QUANTUM ENGINEERING #38: THE STORY OF LIGHT & WATER FOR LIFE PRE-POMC

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The video above was recorded before I ever released the story of POMC and the evolution of man from his cousins.  But if you listen closely, especially at the end of the podcast I opened those doors.  This series of interviews I thought would lead Cory and Robin to the story of melanin biology which is the ultimate battery for sunlight.  We never completed this series because Robin lost interest, and decided to go back to the UK when COVID ended and the tapes were lost.  Cory recovered some of them and tried to improve the audio but this is as good as good could get. The story, however, is intact.  This story is important to understand what evolution did with melanin and the POMC gene.  We capture light via electrons and we move them the same way.  When electrons are moved they have to be controlled.  What controls the flow of electrons?  Semiconductive circuits.  DHA is key to the retinohypothalamic tract that controls circadian biology.  DHA creation had to be made before melanin could be innovated.  DHA and mitochondria innovation at the same time created water for eukaryotes.  That is how the water story began for life.

Organisms are open thermodynamic systems dependent on energy flow. Energy flows in together with materials, & waste products are exported, along with the spent energy that goes to make up entropy. Entropy defines the flow of time.  Molecular clocks are flowmeters of entropy.  And that is how living systems can, in principle, escape from the second law of thermodynamics by staying on the edge of it.  Cells do this by creating order from chaos using cells as a dissipative structure. That structure is built around the AMO physics of atoms in cells.  Their molecular arrangement inside the cell is the key life uses to do the things it does.

Cyanobacteria came sometime between 3.8 – 2.0 billion years ago and they possessed for the first time on Earth the machinery to utilize water as a fuel source by oxidizing it. THEY BURNED WATER TO MAKE ENERGY.  More significantly, the by-product of photosynthesis happened to be oxygen. for the planet.  That creation stimulated the evolution of mitochondria. This event, known as the “Great Oxidation Event,” occurred sometime between 2.4 – 2.1 billion years ago.

Life remained simple with just bacteria and archaea dominating the planet mostly in the oceans where electrons dominated.  Then environmental change happened again on Earth because the light of the sun changed at the Cambrian explosion. This event changed how life began to use water.  It brought water from outside of bacterial walls to the inside of cells to make water do things to light to build complex life.

Mitochondria created a sea of water for life to innovate upon. Water (H2O) is the third most common molecule in the Universe (following the H2 and CO molecule), and its standard chemical structure, based on the hydrogen bond, is actually confined by a simple scheme of charges interacting via static Coulomb forces; that is, liquid water as most humans experience it on Earth is totally reliant on electrostatics and omits all mention of electrodynamics and the consequent radiation field.

Cells have a different experience of liquid water than humans do because cells eliminate the Coulomb force at their scale.  Human cells do not burn water as cyanobacteria did.  We use it as a superconductive highway to move electrons and protons around our tissues to ferry solar light our proteins collect. It has been speculated that a large percentage of effects in condensed matter physics make use of the radiation field in one way or another but it still doesn’t seem to have found a place in much of the basic chemistry of life because it negates water from its understanding.

The POMC gene is the most innovative gene in all of life because it is the most complex condensed matter protein currently on Earth.  In biological systems almost all water is within a fraction of a micron or less from a surface or molecular backbone and so is interfacial water.  In humans, water inside a cell is never too far from coherent water in our cells by design.

This interfascial water behaves in a quantum way, where the Coulomb law of electrostatics does not apply. In these circumstances, charges attract and they do not repel each other.  This is why your mitochondrial matrix is filled with H+.  All of the biology itself depends on this scenario, so as to allow the accumulation of tissues from negatively charged cell bodies.  When you separate charges, you are creating the means to store energy from the sun.  You are creating a mini-sun in your cells to run your life.

SUMMARY

According to the domain system in evolution, the Tree of Life consists of three domains such as Archaea, Bacteria, and Eukaryotes.  The first two are all prokaryotes, single-celled microorganisms without a membrane-bound nucleus. All organisms that have a cell nucleus and other membrane-bound organelles are included in Eukaryotes.  Every domain of life emits light from its cells.  Prokaryotes emit 5000 times more light than eukaryotes do.

The frequency of light from the sun has changed for life many times in our evolutionary history.  The most recent change came from human frontal lobes via our imagination and innovation.  That innovation however is harmful to our POMC biology.

Because of POMC biology, humans need to go on a tech diet more than they need to go on a food diet.

Current versions of mammals are filled with mitochondria that are acclimatized to the specific amount of oxygen on Earth, that we take it for granted. However, oxygen was absent from the Earth’s atmosphere for close to half of its lifespan.  This is when we used other atoms as our terminal electron acceptors.  Their use was the best thermodynamic option in those epochs, but they were not the best choices on the periodic table.   When the earth was formed around 4.5 billion years ago, it had vastly different conditions in the environment. At that time, the earth had a reducing atmosphere, consisting of carbon dioxide, methane, and water vapor, as opposed to the present-day atmosphere which consists primarily of nitrogen (71%) and oxygen (21%).

Though sunlight split the water vapor in the atmosphere into oxygen and hydrogen, the oxygen quickly reacted with methane and got locked into the earth’s crust, barely leaving any traces in the atmosphere. A silent, mysterious force worked to release oxygen steadily until the very composition of the atmosphere changed. That mysterious entity happened to be a microbe: Cyanobacteria.

The earliest onset of life on our planet occurred around 3.8 billion years ago.  This video above begins to explore the history of Earth.   Since oxygen was projected to be absent from the earth at that time, metabolism in living organisms would have been anaerobic, involving the use of minerals present in the ocean to generate energy. This is how energy was transformed at ocean vents for billions of years.

There is also isotopic evidence for autotrophic carbon fixation at 3.7 to 3.8 billion years ago, although there is nothing that indicates that these organisms were photosynthetic. All of these claims for early photosynthesis are highly controversial and have engendered a great deal of spirited discussion in the literature (Buick, 2008).

However, around 2.7 billion years ago, a peculiar group of microbes, known as cyanobacteria, evolved in our seas. Phylogenetic analyses based on 16S and 23s rRNA, genome reconstructions, and fossil evidence have been used to understand the evolutionary characteristics of these early living organisms. These microbes possessed the remarkable ability to perform a different type of photosynthesis than the one we know today. This newfound ability allowed them to generate energy directly from sunlight.

Mammals used the same game plan when they innovated the POMC gene 220 million years ago and this innovation was refined and then amplified 65 million years ago to create man.

This is fractal biology 101.

CITES

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949000/

2023 MELANIN-LEPTIN Rx UPDATE

Morning Rays Keep Off the Pounds

When humans began using the alien portion of the electromagnetic spectrum along with the blue light on every screen in tech gear everywhere is when the obesity curves turned. It was not the food as the slide below shows.  1980 is when TV use really became explosive for color TV and 1995 was when technology spending took off and it created computer screens and terminals.

It was light and that light ruined how mitochondria could or could not handle food electrons and protons in mitochondria. Leptin resistance causes obesity. Leptin resistance = LR. LR = low melatonin because of melanopsin dysfunction. This story should not shock the older members in here but yet again you guys surprise me. Where was leptin found? Subcutaneous fat in 1994 at Rockefeller University.

Where does leptin have to go to tell the body about energy balance according to the old leptin blogs? The hypothalamus.

What connects the two?

Light connects them.

The light you choose, and not the food you eat. Food out of season from the control of photosynthesis is a problem but nothing compared to the light your eye and skin observe and measure.

A lack of full-spectrum solar exposure during the day, or getting man’s light at night is the most common reason for disease epidemics today, and in my opinion, the most overlooked issue in all of medicine these days. When blue light, RF, or microwaves affects melanopsin adenosine biology is altered. This is how adenosine rises and it is when melanopsin receptors are recycled.

Proper ocular melatonin cycling requires that these two frequencies (UV/IR) be present in the AM to stimulate the regeneration processes in the eye during the daytime. This quantized process also requires ABSENCE of blue/green light between 400-560nm post-sunset!!!! When these things are off the result always = INFLAMMATION = too many protons (deuterium) and/or not enough electrons at the mitochondrial cellular level = lowered melatonin levels in the eye, brain, and blood plasma.

The same is now true in the skin and subcutaneous fat because melanopsin is there now too.  The same thing is true about our arteries. That is how leptin resistance occurs at the tissue level. Melanopsin dysfunction turns retinol into a “time bomb”.  That time bomb is a disease.  Free retinol destroys melatonin and DHA atomic lattice in tissues.  This RUINS the band gap conduction in tissues.  Diseases cause you to lose time and a loss of time is because tissue level entropy is increasing.

Moreover, that time bomb ruins the aromatic rings in melanopsin, leptin, and melatonin to ruin their ability to communicate with the hypothalamus to give accurate light/time information about energy balance because information quanta are LOST to the colony of mitochondria in that tissue.

Life is designed to be as predictable as a pair of dice and this is why eukaryotes used viral parts and then stole a bacteria and turned it into mitochondria. It allowed cells to make better predictions using excited electrons, protons, deuterium, and diurnal and seasonal solar light changes to gain that stability by organizing cells to remain far from equilibrium.

Anytime you slow light down with an interaction with matter in a cell your cells become capable of slowing time or losing time and creating and changing a living system.  (Vermont video 2017)

Biochemical FLUX is explained by LIGHT: How does the enzyme know where the substrate is? It follows the path that light left in its wake. That pathway is made by excited electrons that leave the lattice and move within the electron clouds because light only interacts with electrons. Enzymes all work by proton tunneling. Red light is what moves things with mass.  Protons have 1836 times more mass than electrons.  Light moves electrons by exciting them photoelectrically.

Protons work differently with light. Red light moves things with mass, so the mass of the proton and red light’s ability in a cell are yoked to circadian signals inside a cell. So the pathway where a connection needs to be made between two chemicals or atoms in a cell will be lined with protons and neutrons in our protein lattice. It is almost like having a canyon carved into the cell for running water to follow.

In this analogy, the running water is the light that the cell assimilated, harnessed, and frequency adjusted in some way. Cell water does not equal tap water.  Cell water is equivalent to water in our blood plasma. This means the type of protons in water matters deeply to a cell. Blood has more deuterium in it than cell water does for a quantum mechanical reason.  It creates the UVC light that leptin needs.  This is why cell water is capable of acting as a molecular mirror (Vermont 2018 talk) for the 42% of infrared-A light in terrestrial sunlight.

Therefore, the enzyme gains knowledge of the path it should take because light leads it to its partner molecule. This happens are lightning-fast speeds (atto or femtoseconds) because the interaction between light and electrons is instantaneous. This means an enzyme knows the path through “a quantum observation’ of the system dynamically, of course.

The enzyme, a protein, has alpha helices that absorb light in specific spectral frequencies. That is what semiconductors do.  Those helices are tuned to the frequency of the substrates. Infrared spectroscopy demonstrates that each organic molecule has its own unique signature. Amazingly, the alpha-helices are just the right size coils to be easily tuned to the entire infrared and visible spectrum. The enzymes often organize as dimers for depth perception, just as we have two eyes.

THE BASIS OF THE LEPTIN Rx WAS ALWAYS LIGHT BASED

Your body is a collection of semiconductors that DNA has magnetically stored in our nucleic acids.  Those semiconductors only work with visible light.  Melanopsin, retinol, melatonin, and leptin are all biological semiconductors.  How does it work Jack?

Leptin induces two major effects on cells and their mitochondria by triggering a photonic signal transduction cascade: enhancing mitochondrial biogenesis and activity as well as enabling cell propagation and differentiation. The janus kinase-dependent signal transducer and activator of transcription 3 (STAT3), the adenosine monophosphate kinase (AMPK), and the peroxisome proliferator-activated receptor gamma coactivator (PGC)/peroxisome proliferator-activated receptor (PPAR) pathways are converging in supporting mitochondrial function and cellular proliferation.

The diversity of leptin-dependent signaling in the skin is illustrated by the fact that the hypoxia-inducible factor-1α, which controls the expression of multiple different genes, including that of key regulators of angiogenesis and wound healing, is also upregulated by the action of leptin.

THE PHYSICS OF LIFE IS LINKED TO COLOR

The color of absorbed and emitted light both depend on the band gap of the semiconductor. Visible light covers the range of approximately 260-760 nanometers.  This corresponds to 1.8-3.1 eV (electron volts). The color of emitted light from an LED or semiconductor laser (LED) corresponds to the band gap energy and can be read off the color wheel shown below.

So consider the color of the human liver.  It is the source of where gluconeogenesis or animal photosynthesis occurs in us.  The liver is reddish-orange/brown when it is not diseased.  The liver has this reddish orange because it has a lot of Iron oxides and this color confers has a 2.2 eV band gap.  Now look at all the other things distal to the liver in the gut which relies on the band gap present in the liver being accurate as we live.  In diabetics, it is destroyed.  Diabetes is essentially a narrow-band gap disease.

The color of absorbed light in semiconductors includes the band gap energy, but also all colors of higher energy (shorter wavelength), because electrons can be excited from the valence band to a range of energies in the conduction band. Thus semiconductors with band gaps in the infrared range appear black because they absorb all colors of visible light.  Nothing in humans truly is black.  So this tells you in human biology nothing absorbs all colors of visible light from the sun.

They use parts of the spectrum of the sun to communicate information to drive physiology.  This means the spectrum of life we live under is critically important.  Skin and eye MDs tell us the sun is toxic yet modern humans do not live under that light, do they?  And they get modern diseases that were rare before manmade light was created in 1893.

The band gap is a very important property of a semiconductor because it determines its color and conductivity of the semiconductor. Many of the applications of semiconductors are related to band gaps:

  • Narrow band gap materials are used as infrared photodetectors and thermoelectrics (which convert heat to electricity).
  • Wider band gap materials are used in electronics, light-emitting diodes, and solar cells.
  • Biological systems use both.  Bone for example is a wider band gap semiconductor. Cytochrome C oxidase is a narrow band gap semiconductor that creates water by converting mitochondrial heat and light emission.

To be clear let us go back to the liver to explain how color and conduction bands and light link.  The liver has a band gap of 2.2 eV and thus absorbs light best at a λ < 560 nm. It thus appears reddish-orange (the colors of light reflected from Fe2O3 because the semiconductors in the liver absorb green, blue, and violet light best.  It reflects most of the red and orange colors.  Those colors are the most dominant parts of sunlight but aren’t as useful to the cells in the liver.  Hepatocytes have a specific atomic lattice to do the things a liver does.

Hepatocytes are dissipative structures in the liver, but not the only ones. They transform light energy and create order from the disorder in light they use to operate.  When things are broken down in the liver non alcoholic fatty liver disease manifests as a result.

Dissipative structure theory (Prigogine) led to pioneering research in self-organizing systems, as well as philosophical inquiries into the formation of complexity on biological entities and the quest for a creative and irreversible role of time in the natural sciences.  This is why circadian timing is the critical factor in the Leptin Rx.

There is a well-known theorem of minimum entropy production derived by Ilya Prigogine, which states that entropy exported from a system reaches a minimum, or becomes zero, at thermodynamic equilibrium. Prigogine’s theorem is a direct consequence of Onsager’s reciprocity relationship. The principle of internal entropy compensation implies the principle of minimum entropy production, which is valid in dissipative structures built far from thermodynamic equilibrium.

WHAT IS ANOTHER DISSIPATIVE SEMICONDUCTOR IN US?

Hemoglobin is a porphyrin protein. Hemoglobin has a specific absorption spectrum.  Porphyrins are semiconductors in living systems.

The most common examples of porphyrins are the heme proteins found in hemoglobins, myoglobins, P450 enzymes, cytochromes, catalases, peroxidases, chlorophylls, and bacteriochlorophylls.

The porphyrins are heterocyclic ring structures that include four pyrrole rings joined together through carbon (methenyl) bridges. The most abundant porphyrins in nature are found in hemoglobin and chlorophylls. In the center of porphyrins, a metal atom is chelated to the nitrogen atoms of the pyrrole units.

Whole blood has absorption maxima at 545 and 578 nm, as has been previously reported in the literature in cite 3 below.  Hemoglobin is a semiconductor that has an isosbestic point.  It has two forms oxyhemoglobin when it is carrying oxygen toward mitochondria and deoxyhemoglobin when it is carrying blood away from mitochondria back to the heart and lungs. An isosbestic point is observed in overlaid spectra when a chromophoric precursor is converted to a product with a different spectrum so it is often assumed that an isosbestic point occurs only when the precursor is quantitatively converted to a single product.

Isobestic points are used in medicine in a laboratory technique called pulse oximetry to determine hemoglobin concentration, regardless of its saturation rate of oxygen. Oxyhemoglobin and deoxyhemoglobin have isosbestic points at 590 nm and near 800 nm.  RBCs are red because oxy-Hemoglobin does not absorb any light above 600nm.   Hemoglobin makes up 94% of the mass of RBCs but RBCs do not work unless they are in the water.  Blood is 93% water.  Because of the atomic organization inside of cells (AMO physics) there is always light energy stored and available within the cell system.  This is how entropy is limited in cells.  This is the basis of what a dissipative structure is doing at the smallest level.

When sunlight hits RBCs a net negative charge forms adjacent to the RBC membrane in blood plasma (pic above).  The energy derived from the sun is stored coherently in the RBC and in the water it floats in, and is ready for use, over all space-time domains present in tissues. Mitochondrial water production is critical in life’s semiconductive blueprint because porphyrins in cells bind iron, and carries oxygen to our colony of mitochondria in organs and tissues.

Mitochondria create water, CO2, and heat.

The fidelity of this water creation is the basis of the autonomy of organisms. Organisms are never simply at the mercy of their environments on account of the coherent energy stored. When the environment steals this ability from cells (nnEMF) cells are at the mercy of food and exercise.  When you get enough sun food becomes less necessary.  Everyone’s system is set differently because our semiconductors do not have the same band gaps based on genetics, skin color, eye color, haplotype, latitude, or atomic lattice arrangement.

More to the point, we don’t have to eat constantly (Leptin Rx above) when we’re in the sun, leaving plenty of time for other useful, pleasurable activities (SEX) that lead to the next generation of life.  This is the evolutionary directive.  Leptin also controls fecundity in us.  All sex steroid hormone pathways in humans are filled with POMC neurons that create melanin.  This means sunlight, also controls fertility.  I believe because of melanin, the UV part of the spectrum is the most important part of fertility.  This explains why so many young people are infertile today.

WATER IS ALSO A SEMICONDUCTOR

Light absorbed by RBCs changes the atomic/physical structure of the water surrounding RBCs and we can see this change when we see the charge around RBCs that have been irradiated by light.

The other consequences are that the organism is exquisitely sensitive and free from the mechanical constraints of life on Earth; and satisfies, at least, some of the basic conditions for quantum coherence. Water provides those abilities as well.

Liquid water on Earth is quantum coherent even at ordinary temperatures and pressure. This is why Nature got the idea to build cells around liquid water. It functionally is a naturally formed quantum computer. Liquid water made in the mitochondrial matrix is the most wonderous chemical Nature has ever built because the water forms more coherent domains than the water from the hydrology cycle.

Even latitude variation shows how water homogeneity changes as solar inclination affect its molecular arrangements and bond angles in hydrogen in water. Mitochondrial matrix water associates with macromolecules and membranes in cells into a gel-liquid crystalline configuration that enables enzymes and nucleic acids to function as quantum molecular machines that transform and transfer solar energy at close to 100% efficiency.

Liquid crystalline water at interfaces also provides the excitation energy that enables it to split into hydrogen and oxygen in photosynthesis, simultaneously generating electricity for intercommunication and for the redox chemistry that ultimately powers the entire biosphere on the 3rd rock from the sun.

Water is the means, medium, and message of life and it has to be made in large quantities in your mitochondrial matrix for you to remain healthy. Any reduction in its production will lead to some diseases.

SOLID STATE BIOLOGY IS MELANIN-LEPTIN Rx SPECIALTY

How do semiconductors handle a variable spectrum of light in physics?

Increasing the mole fraction of the lighter element (than the semiconductor atom) results in a larger band gap, and thus higher energy of emitted photons.  This is how ELF-UV frequencies are controlled in cells. It is also how mitochondria vary light emission in cells to inform DNA what to do.

EMFs in mitochondria inform DNA what to do. DNA signal organelles how to arrange atoms in cells to store energy by molecular resonance.  Leptin evolved to control this process in your cells.  Light coming through your eyes and skin begins the process.

Mitochondria are dissipative structures in cells, but not the only ones. They transform energy and create order from the disorder in light energy they use to operate.

To understand the last sentence you must understand what semiconductors really do.  Why do they have certain colors and what controls their ability to conduct electricity and create light for optical signaling in cells?

Pure (undoped) semiconductors can conduct electricity when electrons are promoted, either by heat or light, from the valence band to the conduction band. The promotion of an electron(e-) leaves behind a hole (h+) in the valence band. The hole, which is the absence of an electron in a bonding orbital, is also a mobile charge carrier, but with a positive charge.

The motion of holes in the lattice can be pictured as analogous to the movement of an empty seat in a crowded theater. An empty seat in the middle of a row can move to the end of the row (to accommodate a person arriving late to the movie) if everyone moves over by one seat. Because the movement of the hole is in the opposite direction of electron movement, it acts as a positive charge carrier in an electric field or magnetic field.

This solid state physics lesson above taught me to look at the choroid in the human eye to learn something about the future risk for obesity.  This is when I began to get interested in OCT of the retina.

The opposite process of excitation, which creates an electron-hole pair, is their recombination. When a conduction band electron drops down to recombine with a valence band hole, both are annihilated and energy is released. This release of energy is responsible for the emission of light in LEDs.  This is how light is created in cells to make ultraweak UV light spoken about in this book below.

UNDERSTANDING BIOCHEMISTRY IS NOT ENOUGH IN A BLUE-LIT 5G WORLD

Alchemist & Metaphysician = ancestral beliefs that biochemistry in a textbook is the definitive science of how life operates.  This is myopic. In 2023, n fact, it is pure BS.  Biochemistry is really a solid-state story of light and hydrated semiconductive proteins that change their ability as the electromagnetic signals on their surfaces, and this is capable of changing the geometry in their lattice via a change in charge density. All this is done epigenetically by light.

People forget that Einstein taught all of science that light and time are relative.  This means that food is also relative to the time of the day, but the implications of both are not obvious to those who have not that deeply about it. Once you do you’ll understand nature better.

For example, the great thing about telescopes is that they are time machines. Because light travels at a finite speed When we look up at stars we see how the light was in a previous time. The great thing about microscopes is that we can see how time elapses because the speed of light within a tissue varies and is reflective and instructive to our perceptions.

Do you look “at science” or do you look thru science through a lens? I submit that most of us are prisoners to modern science perspectives because we see it via “their lenses”. People who only understand biology via the biochemistry we know are people I avoid.  I look at nature and turn it 90 degrees, 180 degrees, 270 degrees, and degrees in between.  This is what quantum mechanics requires us to do.  Every time I do this, my perspective of a problem changes and I learn a little bit more about what I missed from the fundamental view from which I was taught.

I learned to do this from DaVinci and Michelangelo who were masters of altering the ground and foreground in their works. They changed the sizes and shapes of proportions in their art to make the visualization of the observer more lifelike. They were masters at altering the lens that we see the world through to make it more accurate based on where we were in space and time I view science in the same way. I need to alter the perception of what we currently believe so you can see the parts of science that are unobservable in action. Just because you can’t or don’t see it does not make it immaterial.

On the contrary, it turns out that what you can’t see and do not know are the most important parts of science. Do you look at that lens and observe how it might bend reality? You should because this is the mitochondriac way.

IMPLICATIONS OF THIS LIGHT LESSON

The mass of a body and its direction varies with the surface electric charge it contains. Since RF radiation induces massive surface charges we should have expected the obesity crisis during the technological revolution but we did not because we do not understand how the physics of cells are disorganized by nnEMF. When you add in what microwaves do to bonds and their angles it should be no surprise what melanopsin and retinol damage would do to things like leptin in the skin, blood vessels, and subcutaneous fat, but most people are small thinkers.

Choroidal Vascularity Index is novel parameter for Optical Coherence Tomography (OCT) and the earliest marker I know for oncoming obesity.

The paradigm in control of the truth only believe the fuel input affects the obesity quotient in the system because they do not understand the amazing nuance in how light works inside our cells. This implies that the addition or subtraction of light changes the charge of our cells and tissues, and thusly affects our BMI. In 1998, we found melanopsin in the eye. This is when I realized that when blue light hit the eye some part of the retina had to get larger.  I looked for the answer and I found it.  (pic below)

I knew that some parts of the eye would be losing light energy and have to get larger as a result before the same process happened in the body. The picture below is of a choroid that got larger before a shift worker gained 30 pounds in 4 months.  Melanin-leptin biology ties to the semiconductive circuit in the central retinal pathways.

The choroid gets fatter/thicker before your waistline does.  The physics of light told me that and now the literature has that proof for you to examine.

Until recently, the choroid’s inaccessibility—essentially buried beneath the retina—has made it a little understood anatomical structure. But this thin layer between the sclera and the retina, the “middle coat” of the eye, is vital to ocular health. It supports the outer layers of the retina by supplying nutrients and removing waste. Choroidal melanocytes absorb intraocular scattered photons (light). The superfluous flow of blood through the choroid assists in the removal of heat derived from the metabolism of phototransduction. Also, the suprachoroid lamina provides a safe route of travel for the long posterior ciliary arteries and nerves as they course toward the anterior aspect of the globe.

Choroidal analysis, in addition to retinal imaging, can provide supplemental information regarding disease progression. The thickening of the choroid is the first step in human weight gain.  The thinning of the choroid is an indicator of myopia with advancing stages of non-exudative age-related macular degeneration (AMD).  This then correlates with the rate of visual field loss in eyes with normal tension glaucoma (NTG).

In healthy eyes, the choroid is typically thickest beneath the fovea, where its average thickness ranges from 262µm to 354µm. The surrounding superior and inferior choroidal quadrants within the macular region are generally thicker than the nasal and temporal quadrants. The temporal choroid is thicker than the nasal choroid, which decreases rapidly toward the optic nerve. This is important when one considers the somatotopic organization of the melanopsin system in the eye linked to the RPE.  It is also different and organized around how the visible light spectrum bends in the eye.   Generally, the superior choroid is thicker than the inferior choroid. The choroid tends to be thinner where melanopsin photoreceptors are located.  This thinning of the inferonasal macular choroid marks the location of the embryonic optic fissure of the diencephalon and likely represents a normal “relative coloboma area”.

Additionally, the thinning of the choroid between the fovea and the optic nerve may predispose the formation of peripapillary atrophy. In the optic nerve, the peripapillary choroid is thinnest inferiorly and may contribute to the pathogenesis of glaucoma in susceptible cases of myopia.  Below is an enhanced depth choroidal image of a normal eye, a function of optical coherence tomography (EDI-OCT).

Above is a Gray-scale EDI-OCT of a healthy eye. The white arrows correspond to the choroid/scleral junction.

EDI was pioneered by ophthalmologists Ron Margolis, MD, and Richard F. Spaide, MD, in 2009. Before their work, OCT imaging of the choroid was virtually impossible because of poor light source penetration through the densely pigmented retinal pigment epithelium, light scatter by the choroidal vasculature itself, limited axial resolution and motion artifacts.  Today, we can obtain an OCT with a simple push of a button.

Today, we’re able to image deeper into the eye than ever before, allowing us the opportunity to evaluate choroidal thickness and morphology both for the benefit of patient treatment and for a better understanding of retinal diseases.

That is where I believed obesity began until December 2017. As of December 2017, new data showed melanopsin is also in the skin, subcutaneous fat, and arterioles below the skin and retina I know it can come from damage from either tissue today. Is the final story cast for me today? Nope. I have more expectations that melanopsin is going to be in other places too that explain diseases today medicine is clueless about.

Explaining how it all works is complex as the picture above and below show.

The collateral damage depends on how melanopsin was damaged and what other parts of the electromagnetic spectrum did the damage. This implies obesity is dynamic with respect to light damage too. Everything is relative in life and humans are too myopic to see this perspective.

FOR EXAMPLE: Can a simple blue LED light from a cell phone cause carbon-nitrogen (CN) coupling using copper in you? Yep. Researchers found that “blue light was able to start the photoreduction of a substrate to form an alkyl radical via electron transfer.

Carbon nitrogen coupling is the most common bonding atoms in all of biochemistry. Do you still think you’re immune to all those LED’s TV’s, iPhones, screens, and iPads? If so, Mother Nature is chuckling at your arrogance, if you do.

And if you’re not arrogant about your technology use you are likely quite ignorant of the power of blue light to uncouple your cellular architecture in mitochondria and cells to give you diseases you cannot fathom that are linked to this interaction. ALS, PD, myopia, AD, cancer, heart disease, and diabetes. Yep, every disease you can think of is affected by this. It is time to upgrade your knowledge about light.  HYPERLINK

^^^^The most honest accurate assessment one should have based upon where the science is pointing us in 2023.  Your job is to know this is the way you need to be thinking.

SUMMARY

If you go back now and read this blog and read this one written 20 years apart you will see all the parts but I could not give you all the details because you did not know enough about light, water, and magnetism to understand how POMC fundamentally works with UV light.

This is my Black Swan mitochondriac perspective today. I taught myself to see and now I teach it to the masses who want to learn how we really work. We know BMI is not a universal constant in biology or physics, but we wrongly assume ‘big G’ is such a constant on Earth when we consider gravity. It cannot be a constant because the mass of any body varies with the surface charge given to it via the environment. This means fatness, muscle mass, and body type are a function of the light we live under most. These light waves “sculpt” the colony of bacteria in our gut and the colony of mitochondria in our tissues. This is where variance in humans comes from. It comes from a changing light spectrum.  It is never a story about the food macronutrients contrary to what the simple minds tell you and conventional beliefs about dietary guidelines.

Food gurus keep blaming food and never seem to realize how powerful parts of the electromagnetic spectrum are in regulating melanopsin dysfunction in the eye, skin, and gut. Consider this latest warning from a chronobiologic researcher. “It doesn’t matter if you’re male, female, young or old, or what your ethnicity is, your body’s internal clock regulates half your genome,” says new light research data published in @ScienceTM http://bit.ly/2x7kNII#melanopsinwisdom. I wonder when Nina Teicholz and Gary Taubes will begin to study what really matters instead the blaming the dietary guideline for the obesity crisis.  You must stop blaming food for what artificial partial light spectrum causes.

Food gurus only report on what makes them famous and rich.

CITES

https://www.cdc.gov/obesity/data/prevalence-maps.html

https://www.science.org/doi/10.1126/scitranslmed.aat8806

Barrera FJ, Yust B, Mimun LC, Nash KL, Tsin AT, Sardar DK. Optical and spectroscopic properties of human whole blood and plasma with and without Y2O3 and Nd3þ:Y2O3 nanoparticles. Lasers Med Sci. 2013;28(6):1559-1566.

Mace K A, Yu D H, Praydar K Z, Boudreau N. Sustained expression of HIF-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Rep Reg 2007:  15:  636– 645.

https://twitter.com/DrJackKruse/status/1613298172801044482

QUANTUM ENGINEERING #37: WHERE DO DIABETES & HYPOTHYROIDISM COME FROM DR. HUBERMAN?

video
play-sharp-fill

The butterfly effect from my weekend…..with Rick Rubin and Dr. Huberman continues.  Start the video at the 16:00 mark

Huberman wants to come and visit me in my lab and do a podcast mano y mano with me.  In “light” of this I want Andrew to be aware of the butterfly effects of what I said to him so he is ready for the next round of inquiry on light

KEY BLOG POINT: CLIP = Corticotropin-like intermediate lobe peptide and blue light without the protection of IR-A and UV light in the eye cause ACTH release from cells with POMC and as ACTH rises so does CLIP.  HOW?

Implications of this slide above?  In humans, this is how blue light raises blood glucose and insulin.  CLIP cleavage is the major cause of diabetes in modern man.  A big statement backed up by the picture. CLIP raises insulin in response to blue light exposure without any food exposed to the organism. (see below)  I have posted this picture a thousand times and no one asked me the right question.  How in the hell do the papers listed below explain it?  They couldn’t.  Read on, because I can.  It is all linked to POMC cleavage and retinal anatomy.

CLIP raises insulin in response to blue light exposure without any food exposed to the organism.  This peptide has massive effects on the exocrine pancreas.  CLIP’s physiological role has been investigated in various tissues specifically in the central nervous system.

Big Pharma has been trying to keep a lid on this for a long time.  So beware of where our discussion will go.  What cells specifically make POMC in humans?

Look at the tissues where POMC is located and think about what we teach doctors about the symptoms of diabetes.

Polydipsia

Polyuria

Polyphagia

All are caused by a lack of POMC in the hypothalamus where the central retinal pathways converge before radiating to the rest of the body.  Polydipsia is due to a lack of ADH in the posterior pituitary.  Polyuria is caused at the kidney tubules because there is very little vasopressin in the system to control water balance.  Polyphagia is due to the destruction of the leptin-melanocortin pathways that begin in the retina.

Diabetics carry unusually high risks of retinopathy, nephropathy, and neuropathy.  Do you understand why they do?  The retina anatomy is destroyed by chronic blue light exposure.  The basement membranes of the kidney are destroyed by the chronic elevated blood glucose and insulin related to POMC cleavage due to blue light and neuropathy is caused by a chronic lack of the creation of T3 in peripheral nerves.

THERE ARE MANY MORE IMPLICATIONS ANDREW

Andrew based on our 10 hours of discussion on light/water/magnetism if you look at that list and remember what I told you about in 1923 about mitogenic radiation and NaCl in the CSF you might begin to understand these slides below with new eyes.

^^^^^Please recall Dr. Huberman that the choroid in the eye is where melanin sheets of the RPE and Bruch’s membrane are adjacent to POMC in the retina.   We can do an OCT on the retina to see it before the disease begins!!!!  The white arrows below show the choroid vessels and the highly reflective RPE and Bruch’s membrane is immediately above them.

The entire substructure of the retina is made of collagen and DHA. Both these biomolecules are wide-band gapped semiconductors because of the quantum chemistry of carbon.

Do you see a new reality developing here in front of your eyes yet Andrew???

Dr. Huberman, do you remember during the podcast when I asked you if you knew what part of the visible spectrum bends the most in the eye and you said you did not know?  Remember when I reminded you that melanopsin and POMC are in very specific locations of the retina and I told you Nature does not make mistakes in where she puts things on our semiconductors?  Ya’ know, the AMO physics thing I went on about for ten hours……….

Do you know POMC is also located inside of the ring of POMC too……just not as much of it.  Do you know what light bends the next most?  Blue light does.  It is the reason why so many humans today suffer from visual blur because blue light does not fall on the fovea/macula region of the retina.  The macula is normally yellow to acts as the complementary color to blue to absorb stray blue light to preserve central vision sharpness.  It causes another bigger problem in the development of diabetes.  It destroys the blood vessels in this middle region of the retina.  This is why retinopathy is a diabetic problem.  The waste products of this area of the retinal photoreceptors and semiconductors collect just as we see in arterial disease.

The blue light hazard destroys blood vessels in that region around the fovea that I can see as a neurosurgeon with my ophthalmoscope in my clinic when I am looking for it in all the patients I treat (see picture below).  The last two slides show you how the bending of light links to the anatomy of how melanin, ACTH, POMC, RPE, and blood vessels really work in a quantum fashion. (picture below)

Modern ophthalmology is still in the dark on this linkage of light bending to retinal anatomy and this is why they have no idea the blue light hazard really causes diabetes in humans.

They also have no idea that light is activating POMC via molecular resonance to cleave the POMC peptides from the gene.  This can be studied easily today but no one in diabetes research wants a cure when treating the disease fuels a trillion dollars a year profit center for Big Pharma Andrew.  Many of your labs sponsors and your University are kept afloat by these corporations.

Fluorescence resonance energy transfer (FRET) measurements can be done between single pairs of acceptor and donor fluorophore semiconductive proteins to yield information about structural relationships and distance fluctuations between regions of a single biomolecule or between components of an interacting system of biomolecules.  Someone needs to study this in ophthalmologic research after they read this blog.

Blue light causes a machine gun effect of palor in the retina and blood vessels all around the fovea (below).  Diabetics also show an altered response of pupillary response to blue LED vs red LED if they use both.  I have been doing that in my TBI patients for years now because I understand how this system was built to work.  This blue light toxicity is what causes photophobia in brain injuries. Anything that causes acute hypoxia in the retina can cause these effects due to the change in melanin light emission from the RPE in the periphery of the retina.  This is why POMC and the choriocapillaris have the most interesting relationship to oxygen tensions in the human retina.  More on that coming later in the series.

What else does this all imply Andrew?  Most fat diabetics will also have hypothyroidism because of the quantum arrangements in the retina.  This is how we know their diabetes comes from the eye and the leptin-melanocortin destruction at the hypothalamic level at the paraventricular nucleus. Note below the down and up arrows for the paraventricular nucleus which houses most of the thyroid releasing hormone neurons in humans (TRH).

Thyrotropic-releasing hormone (TRH) released from neurons in the paraventricular nucleus of the hypothalamus is stimulated directly by the hormone, leptin and alpha-MSH as the up arrow shows.  This is why American tend to be fat diabetics with hypothyroidism because they are addicted to their tech screens and iPhones.

As the picture above shows multiple factors, either directly or indirectly, regulate TRH neuron activity. Thyroid hormones (T3/T4) are the most potent negative regulators of TRH. T4, efficiently taken up by epithelial cells of the choroid system in the lateral ventricle, binds to transthyretin (T4-binding prealbumin) and is secreted across the blood–brain barrier into the CSF.  Note the top part of the slide below.  Visualize the retina at the left side adjacent to phenylalanine and the basal ganglia and thalamus adjacent to melanin and dopamine next to dopa.  Realize the pituitary and the PVN at the level where T3 & T4 are in the slide.  This defines the distal end of the semiconductive circuits in the central retinal pathways as we enter the brain substance.

Almost 80% of T3 at the paraventricular nucleus originates from the peripheral conversion of T4 in cells outside the brain. Only 20% of hypothalamic T3 crosses the blood–brain barrier directly from the periphery.  This makes T3 much more important in the human brain.  Melanin and DOPA can be used to stimulate T3 production in the brain even when the thyroid is defective or missing.

The more one can tan the better this ability is.  Most hypothyroid/diabetic patients are horrible at tanning because their skin is atrophic due to a lack of alpha, beta, and gamma MSH. Regular exposure to solar UV light via your eyes and skin stimulates your thyroid and brain to make T3, which balances your body’s metabolism. Tanning increases your metabolism, which in turn helps you maintain a healthier weight. This is all done via POMC biophysics.  Anything that blocks it fattens you and ruins your thyroid function.  T3 is the biophysical manna of longevity for mammals.  T3 function is the best predictor of longevity for the human myocardium and CNS/PNS.  These are the two tissues that kill humans the most.  You won’t hear that from Peter Attia in his new book on longevity.  This completes the lessons I gave you about thyroid function in the cold thermogenesis series of blogs.

The type II deiodinase (Zn/Se), is mainly expressed in third ventricle tanycytes.  You should be asking me what is a tanycyte.  It is an important regulator of TRH neuron activity and plays a major role in T3 availability in the paraventricular nucleus.

Tanycytes are how leptin enters the hypothalamus at night at the median eminence.  They are the most common type of macroglia in the CNS of lower vertebrates. In adult mammals, tanycytes are restricted to certain brain regions where the tissue is rather thin and POMC gene is present. These regions are the wall of the diencephalic third ventricle.  Recall the optic bud and retina are all diencephalic derivatives in the human embryo.

Fasting and infection upregulate tanycyte type II deiodinase expression with Zn/Se atoms, resulting in local increases of hypothalamic T3 which may partially explain the reactive decrease in peripheral TSH observed during fasting or inflammatory diseases. T3 inhibits TRH gene transcription in a classic feedback loop and TSH synthesis. T3 also influences the processing of proTRH neurons adjacent to POMC neurons by altering paraventricular nucleus prohormone convertase (PC) levels. T4 also reduces TRH levels measured in the hypophyseal portal circulation.  This is a very complex dance that few understand because of its optical physics. Understanding biochemistry is not enough.

OUTSIDE THE BRAIN:  TRH has effects

Thyrotropin-releasing hormone (TRH) is expressed throughout the gastrointestinal tract in humans in gastric G cells, in pancreatic islet beta cells, and in neurons constituting the myenteric plexus of the esophagus, stomach, and intestine. In the stomach.  If you are a human and you have a gut problem you have a melanin problem via POMC.  TRH, T3, and T4 are linked back to this story.   TRH modulates pentagastrin-stimulated gastric acid secretion and may attenuate acid secretion in subjects with acid secretory disorders. This is why GERD is fundamentally a nnEMF/blue light story.

In the pancreas, TRH is expressed during perinatal development, and TRH administration in mammals induces pancreatic hyperplasia and inhibits amylase release. TRH also reduces CCK-induced gallbladder smooth muscle contraction and inhibits cholesterol synthesis within the intestinal mucosa but is not trophic to the intestinal mucosa.  Yes, you can get gallbladder pain when you are LACKING SUNLIGHT.  I have a farm member who had this issue and I helped her overcome it using sunlight and the circadian mechanism linked to POMC actions.

Today’s diabetes is a result of mammalian innovation that was used to survive the KT event.  How?  Look closely are POMC and what it does.

Light can be transformed when it hits matter like a semiconductive protein.  (see below all the ways light can be changed)  When looking at the POMC rabbit hole you’ll notice that the central melanin system is hodologically linked to every sensory pathway in mammals whose neural tracts end in the thalamus.  All 5 senses end in the thalamus and then the thalamus projects to the hemispheric lobes of the brain.

The thalamus is the end station of the diencephalon where the optic bud ends in the embryo.  It is obvious to see the connection when you follow it back embryological (above).

Light frequencies and varies changes in amperage in currents are capable of cleave POMC via molecular resonance into action in the retina.

What if I told you that ACTH is cleaved more from its parent protein POMC based upon the frequency of the light most likely to be there?  Recall in the podcast I asked Huberman did he know which part of visible light bends the most and he was stumped by the question.  Blue light bends second most in the retina’s periphery in a circular format.  Would you believe it?  You should.  Might this relationship be present in every mammal retina to bright blue-laden light because blue light was used to stimulate ACTH to create glucocorticoids like cortisol to raise blood glucose when food was sparse and light frequencies changed and the environment got cold?

Well, you should.  Because that is exactly what happened when mammals took over the world and left their holes in the ground and the sun came back. The retina is somatotopically organized to light frequencies.

This exact mechanism was used by ancient mammals and therapod dinosaurs to raise their own blood sugar when photosynthesis was disrupted by an asteroid crash. ACTH was and is upregulated by blue light.  The blue light was present 65 million years ago at the surface level of Earth.  Light created glucose for life to survive.

Today the same effect is causing diabetes in a modern man who has built a world of blue-lit bulbs that has very little UV light to regenerate melanin at the same time this occurs in the retina.  Oh! So you see that now.  Good.  Alpha-MSH and its cousin peptides cannot be liberated or cleaved from POMC unless UV light is present in the anterior chamber of the eye because it is more peripheral to the ipGCRs and melanopsin.

Why is melanopsin the most common opsin in the human brain when blue light cannot pentrate the skull?

Dr. Huberman, do you realize what this also explains?  If explains why modern humans who have the blue light hazard through their eyes are more likely to be obese with diabetes because the leptin-melanocortin pathways from the retina to the hypothalamus are also damaged in this scenario.

Diabetics have melanopsin damage in the peripheral retina (nnEMF/blue light) more in the integument than their eyes will be skinny diabetics.  What else does this imply Andrew?    It means people who have had cataract surgery and get blue light intraocular lenses but have blue light stress on their skin will be skinny diabetics.  Centralized medicine has never been able to explain this difference in the literature.  I gave it to you for 5 bucks.  Do you still think this knowledge is worthless?

MORE NUANCE WITH POMC CLEAVAGE

Do you know that ACTH, cortisol, blood glucose, and insulin all act to decrease melanin’s ability to be renovated on our surface because there was no UV light present?  So, Andrew, this means under blue light conditions mitosis would have been stopped on the skin of mammals and feathers of therapod dinosaurs.  They would have lost their colors and tans as they migrated their melanosomes interiorly.

The bending of light should also now fully explain the anatomy of the retinal blood supply in the mammal eye, don’t you think Dr. Huberman?  Note how in the center of the retina there are no blood vessels that normally have hemoglobin.  RBCs are also devoid of mitochondria as well.  Hemoglobin is a heme porphyrin that has absorption spectra that spans the entire UV spectrum of terrestrial sunlight but also extend deep into the UVC range = 250nm-600nm light.  Hemoglobin has a sharp cut-off at the IR-A region at 600nm.  Do you see how the pieces fit yet with POMC?  The anatomy of the mammalian eyes is 100% a story of how melanin works in us.

Now let us look at what blue light is doing at the same time in the eye in relation to POMC.  You should recall that from my Vermont 2017 talk we found melanopsin is now in blood vessels.  This means modern lighting destroys photoreceptors just around the fovea when it is mostly blue light.  We can see this effect below.  It looks like a machine gun took out everything around the macula.  In most hypothyroid diabetics the macula also loses its yellow pigment and this tells me the blue light hazard is chronic in their eyes.  Yellow pigments come from lutein and zeaxanthin of the xanthophyll family of carotenoids that are loaded in my survivor soup Patreon post.  They are yellow to preserve the sharp central vision of the macula and absorb any stray blue light as a complementary color.  Blue light causes visual blur when your macula is damaged.  Many diabetics have this before they get diagnosed.

On the left below, you see the control where the red specks are mitochondrial and in the center, the mitochondria vanish under the blue light hazard.  On the right, you can see where IR-A light with blue is protective of some of the photoreceptors.

Hey Andrew do you remember what Rick told us in the podcast when was using my advice to mito-hack himself back to health he told you he noticed when he flew in planes from Costa Rica to California he would always lose his tan quickly and he could not figure out why?  Are you connecting any dots yet Andrew?  You know when you disconnect from the Earth and are not grounded to Earth to close the circuit so this would act to speed up the migration of cells not sensing UV light on the surface.  This would cause melanosomes to migrate inside of you following their embryonic neurulation tract.  This is why people lose their tans.

Remember Gurwitsch’s work on mitosis here.  What did Gurwitsch find Andrew about UV light in onion roots in 1923?  The video above shows that at the 16:00 mark.

Now let us have a look back in the eye where POMC and DHA are at the highest level in the human brain.

When you look at this and see “mitosis” and death and you realize those are migrating cells from within that only migrated to the surface skin to deep inside the skull to get to the UV light and when they got there then mitosis showed up on the surface = “neuroectoderm psyops“.

Now for the big bow on the present I gave you during the podcast @hubermanlab

LET’S REVIEW THE LESSON:  Thyrotropic-releasing hormone (TRH) released from neurons in the paraventricular nucleus of the hypothalamus is stimulated directly by the hormone, LEPTIN via the leptin-melanocortin pathways.

MASSIVE BLOG POINT: Leptin normally increases melanocortin (α-MSH) and it is required for TRH expression!   This means people with hypothyroidism cannot make POMC or melanin well!!  This means their longevity will be cut.  This is why hypothyroidism is a gateway disease to many others and leads to an earlier demise.  Those with hypothyroidism need massive solar exposure to change this outcomes.  This also implies that hypothyroid patients should have worse outcomes from melanin-related diseases, and they DO!

This makes their skin pale, and these people will also seem to burn more and not know why.  Many will develop autoimmune conditions in the skin and gut and their docs will remain impotent to know why.  Many will tell you they are allergic to the sun.  I just laugh at these comments.  When you know better you do better.

And this makes their tissues atrophic for sunlight = why so many humans have sun hypersensitivity.  Think of lupus, diabetics, fibromyalgia.  Look at the teeth of diabetics/hypothyroidism and you’ll notice they are more yellow than translucent white.  This is from POMC defects in dentin.  People using Big pharma drugs like phenothiazine, erythromycin, or tetracycline all mimic this sunsentivity because the drugs alter POMC cleavage.

SUMMARY

The melanocortin system anterior to the braincase in the eye where POMC begins is activated by UV light and by blue light in the sun.  It activates the TRH promoter on DNA through the phosphorylation (dopant atom of the wide band gapped semiconductive melanin protein) of the signal transducer and activator of transcription (Stat3). The Stat response element in the TRH promoter is required for the effects of leptin to occur = Leptin-melanocortin tract wisdom

LOOK AT THE TOP ROW OF THE SLIDE BELOW

TRH is present in virtually all parts of the human brain: cerebral cortex, circumventricular structures, neurohypophysis, pineal gland, and spinal cord.  TRH is also found in pancreatic islet cells and in the gastrointestinal tract. Although it exists in low concentration, the total amount in extra hypothalamic tissues exceeds the amount in the hypothalamus!

The extensive extrahypothalamic distribution of TRH, its localization in nerve endings, and the presence of TRH receptors in brain tissue suggest that TRH serves as a neurotransmitter or neuromodulator outside the hypothalamus.  TRH is a general stimulant and induces hyperthermia on intracerebroventricular injection, suggesting a role in central thermoregulation.

Aromatic amino acids that makeup melanin are all linked to this inside your skull and outside your skull.  The system is ubiquitous in humans.  How do you like me now Andrew?

CITES

1. Neuroendocrinology chapter in

Malcolm J. Low, in Williams Textbook of Endocrinology (Thirteenth Edition), 2016

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC377492/

3. Ronald M. Lechan, … Csaba Fekete, in Reference Module in Neuroscience and Biobehavioral Psychology, 2018

4. The Hypothalamic pituitary thyroid axis.  Marco Bonomi, … Luca Persani, in Encyclopedia of Endocrine Diseases (Second Edition), 2019

QUANTUM ENGINEERING #36: THE SUN DOES NOT CAUSE SKIN CANCER, A LACK OF SUN DOES

Finsen figured out long ago the light in the sun was the key to healing many diseases.  In 1893 he showed IR-A light cured smallpox.  No vaccine was needed.

Kellogg, or cereal fame, followed this science and found that the sun truly was miraculous.  Since the 1890’s centralized medicine has tried to demonize the sun & Finsen’s work.  Kellogg knew back at the end of the 19th century that part of the sun was good for us he and his rich friends decided to bury that truth to build an industry around food and drugs to take advantage of this knowledge.

The paper below is over 20 years old.  It says that with repeated UV exposure skin with more melanin is associated with FASTER DNA repair.    This is 180 degrees to the dermatology opinion that the sun is toxic.  This says the more melanin you have in your skin the faster you heal.

Note the color of type 2 skin to type four skin that was mentioned in the paper.  Do you notice that darker skin is a huge advantage?  Most African Americans fall into types 5 and 6 six types and many of them still get sunburn when they go out in the sun as modern humans. Do you know what sunburn means in their case?

Did you know that skin cancer rates in Type 5 & 6 skin are reduced?  Can you venture a guess why now?

People of color have a lower risk of developing skin cancer than people with fair skin tones.  Imagine that.

The paper below shows avoidance of the sun is a risk for death on a par with cigarette smoking.  You cannot make this stuff up.

OVERVIEW OF GURWITSCH’S 1923 ONION ROOT EXPERIMENT FOR REVIEW

To test the hypothesis of the “non-chemical external impulse,” Gurwitsch performed his famous “onion root experiment”. Two onion roots as even and smooth as possible were located perpendicular to each other and mutually centered, so that the tip of root No1 (acting as the “emitter” of the “impulse”) was directed toward the division zone of root No 2 (acting as the “recipient”). The authors made histological sections of the “recipient” root, and calculated the number of mitotic figures in the exposed and non-exposed halves of the root. The exposed side possessed significantly higher proportion of cells in mitosis than the non-exposed side. This phenomenon was called “mitogenetic effect” (MGE).

MGE was also detected, if a quartz plate was fixed between the two roots, and was not detected, if the roots were separated with glass or nontransparent materials ( confirmed by Gurwitsch, 1924; Reiter and Gabor, 1928a). Chemical isolation of the roots did not affect the results. Based on these and other data, the acting factor was concluded to be UV light of very low intensity, and was called “mitogenetic radiation.”

Back to the blog……………..

What are the skin and eye doctors missing?  Neither one knows about Gurwitsch’s work on mitosis and UV light, neither know that cells that can’t divide travel in our body to look for UV light release, and fewer have realized that modern lighting has totally subtracted out all UV light and most of the IR-A light leaving behind mostly blue light which causes massive ACTH release which drives blood glucose and insulin levels through the roof while also causing melanin degradation on our skin.  High blood glucose and insulin make the melanin in your skin atrophy and the lack of environmental UV light allows melanocytes to become mobile in the neuroectoderm migration patterns.  This means you cannot absorb UV light well via your skin even if you were on the equator naked.

Why?

Answer:https://twitter.com/DrJackKruse/status/1636019966947348480

As result what happens? If you cannot absorb UV light because your melanin sheets are disrupted or dysfunctional due to a lack of UV-IR-A light on your surfaces,  the melanosomes deep inside your skull and viscera begin to migrate toward your surface to find UV light at the surface.  Here is where Einstein’s relativity bites you in the ass.  Without UV light created endogenously, you lose the ability to slow electron flow on the inner mitochondrial membrane.  This is why Mother Nature put the VDR receptor there.

When this occurs in mitochondria, we lose the ability to create melatonin in mitochondria deep inside our body, and slowly over time apoptosis becomes defective.  Mitochondria and immune cells take our defective engines.  Without endogenous VUV production, these organelles and cells cannot work well.  What are the acute symptoms we see in our patients that this is ongoing slowly?  Women tend to get melasma and hypothyroidism.  Melanosomes migrate to the surface of their faces from deep in their skulls because of the surface’s use of makeup, sunglasses, and sunscreen.  A lack of UV light and extreme use of blue light drive this process.  This is why I wrote this blog below long ago.

Cancer states all have one thing in common and it links directly back to melanin biology:  Apoptosis physiologically doesn’t operate as designed because the VDR gets redacted on the inner mitochondrial membrane.  You can finally understand the Warburg effect when you understand how POMC biology and a lack of UV light are driving this process. Cancer cells have to keep bringing electrons to ECT, and this process happens because of ACTH from POMC.  65 million years ago this allowed mammals to survive without food.  Today, because UV light has been deleted for longer time periods in humans than it was 65 million years ago, new collateral effects have occurred.  A chronic cleavage of POMC – high levels of ACTH release to drive glucose and insulin levels.  POMc mimics what photosynthesis does, it creates glucose directly from light.  Mammals use blue light frequencies to cleave ACTH directly from POMc to do it when UV light is absent from the environment of the mammal.

This tells us that endogenous UV light has to be liberated in an uncontrolled fashion when this process is present in mitochondria to create a constant source of blood glucose and insulin to maintain the pace.  We know from Pritz Popp’s work when eukaryotic cells have defective mitochondria they emit more UV light.  They are designed not to release light.  Prokaryotes release 5000 times more light than eukaryotic cells by design.  This is a big clue we are using non-linear optics to signal.  It is the control arm of all biochemistry.  65 million years ago this mechanism saved mammals with a disrupted food chain on Earth.  This implies that the acute state of a lack of UV light control helps mammals survive for short periods of time. This situation told me the sun was not disrupted very long because if it was, mammals all would have died from cancer and they clearly did not.  On a chronic basis, the lack of UV light controls on POMC will drive cancer diagnosis and growth.  That is the modern burden of mammals today because this subtraction has gone on since 1893.

Blue light and nnEMF drive this process due to the products in POMC and how they operate with melanin and melatonin production.  I hinted at this in a big way in the Time 9 blog.

A lack of UV light creates chronic diseases in the mammalian system because of POMC biology. Most of what we call today’s mammalian chronic diseases really are just adaptations built into our cells.  The chronic maladaptation of light builds a facade that we call diseases.  A lack of UV light drives insulin, blood glucose, and precocious puberty on an acute basis.  Chronic UV blockade means mammalian cells on their skin cannot get into mitosis.  This makes the grow due to the insulin and growth signals and allows them to migrate.  This is why cancer is exploding in mammals in the 20-21st century.

Only electrons can capture photons.  So what makes cancer worse?  A lack of UV light or a lack of electrons in key spots is a real problem.  Another issue could be too many protons in water, which changes its dielectric constant and refractive index.  This means we cannot absorb enough UV light in water.  These biophysical factors are present in our blood, if you know what to look for, those changes will be in cells bathing in this water.  Once a clinician sees the cellular changes they know by definition what is happening on the quantum levels in hydrogen bonds in water: namely the thickness of the coherent domains in water made inside a cell from mitochondria.

This is why every patient who hires me at my clinic gets a peripheral blood smear.

This may sound tough to figure out until you realize what POMC is really doing.  Once this perspective is in your head, you can never go back to a centralized medicine mindset.  It is a game changer at the larger scales of practice. It fully explains why the Warburg shift works with glucose and glutamine to maintain ECT function while inhibiting apoptosis because UVA and UVB light cannot stop ECT flow before the ATPase.  It is wise for the mitochondriac to remember that the first step in heme synthesis also begins in the mitochondrial matrix.  So it is affected, so will your RBC and hemoglobin.  If they are the melanin renovation Rx will not work.

Anytime intracellular water production is lowered from mitochondrial respiration or physically changed in ways below your perception, proteins are less hydrated and this affects the physical chemistry of divalent ions like calcium and magnesium that work with mitochondria in stressful situations. The velocity and chemical activity of ions is determined by the degree of their hydration and the atomic mass of things in that WATER. This is why dehydration is devastating to cellular metabolism in the cytosol and in the mitochondria.  Both of these ions are paramagnetic and drawn to organelles with inherent magnetic fields.  When mitochondria are stressed their ATPase cannot spin as fast and as such their rotating heads spin less fast.  As a result, these local mitochondria begin to sense time differently, and that effect is seen in the size and shape changes in mitochondria, the formation of IMJ (pic above), and the space between cytochromes.  These are the telltale signs of cellular information loss.

MELANIN RENOVATION Rx

It begins with AM sunlight because this light is loaded with IR-A light.  This pre-conditions your skin to absorb more UV light at the transition at your particular latitude. (more on this topic later in the series)

The effectiveness of UV to induce erythema declines rapidly with longer wavelengths as we get closer to 400nm. To produce the same erythemal response, approximately 1000 times more UVA dose is needed compared with UVB. UVB-induced erythema occurs approximately 4 hr after exposure, peaks around 8 to 24 hr, and fades over a day or so; in fair-skinned and older individuals, UVB erythema may be persistent, sometimes lasting for weeks. The time courses for UVA-induced erythema and tanning are biphasic. Erythema is often evidenced immediately at the end of the irradiation period; it fades in several hr, followed by delayed erythema starting at 6 hr and reaching its peak at 24 hr. Erythema is associated with a wide variety of changes at the cell and molecular levels, but especially with the appearance of apoptotic keratinocytes (sunburn cells). The action spectrum for UV-induced tanning and erythema are almost identical, but UVA is more efficient in inducing tanning whereas UVB is more efficient in inducing erythema. The observation that the action spectrum for erythema is very similar to that for CPD induction suggests that DNA damage is an important trigger for erythema.  You will be shocked to find out that DNA damage induces ROS/RNS that melanin absorbs to charge separate water to liberate 2 electrons.  This mimics the first step in photosynthesis in plants.  This means ROS/RNS are GOOD THINGS, and they are only bad things when melanin is absent.

The story in the literature is filled with papers to fight against the dermatologist’s opinions.  Sunburns won’t give you skin cancer and they certainly not kill you.  They actually may be life-saving as the paper below shows from 1980.

SUNBURNS DO NOT MATTER. Another bad meme people spread is because they are ignorant of the effect of melanin from UV light exposure via POMC.

And the flip side of this argument is sun exposure actually leads to an all-cause drop in mortality. Burn away. I do and I’ll never change that opinion because I am a mammal and I understand my clades genesis and why we flourished when UV went missing.
****All-cause mortality: http://ar.iiarjournals.org/content/38/2/1173.full

Best time to put your Junk in the sun?

UV-B light is the off switch for sex steroids as laid out in the Vermont talk and talked about in blogs. UV-B light inactivates sex steroid creation from sterols to maximize Vitamin D production.

CRITICAL Brain-Gut POINT ALERT: When this chemical effect is CHRONICALLY present, the decision in the cell always has to be made between survival or reproduction based upon how the cell signals using its nuclear hormones.  When we are oxidized we are consuming our hormones. UV light actually inactivates our sex steroid hormones. This is another form of natural childbirth in the summer months when UV light dominates.

When we are reduced we are resupplying them in the great pharmacy in our brains by using melanin to restore pituitary POMC hormones. This means that all the LDL cholesterol that is normally made into pregnenolone will either go into cortisol OR to the progesterone pathway. If all the pregnenolone shunts cortisol’s path, it helps you survive life’s oxidation. The shunting signal that determines that choice is the level of cellular inflammation that oxidizes the cell.

Lipid POINT:  Sunlight reduces cholesterol, LDL, Lpa, and APO B too.  No drugs are needed.  Eumelanin is used to step down UV power to create a small amperage ferroelectric current that lines the surfaces of all mammals.  When that current is interrupted this is where you will see lipid accumulation, endothelial disruption, lack of NO production, and damage to melanopsin chromophores.  POMC will also be destroyed.

When we measure cortisol in the plasma, saliva, or urine, it is often low when we are oxidized chronically. That is a sign the PVN nucleus in our brain is working overtime because melanin there needs renovation, and this is a sign you are oxidizing your cells. You are aging faster than normal.

UV light exposure is the key to reducing a tissue in mammals because electrons are moved into the tissue and protons are moved out and the pH change improves the VUV light power made in the tissues. This stimulates POMC production while renovating the melanin in your cells to regenerate from stem cell depots.  The movement of electrons occurs by inducing Becker’s injury current using ferroelectricity.  The same mechanisms work in the adrenal medulla as well.

This is measured clinically by an adrenal stress index test and really accurate in a low salivary melatonin level and flatlined cortisol curve. The result is all the hormones going the “other way” in the hormone synthesis chain are very low……..that is the “reduction path”. Reduction means you are staying younger because melanin renovation is progressing.

This explains why human babies are supposed to be born during the late spring and summer.  Nature uses sunlight to lower the father’s testosterone and this fits nature’s plans on many levels in the family unit.

Sunlight increases melanin by way of POMC cleavage of the endogenous release of cellular UV light, Vitamin D3, histamine, and sulfhydryl groups while lowering (photolysis) adrenalin, steroids, testosterone, estrogen, thyroid hormone, DNA, and RNA. This is the feedback loop.  Other chemical liberated adjacent to POMC acts to lower the sex steroid hormones.

Secretion of hormones by the anterior pituitary gland can be stimulated or inhibited by paracrine factors that are produced during solar reactions.  While UV stimulates all the things in POMC including ACTH, the product of ACTH is ultimately glucose and glucose provides feedback control to decrease POMC signaling and this stops melanin production via alpha MSH.  The elevated blood glucose continues due to this feedback loop allowing all mammals to survive long periods of time without food.  This is the pathway mammals use to hibernate.  It turns out that elevated glucose acts like antifreeze in mammals and keeps their blood from freezing and it also stimulates another subpopulation of neurons that link to reproduction fitness and thermoregulation.

Kisspeptin, Neurokinin B, and Dynorphin regulate reproduction.

KNDy neurons are located in the hypothalamus region of human brains due to conservation across ALL mammalian species. Other roles of KNDy neurons include influences on prolactin production; puberty; stress’ effects on reproduction; and the control of thermoregulation.

The mature male testis has two primary functions: sex steroid hormone production and spermatogenesis both of which are needed for mammalian survival

The roles of testosterone and 5-alpha-dihydrotestosterone (DHT) in male sexual differentiation are not germane to this blog.

THE HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS

This axis is controlled by a classic feedback loop. The major endocrine stimulators of human testes are luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are made by the anterior pituitary via light coming through and energizing the central retinal pathways and secreted into the systemic circulation. LH stimulates the testicular synthesis of testosterone and its two major active metabolites, estradiol and 5-alpha-dihydrotestosterone (DHT). LH is secreted in a pulsatile pattern with peaks approximately every 90 to 120 minutes. FSH has a subtler pattern of pulsatility. LH and FSH secretion is stimulated by the pulsatile release of gonadotropin-releasing hormone (GnRH) from neurons in the hypothalamus; GnRH reaches the gonadotroph cells of the anterior pituitary via a portal vascular system.

The hypothalamus GnRH pulse generator reacts to light — The medial basal region of the hypothalamus (particularly the arcuate nucleus) contains neurons that secrete a gonadotropin-releasing hormone (GnRH) from axon terminals in the median eminence (has no BBB) into the hypothalamic-pituitary portal system. These neurons constitute the GnRH pulse generator and act as the metronome of the axis. Because serum concentrations of GnRH in the portal system are normally low, peripheral circulating GnRH concentrations are very low and not measurable in humans. Several hormones, neuropeptides, neurotransmitters, and cytokines modulate GnRH secretion.

Kisspeptin and its hypothalamic receptor, KISS1R (formerly called GPR54), play a major role in stimulating GnRH secretion, and it is likely that a synchronized interaction between the secretion of kisspeptin and the coexpressed neuropeptides, neurokinin B and dynorphin (from KNDy neurons of the arcuate nucleus), regulate the pulsatility of GnRH secretion. A number of neurotransmitters and hormones regulate GnRH secretion, including gamma-aminobutyric acid (GABA), glutamate, and leptin (stimulatory) and sex steroid hormones, corticosteroids, and opioids (inhibitory).

Kp does not work alone.  DYN A is an endogenous opioid that inhibits GnRH.

Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive functions, recent data described its action in the control of metabolism. Of particular interest for the review is the population of Kp neurons localized in the arcuate nucleus (ARC) of the hypothalamus, the site of the brain where reproductive and metabolic cross-talk occurs.

Sunlight induces biochemical reactions via photolysis and it induces coordinated endocrine adaptation effects in the eye and the skin surfaces where melanin and leptin dominate in mammalian physiology. It affects the sympathetic and parasympathetic systems where POMC dominates in these neurons.

It is the stimulus for the circadian timing mechanism of the body clock via the central retinal pathways. All these effects are built into the electronic state of your semiconductive proteins under solar power and magnetic flux.

If you re-read Brain Gut 11 you will see what a chronic low cortisol level buys us. Poor solar exposure chronically = chronic Low cortisol = low mitochondrial melatonin = epithelial cancers = Leptin Resistance = a lack of melanin in that tissue. These are the chronic effects.

Acute light stress with blue light will stimulate glucose and insulin production and precocious puberty in mammals.  Mammals used this on an acute basis to survive the interruption of sunlight and still procreate.

We tend to get cancer as we age. It follows then that oxidation = Leptin Resistance and LR = aging. Low cortisol is not a good thing for a human long term, but short term it could be adaptive.

When the process first begins……ACUTELY, you will have hypercortisolism for a time, until you fatigue the output of your PVN nucleus in the hypothalamus. That PVN nucleus is just one of the major pharmacies that function in your brain. Oxidation occurs when you cannot use the TCA or urea cycle optimally. If you do that long enough, you oxidize (age) your body, while simultaneously destroying your sleep, causing your body to slowly begin to fail while your body composition declines.

For example, Hashimoto’s disease is a disease of chronic oxidation with melanin degradation throughout the human nervous system. It depletes you of the life-giving chemicals in the pharmacy that resides in your brain. This is why it is associated with so many other neolithic diseases.  These are all due to a lack of melanin where T3 and T4 are made.  The slide below shows you melanin can be used to restore thyroid hormones.  These are reversible reactions in all mammals.

SUMMARY

Realize that the number of genes an organism has in its genome is linked to the amount of energy the organism can transform.  This means the gene expression is also directly correlated by probabilities to how it is expressed.  POMC in mammals is critical in this energy linkage.  This is a function of the energy/information flow from their environment to their skin/eyes/guts, and not the anatomy of the genome itself.  It is also related to the redox potential of the organism in question.  Ultimately, All energy in life ultimately comes from sunlight.  It is stored in every cell membrane and in the electronic state of cells.  Most of these stores of energy available to cells are not accounted for in any biochemistry book.  Get some sun today to give your genome the day off to rest once in a while.  Your health will benefit if you do.

The POMC system was built in animals before the age of mammals 210 million years ago but mammals refined and now define this ancient light system (controls their entire epigenome) and brought it to prominence in their clade when dinosaurs were dying due to an asteroid collision.

The change in light frequency from this impact is what sculpted mammals to amplify this system.  The POMC system in the mammalian skin and fur was key to their survival.  From this point in their history, they amplified POMC in all neuroectodermal derivatives and this meant they did not need more genes to advance from an evolutionary perspective as all other animals had in the past.

Fast forward 65 million years, and now humans are the trophy “mammal” on Earth.  They are at the top of the food chain of all mammals because of how they have used the POMC system to sculpt their neuroectoderm compared to any other member of the family.  This idea explains a paradox from the human genome project as well.

Scientists were shocked to find humans and primates are almost genetic equivalents.  This goes from primitive primates to humans.  POMC biology explains fully why humans (mammals) have virtually the same number of genes as their recent ancestors.  In the last 2-4 million years homo-sapiens primates have used melanin to sculpt their nervous system using a light-saber from the heavens.  Melanin biology links directly to mitochondrial redox power and this is why the energy power laws still exist in mammals.

At this point, embracing technology and nnEMF is like booking a ticket on the Titanic or getting in the car with Thelma and Louise.   The reality is this: As a result of your awesome internet connection, you’ll get an awesome connection with the hospital too!

Unless humans can make their original adaptations to our environment as rapidly as their science can alter Earth, our culture and society will continue to drive our species to extinction.  The development of a bio-physics understanding of mammalian biology is a critical prescription for the protection of the species requiring the experimental spirit of the modernist vanguard.