti-inflammatory agent is known for protection of normal tissues against ionizing irradiation. This tells us that is has to be a control switch for ROS creation. Bright light and heat lowers melatonin effects and dark and cold temperatures increase its effects. Melatonin clearly is linked to ROS creation in some novel way. What do we know about sunrise? Light dominates the environment and the electric ield in the plasma called the ionosphere increases. The magnetic field of the gases in that ionosphere increases. 21% of the atmosphere is made of oxygen that is paramagnetic and this causes it to be drawn to tissues with high mitochondrial capacity. lWhen the sun rises, ight (photons) begins transfers energy to matter, causing the electrons to be emitted. What is it about electrons that maybe the clue to this mystery?

If you look back to Becker’s work he warned us about about the negative effects of electropollution. He also taught us about magneto pollution to a lesser degree. He also showed us how strong gauss magnets were able to induce anesthesia in salamanders before surgical procedures. He told us about the effects he and Marino found along electric power lines in Upstate New York in human subjects.

MAMMALIAN IMPLICATIONS OF THIS?

The TCA cycle produces more reducing power with a 22 ATP gain from its reducing power while glycolysis only produces 6 ATP from reducing power and Pentose phosphate group varies in the number of reducing power it produces. This tells us glycolysis and the TCA cycle on a relative basis vary greatly in how much ATP and ROS they produce.

Metabolic rate, when viewed from ATP creation is driving a developmental timing mechanism in a cell. But something must act as an off and on switch.

We know from the video about that 1270nm light equalizes the amount of ATP and ROS they produce. This appears to be the tipping point between day and night to act as an off and on switch in some way.

The implications are vast for many diseases from cancer, healing, autoimmunity, and to mastocytosis. How so?

For close to 15 years I have been giving major clues out to my tribe that magnetic fields are linked to circadain clock biology. How do they link is the biggest mystery in decentralized science. This blog explains the link CLEARLY.

The centralized assumption that I have always rejected has always been that the eye mainly senses light, whose local distribution is transmitted to the brain in a kind of copy by a mosaic of impulses. This is an idea so obvious to abuse by Nature to encode a hidden message in how life really operates. Instead of accepting that assumption, I looked for evidence in the literature of researchers who were wiser and actually thought about attaching electrodes to the animals who made it through the last extinction effect optic nerves so we might be able to eavesdrop on the signals Nature was really sending to message. I found evidence in amphibians where researchers positioned an aluminum hemisphere around a frog’s eye and moved objects attached to small magnets along the inner surface of the sphere by moving a large magnet on its outer side. This effect was eerily similar to the effects found in Becker’s work on regeneration and salamanders. This simple experiment showed me that non visual photoreception was the mysterious behind what Nature was doing. Then I jumped hard and looked for more zebra’s. And I found them in the eye of mammals and wrote the evidence in slides for talks I gave all over the world.

WHAT IS THE ELECTROMAGENTIC INFORMATION CELLS LOSE WHEN OUR EYES GO AWRY?

Think about what I have said about the European Robin eyes and the cryptochrome gene for 20 years now. The answer is buried there.

The development of the radical pair mechanism used for magnetoreception in bird retina has allowed for explanation of the fact that magnetic fields are observed to have an effect on chemical reactions speed in animals that made it through the last extinction event. It turns out the same mechanism found in birds, and their ancestors, theropod dinosaurs is also found in all mammals. The eye speaks to the brain using Nature’s most hidden recipe built in a language already highly organized in atomic physics, clocked and expertly interpreted, instead of transmitting some more or less accurate copy of the distribution of light on the receptors.

This quantum mechanism describes how an external magnetic field can alter chemical yields by interacting with the spin state of a pair of radicals.

The radical pair mechanism is based on the dependence of product yields on

1) the hyperfine interaction involving electron spins and neighboring nuclear spins of atoms and

2) the intensity and orientation of the geomagnetic field.

3) the chemical reaction kinetics in radical pair mechanism (RPM) is related directly to the qualities contained in the magnetic field in question. Overall, the spin evolution between singlet and triplet states in ROS/RNS radicals are affected by the magnetic field, is the key feature for radical pair mechanism.

4) Early proponents & biophysicists missed the magnetochemical effect in cells and focused on light chromophores.

This told my decentralized mind that one needs to know the general scheme of chemical reactions involving radical pairs generated from singlet and triplet precursors; one needs to understand the spin dynamics of the radical pairs; and the magnetic field dependence of product yields caused by the radical pair mechanism. It also told me I needed to understand solar cycles and disease patterns better.  This told me I needed to look carefully at the eye of birds where the RPM mechanism was discovered in the mid 1970s. So that is what I did. If you go back and look at the Cold Thermogenesis #6 blog post you’ll see what I said there about the eye and spin dynamics. It was all there early.

During summer solstices did you know that pipes corrode faster than normal? Do you know why this happens? It is the same reason bipolar patients symptoms get worse during the summer solstice: Magnetic field strength is at its strongest. Did you know the Pandemic of 1918 also was linked to solar dynamics and magnetic strength? The majority of pandemic influenza outbreaks since 1700 CE were associated with minima and maxima of sun spot numbers linked to the 11 year solar cycle. In fact, seventy-four percent of influenza pandemics and epidemics (26/35 events) since 1700 occurred at or within one year of the peak or trough in sunspot numbers, increasing to 89 percent (31/35) within two years. This links magnetic field strength to immune function.

Chemical reactions in our immune system that involve radical intermediates are influenced greatly by magnetic fields. These fields act to alter their rate, yield, or product distribution. These effects have been studied extensively in liquids, solids, and constrained media such as micelles. None of these are well studied in centralized medicine. They will be well studied in El Salvador’s new decentralized system. It maybe the earliest detection system of disease we have today.

CONSIDER THIS EXAMPLE:

The involvement of singlet oxygen in biophoton emission has implications for our understanding of many diseases like mast cell disease in the skin that links to immune function. Mast cell dysfunction is linked to an absence of 1270 nm light in skin of mammals. Singlet oxygen is known to liberate this frequency of light as the picture below shows. People with mast cell disorders do not make enough hydrogen peroxide from their mitochondrial respiration. As a result, with a comorbid lack of sunlight containing 1270 nm light and lack of H202 creation in tissues is asosciated with immune dysfunction in mast cells. There is a lesson here that radishes are teaching us about mastocytosis.

People with cancer, autoimmunity, mastocytosis, and poor wound healing always are deficient in AM sunlight. Why? This is when we get a lot of NIR light that has 1270nm light. Early morning 6AM -9AM sunlight has a relative irradiance that has a higher amount of photons in the visible and NIR spectrum compared to midday exposure (noon). The picture tells why you decentralized medicine always recommends AM sunlight. This sun time = TINA = THERE IS NO ALTERNATIVE. You remember that recent blog?

All of you know about the COVID pandemic. Do you know that it began during a weak solar cycle. This was my first evidence that the 2020 Wuhan flu was manufactured because it made no sense based on what I know about immune cell function. What prediction can I make right now about those who took the experimental treatment? 2024-2026 will be deadly for those people. Why?

The 1918–1919 pandemic flu virus happened during during an exceptionally strong solar cycle and caused acute swelling of and bleeding from the lungs from the healtiest people on Earth, and people who were infected typically suffocated within one to two days. Most were men in great metabolic shape. The second wave of the pandemic was responsible for the most deaths, due to an unusually severe hemorrhagic pneumonia. Today, in 2024 we just had 4 massive CMEs where the aurora’s were seen into the tropics, and the people who were the most healthy are dying at unbelievable rates now as evidence by my Tweets over the last 9 months. How did i know in 2020 this was coming. I know history and I know about the RPM mode of transmission to ROS/RNS.

H5N1 is bird flu. Why is the CDC, FDA, and WHO warning today’s COVID jab victims today about bird flu? Because they know they caused the COVID pandemic accidentally via gain of function study in Wuhan and now they are seeing evidence of patients in the experimental group who are beginning to experience similar pathologies to those of the 1918–1919 pandemic. Namely they are EXPECTING MASSIVE acute respiratory distress syndrome to overwhelm high vaccinated populations. This is the collateral effect they fear. The act of blocking your eye or skin from the sun around these coming dates might be a deadily choice for many. Also on these dates I expect we will have serious political and economic news hit to change sentiment rather quickly. Neurologic processing changes this way when ROS/RNS peaks.

HOW DO YOU TREAT IT BEST?

ARTIFICIAL RED PANELS DO NOT EQUAL AM SUNLIGHT EVER.

The radical-pair mechanism explains how a magnetic field can affect reaction kinetics by affecting electron spin dynamics. Most commonly demonstrated in reactions of organic compounds in cells involving their radical intermediates, and a strong magnetic field can speed up a reaction rates by decreasing the frequency of reverse reactions. This is why bipolar patients are acting very bizarre this year. It is also why those with neurodegeneration are having wild swings in their symptoms day to day now. Look at the narratives around Biden’s behavior lately. It is all controlled by the puse of ROS his defective mitochondria are making during this tumultuous time as we revovled around the sun.

Mitochondria act as signaling organelles in low-oxygen conditions. Hypoxia (0.5–3% oxygen) increases mitochondrial ROS that activate transcription of adaptive genes. Anoxia (0–0.5% oxygen) initiates mitochondrial outer membrane permeabilization (MOMP) to activate cell death. You’ve been given an amazing piece of decentralized science today. Use it wisely.

My predictions for my tribe in SOLAR CYCLE 25?

Know your solar history and you choices around the jab. On September 15, 2020, the solar minimum occured between Solar Cycle 24 and 25 – the period when the sun is least active – happened in December 2019 when Wuhan virus escaped. When I reviewed the 13-month period, the smoothed sunspot number fell to 1.8. The only part of the government who told the truth at this time was NOAA and NASA. According to the Solar Cycle 25 Prediction Panel they are praying for weak Solar Cycle 25 because of the lab leak. Early 2024 results however, have showed their guesses were WRONG. They expected peak sunspot activity expected in July of 2025, but within the last month we have had spectacular CME from sunspot activity that hit Earth. This is why so many people with jab injuries, mental illness, clots and cancer are hitting my emergency room like nuts the past 6 months. I expect the July 2024 – July 2025 Solar cycle to be DEADLY.

The Solar wind energy striking the Earth’s magnetosphere affects the entire environment because the pressure on the region increases and the magnetosphere shrinks sometimes four Earth’s radii. This sudden compression causes earthquakes in specific plates. We’ve had a quite a few more earthquakes in El Salvador the first 6 months of 2024. Maximum quake frequency occurs at times of moderately high and fluctuating solar activity. Terrestrial solar flare effects which are the actual coupling mechanisms which trigger quakes appear to be either abrupt accelerations in the earth’s angular velocity or surges of telluric currents in the earth’s crust. It appears even earthquakes are magnetochemical.

Solar Cycle 24 was average in length, at 11 years, and had the 4th-smallest intensity since regular record keeping began with Solar Cycle 1 in 1755. It was also the weakest cycle in 100 years. Solar maximum occurred in April 2014 with sunspots peaking at 114 for the solar cycle, well below average, which is 179.

Solar Cycle 24’s progression was also unusual and why NO PANDEMIC should have hit us at this time. This is why I knew in 2020 that this was a gain of function Lab leak manufactured problem. Now you know why I was so on top of it. in 2024 the Sun’s Northern Hemisphere led the sunspot cycle, peaking over two years ahead of the Southern Hemisphere sunspot peak. This resulted in solar maximum having fewer sunspots than if the two hemispheres were in phase. This has a lot to do with the changing of the magnetic poles in the Northern hemisphere now. The magnetic North Pole is now in the UK. Recall, last summer I visited this area. Now you know why.

Solar Cycle 25 PREDICTIONS for the EXPERIMENTAL GROUP AND THOSE WITH LOW REDOX
For the last eight months of 2023, activity on the sun steadily increased, indicating we transitioned much more rapidly to Solar Cycle 25 in the first 6 months of 2024. More people already sick with diseases will die sooner. Kids with autism will struggle more this year. People who have a framshifted genome will get sicker quicker and die more rapidly than their centralized MDs expect. The more healthy they are, the more likely they will get sick and die. It is only shocking when you DO NOT UNDERSTAND THE BIOPHYSICAL LESSONS IN THIS BLOG.

I have a sense Solar cycle 25 is also going to be be unusual with more strength and higher peak of sunspots than NASA and NOAA expects. In Solar cycle 25 NASA said they expected only 115 sunspots. The first 6 months of 2024 told me otherwise. We are experiencing it right now based on the recent auroras and the weather in the tropics. We are seeing this in the radical changes in President Biden’s behavior and his mental state. Right now El Salvador is getting smoked by harsh weather NOAA/NASA/Bukele did not expected. This is why I am making my predictions to you right now. Right now people are getting more sick and dying who should not. I know why. This blog has those answers. ROS is out of control in living things.  Few see what I see.

What was buried in the CT #6 blog? How quickly solar activity rises is an indicator on how strong the solar cycle will be and how diseases states will react. Share this uncommon adivce with your loved ones.

CITES

https://pubmed.ncbi.nlm.nih.gov/20106674/

Rodgers, C. T. Magnetic field effects in chemical systems. Pure Appl. Chem. 2009, 81 (1), 19–43

https://www.patreon.com/posts/19082581

 

There has been some recent news out about folate levels, sunlight and artificial light. Many people do not know folate is a photosynthetic chemical and it links dark skin (melanin) for natural folate protection.

We have clear evidence (Cite 1) that ultraviolet radiation affects directly in proportion to folate human blood. Seasonal cycles repeat annually and light stability is more common at low latitudes. Therefore, the amount of photosynthetic chemicals we use acts as a photosensitizer to our chromophore proteins. This has big implications inside the tropics. The percentage of low folate values increases in summer by almost 3.5 percent in comparison to winter. Moreover, geneder differences are huge. Overall folate levels are lower in men as compared to women, regardless of seasonality. This makes sense because of who has the children.

Vitamin B9 (Folate) was first extracted from spinach leaves in 1941. The term folate comes from the same root as foliage: green and leafy. Folates are vital: they accept carbon atoms and pass them on as needed as the fundamental basis for proper methylation. This implies that during summer months folate levels should be expected to be at their lowest levels NATURALLY.
Folate biology has a specific and tight seasonal control mechanism linked to light.  This is not a food story at all 

What if there is no seasonal or light controls in place? 

Folate is often given to pregnant women to prevent spinal dysraphisms today. This is something pediatric neurosurgeons deal with and why I know a lot about them.  The incidence of these conditions has dropped but it is has done at a COST.  Why?  but too much folate/folic acid causes cognitive haze and sleep difficulty and may cause neural migration problems in artificially lit environments.  This should awaken you what I wrote in Quantum Engineering #45..   In North America, (CAN/USA) folic acid was added to all grains in 1996.  This is only a few decades ago and we are seeing the transgenerational effects of this right now in our children’s disease phenotypes.

In general, it does not appear that even large amounts of folic acid taken orally are acutely toxic in adults. However, given the fundamental role of folate levels in synthesizing nucleotides (including RNA and DNA) and in methylation reactions as a methyl donor, high levels may have inadvertent implications for proper methylation of DNA during times of rapid cell division, such as in prenatal development. You’d think the idea that adding folic acid to the food supply might have caused centralized medicine to expect unintended consequences.  Few thought about, much less studied it.  I have always been worried about this effect since I learned that B12 was a photoreceptor in humans.  (slide from Vermont)

This idea has been speculated in research circles as early as 2005, and specifically speculated to be relevant for the increase in autism in 2011.
MOST PEOPLE WITH MTHFR DEFECTS ARE SUPERSENSITIVE TO LIGHT VARIATIONS

An early review of potential problems with mass folic acid supplementation of the food supply was undertaken by Lucock and Yates. Here, they noted that a drastic increase in folates could lead to a selection for the previously rare MTHFR genetic substitution of T for C at area 677 (MTHFR C677T), and that if folic acid is supplemented at doses above 400 mcg that unmetabolized folic acid will circulate in the blood supply at a level largely consistent with the excess dose. In 2005, Lucock and Yates noted that high levels of folic acid in the blood does not generally occur as a result of ingesting natural folates and that “no work has been done so far to evaluate the biological and genetic consequences of excess long term exposure” to these circulating folic acids on DNA/RNA biology. After that review, there were two separate findings of unexpected increases in asthma and breathing problems associated with folic acid use.
It now appears that we have clear data that excessive methyl donor transfer has significant epigenetic effects in humans. This work dovetailed with another review questioning the wisdom of mass folic acid supplementation published in 1996. Smith et al. pointed out that by supplementing the food supply; several hundred thousands of persons are exposed to greatly increased levels of folic acid. These authors noted that prior research had shown that expectant mothers with low vitamin B-12 (most vegans/vegetarians) AND high levels of folic acid were associated with offspring having an unexpected increased risk for insulin resistance and disease associated with this condition.  This is worrisome when you know that blue light exposure does the same thing and more.

Troen et al. found that some women past childbearing age subjected to high folic acid supplementation may be at risk for reduced immune system functioning causing inflammatory autoimmune conditions to spike. This problem has gotten worse since I first looked into it in 2005.

Did you know mammals exhibit genomic instability under conditions of folate deficiency in the skin. Remmber your skin is a neuroectodermal derivative. A lack of folate adversely effects your skin’s cellular capacity to handle UVR light. This is why so make pale gingers burn so fast. Moreover, did you know that optimizing folate levels in skin is beneficial in preventing or repairing the pro-carcinogenic effects of UVR exposure? Folate restriction by any modern excuse leads to rapid depletion of intracellular reduced folates resulting in S-phase growth arrest. Did you know this leads to ncreased levels of inherent DNA damage, and it causes increased uracil misincorporation into DNA. This is called a frame shift mutation and it is how light can cause transepigenetic signaling. This frameshift mutation will not cause a significant loss in overall cellular viability. It is how mammals adapt to changing seasonal light environments. Folate depleted keratinocytes can be sensitized toward UVR induced apoptosis. This changes the biophoton spectra emission from mtDNA and this displays a diminished capacity to remove DNA breaks. This allows for changes in phenotype. This occurs by photo and oxidative DNA alterations. Your dermatologist likes to call this damage, but Mother Nature uses this for seasonal adaptation in your skin. When this occurs more UVR = more melanin production. This protects your folate stores from degrading. Nature is amazing when you see her recipes. Dermatolgyis dangerous because they do not understand what she is doing on your behalf. Thus, folate deficiency creates a “permissive environment for genomic instability to allow for seasonal change. It is not an early event in the process of skin carcinogenesis or autism. If one abuses the use of folic acid and blue light than you can and will get diseases. The effects of folate restriction, even in severely depleted, growth-arrested keratinocytes, were reversible by repletion with folate foods. In summertime, foods with folate are plentiful in the tropics for this reason. Photosynethesis always has our cells backs.

 

FOLIC ACID SUPPLEMENTS EXACERBATE MTHFR DEFECTS

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme encoded by the MTHFR gene and has significant implications in the field of decentralized medicine. This enzyme plays a critical role in the folate metabolism pathway, which is integral for processes like DNA synthesis and repair, as well as epigenetic alterations via methylation by light variation. Variants of the MTHFR gene are associated with altered enzyme activity, which can, in turn, affect mtDNA heteroplasmy and disease phenotypes. This happens by alterations created in the spectra of biophotons made via metabolism. You’ll hear more about that soon enough.

Increased consumption of folic acid is prevalent in our modern world, and has negative consequences for MTHFR patients.. The effects of folic acid on the liver, the primary organ for folate metabolism, are now being unfolded. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions.

New data now suggests that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTHFR deficiency in the liver and skin of mammals. This deficiency results in hepatocyte and keritinocyte degeneration in both organs, suggesting a 2-hit mechanism whereby mutant hepatocytes cannot accommodate the lipid disturbances (how fatty acid carbon lenghts are dealt with and how melanin operates in the skin) and altered membrane integrity arising from changes in phospholipid/lipid metabolism. People forget the skin biology needs optimal light to control the lipid rafts in the skin as seasons change. Folic acid destroys this ability. This data has clinical implications for individuals consuming high-dose folic acid supplements, particularly those who are MTHFR deficient.

WHAT ABOUT CYP VARIANTS?

CYP enzymes are heme based and subject to blue light toxicity. They have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, archaea, and even in viruses. This is why so many astronauts have viral particles in the blood and space is known to foster cataracts and protein folding issues in the eye. However, they are not omnipresent in all bacteria; So space blood infections vary compared to the ones we see on Earth. More than 50,000 distinct CYP proteins are known to man.

Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen). Remember electrons must be excited by sunlight to use the photoelectric effect in the photon traps in aromatic amino acids. Based on the nature of the electron transfer proteins, CYPs can be classified into several groups: I covered this with Rohan during a past Sunday Q & A that lasted 5 hours. Members should listen back to those recorded Q & As to refresh their minds.

• Microsomal P450 systems, in which electrons are transferred from NADPH via cytochrome P450 reductase (variously CPR, POR, or CYPOR). Cytochrome b5 (cyb5) can also contribute to reducing power to this system after being reduced by cytochrome b5 reductase (CYB5R).
• Mitochondrial P450 systems, employ adrenodoxin reductase and adrenodoxin to transfer electrons from NADPH to P450.
• Bacterial P450 systems, employ a ferredoxin reductase and a ferredoxin to transfer electrons to P450.
• CYB5R/cyb5/P450 systems, in which both electrons required by the CYP come from cytochrome b5.
• FMN/Fd/P450 systems, originally found in Rhodococcus species, in which an FMN-domain-containing reductase is fused to the CYP. (cytochrome 2 in humans is related to this system.
• P450-only systems, which do not require external reducing power. Notable ones include thromboxane synthase (CYP5) for platelets, prostacyclin synthase (CYP8) for PG synthesis, and CYP74A (allene oxide synthase). You should begin to see just how we are beings of light who need solar programming by sunlight and not man-made light.

Anything transferring electrons to proteins = a semiconductive circuit. When you understand the photoelectric effect only works with photons and electrons you begin to see why SNP status are mostly superfluous and generally do not matter when you’re in the sun chronically and you have melanin in your integument and interior properly renovated.

Melanin operates in us to charge separate water into its components of H+ and oxygen and 2 -4 electrons. The level of oxygen dissolved in cells is critical in varying the ultraweak biophoton signature from metaboilsm. Those two electrons liberated from charge separation obviate the need for exogenous and endogenous sources of electrons (grounding/food). SNPs evolved because mammals varying in how they ground and what they eat based on latitude and what photosynethesis can provide. SNPs and SAPs tell vary in how melanin biology is operating. They are like equalzer buttons for music made in cells.

People with a lack of melanin think SNPs matter way more than they do because functional medicine MDs tell them this. This is incorrect. Pale people without enough melanin lack electrons to run their semiconductive circuits. You’d be wise to avoid that level of centralized thinking in the future. Folic acid lowers electrons = lowers your redox power.

How humans operate is specific to humans and not to other mammals. Most of the BH4 and Vitamin C used as cofactors deliver electrons to the biochemicals. BH4 and Vitamin C deliver the exogenous sources. Melanin delivers the endogenous source of electrons. Humans create massive amounts of electrons when POMC is operational in their tissues. Here you see Noether’s thereom show up yet again.

THE SUN IS THE BEST SOLUTION TO THIS PROBLEM

SUNLIGHT reduces all these risks, while modern lighting exacerbates it.  Moreover, it appears nature is trying to tell us that the sun raises melanin and melanin is protective.  Strong solar cycles in photosynthesis seem to simultaneously lower folate in foods in the summertime for a deep reason. That reason is epigenetic hypermethylation which can lead to sleep apnea and cancer formations later in life due to altered DNA methyl marking. This process also alters how RBC circadian cycles (ferrodoxin) can work within their circadian cycles with the innate immune system and TOLL receptors.  Most people with anemias have this intrinsic problem linked to modern behaviors around light.

Folate is destroyed by strong sunlight with both UVA and UVC light. Darkened skin protects the stores we have, but there is now proof that folate levels are designed to be low when the solar radiation is strong in the local environment. These days most people are eating food humans have been engineered and/or genetically altered in some way. Then add in the effect of Artifiical light day and night.  This throws off the normal variation of the natural folate cycle during seasons. Today, people in developed countries are getting MASSIVE amounts of folates in the form of folic acid. This is the real reason to avoid grains.  Folates are now being ingested in three ways: as natural folates from food, as synthetic folic acid added to processed grains and synthetic from vitamin supplements.  All of these idea are counter evolutionary to Nature’s laws.

SUMMARY

Methylation patterns are linked to how light is transformed in a cell. When sunlight is absent for any reason mitochondrial redox drops. When this happens energy transformation drops. As a result of a lack of energy methylation problems shows up in both genomes. Decentralized clinicians know what to look for. Allopathic and function docs would know what to look for because they still have no idea that light controls the enzymatic flux in metabolic pathways.

Loss of mitochondrial redox power causes methylation problems to manifest in your labs without any SAP/SNP issues present in your MTHFR survey or nuclear genome. Very few clinicians know a lack of sunlight causes methylation defects.
It shows up in your labs in a very specific pattern of results as an accumulation of methionine and S-adenosylhomocysteine, with low or low-normal levels of S-adenosylmethionine (SAM) and homocysteine. PBM treatment fixes it. Sunlight is always the best treatment. Supplements not so good.

As a result of the supplementation of folic acid, the circulating level of unmetabolized folic acid, as well as total folates, has greatly increased over the past generation, probably to levels largely unprecedented in human history.

Folic acid has been shown to be able to epigenetically alter the functioning of the genome and to have long term effects on gene expression as I mentioned above.

The Centers for Disease Control Vaccine Safety Datalink data set compared children with autism to control children on several variables. Many people who think the link of vaccines to autism might be shocked to find out that folic acid supplementation during gestation is associated with a serious increased risk for autism. I believe the combination of artificial light and folic acid supplementation are causing neural migration problems.  This is why parental melanin levels are important clues.  This effect remains even when health-seeking behaviors and other variables are controlled. This is information parents of kids with AUTISM need to know. Autism, asthma, allergy, ectopy, eczema, diabetes T1D, T2D, and MODY, auto-immunity, and spinal abnormalities have their lowest incidence is lowest in equatorial environments and it appears now we know why this is the case.  This is decentralized medicine 101 I will bring to El Salvador.

CITES

 

1. Valencia-Vera E, Aguilera J, Cobos A, Bernabó JL, Pérez-Valero V, Herrera-Ceballos E.. ‘Association between seasonal serum folate levels and ultraviolet radiation’. ‘J Photochem Photobiol B’. 2019 Jan;190:66-71

2. https://threadreaderapp.com/thread/1656714608793485326?refresh=1683832764

3. https://www.linkedin.com/article/edit/6330012027309875200/

4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/

5. https://en.rattibha.com/thread/1798513232203673687

The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Massive amounts of emerging evidence suggests that circadian regulation is critically linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to all diseases. Conversely, metabolic signals feed back into the circadian system, modulate by applying what circadian gene expression is based on the light sensing from the environment. This alters behavior and disease phenotype. A loss of circadian periodicity causes metabolic derangement. Light controls food at all levels.

The podcast above was all about the treatment of idiopathic intracranial hypertension that manifests with optic nerve swelling, visual changes due to retinal blood vessel defects, and headache.  You might be surprised to know that idiopathic intracranial hypertension (IIH) is also associated with tinnitus.  That should stop you dead in your tracks if you are black swan mitochondria considering my recent podcasts and blogs here.  You now know that your cochlea is lined with melanin.  In fact, every sense organ is between the environment and the brain.

CPC stands for a clinico-pathologic conference that we often see in medical schools that are used for teaching students and doctors.

Today you are going to medical school, albeit, a decentralized medical school lesson how why light trumps food.

What did the centralized podcast lesson above miss?  Melanopsin has been found as the dominant opsin in the human brain but it is also found in blood vessels of the brain and is critical in relaxing these blood vessels.  What happens when there is melanopsin damage to the vessels of the retina and brain when there is associated melanopsin damage?  Do blood vessels relax or do they become stenotic?  Might this be what the group of endovascular neurosurgeons missed above?

I think so.

What happens when melanopsin damage occurs?  The weak covalent bond between it and vitamin is broken and Vitamin A is liberated.  The freed vitamin A destroys all the photoreceptors like heme proteins, nitric oxide, B12, monoamine oxidase, glutathione, and many others.  It ruins the ability of cells to use light to signal to and fro. Fidelity of signaling is destroyed.

Vitamin A is the first discovered fat-soluble vitamin and is primarily found in animal products or converted from dietary carotenoids in plant products. It is not a single compound but a group of derivatives including retinol, retinal, retinoic acid (RA), and some carotenoids according to different terminal functional groups.  In general, vitamin A refers to retinol, while retinoid refers to a general term that includes vitamin A metabolites and compounds and exhibits vitamin A-like biological activity.

Preformed vitamin A (usually from animal products) and provitamin A (including beta-carotene, usually from plant-derived food) are the two forms of vitamin A in the human diet. After being absorbed in the intestines, these two forms of vitamin A are converted to retinol and then oxidized to form retinal and RA to support the biological functions of vitamin A. The retinyl ester is the storage form of vitamin A in the liver and must be converted to retinol before being utilized, and these vitamin A derivatives are finally metabolized by the CYP26 family enzyme.

CYP26 enzymes = the cytochrome P450 family 26 enzymes in ALL chordates. This includes all mammals.

The metabolic barrier provided by CYP26 enzymes in various tissues such as the testes likely ensures that RA gradients are regulated by enzyme expression and activity within the tissue and not by circulating concentrations. Therefore, understanding the destruction, activity, and expression of CYP26 enzymes in individual tissues and cell types is critically important for defining the relationship between all trans RA concentrations and biological outcomes within a tissue. This means retinoic acids also control all sexual behavior and fertility as well. Today we have record rates of infertility and transgenerderism. The link both are linked to the light humans live under. Few see this links.

Previous studies have shown that retinoic acid (RA), the bioactive form of vitamin A, is involved in the regulation of various intracellular responses related to biological rhythms. RA is reported to affect the circadian rhythm by binding to RA receptors, such as receptors in the circadian feedback loops in the mammalian suprachiasmatic nucleus.

Many people wrongly believe solar light cycles are tied to Vitamin D and its receptor in the skin, eye, and brain. Few know about vitamin A and how it controls the human photoperiod in our brains where our POMC neurons exist. It is the major player in determining photoperiodicity in the human brain because of how Vitamin A is covalently bonded WEAKLY to melanopsin. When blue light dominates an environment humans lost their photoperiodicity and develop sleep problems.

Photoperiodicity is accounted for by biophysical changes in Vitamin A in the brain. It accurately mirrors the changes in the brain and the body that occur between the seasons when you are a careful observer.

At the equator, light doesn’t vary at any time of the year. As latitude rises light variation increases. Your body responds to every degree of latitude change via Vitamin A biology and POMC translation. Read that again.

When comparing the effects of the short days that occur in winter with the long days that occur in the summer Vitamin A (retinoic acid) swings in massive amounts. Researchers are finally beginning to understand how the brain converts the electromagnetic signal of light, first to an electric message (DC current), and then to a chemical one in the neuron synapse called a neurotransmitter. Vitamin A entangles the brain to the skin with its cousin Vitamin D. It is also critical in ephaptic communication I mentioned it to Dr. Huberman on Twitter and he brought it up during the Rubin podcast. Ephaptic signaling refers to extracellular signals generated by either a single neuron or a population of neurons, and the neurons need not be in physical contact. This likely has a quantum mechanical basis linked to coherence.

SUMMARY

Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. Hypothalamic tanycytes sense vitamin A levels in the CSF. Did you know this?

We know that there are big changes between seasonal conditions on the planet even at the equator, and that seems to be how the wild animal controls weight gain and energy balance naturally in the environment. It also explains why obese women with IIH have massive alterations of Vitamin A too. Modern humans tend to gain weight in winter, and this is likely a new phenomenon related to their light environments. This is when they should be losing weight according to Nature’s laws. If you open any newspaper in January in the northern hemisphere, you will see tons of ads for New Year’s resolutions and gym memberships at this time to humans lose weight. This is unusual when you consider that wild animals do the opposite in January. Wild animals tend to get fatter going into the summer, and leaner into the winter when the light cycle is lowest and food is more sparse.

We now know that the human brain can sense retinoids, and regulate whole-body retinoid balance. This is how seasonal; light changes and local light changes sculpt the human ectoderm.

The reason becomes quite obvious when you consider that wild animals live by the dictums of their environment, but modern humans create their own environment via culture and socialization. This creation of their own environments destroys their photoperiodicity and dramatically alters Vitamin A signaling in the brain. Vitamin A is crucial in properly regulating the clocks tied to the hypothalamus that controls appetite, feeding, and energy balance. This is how quantum time is altered.

Today researchers have found that between winter and summer, retinoic acid changes dramatically in all mammals. There is a lot more to this ‘quantum dance’ of Vitamin A too. It appears there is much more powerful retinoic acid signaling during the periods of summer compared to the short days of winter. This implies that Vitamin A levels in the brain must be correctly tied to the seasonal alterations in ‘adiposity’ and depression result. Vitamin D gets all the press in the media, but Vitamin A control in your brain is way more important seasonally because of how it links to the POMC biology of melanin inside your body. It seems counterintuitive until you understand how QED works in the brain.

CITES

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432198/

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283048/

3. https://advances.nutrition.org/article/S2161-8313(22)00023-0/fulltext

4. https://onlinelibrary.wiley.com/doi/10.1111/jne.12886